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Items: 9


Cooperative Immune-Mediated Mechanisms of the HDAC Inhibitor Entinostat, an IL15 Superagonist, and a Cancer Vaccine Effectively Synergize as a Novel Cancer Therapy.

Hicks KC, Knudson KM, Lee KL, Hamilton DH, Hodge JW, Figg WD, Ordentlich P, Jones FR, Rabizadeh S, Soon-Shiong P, Schlom J, Gameiro SR.

Clin Cancer Res. 2020 Feb 1;26(3):704-716. doi: 10.1158/1078-0432.CCR-19-0727. Epub 2019 Oct 23.


Efficient Tumor Clearance and Diversified Immunity through Neoepitope Vaccines and Combinatorial Immunotherapy.

Lee KL, Benz SC, Hicks KC, Nguyen A, Gameiro SR, Palena C, Sanborn JZ, Su Z, Ordentlich P, Rohlin L, Lee JH, Rabizadeh S, Soon-Shiong P, Niazi K, Schlom J, Hamilton DH.

Cancer Immunol Res. 2019 Aug;7(8):1359-1370. doi: 10.1158/2326-6066.CIR-18-0620. Epub 2019 Jul 10.


Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy.

Knudson KM, Hicks KC, Alter S, Schlom J, Gameiro SR.

J Immunother Cancer. 2019 Mar 21;7(1):82. doi: 10.1186/s40425-019-0551-y.


Epigenetic priming of both tumor and NK cells augments antibody-dependent cellular cytotoxicity elicited by the anti-PD-L1 antibody avelumab against multiple carcinoma cell types.

Hicks KC, Fantini M, Donahue RN, Schwab A, Knudson KM, Tritsch SR, Jochems C, Clavijo PE, Allen CT, Hodge JW, Tsang KY, Schlom J, Gameiro SR.

Oncoimmunology. 2018 Jul 30;7(11):e1466018. doi: 10.1080/2162402X.2018.1466018. eCollection 2018.


M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine.

Knudson KM, Hicks KC, Luo X, Chen JQ, Schlom J, Gameiro SR.

Oncoimmunology. 2018 Feb 14;7(5):e1426519. doi: 10.1080/2162402X.2018.1426519. eCollection 2018. Erratum in: Oncoimmunology. 2019 Feb 27;8(5):e1584435.


Sprouty2 protein regulates hypoxia-inducible factor-α (HIFα) protein levels and transcription of HIFα-responsive genes.

Hicks KC, Patel TB.

J Biol Chem. 2017 Feb 17;292(7):3060. doi: 10.1074/jbc.A116.714139. No abstract available.


Hypoxia inducible factors regulate the transcription of the sprouty2 gene and expression of the sprouty2 protein.

Gao X, Hicks KC, Neumann P, Patel TB.

PLoS One. 2017 Feb 14;12(2):e0171616. doi: 10.1371/journal.pone.0171616. eCollection 2017.


Sprouty2 Protein Regulates Hypoxia-inducible Factor-α (HIFα) Protein Levels and Transcription of HIFα-responsive Genes.

Hicks KC, Patel TB.

J Biol Chem. 2016 Aug 5;291(32):16787-801. doi: 10.1074/jbc.M116.714139. Epub 2016 Jun 8. Erratum in: J Biol Chem. 2017 Feb 17;292(7):3060.


Regulation of cellular levels of Sprouty2 protein by prolyl hydroxylase domain and von Hippel-Lindau proteins.

Anderson K, Nordquist KA, Gao X, Hicks KC, Zhai B, Gygi SP, Patel TB.

J Biol Chem. 2011 Dec 9;286(49):42027-36. doi: 10.1074/jbc.M111.303222. Epub 2011 Oct 17.

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