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Items: 1 to 50 of 78

1.

Water-in-Oil-Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6-Dependent Pathway.

Riteau N, Radtke AJ, Shenderov K, Mittereder L, Oland SD, Hieny S, Jankovic D, Sher A.

J Immunol. 2016 Nov 15;197(10):3884-3893. Epub 2016 Oct 17.

2.

The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.

Tosh KW, Mittereder L, Bonne-Annee S, Hieny S, Nutman TB, Singer SM, Sher A, Jankovic D.

J Immunol. 2016 Jan 1;196(1):345-56. doi: 10.4049/jimmunol.1501558. Epub 2015 Nov 23.

3.

Cutting edge: Endoplasmic reticulum stress licenses macrophages to produce mature IL-1β in response to TLR4 stimulation through a caspase-8- and TRIF-dependent pathway.

Shenderov K, Riteau N, Yip R, Mayer-Barber KD, Oland S, Hieny S, Fitzgerald P, Oberst A, Dillon CP, Green DR, Cerundolo V, Sher A.

J Immunol. 2014 Mar 1;192(5):2029-2033. doi: 10.4049/jimmunol.1302549. Epub 2014 Jan 31.

4.

Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.

Shenderov K, Barber DL, Mayer-Barber KD, Gurcha SS, Jankovic D, Feng CG, Oland S, Hieny S, Caspar P, Yamasaki S, Lin X, Ting JP, Trinchieri G, Besra GS, Cerundolo V, Sher A.

J Immunol. 2013 Jun 1;190(11):5722-30. doi: 10.4049/jimmunol.1203343. Epub 2013 Apr 29.

5.

Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.

Koblansky AA, Jankovic D, Oh H, Hieny S, Sungnak W, Mathur R, Hayden MS, Akira S, Sher A, Ghosh S.

Immunity. 2013 Jan 24;38(1):119-30. doi: 10.1016/j.immuni.2012.09.016. Epub 2012 Dec 13.

6.

NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection.

Goldszmid RS, Caspar P, Rivollier A, White S, Dzutsev A, Hieny S, Kelsall B, Trinchieri G, Sher A.

Immunity. 2012 Jun 29;36(6):1047-59. doi: 10.1016/j.immuni.2012.03.026.

7.

Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.

Mayer-Barber KD, Andrade BB, Barber DL, Hieny S, Feng CG, Caspar P, Oland S, Gordon S, Sher A.

Immunity. 2011 Dec 23;35(6):1023-34. doi: 10.1016/j.immuni.2011.12.002.

8.

Th1-driven immune reconstitution disease in Mycobacterium avium-infected mice.

Barber DL, Mayer-Barber KD, Antonelli LR, Wilson MS, White S, Caspar P, Hieny S, Sereti I, Sher A.

Blood. 2010 Nov 4;116(18):3485-93. doi: 10.1182/blood-2010-05-286336. Epub 2010 Jul 23.

9.

Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo.

Mayer-Barber KD, Barber DL, Shenderov K, White SD, Wilson MS, Cheever A, Kugler D, Hieny S, Caspar P, Núñez G, Schlueter D, Flavell RA, Sutterwala FS, Sher A.

J Immunol. 2010 Apr 1;184(7):3326-30. doi: 10.4049/jimmunol.0904189. Epub 2010 Mar 3.

10.

Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo.

Sassi A, Brichacek B, Hieny S, Yarovinsky F, Golding H, Grivel JC, Sher A, Margolis L.

Microbes Infect. 2009 Dec;11(14-15):1106-13. doi: 10.1016/j.micinf.2009.08.004. Epub 2009 Aug 9.

11.

Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology.

Yarovinsky F, Hieny S, Sher A.

J Immunol. 2008 Dec 15;181(12):8478-84.

12.

The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death.

Feng CG, Zheng L, Jankovic D, Báfica A, Cannons JL, Watford WT, Chaussabel D, Hieny S, Caspar P, Schwartzberg PL, Lenardo MJ, Sher A.

Nat Immunol. 2008 Nov;9(11):1279-87. doi: 10.1038/ni.1653. Epub 2008 Sep 21.

13.

NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis.

Feng CG, Kaviratne M, Rothfuchs AG, Cheever A, Hieny S, Young HA, Wynn TA, Sher A.

J Immunol. 2006 Nov 15;177(10):7086-93.

14.

Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response.

Yarovinsky F, Kanzler H, Hieny S, Coffman RL, Sher A.

Immunity. 2006 Oct;25(4):655-64. Epub 2006 Sep 28.

15.
16.

TLR11 activation of dendritic cells by a protozoan profilin-like protein.

Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A.

Science. 2005 Jun 10;308(5728):1626-9. Epub 2005 Apr 28.

17.

Maintenance of pulmonary Th1 effector function in chronic tuberculosis requires persistent IL-12 production.

Feng CG, Jankovic D, Kullberg M, Cheever A, Scanga CA, Hieny S, Caspar P, Yap GS, Sher A.

J Immunol. 2005 Apr 1;174(7):4185-92.

20.

Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia.

Feng CG, Collazo-Custodio CM, Eckhaus M, Hieny S, Belkaid Y, Elkins K, Jankovic D, Taylor GA, Sher A.

J Immunol. 2004 Jan 15;172(2):1163-8.

22.
23.

Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells.

Aliberti J, Valenzuela JG, Carruthers VB, Hieny S, Andersen J, Charest H, Reis e Sousa C, Fairlamb A, Ribeiro JM, Sher A.

Nat Immunol. 2003 May;4(5):485-90. Epub 2003 Mar 31.

PMID:
12665855
25.
26.

Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity.

Aliberti J, Hieny S, Reis e Sousa C, Serhan CN, Sher A.

Nat Immunol. 2002 Jan;3(1):76-82. Epub 2001 Dec 17.

PMID:
11743584
27.

CCR5 provides a signal for microbial induced production of IL-12 by CD8 alpha+ dendritic cells.

Aliberti J, Reis e Sousa C, Schito M, Hieny S, Wells T, Huffnagle GB, Sher A.

Nat Immunol. 2000 Jul;1(1):83-7.

PMID:
10881180
28.

Host resistance and immune deviation in pigeon cytochrome c T-cell receptor transgenic mice infected with Toxoplasma gondii.

Collazo CM, Miller C, Yap G, Hieny S, Caspar P, Schwartz RH, Sher A.

Infect Immun. 2000 May;68(5):2713-9.

29.

Paralysis of dendritic cell IL-12 production by microbial products prevents infection-induced immunopathology.

Reis e Sousa C, Yap G, Schulz O, Rogers N, Schito M, Aliberti J, Hieny S, Sher A.

Immunity. 1999 Nov;11(5):637-47.

30.

The role of dendritic cells in the initiation of host resistance to Toxoplasma gondii.

Sher A, Hieny S, Charest H, Scharton-Kersten T, Collazo C, Germain RN, Reis e Sousa C.

Adv Exp Med Biol. 1998;452:103-10. Review. No abstract available.

PMID:
9889964
31.

Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms.

Jankovic D, Wynn TA, Kullberg MC, Hieny S, Caspar P, James S, Cheever AW, Sher A.

J Immunol. 1999 Jan 1;162(1):345-51.

32.

Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism.

Kullberg MC, Ward JM, Gorelick PL, Caspar P, Hieny S, Cheever A, Jankovic D, Sher A.

Infect Immun. 1998 Nov;66(11):5157-66.

33.
34.

IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease.

Wynn TA, Cheever AW, Williams ME, Hieny S, Caspar P, Kühn R, Müller W, Sher A.

J Immunol. 1998 May 1;160(9):4473-80.

35.

In vivo microbial stimulation induces rapid CD40 ligand-independent production of interleukin 12 by dendritic cells and their redistribution to T cell areas.

Reis e Sousa C, Hieny S, Scharton-Kersten T, Jankovic D, Charest H, Germain RN, Sher A.

J Exp Med. 1997 Dec 1;186(11):1819-29.

36.

Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.

Wynn TA, Morawetz R, Scharton-Kersten T, Hieny S, Morse HC 3rd, Kühn R, Müller W, Cheever AW, Sher A.

J Immunol. 1997 Nov 15;159(10):5014-23.

PMID:
9366429
37.

Identification and characterization of protozoan products that trigger the synthesis of IL-12 by inflammatory macrophages.

Gazzinelli RT, Camargo MM, Almeida IC, Morita YS, Giraldo M, Acosta-Serrano A, Hieny S, Englund PT, Ferguson MA, Travassos LR, Sher A.

Chem Immunol. 1997;68:136-52. Review. No abstract available.

PMID:
9329220
38.
39.

IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite.

Wynn TA, Reynolds A, James S, Cheever AW, Caspar P, Hieny S, Jankovic D, Strand M, Sher A.

J Immunol. 1996 Nov 1;157(9):4068-78.

PMID:
8892641
40.

In the absence of endogenous IFN-gamma, mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection.

Scharton-Kersten TM, Wynn TA, Denkers EY, Bala S, Grunvald E, Hieny S, Gazzinelli RT, Sher A.

J Immunol. 1996 Nov 1;157(9):4045-54.

PMID:
8892638
41.

In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

Gazzinelli RT, Wysocka M, Hieny S, Scharton-Kersten T, Cheever A, Kühn R, Müller W, Trinchieri G, Sher A.

J Immunol. 1996 Jul 15;157(2):798-805.

PMID:
8752931
42.

Biochemical characterization and protein kinase C dependency of monokine-inducing activities of Toxoplasma gondii.

Grunvald E, Chiaramonte M, Hieny S, Wysocka M, Trinchieri G, Vogel SN, Gazzinelli RT, Sher A.

Infect Immun. 1996 Jun;64(6):2010-8.

43.

Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice.

Carrera L, Gazzinelli RT, Badolato R, Hieny S, Muller W, Kuhn R, Sacks DL.

J Exp Med. 1996 Feb 1;183(2):515-26.

44.
45.
46.

IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma.

Wynn TA, Jankovic D, Hieny S, Zioncheck K, Jardieu P, Cheever AW, Sher A.

J Immunol. 1995 Apr 15;154(8):3999-4009.

PMID:
7706739
47.

Linked in vivo expression of soluble interleukin-4 receptor and interleukin-4 in murine schistosomiasis.

Fernandez-Botran R, Wynn TA, Hieny S, Caspar P, Chilton PM, Sher A.

Eur J Immunol. 1995 Mar;25(3):649-56.

PMID:
7705393
48.

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

Gazzinelli RT, Wysocka M, Hayashi S, Denkers EY, Hieny S, Caspar P, Trinchieri G, Sher A.

J Immunol. 1994 Sep 15;153(6):2533-43.

PMID:
7915739
49.

Anti-IL-4 treatment of Schistosoma mansoni-infected mice inhibits development of T cells and non-B, non-T cells expressing Th2 cytokines while decreasing egg-induced hepatic fibrosis.

Cheever AW, Williams ME, Wynn TA, Finkelman FD, Seder RA, Cox TM, Hieny S, Caspar P, Sher A.

J Immunol. 1994 Jul 15;153(2):753-9.

PMID:
8021510
50.

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