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Am J Health Behav. 2005 May-Jun;29(3):240-9.

Bupropion SR vs placebo for smoking cessation in health care professionals.

Author information

1
University Medical Policlinic, 10011 Lausanne, Switzerland. zellwegerjp@swissonline.ch

Abstract

OBJECTIVE:

To evaluate bupropion SR for smoking cessation in physicians and nurses.

METHODS:

This double-blind prospective 26-center, 12-country trial randomized 687 subjects to smoking cessation counselling with bupropion SR or placebo for 7 weeks. The participants were followed for 52 weeks.

RESULTS:

Bupropion SR was superior to placebo (50% vs 40%, P=0.013) on the 4-week primary outcome variable. Due to a high placebo response in this health care population, statistical differences were not maintained after treatment was discontinued.

CONCLUSIONS:

Bupropion SR is effective and well tolerated in health care professionals. Relapse prevention measures are needed to attain long-term abstinence.

PMID:
15899687
DOI:
10.5993/ajhb.29.3.5
[Indexed for MEDLINE]

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