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MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts.

Chang EY, Tsai S, Aristizabal MJ, Wells JP, Coulombe Y, Busatto FF, Chan YA, Kumar A, Dan Zhu Y, Wang AY, Fournier LA, Hieter P, Kobor MS, Masson JY, Stirling PC.

Nat Commun. 2019 Sep 19;10(1):4265. doi: 10.1038/s41467-019-12271-w.


MinION-based long-read sequencing and assembly extends the Caenorhabditis elegans reference genome.

Tyson JR, O'Neil NJ, Jain M, Olsen HE, Hieter P, Snutch TP.

Genome Res. 2018 Feb;28(2):266-274. doi: 10.1101/gr.221184.117. Epub 2017 Dec 22.


The Chromosome Transmission Fidelity Assay for Measuring Chromosome Loss in Yeast.

Duffy S, Hieter P.

Methods Mol Biol. 2018;1672:11-19. doi: 10.1007/978-1-4939-7306-4_2.


Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research.

Wangler MF, Yamamoto S, Chao HT, Posey JE, Westerfield M, Postlethwait J; Members of the Undiagnosed Diseases Network (UDN), Hieter P, Boycott KM, Campeau PM, Bellen HJ.

Genetics. 2017 Sep;207(1):9-27. doi: 10.1534/genetics.117.203067. Review.


Synthetic lethality and cancer.

O'Neil NJ, Bailey ML, Hieter P.

Nat Rev Genet. 2017 Oct;18(10):613-623. doi: 10.1038/nrg.2017.47. Epub 2017 Jun 26. Review.


International Cooperation to Enable the Diagnosis of All Rare Genetic Diseases.

Boycott KM, Rath A, Chong JX, Hartley T, Alkuraya FS, Baynam G, Brookes AJ, Brudno M, Carracedo A, den Dunnen JT, Dyke SOM, Estivill X, Goldblatt J, Gonthier C, Groft SC, Gut I, Hamosh A, Hieter P, Höhn S, Hurles ME, Kaufmann P, Knoppers BM, Krischer JP, Macek M Jr, Matthijs G, Olry A, Parker S, Paschall J, Philippakis AA, Rehm HL, Robinson PN, Sham PC, Stefanov R, Taruscio D, Unni D, Vanstone MR, Zhang F, Brunner H, Bamshad MJ, Lochmüller H.

Am J Hum Genet. 2017 May 4;100(5):695-705. doi: 10.1016/j.ajhg.2017.04.003.


CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Xu H, Di Antonio M, McKinney S, Mathew V, Ho B, O'Neil NJ, Santos ND, Silvester J, Wei V, Garcia J, Kabeer F, Lai D, Soriano P, Banáth J, Chiu DS, Yap D, Le DD, Ye FB, Zhang A, Thu K, Soong J, Lin SC, Tsai AH, Osako T, Algara T, Saunders DN, Wong J, Xian J, Bally MB, Brenton JD, Brown GW, Shah SP, Cescon D, Mak TW, Caldas C, Stirling PC, Hieter P, Balasubramanian S, Aparicio S.

Nat Commun. 2017 Feb 17;8:14432. doi: 10.1038/ncomms14432.


Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase.

Ang JS, Duffy S, Segovia R, Stirling PC, Hieter P.

Genetics. 2016 Nov;204(3):975-986. doi: 10.1534/genetics.116.192211. Epub 2016 Aug 31.


Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.

Duffy S, Fam HK, Wang YK, Styles EB, Kim JH, Ang JS, Singh T, Larionov V, Shah SP, Andrews B, Boerkoel CF, Hieter P.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9967-76. doi: 10.1073/pnas.1611839113. Epub 2016 Aug 22.


Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability.

Stirling PC, Hieter P.

J Mol Biol. 2017 Oct 27;429(21):3132-3138. doi: 10.1016/j.jmb.2016.07.014. Epub 2016 Jul 22.


Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants.

Hamza A, Tammpere E, Kofoed M, Keong C, Chiang J, Giaever G, Nislow C, Hieter P.

Genetics. 2015 Nov;201(3):1263-74. doi: 10.1534/genetics.115.181099. Epub 2015 Sep 9.


Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.

Bailey ML, Singh T, Mero P, Moffat J, Hieter P.

Genetics. 2015 Nov;201(3):885-95. doi: 10.1534/genetics.115.180653. Epub 2015 Sep 8.


An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes.

Kofoed M, Milbury KL, Chiang JH, Sinha S, Ben-Aroya S, Giaever G, Nislow C, Hieter P, Stirling PC.

G3 (Bethesda). 2015 Jul 14;5(9):1879-87. doi: 10.1534/g3.115.019174.


Understanding rare disease pathogenesis: a grand challenge for model organisms.

Hieter P, Boycott KM.

Genetics. 2014 Oct;198(2):443-5. doi: 10.1534/genetics.114.170217.


Mechanisms of genome instability induced by RNA-processing defects.

Chan YA, Hieter P, Stirling PC.

Trends Genet. 2014 Jun;30(6):245-53. doi: 10.1016/j.tig.2014.03.005. Epub 2014 May 1. Review.


Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip.

Chan YA, Aristizabal MJ, Lu PY, Luo Z, Hamza A, Kobor MS, Stirling PC, Hieter P.

PLoS Genet. 2014 Apr 17;10(4):e1004288. doi: 10.1371/journal.pgen.1004288. eCollection 2014 Apr.


Synthetic cytotoxicity: digenic interactions with TEL1/ATM mutations reveal sensitivity to low doses of camptothecin.

Li X, O'Neil NJ, Moshgabadi N, Hieter P.

Genetics. 2014 Jun;197(2):611-23. doi: 10.1534/genetics.114.161307. Epub 2014 Mar 20.


An E4 ligase facilitates polyubiquitination of plant immune receptor resistance proteins in Arabidopsis.

Huang Y, Minaker S, Roth C, Huang S, Hieter P, Lipka V, Wiermer M, Li X.

Plant Cell. 2014 Jan;26(1):485-96. doi: 10.1105/tpc.113.119057. Epub 2014 Jan 21.


Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition.

Bailey ML, O'Neil NJ, van Pel DM, Solomon DA, Waldman T, Hieter P.

Mol Cancer Ther. 2014 Mar;13(3):724-32. doi: 10.1158/1535-7163.MCT-13-0749. Epub 2013 Dec 19.


Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae.

Stirling PC, Shen Y, Corbett R, Jones SJ, Hieter P.

Genetics. 2014 Feb;196(2):403-12. doi: 10.1534/genetics.113.159806. Epub 2013 Dec 13.


Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells.

Sajesh BV, Bailey M, Lichtensztejn Z, Hieter P, McManus KJ.

Genetics. 2013 Nov;195(3):757-67. doi: 10.1534/genetics.113.156836. Epub 2013 Sep 3.


The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity.

Bhavsar AP, Brown NF, Stoepel J, Wiermer M, Martin DD, Hsu KJ, Imami K, Ross CJ, Hayden MR, Foster LJ, Li X, Hieter P, Finlay BB.

PLoS Pathog. 2013;9(7):e1003518. doi: 10.1371/journal.ppat.1003518. Epub 2013 Jul 25.


From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II.

Braberg H, Jin H, Moehle EA, Chan YA, Wang S, Shales M, Benschop JJ, Morris JH, Qiu C, Hu F, Tang LK, Fraser JS, Holstege FC, Hieter P, Guthrie C, Kaplan CD, Krogan NJ.

Cell. 2013 Aug 15;154(4):775-88. doi: 10.1016/j.cell.2013.07.033. Epub 2013 Aug 8.


Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A.

Price JC, Pollock LM, Rudd ML, Fogoros SK, Mohamed H, Hanigan CL, Le Gallo M; NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Zhang S, Cruz P, Cherukuri PF, Hansen NF, McManus KJ, Godwin AK, Sgroi DC, Mullikin JC, Merino MJ, Hieter P, Bell DW.

PLoS One. 2013 Jun 3;8(6):e63313. doi: 10.1371/journal.pone.0063313. Print 2014.


The 2013 Thomas Hunt Morgan Medal: Thomas Douglas Petes.

Jinks-Robertson S, Hieter P.

Genetics. 2013 May;194(1):1-4. doi: 10.1534/genetics.113.150664.


Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.

van Pel DM, Stirling PC, Minaker SW, Sipahimalani P, Hieter P.

G3 (Bethesda). 2013 Feb;3(2):273-82. doi: 10.1534/g3.112.004754. Epub 2013 Feb 1.


An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.

van Pel DM, Barrett IJ, Shimizu Y, Sajesh BV, Guppy BJ, Pfeifer T, McManus KJ, Hieter P.

PLoS Genet. 2013;9(1):e1003254. doi: 10.1371/journal.pgen.1003254. Epub 2013 Jan 31. Erratum in: PLoS Genet. 2013 Feb;9(2). doi: 10.1371/annotation/a26cb527-ec18-46ec-a63f-c69d0983add6.


Synthetic lethality and cancer: cohesin and PARP at the replication fork.

O'Neil NJ, van Pel DM, Hieter P.

Trends Genet. 2013 May;29(5):290-7. doi: 10.1016/j.tig.2012.12.004. Epub 2013 Jan 18. Review.


Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.

Minaker SW, Filiatrault MC, Ben-Aroya S, Hieter P, Stirling PC.

Genetics. 2013 Mar;193(3):853-64. doi: 10.1534/genetics.112.148726. Epub 2012 Dec 24.


Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.

Le Gallo M, O'Hara AJ, Rudd ML, Urick ME, Hansen NF, O'Neil NJ, Price JC, Zhang S, England BM, Godwin AK, Sgroi DC; NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Hieter P, Mullikin JC, Merino MJ, Bell DW.

Nat Genet. 2012 Dec;44(12):1310-5. doi: 10.1038/ng.2455. Epub 2012 Oct 28.


Synthetic lethality of cohesins with PARPs and replication fork mediators.

McLellan JL, O'Neil NJ, Barrett I, Ferree E, van Pel DM, Ushey K, Sipahimalani P, Bryan J, Rose AM, Hieter P.

PLoS Genet. 2012;8(3):e1002574. doi: 10.1371/journal.pgen.1002574. Epub 2012 Mar 8.


G3, GENETICS, and the GSA: Two Journals, One Mission.

Andrews BJ, Johnston M, Hawley RS, Sternberg PW, Hieter P, Schedl T.

G3 (Bethesda). 2011 Sep;1(4):245-6. doi: 10.1534/g3.111.000877. Epub 2011 Sep 1. No abstract available.


R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.

Stirling PC, Chan YA, Minaker SW, Aristizabal MJ, Barrett I, Sipahimalani P, Kobor MS, Hieter P.

Genes Dev. 2012 Jan 15;26(2):163-75. doi: 10.1101/gad.179721.111.


Mutability and mutational spectrum of chromosome transmission fidelity genes.

Stirling PC, Crisp MJ, Basrai MA, Tucker CM, Dunham MJ, Spencer FA, Hieter P.

Chromosoma. 2012 Jun;121(3):263-75. doi: 10.1007/s00412-011-0356-3. Epub 2011 Dec 24.


G3, GENETICS, and the GSA: Two Journals, One Mission.

Johnston M, Andrews BJ, Hawley RS, Sternberg PW, Hieter P, Schedl T.

Genetics. 2011 Sep;189(1):1-2. doi: 10.1534/genetics.111.133777. No abstract available.


Predisposition to cancer caused by genetic and functional defects of mammalian Atad5.

Bell DW, Sikdar N, Lee KY, Price JC, Chatterjee R, Park HD, Fox J, Ishiai M, Rudd ML, Pollock LM, Fogoros SK, Mohamed H, Hanigan CL; NISC Comparative Sequencing Program, Zhang S, Cruz P, Renaud G, Hansen NF, Cherukuri PF, Borate B, McManus KJ, Stoepel J, Sipahimalani P, Godwin AK, Sgroi DC, Merino MJ, Elliot G, Elkahloun A, Vinson C, Takata M, Mullikin JC, Wolfsberg TG, Hieter P, Lim DS, Myung K.

PLoS Genet. 2011 Aug;7(8):e1002245. doi: 10.1371/journal.pgen.1002245. Epub 2011 Aug 25.


The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components.

Stirling PC, Bloom MS, Solanki-Patil T, Smith S, Sipahimalani P, Li Z, Kofoed M, Ben-Aroya S, Myung K, Hieter P.

PLoS Genet. 2011 Apr;7(4):e1002057. doi: 10.1371/journal.pgen.1002057. Epub 2011 Apr 28.


YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification.

Davies AH, Barrett I, Pambid MR, Hu K, Stratford AL, Freeman S, Berquin IM, Pelech S, Hieter P, Maxwell C, Dunn SE.

Oncogene. 2011 Aug 25;30(34):3649-60. doi: 10.1038/onc.2011.82. Epub 2011 Mar 21.


Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair.

Fridman Y, Palgi N, Dovrat D, Ben-Aroya S, Hieter P, Aharoni A.

PLoS Biol. 2010 Oct 12;8(10):e1000507. doi: 10.1371/journal.pbio.1000507.


Making temperature-sensitive mutants.

Ben-Aroya S, Pan X, Boeke JD, Hieter P.

Methods Enzymol. 2010;470:181-204. doi: 10.1016/S0076-6879(10)70008-2. Epub 2010 Mar 1.


Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.

Ben-Aroya S, Agmon N, Yuen K, Kwok T, McManus K, Kupiec M, Hieter P.

PLoS Genet. 2010 Feb 19;6(2):e1000852. doi: 10.1371/journal.pgen.1000852.


Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target.

McLellan J, O'Neil N, Tarailo S, Stoepel J, Bryan J, Rose A, Hieter P.

Mol Biol Cell. 2009 Dec;20(24):5306-13. doi: 10.1091/mbc.E09-08-0699.


Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.

McManus KJ, Barrett IJ, Nouhi Y, Hieter P.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3276-81. doi: 10.1073/pnas.0813414106. Epub 2009 Feb 13.


Correlation between the secondary structure of pre-mRNA introns and the efficiency of splicing in Saccharomyces cerevisiae.

Rogic S, Montpetit B, Hoos HH, Mackworth AK, Ouellette BF, Hieter P.

BMC Genomics. 2008 Jul 29;9:355. doi: 10.1186/1471-2164-9-355.


Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae.

Ben-Aroya S, Coombes C, Kwok T, O'Donnell KA, Boeke JD, Hieter P.

Mol Cell. 2008 Apr 25;30(2):248-58. doi: 10.1016/j.molcel.2008.02.021.


Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.

Barber TD, McManus K, Yuen KW, Reis M, Parmigiani G, Shen D, Barrett I, Nouhi Y, Spencer F, Markowitz S, Velculescu VE, Kinzler KW, Vogelstein B, Lengauer C, Hieter P.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3443-8. doi: 10.1073/pnas.0712384105. Epub 2008 Feb 25.


Systematic genome instability screens in yeast and their potential relevance to cancer.

Yuen KW, Warren CD, Chen O, Kwok T, Hieter P, Spencer FA.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3925-30. Epub 2007 Feb 28.


Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map.

Collins SR, Miller KM, Maas NL, Roguev A, Fillingham J, Chu CS, Schuldiner M, Gebbia M, Recht J, Shales M, Ding H, Xu H, Han J, Ingvarsdottir K, Cheng B, Andrews B, Boone C, Berger SL, Hieter P, Zhang Z, Brown GW, Ingles CJ, Emili A, Allis CD, Toczyski DP, Weissman JS, Greenblatt JF, Krogan NJ.

Nature. 2007 Apr 12;446(7137):806-10. Epub 2007 Feb 21.


The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3.

Martin DG, Baetz K, Shi X, Walter KL, MacDonald VE, Wlodarski MJ, Gozani O, Hieter P, Howe L.

Mol Cell Biol. 2006 Nov;26(21):7871-9. Epub 2006 Aug 21.


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