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Items: 1 to 50 of 138

1.

Correction: Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma.

Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS.

Oncogene. 2019 Jun;38(25):5107. doi: 10.1038/s41388-019-0829-z.

PMID:
31068667
2.

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity.

Aho ER, Wang J, Gogliotti RD, Howard GC, Phan J, Acharya P, Macdonald JD, Cheng K, Lorey SL, Lu B, Wenzel S, Foshage AM, Alvarado J, Wang F, Shaw JG, Zhao B, Weissmiller AM, Thomas LR, Vakoc CR, Hall MD, Hiebert SW, Liu Q, Stauffer SR, Fesik SW, Tansey WP.

Cell Rep. 2019 Mar 12;26(11):2916-2928.e13. doi: 10.1016/j.celrep.2019.02.047.

3.

Kaiso is required for MTG16-dependent effects on colitis-associated carcinoma.

Short SP, Barrett CW, Stengel KR, Revetta FL, Choksi YA, Coburn LA, Lintel MK, McDonough EM, Washington MK, Wilson KT, Prokhortchouk E, Chen X, Hiebert SW, Reynolds AB, Williams CS.

Oncogene. 2019 Jun;38(25):5091-5106. doi: 10.1038/s41388-019-0777-7. Epub 2019 Mar 11. Erratum in: Oncogene. 2019 May 8;:.

4.

The CDK7 inhibitor THZ1 alters RNA polymerase dynamics at the 5' and 3' ends of genes.

Sampathi S, Acharya P, Zhao Y, Wang J, Stengel KR, Liu Q, Savona MR, Hiebert SW.

Nucleic Acids Res. 2019 May 7;47(8):3921-3936. doi: 10.1093/nar/gkz127.

5.

BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML.

Zhang S, Zhao Y, Heaster TM, Fischer MA, Stengel KR, Zhou X, Ramsey H, Zhou MM, Savona MR, Skala MC, Hiebert SW.

J Cell Biochem. 2018 Nov 11. doi: 10.1002/jcb.28005. [Epub ahead of print]

PMID:
30417424
6.

Nascent RNA sequencing analysis provides insights into enhancer-mediated gene regulation.

Wang J, Zhao Y, Zhou X, Hiebert SW, Liu Q, Shyr Y.

BMC Genomics. 2018 Aug 23;19(1):633. doi: 10.1186/s12864-018-5016-z.

7.

MTG16 is a tumor suppressor in colitis-associated carcinoma.

McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Thompson JJ, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS.

JCI Insight. 2017 Aug 17;2(16). pii: 78210. doi: 10.1172/jci.insight.78210. eCollection 2017 Aug 17.

8.

The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia.

Kim HG, LeGrand J, Swindle CS, Nick HJ, Oster RA, Chen D, Purohit-Ghelani S, Cotta CV, Ko R, Gartland L, Reddy V, Hiebert SW, Friedman AD, Klug CA.

Leukemia. 2017 Oct;31(10):2267-2271. doi: 10.1038/leu.2017.236. Epub 2017 Jul 28. No abstract available.

9.

Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development.

Stengel KR, Barnett KR, Wang J, Liu Q, Hodges E, Hiebert SW, Bhaskara S.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8608-8613. doi: 10.1073/pnas.1701610114. Epub 2017 Jul 24.

10.

HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning.

Ferrari A, Longo R, Fiorino E, Silva R, Mitro N, Cermenati G, Gilardi F, Desvergne B, Andolfo A, Magagnotti C, Caruso D, Fabiani E, Hiebert SW, Crestani M.

Nat Commun. 2017 Jul 21;8(1):93. doi: 10.1038/s41467-017-00182-7.

11.

Autofluorescence imaging identifies tumor cell-cycle status on a single-cell level.

Heaster TM, Walsh AJ, Zhao Y, Hiebert SW, Skala MC.

J Biophotonics. 2018 Jan;11(1). doi: 10.1002/jbio.201600276. Epub 2017 May 9.

12.

Identification of active miRNA promoters from nuclear run-on RNA sequencing.

Liu Q, Wang J, Zhao Y, Li CI, Stengel KR, Acharya P, Johnston G, Hiebert SW, Shyr Y.

Nucleic Acids Res. 2017 Jul 27;45(13):e121. doi: 10.1093/nar/gkx318.

13.

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.

Jiang Y, Ortega-Molina A, Geng H, Ying HY, Hatzi K, Parsa S, McNally D, Wang L, Doane AS, Agirre X, Teater M, Meydan C, Li Z, Poloway D, Wang S, Ennishi D, Scott DW, Stengel KR, Kranz JE, Holson E, Sharma S, Young JW, Chu CS, Roeder RG, Shaknovich R, Hiebert SW, Gascoyne RD, Tam W, Elemento O, Wendel HG, Melnick AM.

Cancer Discov. 2017 Jan;7(1):38-53. doi: 10.1158/2159-8290.CD-16-0975. Epub 2016 Oct 12.

14.

High-Resolution Mapping of RNA Polymerases Identifies Mechanisms of Sensitivity and Resistance to BET Inhibitors in t(8;21) AML.

Zhao Y, Liu Q, Acharya P, Stengel KR, Sheng Q, Zhou X, Kwak H, Fischer MA, Bradner JE, Strickland SA, Mohan SR, Savona MR, Venters BJ, Zhou MM, Lis JT, Hiebert SW.

Cell Rep. 2016 Aug 16;16(7):2003-16. doi: 10.1016/j.celrep.2016.07.032. Epub 2016 Aug 4.

15.

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design.

Hargrove TY, Friggeri L, Wawrzak Z, Sivakumaran S, Yazlovitskaya EM, Hiebert SW, Guengerich FP, Waterman MR, Lepesheva GI.

J Lipid Res. 2016 Aug;57(8):1552-63. doi: 10.1194/jlr.M069229. Epub 2016 Jun 16.

16.

Myeloid translocation genes differentially regulate colorectal cancer programs.

Parang B, Bradley AM, Mittal MK, Short SP, Thompson JJ, Barrett CW, Naik RD, Bilotta AJ, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Hiebert SW, Williams CS.

Oncogene. 2016 Dec 8;35(49):6341-6349. doi: 10.1038/onc.2016.167. Epub 2016 Jun 6.

17.

Myc Induces miRNA-Mediated Apoptosis in Response to HDAC Inhibition in Hematologic Malignancies.

Adams CM, Hiebert SW, Eischen CM.

Cancer Res. 2016 Feb 1;76(3):736-48. doi: 10.1158/0008-5472.CAN-15-1751. Epub 2015 Dec 16. Erratum in: Cancer Res. 2017 Dec 1;77(23 ):6789.

18.

Histone Deacetylase 3 Is Required for Efficient T Cell Development.

Stengel KR, Zhao Y, Klus NJ, Kaiser JF, Gordy LE, Joyce S, Hiebert SW, Summers AR.

Mol Cell Biol. 2015 Nov;35(22):3854-65. doi: 10.1128/MCB.00706-15. Epub 2015 Aug 31.

19.

FOXP3⁺ regulatory T cell development and function require histone/protein deacetylase 3.

Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Akimova T, Greene MI, Hiebert SW, Hancock WW.

J Clin Invest. 2015 Aug 3;125(8):3304. doi: 10.1172/JCI83084. Epub 2015 Aug 3. No abstract available.

20.

Histone Deacetylase 3 Is Required for T Cell Maturation.

Hsu FC, Belmonte PJ, Constans MM, Chen MW, McWilliams DC, Hiebert SW, Shapiro VS.

J Immunol. 2015 Aug 15;195(4):1578-90. doi: 10.4049/jimmunol.1500435. Epub 2015 Jul 10.

21.

Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells.

Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M.

Cell Stem Cell. 2015 May 7;16(5):477-87. doi: 10.1016/j.stem.2015.04.008.

22.

FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.

Wang L, Liu Y, Han R, Beier UH, Bhatti TR, Akimova T, Greene MI, Hiebert SW, Hancock WW.

J Clin Invest. 2015 Mar 2;125(3):1111-23. doi: 10.1172/JCI77088. Epub 2015 Feb 2. Erratum in: J Clin Invest. 2015 Aug 3;125(8):3304.

23.

Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury.

Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G562-71. doi: 10.1152/ajpgi.00253.2014. Epub 2015 Jan 8.

24.

The transcriptional corepressor MTGR1 regulates intestinal secretory lineage allocation.

Parang B, Rosenblatt D, Williams AD, Washington MK, Revetta F, Short SP, Reddy VK, Hunt A, Shroyer NF, Engel ME, Hiebert SW, Williams CS.

FASEB J. 2015 Mar;29(3):786-95. doi: 10.1096/fj.14-254284. Epub 2014 Nov 14.

25.

ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2.

Ghosh HS, Ceribelli M, Matos I, Lazarovici A, Bussemaker HJ, Lasorella A, Hiebert SW, Liu K, Staudt LM, Reizis B.

J Exp Med. 2014 Jul 28;211(8):1623-35. doi: 10.1084/jem.20132121. Epub 2014 Jun 30.

26.

Class I HDACs Affect DNA Replication, Repair, and Chromatin Structure: Implications for Cancer Therapy.

Stengel KR, Hiebert SW.

Antioxid Redox Signal. 2015 Jul 1;23(1):51-65. doi: 10.1089/ars.2014.5915. Epub 2014 Jun 26. Review.

27.

HDAC3 is essential for DNA replication in hematopoietic progenitor cells.

Summers AR, Fischer MA, Stengel KR, Zhao Y, Kaiser JF, Wells CE, Hunt A, Bhaskara S, Luzwick JW, Sampathi S, Chen X, Thompson MA, Cortez D, Hiebert SW.

J Clin Invest. 2013 Jul;123(7):3112-23. doi: 10.1172/JCI60806. Epub 2013 Jun 10.

28.

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM, Kormaksson M, MacKerell AD Jr, Xue F, Mason CE, Hiebert SW, Prive GG, Cerchietti L, Bardwell VJ, Elemento O, Melnick A.

Cell Rep. 2013 Aug 15;4(3):578-88. doi: 10.1016/j.celrep.2013.06.016. Epub 2013 Aug 1.

29.

Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma.

Wells CE, Bhaskara S, Stengel KR, Zhao Y, Sirbu B, Chagot B, Cortez D, Khabele D, Chazin WJ, Cooper A, Jacques V, Rusche J, Eischen CM, McGirt LY, Hiebert SW.

PLoS One. 2013 Jul 22;8(7):e68915. doi: 10.1371/journal.pone.0068915. Print 2013.

30.

Kaiso directs the transcriptional corepressor MTG16 to the Kaiso binding site in target promoters.

Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp RD, Wilson KT, Hiebert SW, Reynolds AB, Williams CS.

PLoS One. 2012;7(12):e51205. doi: 10.1371/journal.pone.0051205. Epub 2012 Dec 12.

31.

The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB.

Ziesché E, Kettner-Buhrow D, Weber A, Wittwer T, Jurida L, Soelch J, Müller H, Newel D, Kronich P, Schneider H, Dittrich-Breiholz O, Bhaskara S, Hiebert SW, Hottiger MO, Li H, Burstein E, Schmitz ML, Kracht M.

Nucleic Acids Res. 2013 Jan 7;41(1):90-109. doi: 10.1093/nar/gks916. Epub 2012 Oct 19.

32.

MTG16 contributes to colonic epithelial integrity in experimental colitis.

Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM Jr, Wilson KT, Hiebert SW.

Gut. 2013 Oct;62(10):1446-55. doi: 10.1136/gutjnl-2011-301439. Epub 2012 Jul 24.

33.

Myeloid translocation gene 16 is required for maintenance of haematopoietic stem cell quiescence.

Fischer MA, Moreno-Miralles I, Hunt A, Chyla BJ, Hiebert SW.

EMBO J. 2012 Mar 21;31(6):1494-505. doi: 10.1038/emboj.2011.500. Epub 2012 Jan 20.

34.

Integrative network analysis identifies key genes and pathways in the progression of hepatitis C virus induced hepatocellular carcinoma.

Zheng S, Tansey WP, Hiebert SW, Zhao Z.

BMC Med Genomics. 2011 Aug 8;4:62. doi: 10.1186/1755-8794-4-62.

35.

The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells.

Wilson AJ, Holson E, Wagner F, Zhang YL, Fass DM, Haggarty SJ, Bhaskara S, Hiebert SW, Schreiber SL, Khabele D.

Cancer Biol Ther. 2011 Sep 15;12(6):484-93. doi: 10.4161/cbt.12.6.15956. Epub 2011 Sep 15.

36.

Analysis of protein dynamics at active, stalled, and collapsed replication forks.

Sirbu BM, Couch FB, Feigerle JT, Bhaskara S, Hiebert SW, Cortez D.

Genes Dev. 2011 Jun 15;25(12):1320-7. doi: 10.1101/gad.2053211.

37.

Mtg16/Eto2 contributes to murine T-cell development.

Hunt A, Fischer M, Engel ME, Hiebert SW.

Mol Cell Biol. 2011 Jul;31(13):2544-51. doi: 10.1128/MCB.01458-10. Epub 2011 May 2.

38.

Role for histone deacetylase 3 in maintenance of genome stability.

Bhaskara S, Hiebert SW.

Cell Cycle. 2011 Mar 1;10(5):727-8. Epub 2011 Mar 1. No abstract available.

39.

MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.

Barrett CW, Fingleton B, Williams A, Ning W, Fischer MA, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS.

Cancer Res. 2011 Feb 15;71(4):1302-12. doi: 10.1158/0008-5472.CAN-10-3317. Epub 2011 Feb 8.

40.

Hdac3 is essential for the maintenance of chromatin structure and genome stability.

Bhaskara S, Knutson SK, Jiang G, Chandrasekharan MB, Wilson AJ, Zheng S, Yenamandra A, Locke K, Yuan JL, Bonine-Summers AR, Wells CE, Kaiser JF, Washington MK, Zhao Z, Wagner FF, Sun ZW, Xia F, Holson EB, Khabele D, Hiebert SW.

Cancer Cell. 2010 Nov 16;18(5):436-47. doi: 10.1016/j.ccr.2010.10.022.

41.

Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat.

Razidlo DF, Whitney TJ, Casper ME, McGee-Lawrence ME, Stensgard BA, Li X, Secreto FJ, Knutson SK, Hiebert SW, Westendorf JJ.

PLoS One. 2010 Jul 9;5(7):e11492. doi: 10.1371/journal.pone.0011492.

42.

The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation.

Huang F, Chandrasekharan MB, Chen YC, Bhaskara S, Hiebert SW, Sun ZW.

J Biol Chem. 2010 Aug 6;285(32):24548-61. doi: 10.1074/jbc.M110.117333. Epub 2010 Jun 9.

43.

The enemy within: dormant retroviruses awaken.

Engel ME, Hiebert SW.

Nat Med. 2010 May;16(5):517-8. doi: 10.1038/nm0510-517. No abstract available.

PMID:
20448571
44.

Anticancer therapy SMRT-ens up: targeting the BCL6-SMRT interaction in B cell lymphoma.

Compton LA, Hiebert SW.

Cancer Cell. 2010 Apr 13;17(4):315-6. doi: 10.1016/j.ccr.2010.03.012.

45.

Myeloid translocation gene 16 (MTG16) interacts with Notch transcription complex components to integrate Notch signaling in hematopoietic cell fate specification.

Engel ME, Nguyen HN, Mariotti J, Hunt A, Hiebert SW.

Mol Cell Biol. 2010 Apr;30(7):1852-63. doi: 10.1128/MCB.01342-09. Epub 2010 Feb 1.

46.

Eto2/MTG16 and MTGR1 are heteromeric corepressors of the TAL1/SCL transcription factor in murine erythroid progenitors.

Cai Y, Xu Z, Xie J, Ham AJ, Koury MJ, Hiebert SW, Brandt SJ.

Biochem Biophys Res Commun. 2009 Dec 11;390(2):295-301. doi: 10.1016/j.bbrc.2009.09.111. Epub 2009 Sep 30.

47.

Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.

Engel ME, Hiebert SW.

Cancer Treat Res. 2010;145:127-47. doi: 10.1007/978-0-387-69259-3_8. Review.

PMID:
20306249
48.

RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis.

Yan M, Ahn EY, Hiebert SW, Zhang DE.

Blood. 2009 Jan 22;113(4):883-6. doi: 10.1182/blood-2008-04-153742. Epub 2008 Nov 25.

49.

Deletion of Mtg16, a target of t(16;21), alters hematopoietic progenitor cell proliferation and lineage allocation.

Chyla BJ, Moreno-Miralles I, Steapleton MA, Thompson MA, Bhaskara S, Engel M, Hiebert SW.

Mol Cell Biol. 2008 Oct;28(20):6234-47. doi: 10.1128/MCB.00404-08. Epub 2008 Aug 18.

50.

Inactivation of the p19(ARF) tumor suppressor affects intestinal epithelial cell proliferation and integrity.

Farmer TE, Williams CS, Washington MK, Hiebert SW.

J Cell Biochem. 2008 Aug 15;104(6):2228-40. doi: 10.1002/jcb.21779.

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