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A multiplexed in vitro assay system for evaluating human skeletal muscle functionality in response to drug treatment.

Najjar SA, Smith AST, Long CJ, McAleer CW, Cai Y, Srinivasan B, Martin C, Vandenburgh HH, Hickman JJ.

Biotechnol Bioeng. 2019 Nov 23. doi: 10.1002/bit.27231. [Epub ahead of print]


Microphysiological systems.

Hickman JJ, Huh D, Kamm RD.

APL Bioeng. 2019 Oct 29;3(4):040401. doi: 10.1063/1.5130170. eCollection 2019 Dec. No abstract available.


Temporal Characterization of Neuronal Migration Behavior on Chemically Patterned Neuronal Circuits in a Defined in Vitro Environment.

Natarajan A, Smith AST, Berry B, Lambert S, Molnar P, Hickman JJ.

ACS Biomater Sci Eng. 2018 Oct 8;4(10):3460-3470. doi: 10.1021/acsbiomaterials.8b00610. Epub 2018 Aug 27.


A human in vitro platform for the evaluation of pharmacology strategies in cardiac ischemia.

Oleaga C, Jalilvand G, Legters G, Martin C, Ekman G, McAleer CW, Long CJ, Hickman JJ.

APL Bioeng. 2019 Aug 13;3(3):036103. doi: 10.1063/1.5089237. eCollection 2019 Sep.


A human-on-a-chip approach to tackling rare diseases.

de Mello CPP, Rumsey J, Slaughter V, Hickman JJ.

Drug Discov Today. 2019 Nov;24(11):2139-2151. doi: 10.1016/j.drudis.2019.08.001. Epub 2019 Aug 11. Review.


On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships.

McAleer CW, Pointon A, Long CJ, Brighton RL, Wilkin BD, Bridges LR, Narasimhan Sriram N, Fabre K, McDougall R, Muse VP, Mettetal JT, Srivastava A, Williams D, Schnepper MT, Roles JL, Shuler ML, Hickman JJ, Ewart L.

Sci Rep. 2019 Jul 3;9(1):9619. doi: 10.1038/s41598-019-45656-4.


Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.

McAleer CW, Long CJ, Elbrecht D, Sasserath T, Bridges LR, Rumsey JW, Martin C, Schnepper M, Wang Y, Schuler F, Roth AB, Funk C, Shuler ML, Hickman JJ.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaav1386. doi: 10.1126/scitranslmed.aav1386.


Polarity Induced in Human Stem Cell Derived Motoneurons on Patterned Self-Assembled Monolayers.

Gonzalez M, Guo X, Lin M, Stancescu M, Molnar P, Spradling S, Hickman JJ.

ACS Chem Neurosci. 2019 Jun 19;10(6):2756-2764. doi: 10.1021/acschemneuro.8b00682. Epub 2019 May 22.


Evaluation of Holistic Treatment for ALS Reveals Possible Mechanism and Therapeutic Potential.

Lavado A, Guo X, Smith AS, Akanda N, Martin C, Cai Y, Elbrecht D, Tran M, Bryant JP, Colon A, Long CJ, Lambert S, Morgan D, Hickman JJ.

Int J Pharm Pharm Res. 2017 Dec;11(1):348-374. Epub 2017 Dec 30.


Recent Advances in Body-on-a-Chip Systems.

Sung JH, Wang YI, Narasimhan Sriram N, Jackson M, Long C, Hickman JJ, Shuler ML.

Anal Chem. 2019 Jan 2;91(1):330-351. doi: 10.1021/acs.analchem.8b05293. Epub 2018 Dec 11. No abstract available.


Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system.

Oleaga C, Riu A, Rothemund S, Lavado A, McAleer CW, Long CJ, Persaud K, Narasimhan NS, Tran M, Roles J, Carmona-Moran CA, Sasserath T, Elbrecht DH, Kumanchik L, Bridges LR, Martin C, Schnepper MT, Ekman G, Jackson M, Wang YI, Note R, Langer J, Teissier S, Hickman JJ.

Biomaterials. 2018 Nov;182:176-190. doi: 10.1016/j.biomaterials.2018.07.062. Epub 2018 Aug 4.


Physiological Aβ Concentrations Produce a More Biomimetic Representation of the Alzheimer's Disease Phenotype in iPSC Derived Human Neurons.

Berry BJ, Smith AST, Long CJ, Martin CC, Hickman JJ.

ACS Chem Neurosci. 2018 Jul 18;9(7):1693-1701. doi: 10.1021/acschemneuro.8b00067. Epub 2018 May 22.


Stem cell derived phenotypic human neuromuscular junction model for dose response evaluation of therapeutics.

Santhanam N, Kumanchik L, Guo X, Sommerhage F, Cai Y, Jackson M, Martin C, Saad G, McAleer CW, Wang Y, Lavado A, Long CJ, Hickman JJ.

Biomaterials. 2018 Jun;166:64-78. doi: 10.1016/j.biomaterials.2018.02.047. Epub 2018 Feb 27.


Comparison of NMDA and AMPA Channel Expression and Function between Embryonic and Adult Neurons Utilizing Microelectrode Array Systems.

Edwards D, Sommerhage F, Berry B, Nummer H, Raquet M, Clymer B, Stancescu M, Hickman JJ.

ACS Biomater Sci Eng. 2017 Dec 11;3(12):3525-3533. doi: 10.1021/acsbiomaterials.7b00596. Epub 2017 Nov 13.


Functional analysis of human intrafusal fiber innervation by human γ-motoneurons.

Colón A, Guo X, Akanda N, Cai Y, Hickman JJ.

Sci Rep. 2017 Dec 8;7(1):17202. doi: 10.1038/s41598-017-17382-2.


Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges.

Wang YI, Carmona C, Hickman JJ, Shuler ML.

Adv Healthc Mater. 2018 Jan;7(2). doi: 10.1002/adhm.201701000. Epub 2017 Dec 4. Review.


Self-contained, low-cost Body-on-a-Chip systems for drug development.

Wang YI, Oleaga C, Long CJ, Esch MB, McAleer CW, Miller PG, Hickman JJ, Shuler ML.

Exp Biol Med (Maywood). 2017 Nov;242(17):1701-1713. doi: 10.1177/1535370217694101. Epub 2017 Feb 17. Review.


Fetal Bovine Serum (FBS): Past - Present - Future.

van der Valk J, Bieback K, Buta C, Cochrane B, Dirks WG, Fu J, Hickman JJ, Hohensee C, Kolar R, Liebsch M, Pistollato F, Schulz M, Thieme D, Weber T, Wiest J, Winkler S, Gstraunthaler G.

ALTEX. 2018;35(1):99-118. doi: 10.14573/altex.1705101. Epub 2017 Aug 9.


Tissue engineering the mechanosensory circuit of the stretch reflex arc with human stem cells: Sensory neuron innervation of intrafusal muscle fibers.

Guo X, Colon A, Akanda N, Spradling S, Stancescu M, Martin C, Hickman JJ.

Biomaterials. 2017 Apr;122:179-187. doi: 10.1016/j.biomaterials.2017.01.005. Epub 2017 Jan 3.


Body-on-a-chip systems for animal-free toxicity testing.

Mahler GJ, Esch MB, Stokol T, Hickman JJ, Shuler ML.

Altern Lab Anim. 2016 Oct;44(5):469-478. Review.


Modeling Barrier Tissues In Vitro: Methods, Achievements, and Challenges.

Sakolish CM, Esch MB, Hickman JJ, Shuler ML, Mahler GJ.

EBioMedicine. 2016 Feb 13;5:30-9. doi: 10.1016/j.ebiom.2016.02.023. eCollection 2016 Mar. Review.


Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs.

Oleaga C, Bernabini C, Smith AS, Srinivasan B, Jackson M, McLamb W, Platt V, Bridges R, Cai Y, Santhanam N, Berry B, Najjar S, Akanda N, Guo X, Martin C, Ekman G, Esch MB, Langer J, Ouedraogo G, Cotovio J, Breton L, Shuler ML, Hickman JJ.

Sci Rep. 2016 Feb 3;6:20030. doi: 10.1038/srep20030.


Morphological and functional characterization of human induced pluripotent stem cell-derived neurons (iCell Neurons) in defined culture systems.

Berry BJ, Akanda N, Smith AS, Long CJ, Schnepper MT, Guo X, Hickman JJ.

Biotechnol Prog. 2015 Nov-Dec;31(6):1613-22. doi: 10.1002/btpr.2160. Epub 2015 Sep 11.


A phenotypic in vitro model for the main determinants of human whole heart function.

Stancescu M, Molnar P, McAleer CW, McLamb W, Long CJ, Oleaga C, Prot JM, Hickman JJ.

Biomaterials. 2015 Aug;60:20-30. doi: 10.1016/j.biomaterials.2015.04.035. Epub 2015 May 14.


Functional myotube formation from adult rat satellite cells in a defined serum-free system.

McAleer CW, Rumsey JW, Stancescu M, Hickman JJ.

Biotechnol Prog. 2015 Jul-Aug;31(4):997-1003. doi: 10.1002/btpr.2063. Epub 2015 Mar 4.


Charge Relaxation Dynamics of an Electrolytic Nanocapacitor.

Thakore V, Hickman JJ.

J Phys Chem C Nanomater Interfaces. 2015 Jan 29;119(4):2121-2132. Epub 2014 Oct 30.


TEER measurement techniques for in vitro barrier model systems.

Srinivasan B, Kolli AR, Esch MB, Abaci HE, Shuler ML, Hickman JJ.

J Lab Autom. 2015 Apr;20(2):107-26. doi: 10.1177/2211068214561025. Epub 2015 Jan 13. Review.


Combining an optical resonance biosensor with enzyme activity kinetics to understand protein adsorption and denaturation.

Wilson KA, Finch CA, Anderson P, Vollmer F, Hickman JJ.

Biomaterials. 2015 Jan;38:86-96. doi: 10.1016/j.biomaterials.2014.10.002. Epub 2014 Nov 1.


Utilization of microscale silicon cantilevers to assess cellular contractile function in vitro.

Smith AS, Long CJ, McAleer C, Bobbitt N, Srinivasan B, Hickman JJ.

J Vis Exp. 2014 Oct 3;(92):e51866. doi: 10.3791/51866.


Mechanistic investigation of adult myotube response to exercise and drug treatment in vitro using a multiplexed functional assay system.

McAleer CW, Smith AS, Najjar S, Pirozzi K, Long CJ, Hickman JJ.

J Appl Physiol (1985). 2014 Dec 1;117(11):1398-405. doi: 10.1152/japplphysiol.00612.2014. Epub 2014 Oct 9.


Toward in vitro models of brain structure and function.

Shuler ML, Hickman JJ.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13682-3. doi: 10.1073/pnas.1414484111. Epub 2014 Sep 5. No abstract available.


A phenotypic culture system for the molecular analysis of CNS myelination in the spinal cord.

Davis H, Gonzalez M, Stancescu M, Love R, Hickman JJ, Lambert S.

Biomaterials. 2014 Oct;35(31):8840-8845. doi: 10.1016/j.biomaterials.2014.07.007. Epub 2014 Jul 23.


Modeling of action potential generation in NG108-15 cells.

Molnar P, Hickman JJ.

Methods Mol Biol. 2014;1183:253-61. doi: 10.1007/978-1-4939-1096-0_16.


Synaptic connectivity in engineered neuronal networks.

Molnar P, Kang JF, Bhargava N, Das M, Hickman JJ.

Methods Mol Biol. 2014;1183:243-52. doi: 10.1007/978-1-4939-1096-0_15.


Using physiologically-based pharmacokinetic-guided "body-on-a-chip" systems to predict mammalian response to drug and chemical exposure.

Sung JH, Srinivasan B, Esch MB, McLamb WT, Bernabini C, Shuler ML, Hickman JJ.

Exp Biol Med (Maywood). 2014 Sep;239(9):1225-39. doi: 10.1177/1535370214529397. Epub 2014 Jun 20. Review.


A multiplexed chip-based assay system for investigating the functional development of human skeletal myotubes in vitro.

Smith AS, Long CJ, Pirozzi K, Najjar S, McAleer C, Vandenburgh HH, Hickman JJ.

J Biotechnol. 2014 Sep 20;185:15-8. doi: 10.1016/j.jbiotec.2014.05.029. Epub 2014 Jun 5.


Microphysiological systems and low-cost microfluidic platform with analytics.

Smith AS, Long CJ, Berry BJ, McAleer C, Stancescu M, Molnar P, Miller PG, Esch MB, Prot JM, Hickman JJ, Shuler ML.

Stem Cell Res Ther. 2013;4 Suppl 1:S9. doi: 10.1186/scrt370. Epub 2013 Dec 20. Review.


How multi-organ microdevices can help foster drug development.

Esch MB, Smith AS, Prot JM, Oleaga C, Hickman JJ, Shuler ML.

Adv Drug Deliv Rev. 2014 Apr;69-70:158-69. doi: 10.1016/j.addr.2013.12.003. Epub 2014 Jan 9. Review.


Myelination and node of Ranvier formation on sensory neurons in a defined in vitro system.

Rumsey JW, McAleer C, Das M, Bhalkikar A, Wilson K, Stancescu M, Lambert S, Hickman JJ.

In Vitro Cell Dev Biol Anim. 2013 Sep;49(8):608-618. doi: 10.1007/s11626-013-9647-8. Epub 2013 Aug 16.



Finch C, Clarke T, Hickman JJ.

J Comput Phys. 2013 Jul 1;244:212-222.


Two cell circuits of oriented adult hippocampal neurons on self-assembled monolayers for use in the study of neuronal communication in a defined system.

Edwards D, Stancescu M, Molnar P, Hickman JJ.

ACS Chem Neurosci. 2013 Aug 21;4(8):1174-82. doi: 10.1021/cn300206k. Epub 2013 May 20.


Derivation of sensory neurons and neural crest stem cells from human neural progenitor hNP1.

Guo X, Spradling S, Stancescu M, Lambert S, Hickman JJ.

Biomaterials. 2013 Jun;34(18):4418-27. doi: 10.1016/j.biomaterials.2013.02.061. Epub 2013 Mar 15.


Rat Cortical Oligodendrocyte-Embryonic Motoneuron Co-Culture: An In Vitro Axon-Oligodendrocyte Interaction Model.

Davis H, Gonzalez M, Bhargava N, Stancescu M, Hickman JJ, Lambert S.

J Biomater Tissue Eng. 2012 Sep;2(3):206-214.


Comparative analysis of system identification techniques for nonlinear modeling of the neuron-microelectrode junction.

Khan SA, Thakore V, Behal A, Bölöni L, Hickman JJ.

J Comput Theor Nanosci. 2013 Mar;10(3):573-580. doi: 10.1166/jctn.2013.2736.


Microfabricated mammalian organ systems and their integration into models of whole animals and humans.

Sung JH, Esch MB, Prot JM, Long CJ, Smith A, Hickman JJ, Shuler ML.

Lab Chip. 2013 Apr 7;13(7):1201-12. doi: 10.1039/c3lc41017j. Review.


A functional system for high-content screening of neuromuscular junctions in vitro.

Smith AS, Long CJ, Pirozzi K, Hickman JJ.

Technology (Singap World Sci). 2013;1(1):37-48.


An optimization-based study of equivalent circuit models for representing recordings at the neuron-electrode interface.

Thakore V, Molnar P, Hickman JJ.

IEEE Trans Biomed Eng. 2012 Aug;59(8):2338-47. doi: 10.1109/TBME.2012.2203820. Epub 2012 Jun 8.


Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons.

Guo X, Ayala JE, Gonzalez M, Stancescu M, Lambert S, Hickman JJ.

Biomaterials. 2012 Aug;33(23):5723-31. doi: 10.1016/j.biomaterials.2012.04.042. Epub 2012 May 15.


Small Molecule Induction of Human Umbilical Stem Cells into MBP-positive Oligodendrocytes in a Defined Three-Dimensional Environment.

Davis H, Guo X, Lambert S, Stancescu M, Hickman JJ.

ACS Chem Neurosci. 2012 Jan 18;3(1):31-39. Epub 2011 Nov 29.

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