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In vitro modelling of alveolar repair at the air-liquid interface using alveolar epithelial cells derived from human induced pluripotent stem cells.

van Riet S, Ninaber DK, Mikkers HMM, Tetley TD, Jost CR, Mulder AA, Pasman T, Baptista D, Poot AA, Truckenmüller R, Mummery CL, Freund C, Rottier RJ, Hiemstra PS.

Sci Rep. 2020 Mar 26;10(1):5499. doi: 10.1038/s41598-020-62226-1.


ERS International Congress, Madrid, 2019: highlights from the Basic and Translational Science Assembly.

Ubags ND, Baker J, Boots A, Costa R, El-Merhie N, Fabre A, Faiz A, Heijink IH, Hiemstra PS, Lehmann M, Meiners S, Rolandsson Enes S, Bartel S.

ERJ Open Res. 2020 Mar 2;6(1). pii: 00350-2019. doi: 10.1183/23120541.00350-2019. eCollection 2020 Jan. Review.


Tumor mutational load, CD8+ T cells, expression of PD-L1 and HLA class I to guide immunotherapy decisions in NSCLC patients.

Hurkmans DP, Kuipers ME, Smit J, van Marion R, Mathijssen RHJ, Postmus PE, Hiemstra PS, Aerts JGJV, von der Thüsen JH, van der Burg SH.

Cancer Immunol Immunother. 2020 Feb 12. doi: 10.1007/s00262-020-02506-x. [Epub ahead of print]


Modulating local airway immune responses to treat allergic asthma: lessons from experimental models and human studies.

Voskamp AL, Kormelink TG, van Wijk RG, Hiemstra PS, Taube C, de Jong EC, Smits HH.

Semin Immunopathol. 2020 Feb;42(1):95-110. doi: 10.1007/s00281-020-00782-4. Epub 2020 Feb 4. Review.


Author Correction: Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells.

Ali MN, Mori M, Mertens TCJ, Siddhuraj P, Erjefält JS, Önnerfjord P, Hiemstra PS, Egesten A.

Sci Rep. 2020 Jan 15;10(1):754. doi: 10.1038/s41598-020-57447-3.


Innate Immunity of the Lung.

Greene CM, Hiemstra PS.

J Innate Immun. 2020;12(1):1-3. doi: 10.1159/000504621. Epub 2019 Dec 4. No abstract available.


Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease.

Aghapour M, Remels AHV, Pouwels SD, Bruder D, Hiemstra PS, Cloonan SM, Heijink IH.

Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L149-L164. doi: 10.1152/ajplung.00329.2019. Epub 2019 Nov 6.


Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells.

Ali MN, Mori M, Mertens TCJ, Siddhuraj P, Erjefält JS, Önnerfjord P, Hiemstra PS, Egesten A.

Sci Rep. 2019 Oct 29;9(1):15566. doi: 10.1038/s41598-019-52208-3. Erratum in: Sci Rep. 2020 Jan 15;10(1):754.


The respiratory virome and exacerbations in patients with chronic obstructive pulmonary disease.

van Rijn AL, van Boheemen S, Sidorov I, Carbo EC, Pappas N, Mei H, Feltkamp M, Aanerud M, Bakke P, Claas ECJ, Eagan TM, Hiemstra PS, Kroes ACM, de Vries JJC.

PLoS One. 2019 Oct 24;14(10):e0223952. doi: 10.1371/journal.pone.0223952. eCollection 2019.


Translation of in vitro findings to patients with asthma: a timely and compelling challenge.

Hiemstra PS, Sterk PJ.

Eur Respir J. 2019 Oct 10;54(4). pii: 1901759. doi: 10.1183/13993003.01759-2019. Print 2019 Oct. No abstract available.


Perioperative proADM-change is associated with the development of acute respiratory distress syndrome in critically ill cardiac surgery patients: a prospective cohort study.

van Paassen J, van Dissel JT, Hiemstra PS, Zwaginga JJ, Cobbaert CM, Juffermans NP, de Wilde RB, Stijnen T, de Jonge E, Klautz RJ, Arbous MS.

Biomark Med. 2019 Sep;13(13):1081-1091. doi: 10.2217/bmm-2019-0028. Epub 2019 Sep 23.


Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients.

Tangedal S, Nielsen R, Aanerud M, Persson LJ, Wiker HG, Bakke PS, Hiemstra PS, Eagan TM.

PLoS One. 2019 Sep 17;14(9):e0222449. doi: 10.1371/journal.pone.0222449. eCollection 2019.


Airway and alveolar epithelial cells in culture.

Hiemstra PS, Tetley TD, Janes SM.

Eur Respir J. 2019 Nov 7;54(5). pii: 1900742. doi: 10.1183/13993003.00742-2019. Print 2019 Nov. No abstract available.


Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma.

George L, Taylor AR, Esteve-Codina A, Soler Artigas M, Thun GA, Bates S, Pavlidis S, Wagers S, Boland A, Prasse A, Boschetto P, Parr DG, Nowinski A, Barta I, Hohlfeld J, Greulich T, van den Berge M, Hiemstra PS, Timens W, Hinks T, Wenzel S, Siddiqui S, Richardson M, Venge P, Heath S, Gut I, Tobin MD, Edwards L, Riley JH, Djukanovic R, Auffray C, De-Meulder B, Erik-Dahlen S, Adcock IM, Chung KF, Ziegler-Heitbrock L, Sterk PJ, Singh D, Brightling CE; U-BIOPRED and the EvA study teams.

Allergy. 2020 Feb;75(2):370-380. doi: 10.1111/all.14016. Epub 2019 Sep 10.


Extract of Helicobacter pylori Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia following Repeated Allergen Exposure.

van Wijck Y, John-Schuster G, van Schadewijk A, van den Oever RL, Obieglo K, Hiemstra PS, Müller A, Smits HH, Taube C.

Int Arch Allergy Immunol. 2019;180(1):1-9. doi: 10.1159/000500598. Epub 2019 Jun 26.


Prediction of Airflow Obstruction and the Risk of Complications in Morbidly Obese Patients Undergoing Bariatric Surgery.

Türk Y, Singh HK, van Huisstede A, Birnie E, Biter U, Hiemstra PS, Braunstahl GJ.

Obes Surg. 2019 Sep;29(9):3076-3080. doi: 10.1007/s11695-019-03941-1.


From the pathophysiology of the human lung alveolus to epigenetic editing: Congress 2018 highlights from ERS Assembly 3 "Basic and Translational Science."

Nikolić MZ, Garrido-Martin EM, Greiffo FR, Fabre A, Heijink IH, Boots A, Greene CM, Hiemstra PS, Bartel S.

ERJ Open Res. 2019 May 10;5(2). pii: 00194-2018. doi: 10.1183/23120541.00194-2018. eCollection 2019 Apr. Review.


Macrophage function in chronic obstructive pulmonary disease: The many faces of notch signalling.

Hiemstra PS.

EBioMedicine. 2019 May;43:22-23. doi: 10.1016/j.ebiom.2019.04.035. Epub 2019 Apr 30. No abstract available.


Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects.

van der Does AM, Hiemstra PS, Mookherjee N.

Adv Exp Med Biol. 2019;1117:149-171. doi: 10.1007/978-981-13-3588-4_10. Review.


TGF-β1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms.

Schrumpf JA, Ninaber DK, van der Does AM, Hiemstra PS.

J Innate Immun. 2020;12(1):74-89. doi: 10.1159/000497415. Epub 2019 Apr 10.


TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.

Ng-Blichfeldt JP, de Jong T, Kortekaas RK, Wu X, Lindner M, Guryev V, Hiemstra PS, Stolk J, Königshoff M, Gosens R.

Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1;317(1):L14-L28. doi: 10.1152/ajplung.00400.2018. Epub 2019 Apr 10.


Effect of long-term corticosteroid treatment on microRNA and gene-expression profiles in COPD.

Faiz A, Steiling K, Roffel MP, Postma DS, Spira A, Lenburg ME, Borggrewe M, Eijgenraam TR, Jonker MR, Koppelman GH, Pouwels SD, Liu G, Alekseyev YO, Lam S, Hiemstra PS, Sterk PJ, Timens W, Brandsma CA, Heijink IH, van den Berge M.

Eur Respir J. 2019 Apr 25;53(4). pii: 1801202. doi: 10.1183/13993003.01202-2018. Print 2019 Apr.


Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls.

van der Does AM, Heijink M, Mayboroda OA, Persson LJ, Aanerud M, Bakke P, Eagan TM, Hiemstra PS, Giera M.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):224-233. doi: 10.1016/j.bbalip.2018.11.012. Epub 2018 Dec 5.


How to write a response to the reviewers of your manuscript.

Hiemstra PS.

Breathe (Sheff). 2018 Dec;14(4):319-321. doi: 10.1183/20734735.025818.


Electronic cigarettes: a task force report from the European Respiratory Society.

Bals R, Boyd J, Esposito S, Foronjy R, Hiemstra PS, Jiménez-Ruiz CA, Katsaounou P, Lindberg A, Metz C, Schober W, Spira A, Blasi F.

Eur Respir J. 2019 Jan 31;53(2). pii: 1801151. doi: 10.1183/13993003.01151-2018. Print 2019 Feb.


An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R 3rd, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG.

J Clin Invest. 2019 Jan 2;129(1):169-181. doi: 10.1172/JCI121087. Epub 2018 Nov 26.


Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.

Ng-Blichfeldt JP, Schrik A, Kortekaas RK, Noordhoek JA, Heijink IH, Hiemstra PS, Stolk J, Königshoff M, Gosens R.

EBioMedicine. 2018 Oct;36:461-474. doi: 10.1016/j.ebiom.2018.09.002. Epub 2018 Sep 17.


microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.

Tasena H, Faiz A, Timens W, Noordhoek J, Hylkema MN, Gosens R, Hiemstra PS, Spira A, Postma DS, Tew GW, Grimbaldeston MA, van den Berge M, Heijink IH, Brandsma CA.

Eur Respir J. 2018 Sep 6;52(3). pii: 1701556. doi: 10.1183/13993003.01556-2017. Print 2018 Sep.


Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases.

van der Does AM, Amatngalim GD, Keijser B, Hiemstra PS, Villenave R.

Vaccines (Basel). 2018 Jul 28;6(3). pii: E49. doi: 10.3390/vaccines6030049. Review.


Stem cell-based Lung-on-Chips: The best of both worlds?

Nawroth JC, Barrile R, Conegliano D, van Riet S, Hiemstra PS, Villenave R.

Adv Drug Deliv Rev. 2019 Feb 1;140:12-32. doi: 10.1016/j.addr.2018.07.005. Epub 2018 Jul 25. Review.


Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D3 as host directed therapy.

Rekha RS, Mily A, Sultana T, Haq A, Ahmed S, Mostafa Kamal SM, van Schadewijk A, Hiemstra PS, Gudmundsson GH, Agerberth B, Raqib R.

BMC Infect Dis. 2018 Jul 4;18(1):303. doi: 10.1186/s12879-018-3203-9.


Serum periostin does not reflect type 2-driven inflammation in COPD.

Carpaij OA, Muntinghe FOW, Wagenaar MB, Habing JW, Timens W, Kerstjens HAM, Nawijn MC, Kunz LIZ, Hiemstra PS, Tew GW, Holweg CTJ, Brandsma CA, van den Berge M.

Respir Res. 2018 Jun 7;19(1):112. doi: 10.1186/s12931-018-0818-8.


Immunomodulatory innate defence regulator (IDR) peptide alleviates airway inflammation and hyper-responsiveness.

Piyadasa H, Hemshekhar M, Altieri A, Basu S, van der Does AM, Halayko AJ, Hiemstra PS, Mookherjee N.

Thorax. 2018 Oct;73(10):908-917. doi: 10.1136/thoraxjnl-2017-210739. Epub 2018 May 31.


Aerobic Exercise Protects from Pseudomonas aeruginosa-Induced Pneumonia in Elderly Mice.

Stravinskas Durigon T, MacKenzie B, Carneiro Oliveira-Junior M, Santos-Dias A, De Angelis K, Malfitano C, Kelly da Palma R, Moreno Guerra J, Damaceno-Rodrigues NR, Garcia Caldini E, de Almeida FM, Aquino-Santos HC, Rigonato-Oliveira NC, Leal de Oliveira DB, Aimbire F, Ligeiro de Oliveira AP, Franco de Oliveira LV, Durigon EL, Hiemstra PS, Vieira RP.

J Innate Immun. 2018;10(4):279-290. doi: 10.1159/000488953. Epub 2018 May 29.


A novel method for expansion and differentiation of mouse tracheal epithelial cells in culture.

Eenjes E, Mertens TCJ, Buscop-van Kempen MJ, van Wijck Y, Taube C, Rottier RJ, Hiemstra PS.

Sci Rep. 2018 May 9;8(1):7349. doi: 10.1038/s41598-018-25799-6.


Basic and translational research in the European Respiratory Journal.

Farré R, Hiemstra PS, Dinh-Xuan AT.

Eur Respir J. 2018 May 3;51(5). pii: 1800377. doi: 10.1183/13993003.00377-2018. Print 2018 May. No abstract available.


Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD.

Hartjes FJ, Vonk JM, Faiz A, Hiemstra PS, Lapperre TS, Kerstjens HAM, Postma DS, van den Berge M; Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group.

Respirology. 2018 Nov;23(11):1023-1031. doi: 10.1111/resp.13312. Epub 2018 Apr 26.


Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease.

Amatngalim GD, Hiemstra PS.

Chin Med J (Engl). 2018 May 5;131(9):1099-1107. doi: 10.4103/0366-6999.230743. No abstract available.


Response to Comment on "Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease".

van Wijck Y, Hiemstra PS, Taube C.

J Immunol. 2018 May 1;200(9):3027-3028. doi: 10.4049/jimmunol.1800260. No abstract available.


Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?

Broekman W, Khedoe PPSJ, Schepers K, Roelofs H, Stolk J, Hiemstra PS.

Thorax. 2018 Jun;73(6):565-574. doi: 10.1136/thoraxjnl-2017-210672. Epub 2018 Apr 13. Review.


Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence.

Amatngalim GD, Schrumpf JA, Dishchekenian F, Mertens TCJ, Ninaber DK, van der Linden AC, Pilette C, Taube C, Hiemstra PS, van der Does AM.

Eur Respir J. 2018 Apr 26;51(4). pii: 1701009. doi: 10.1183/13993003.01009-2017. Print 2018 Apr.


Effects of E-Cigarette Use on Human Lung Tissue. On Harm Reduction and Causing Harm.

Hiemstra PS, Bals R.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):6-7. doi: 10.1164/rccm.201802-0299ED. No abstract available.


Assembly 3: Basic and Translational Sciences.

Greene CM, Hiemstra PS.

Breathe (Sheff). 2018 Mar;14(1):67-68. doi: 10.1183/20734735.020017.


Farm dust reduces viral load in human bronchial epithelial cells by increasing barrier function and antiviral responses.

van der Vlugt LEPM, Eger K, Müller C, Ninaber DK, Zarcone MC, Amatngalim GD, Bracher F, von Mutius E, Smits HH, Hiemstra PS.

J Allergy Clin Immunol. 2018 May;141(5):1949-1952.e8. doi: 10.1016/j.jaci.2018.01.025. Epub 2018 Feb 7. No abstract available.


Effect of diesel exhaust generated by a city bus engine on stress responses and innate immunity in primary bronchial epithelial cell cultures.

Zarcone MC, Duistermaat E, Alblas MJ, van Schadewijk A, Ninaber DK, Clarijs V, Moerman MM, Vaessen D, Hiemstra PS, Kooter IM.

Toxicol In Vitro. 2018 Apr;48:221-231. doi: 10.1016/j.tiv.2018.01.024.


Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease.

van Wijck Y, de Kleijn S, John-Schuster G, Mertens TCJ, Hiemstra PS, Müller A, Smits HH, Taube C.

J Immunol. 2018 Mar 1;200(5):1570-1579. doi: 10.4049/jimmunol.1700987. Epub 2018 Jan 19.


Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population.

Rafiq R, Thijs W, Prein R, de Jongh RT, Taube C, Hiemstra PS, de Mutsert R, den Heijer M.

Nutrients. 2018 Jan 3;10(1). pii: E35. doi: 10.3390/nu10010035.


Pulmonary function, exhaled nitric oxide and symptoms in asthma patients with obesity: a cross-sectional study.

Kasteleyn MJ, Bonten TN, de Mutsert R, Thijs W, Hiemstra PS, le Cessie S, Rosendaal FR, Chavannes NH, Taube C.

Respir Res. 2017 Dec 7;18(1):205. doi: 10.1186/s12931-017-0684-9.


Reprogramming of cellular metabolism: driver for airway remodelling in COPD?

Hiemstra PS, van der Does AM.

Eur Respir J. 2017 Nov 30;50(5). pii: 1702197. doi: 10.1183/13993003.02197-2017. Print 2017 Nov. No abstract available.


Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions.

Hiemstra PS, Grootaers G, van der Does AM, Krul CAM, Kooter IM.

Toxicol In Vitro. 2018 Mar;47:137-146. doi: 10.1016/j.tiv.2017.11.005. Epub 2017 Nov 15. Review.

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