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Items: 1 to 50 of 124

1.

Animal models for benign prostatic hyperplasia.

Hieble JP.

Handb Exp Pharmacol. 2011;(202):69-79. doi: 10.1007/978-3-642-16499-6_4. Review.

PMID:
21290222
2.

Modulation of bladder function by prostaglandin EP3 receptors in the central nervous system.

Su X, Leon LA, Wu CW, Morrow DM, Jaworski JP, Hieble JP, Lashinger ES, Jin J, Edwards RM, Laping NJ.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F984-94. doi: 10.1152/ajprenal.90373.2008. Epub 2008 Jul 16.

3.

AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome.

Lashinger ES, Steiginga MS, Hieble JP, Leon LA, Gardner SD, Nagilla R, Davenport EA, Hoffman BE, Laping NJ, Su X.

Am J Physiol Renal Physiol. 2008 Sep;295(3):F803-10. doi: 10.1152/ajprenal.90269.2008. Epub 2008 Jun 18.

4.

An excitatory role for peripheral EP3 receptors in bladder afferent function.

Su X, Lashinger ES, Leon LA, Hoffman BE, Hieble JP, Gardner SD, Fries HE, Edwards RM, Li J, Laping NJ.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F585-94. doi: 10.1152/ajprenal.90273.2008. Epub 2008 Jun 18.

5.

Analysis of efficacy of chiral adrenergic agonists.

Patil PN, Li C, Kumari V, Hieble JP.

Chirality. 2008 Mar;20(3-4):529-43. doi: 10.1002/chir.20506. Erratum in: Chirality. 2008 Jun;20(6):813-4.

PMID:
18172836
6.

The effects and selectivity of beta-adrenoceptor agonists in rat myometrium and urinary bladder.

Clouse AK, Riedel E, Hieble JP, Westfall TD.

Eur J Pharmacol. 2007 Nov 14;573(1-3):184-9. Epub 2007 Jun 27.

PMID:
17632099
7.

GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog.

Hicks A, McCafferty GP, Riedel E, Aiyar N, Pullen M, Evans C, Luce TD, Coatney RW, Rivera GC, Westfall TD, Hieble JP.

J Pharmacol Exp Ther. 2007 Oct;323(1):202-9. Epub 2007 Jul 12.

PMID:
17626794
8.
9.

Subclassification and nomenclature of alpha- and beta-adrenoceptors.

Hieble JP.

Curr Top Med Chem. 2007;7(2):129-34.

PMID:
17266601
10.

Effects of potassium channel modulators on human detrusor smooth muscle myogenic phasic contractile activity: potential therapeutic targets for overactive bladder.

Darblade B, Behr-Roussel D, Oger S, Hieble JP, Lebret T, Gorny D, Benoit G, Alexandre L, Giuliano F.

Urology. 2006 Aug;68(2):442-8.

PMID:
16904481
11.

Dual, but not selective, COX-1 and COX-2 inhibitors, attenuate acetic acid-evoked bladder irritation in the anaesthetised female cat.

Wibberley A, McCafferty GP, Evans C, Edwards RM, Hieble JP.

Br J Pharmacol. 2006 May;148(2):154-61.

12.

Piboserod (SB 207266), a selective 5-HT4 receptor antagonist, reduces serotonin potentiation of neurally-mediated contractile responses of human detrusor muscle.

Darblade B, Behr-Roussel D, Gorny D, Lebret T, Benoit G, Hieble JP, Brooks D, Alexandre L, Giuliano F.

World J Urol. 2005 Jun;23(2):147-51. Epub 2005 May 18.

PMID:
15902472
13.

Alpha1-adrenoceptor subtype substitution in knockout mice.

Hieble JP.

Br J Pharmacol. 2004 Jul;142(6):919. Epub 2004 Jun 21. No abstract available.

14.

Small and intermediate conductance Ca(2+)-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum.

Chen MX, Gorman SA, Benson B, Singh K, Hieble JP, Michel MC, Tate SN, Trezise DJ.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):602-15. Epub 2004 May 1.

PMID:
15127180
15.

Effect of endothelin on bladder contraction: potential role in bladder hyperactivity.

Westfall TD, McCafferty GP, Pullen M, Ventre J, Eybye M, Jugus MJ, Brooks SA, Hieble JP, Brooks DP.

Pharmacology. 2003 Sep;69(1):7-11.

PMID:
12886024
16.

Expression and functional role of Rho-kinase in rat urinary bladder smooth muscle.

Wibberley A, Chen Z, Hu E, Hieble JP, Westfall TD.

Br J Pharmacol. 2003 Mar;138(5):757-66.

17.

Characterization of neuromedin U effects in canine smooth muscle.

Westfall TD, McCafferty GP, Pullen M, Gruver S, Sulpizio AC, Aiyar VN, Disa J, Contino LC, Mannan IJ, Hieble JP.

J Pharmacol Exp Ther. 2002 Jun;301(3):987-92.

PMID:
12023529
18.

Rabbit alpha2-adrenoceptors: both platelets and adipocytes have alpha2A-pharmacology.

Naselsky DP, Ashton D, Ruffolo RR Jr, Hieble JP.

J Pharmacol Exp Ther. 2001 Jul;298(1):219-25.

PMID:
11408545
19.

Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.

Ames RS, Lee D, Foley JJ, Jurewicz AJ, Tornetta MA, Bautsch W, Settmacher B, Klos A, Erhard KF, Cousins RD, Sulpizio AC, Hieble JP, McCafferty G, Ward KW, Adams JL, Bondinell WE, Underwood DC, Osborn RR, Badger AM, Sarau HM.

J Immunol. 2001 May 15;166(10):6341-8.

20.

Cloning, expression, and pharmacological characterization of a novel human histamine receptor.

Zhu Y, Michalovich D, Wu H, Tan KB, Dytko GM, Mannan IJ, Boyce R, Alston J, Tierney LA, Li X, Herrity NC, Vawter L, Sarau HM, Ames RS, Davenport CM, Hieble JP, Wilson S, Bergsma DJ, Fitzgerald LR.

Mol Pharmacol. 2001 Mar;59(3):434-41.

PMID:
11179436
21.

Activity of N-(phenethyl)phenylethanolamines at beta(1) and beta(2) adrenoceptors: structural modifications can result in selectivity for either subtype.

Urtishak K, McCafferty G, Zaratin P, Scheideler M, Grugni M, Artico M, Hieble JP.

Pharmacology. 2001 Feb;62(2):113-8.

PMID:
11174082
22.
23.

Role of neurokinin receptors in the behavioral effect of intravesical antigen infusion in guinea pig bladder.

Ruggieri MR, Filer-Maerten S, Hieble JP, Hay DW.

J Urol. 2000 Jul;164(1):197-202.

PMID:
10840459
24.

Adrenoceptor subclassification: an approach to improved cardiovascular therapeutics.

Hieble JP.

Pharm Acta Helv. 2000 Mar;74(2-3):163-71. Review.

PMID:
10812954
25.

Characterization of postjunctional alpha-adrenoceptors in the pithed mouse.

McCafferty GP, Naselsky DP, Hieble JP.

Gen Pharmacol. 1999 Jul;33(1):99-105.

PMID:
10428022
26.

Effects of alpha1-adrenoceptor antagonists on agonist and tilt-induced changes in blood pressure: relationships to uroselectivity.

Hieble JP, Kolpak DC, McCafferty GP, Ruffolo RR Jr, Testa R, Leonardi A.

Eur J Pharmacol. 1999 May 28;373(1):51-62.

PMID:
10408251
27.

Adrenoceptor pharmacology: urogenital applications.

Ruffolo RR Jr, Hieble JP.

Eur Urol. 1999;36 Suppl 1:17-22. Review.

PMID:
10393468
28.

Molecular basis for the stereoselective interactions of catecholamines with alpha-adrenoceptors.

Hieble JP, Hehr A, Li YO, Ruffolo RR Jr.

Proc West Pharmacol Soc. 1998;41:225-8. Review.

PMID:
9836297
29.

Comparison of metoprolol and carvedilol pharmacology and cardioprotection in rabbit ischemia and reperfusion model.

Feuerstein G, Liu GL, Yue TL, Cheng HY, Hieble JP, Arch JR, Ruffolo RR Jr, Ma XL.

Eur J Pharmacol. 1998 Jun 26;351(3):341-50.

PMID:
9721026
30.

Ser165 of transmembrane helix IV is not involved in the interaction of catecholamines with the alpha-2a-adrenoceptor.

Hehr A, Hieble JP, Li YO, Bergsma DJ, Swift AM, Ganguly S, Ruffolo RR Jr.

Pharmacology. 1997 Jul;55(1):18-24.

PMID:
9309797
31.

Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, part II.

Testa R, Guarneri L, Angelico P, Poggesi E, Taddei C, Sironi G, Colombo D, Sulpizio AC, Naselsky DP, Hieble JP, Leonardi A.

J Pharmacol Exp Ther. 1997 Jun;281(3):1284-93.

PMID:
9190864
32.

Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, part I.

Leonardi A, Hieble JP, Guarneri L, Naselsky DP, Poggesi E, Sironi G, Sulpizio AC, Testa R.

J Pharmacol Exp Ther. 1997 Jun;281(3):1272-83.

PMID:
9190863
33.

Recent advances in the identification of alpha1- and alpha2-adrenoceptor subtypes: therapeutic implications.

Hieble JP, Ruffolo RR Jr.

Expert Opin Investig Drugs. 1997 Apr;6(4):367-87.

PMID:
15989605
34.

"Vinylogs" and "acetylenylogs" of beta-adrenergic agents.

Nudelman A, Binnes Y, Shmueli-Broide N, Odessa Y, Hieble JP, Sulpizio AC.

Arch Pharm (Weinheim). 1996 Mar;329(3):125-32.

PMID:
9005811
35.
36.

Subclassification and nomenclature of alpha 1- and alpha 2-adrenoceptors.

Hieble JP, Ruffolo RR Jr.

Prog Drug Res. 1996;47:81-130. Review. No abstract available.

PMID:
8961765
37.

Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

Ruffolo RR Jr, Bondinell W, Hieble JP.

J Med Chem. 1995 Sep 15;38(19):3681-716. Review. No abstract available.

PMID:
7562902
38.

Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.

Hieble JP, Bondinell WE, Ruffolo RR Jr.

J Med Chem. 1995 Sep 1;38(18):3415-44. Review. No abstract available.

PMID:
7658428
39.

Possible structural and functional relationships between imidazoline receptors and alpha 2-adrenoceptors.

Hieble JP, Ruffolo RR Jr.

Ann N Y Acad Sci. 1995 Jul 12;763:8-21. Review.

PMID:
7677390
40.

International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update.

Hieble JP, Bylund DB, Clarke DE, Eikenburg DC, Langer SZ, Lefkowitz RJ, Minneman KP, Ruffolo RR Jr.

Pharmacol Rev. 1995 Jun;47(2):267-70. Review. No abstract available.

PMID:
7568329
41.

Vascular alpha-adrenoceptors: from the gene to the human.

Bylund DB, Regan JW, Faber JE, Hieble JP, Triggle CR, Ruffolo RR Jr.

Can J Physiol Pharmacol. 1995 May;73(5):533-43. Review.

PMID:
7585318
42.

Alpha 1-adrenoceptors: pharmacological classification and newer therapeutic applications.

Ruffolo RR Jr, Bondinell W, Ku T, Naselsky DP, Hieble JP.

Proc West Pharmacol Soc. 1995;38:121-6. Review. No abstract available.

PMID:
7480003
43.

New directions in adrenoceptor pharmacology.

Hieble JP, Bond RA.

Trends Pharmacol Sci. 1994 Nov;15(11):397-9. No abstract available.

PMID:
7855898
44.

International Union of Pharmacology nomenclature of adrenoceptors.

Bylund DB, Eikenberg DC, Hieble JP, Langer SZ, Lefkowitz RJ, Minneman KP, Molinoff PB, Ruffolo RR Jr, Trendelenburg U.

Pharmacol Rev. 1994 Jun;46(2):121-36. Review. No abstract available.

PMID:
7938162
45.

Alpha-adrenoceptors: recent developments.

Ruffolo RR Jr, Stadel JM, Hieble JP.

Med Res Rev. 1994 Mar;14(2):229-70. Review. No abstract available.

PMID:
7910646
46.

Alpha 1-adrenoceptors: pharmacological subclassification and therapeutic applications.

Hieble JP, Ruffolo RR.

Proc West Pharmacol Soc. 1994;37:163-7. Review. No abstract available.

PMID:
7984656
47.

Alpha-adrenoceptors.

Ruffolo RR Jr, Hieble JP.

Pharmacol Ther. 1994;61(1-2):1-64. Review.

PMID:
7938167
48.
49.

Pharmacologic and therapeutic applications of alpha 2-adrenoceptor subtypes.

Ruffolo RR Jr, Nichols AJ, Stadel JM, Hieble JP.

Annu Rev Pharmacol Toxicol. 1993;33:243-79. Review. No abstract available.

PMID:
8098595

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