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Bioequivalence of Ertugliflozin/Sitagliptin Fixed-Dose Combination Tablets and Coadministration of Respective Strengths of Individual Components.

Fediuk DJ, Matschke K, Liang Y, Pelletier KB, Wei H, Shi H, Bass A, Hickman A, Terra SG, Zhou S, Krishna R, Sahasrabudhe V.

Clin Pharmacol Drug Dev. 2019 Jun 20. doi: 10.1002/cpdd.722. [Epub ahead of print]


Bioequivalence of Ertugliflozin/Metformin Fixed-Dose Combination Tablets and Coadministration of Respective Strengths of Individual Components.

Dawra VK, Liang Y, Wei H, Pelletier K, Shi H, Hickman A, Bass A, Terra SG, Zhou S, Krishna R, Sahasrabudhe V.

Clin Pharmacol Drug Dev. 2019 Jun 17. doi: 10.1002/cpdd.703. [Epub ahead of print]


Autism risk genes are evolutionarily ancient and maintain a unique feature landscape that echoes their function.

Casanova EL, Switala AE, Dandamudi S, Hickman AR, Vandenbrink J, Sharp JL, Feltus FA, Casanova MF.

Autism Res. 2019 Jun;12(6):860-869. doi: 10.1002/aur.2112. Epub 2019 Apr 26.


Pharmacokinetic Properties of Single and Multiple Doses of Ertugliflozin, a Selective Inhibitor of SGLT2, in Healthy Chinese Subjects.

Li Y, Mu Y, Shi H, Liang Y, Liu Z, Matschke K, Hickman A, Krishna R, Sahasrabudhe V.

Clin Pharmacol Drug Dev. 2019 Apr 1. doi: 10.1002/cpdd.686. [Epub ahead of print]


A PK/PD study comparing twice-daily to once-daily dosing regimens of ertugliflozin in healthy subjects

Dawra VK, Liang Y, Shi H, Bass A, Hickman A, Terra SG, Zhou S, Cutler D, Sahasrabudhe V.

Int J Clin Pharmacol Ther. 2019 Apr;57(4):207-216. doi: 10.5414/CP203343.


Ocean colour signature of climate change.

Dutkiewicz S, Hickman AE, Jahn O, Henson S, Beaulieu C, Monier E.

Nat Commun. 2019 Feb 4;10(1):578. doi: 10.1038/s41467-019-08457-x.


Evaluation of air quality at the Birmingham New Street Railway Station.

Hickman AL, Baker CJ, Cai X, Delgado-Saborit JM, Thornes JE.

Proc Inst Mech Eng F J Rail Rapid Transit. 2018 Jul;232(6):1864-1878. doi: 10.1177/0954409717752180. Epub 2018 Jan 16.


Acid Suppression to Prevent Gastrointestinal Bleeding in Patients With Ventricular Assist Devices.

Hickman AW, Lonardo NW, Mone MC, Presson AP, Zhang C, Barton RG, Selzman CH, Drakos SG, Koliopoulou A, McKellar SH.

J Surg Res. 2019 Feb;234:96-102. doi: 10.1016/j.jss.2018.08.023. Epub 2018 Oct 5.


Effect of Food on the Pharmacokinetics of Ertugliflozin and Its Fixed-Dose Combinations Ertugliflozin/Sitagliptin and Ertugliflozin/Metformin.

Sahasrabudhe V, Fediuk DJ, Matschke K, Shi H, Liang Y, Hickman A, Bass A, Terra SG, Zhou S, Krishna R, Dawra VK.

Clin Pharmacol Drug Dev. 2019 Jul;8(5):619-627. doi: 10.1002/cpdd.629. Epub 2018 Nov 14.


Structural insights into the mechanism of double strand break formation by Hermes, a hAT family eukaryotic DNA transposase.

Hickman AB, Voth AR, Ewis H, Li X, Craig NL, Dyda F.

Nucleic Acids Res. 2018 Nov 2;46(19):10286-10301. doi: 10.1093/nar/gky838.


Pharmacokinetics of Single-dose Ertugliflozin in Patients With Hepatic Impairment.

Sahasrabudhe V, Terra SG, Hickman A, Saur D, Raje S, Shi H, Matschke K, Zhou S, Cutler DL.

Clin Ther. 2018 Oct;40(10):1701-1710. doi: 10.1016/j.clinthera.2018.06.015. Epub 2018 Sep 14.


Effect of Rifampin on the Pharmacokinetics of Ertugliflozin in Healthy Subjects.

Dawra VK, Sahasrabudhe V, Liang Y, Matschke K, Shi H, Hickman A, Saur D, Terra SG, Cutler DL.

Clin Ther. 2018 Sep;40(9):1538-1547. doi: 10.1016/j.clinthera.2018.07.014. Epub 2018 Aug 28.


Effects of placental growth factor deficiency on behavior, neuroanatomy, and cerebrovasculature of mice.

Kay VR, Rätsep MT, Cahill LS, Hickman AF, Zavan B, Newport ME, Ellegood J, Laliberte CL, Reynolds JN, Carmeliet P, Tayade C, Sled JG, Croy BA.

Physiol Genomics. 2018 Oct 1;50(10):862-875. doi: 10.1152/physiolgenomics.00076.2018. Epub 2018 Aug 17.


Assessment of the Drug Interaction Potential of Ertugliflozin With Sitagliptin, Metformin, Glimepiride, or Simvastatin in Healthy Subjects.

Dawra VK, Cutler DL, Zhou S, Krishna R, Shi H, Liang Y, Alvey C, Hickman A, Saur D, Terra SG, Sahasrabudhe V.

Clin Pharmacol Drug Dev. 2019 Apr;8(3):314-325. doi: 10.1002/cpdd.472. Epub 2018 May 22.


Targeting IS608 transposon integration to highly specific sequences by structure-based transposon engineering.

Morero NR, Zuliani C, Kumar B, Bebel A, Okamoto S, Guynet C, Hickman AB, Chandler M, Dyda F, Barabas O.

Nucleic Acids Res. 2018 May 4;46(8):4152-4163. doi: 10.1093/nar/gky235.


Helraiser intermediates provide insight into the mechanism of eukaryotic replicative transposition.

Grabundzija I, Hickman AB, Dyda F.

Nat Commun. 2018 Mar 29;9(1):1278. doi: 10.1038/s41467-018-03688-w.


Lymphoid aggregates in desmoplastic melanoma have features of tertiary lymphoid structures.

Stowman AM, Hickman AW, Mauldin IS, Mahmutovic A, Gru AA, Slingluff CL Jr.

Melanoma Res. 2018 Jun;28(3):237-245. doi: 10.1097/CMR.0000000000000439.


Semiclassical analysis of jm → j'm' transitions in rotationally inelastic collisions in cell experiments.

Price TJ, Hickman AP.

J Chem Phys. 2018 Feb 21;148(7):074105. doi: 10.1063/1.4996877.


Sequence-specific DNA binding activity of the cross-brace zinc finger motif of the piggyBac transposase.

Morellet N, Li X, Wieninger SA, Taylor JL, Bischerour J, Moriau S, Lescop E, Bardiaux B, Mathy N, Assrir N, Bétermier M, Nilges M, Hickman AB, Dyda F, Craig NL, Guittet E.

Nucleic Acids Res. 2018 Mar 16;46(5):2660-2677. doi: 10.1093/nar/gky044.


A Phase 1, Randomized, Placebo- and Active-Controlled Crossover Study to Determine the Effect of Single-Dose Ertugliflozin on QTc Interval in Healthy Volunteers.

Sahasrabudhe V, Saur D, Matschke K, Terra SG, Hickman A, Huyghe I, Shi H, Cutler DL.

Clin Pharmacol Drug Dev. 2018 Jun;7(5):513-523. doi: 10.1002/cpdd.421. Epub 2018 Jan 18.


Rotationally inelastic collisions of excited NaK and NaCs molecules with noble gas and alkali atom perturbers.

Jones J, Richter K, Price TJ, Ross AJ, Crozet P, Faust C, Malenda RF, Carlus S, Hickman AP, Huennekens J.

J Chem Phys. 2017 Oct 14;147(14):144303. doi: 10.1063/1.4997577.


Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells.

Srikakulapu P, Upadhye A, Rosenfeld SM, Marshall MA, McSkimming C, Hickman AW, Mauldin IS, Ailawadi G, Lopes MBS, Taylor AM, McNamara CA.

Front Physiol. 2017 Sep 22;8:719. doi: 10.3389/fphys.2017.00719. eCollection 2017.


The Effect of Renal Impairment on the Pharmacokinetics and Pharmacodynamics of Ertugliflozin in Subjects With Type 2 Diabetes Mellitus.

Sahasrabudhe V, Terra SG, Hickman A, Saur D, Shi H, O'Gorman M, Zhou Z, Cutler DL.

J Clin Pharmacol. 2017 Nov;57(11):1432-1443. doi: 10.1002/jcph.955. Epub 2017 Jul 13.


Histopathologic review of negative sentinel lymph node biopsies in thin melanomas: an argument for the routine use of immunohistochemistry.

Stowman AM, Hickman AW, Gru AA, Slingluff CL Jr.

Melanoma Res. 2017 Aug;27(4):369-376. doi: 10.1097/CMR.0000000000000361. Review.


A theoretical study of the dissociative recombination of SH+ with electrons through the 2Π states of SH.

Kashinski DO, Talbi D, Hickman AP, Di Nallo OE, Colboc F, Chakrabarti K, Schneider IF, Mezei JZ.

J Chem Phys. 2017 May 28;146(20):204109. doi: 10.1063/1.4983690.


Mechanisms of Evolution in High-Consequence Drug Resistance Plasmids.

He S, Chandler M, Varani AM, Hickman AB, Dekker JP, Dyda F.

MBio. 2016 Dec 6;7(6). pii: e01987-16. doi: 10.1128/mBio.01987-16.


Poster 129 Assessment of Introductory Residency Musculoskeletal Ultrasound Curriculum.

Contract DZ, Hickman A.

PM R. 2016 Sep;8(9S):S203-S204. doi: 10.1016/j.pmrj.2016.07.171. Epub 2016 Sep 24. No abstract available.


A Model for Transposition of the Colistin Resistance Gene mcr-1 by ISApl1.

Snesrud E, He S, Chandler M, Dekker JP, Hickman AB, McGann P, Dyda F.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6973-6976. doi: 10.1128/AAC.01457-16. Print 2016 Nov.


DNA Transposition at Work.

Hickman AB, Dyda F.

Chem Rev. 2016 Oct 26;116(20):12758-12784. doi: 10.1021/acs.chemrev.6b00003. Epub 2016 May 17. Review.


The Elsevier trophoblast research award lecture: Impacts of placental growth factor and preeclampsia on brain development, behaviour, and cognition.

Rätsep MT, Hickman AF, Croy BA.

Placenta. 2016 Dec;48 Suppl 1:S40-S46. doi: 10.1016/j.placenta.2016.02.001. Epub 2016 Feb 6.


Impact of preeclampsia on cognitive function in the offspring.

Rätsep MT, Hickman AF, Maser B, Pudwell J, Smith GN, Brien D, Stroman PW, Adams MA, Reynolds JN, Croy BA, Paolozza A.

Behav Brain Res. 2016 Apr 1;302:175-81. doi: 10.1016/j.bbr.2016.01.030. Epub 2016 Jan 16.


Brain Structural and Vascular Anatomy Is Altered in Offspring of Pre-Eclamptic Pregnancies: A Pilot Study.

Rätsep MT, Paolozza A, Hickman AF, Maser B, Kay VR, Mohammad S, Pudwell J, Smith GN, Brien D, Stroman PW, Adams MA, Reynolds JN, Croy BA, Forkert ND.

AJNR Am J Neuroradiol. 2016 May;37(5):939-45. doi: 10.3174/ajnr.A4640. Epub 2015 Dec 31.


The casposon-encoded Cas1 protein from Aciduliprofundum boonei is a DNA integrase that generates target site duplications.

Hickman AB, Dyda F.

Nucleic Acids Res. 2015 Dec 15;43(22):10576-87. doi: 10.1093/nar/gkv1180. Epub 2015 Nov 16.


Mechanisms of DNA Transposition.

Hickman AB, Dyda F.

Microbiol Spectr. 2015 Apr;3(2):MDNA3-0034-2014. doi: 10.1128/microbiolspec.MDNA3-0034-2014. Review.


Theoretical calculations of rotationally inelastic collisions of He with NaK(A (1)Σ(+)): Transfer of population, orientation, and alignment.

Malenda RF, Price TJ, Stevens J, Uppalapati SL, Fragale A, Weiser PM, Kuczala A, Talbi D, Hickman AP.

J Chem Phys. 2015 Jun 14;142(22):224301. doi: 10.1063/1.4922161.


Insertion Sequence IS26 Reorganizes Plasmids in Clinically Isolated Multidrug-Resistant Bacteria by Replicative Transposition.

He S, Hickman AB, Varani AM, Siguier P, Chandler M, Dekker JP, Dyda F.

MBio. 2015 Jun 9;6(3):e00762. doi: 10.1128/mBio.00762-15.


Mechanism of spacer integration links the CRISPR/Cas system to transposition as a form of mobile DNA.

Dyda F, Hickman AB.

Mob DNA. 2015 May 12;6:9. doi: 10.1186/s13100-015-0039-3. eCollection 2015.


Eram, ergo sum? A 1-year retrospective study of General Pharmaceutical Council fitness to practise hearings.

Gallagher CT, Greenland VA, Hickman AC.

Int J Pharm Pract. 2015 Jun;23(3):205-11. doi: 10.1111/ijpp.12151. Epub 2014 Nov 3.


CRISPR-Cas immunity and mobile DNA: a new superfamily of DNA transposons encoding a Cas1 endonuclease.

Hickman AB, Dyda F.

Mob DNA. 2014 Aug 26;5:23. doi: 10.1186/1759-8753-5-23. eCollection 2014.


A prospectus for UK marine sustained observations.

Postlethwaite CF, Hickman AE, McQuatters-Gollop A, Bryden H, Woodworth P.

Philos Trans A Math Phys Eng Sci. 2014 Sep 28;372(2025). pii: 20130341. doi: 10.1098/rsta.2013.0341. No abstract available.


Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica.

Hickman AB, Ewis HE, Li X, Knapp JA, Laver T, Doss AL, Tolun G, Steven AC, Grishaev A, Bax A, Atkinson PW, Craig NL, Dyda F.

Cell. 2014 Jul 17;158(2):353-367. doi: 10.1016/j.cell.2014.05.037.


The effect of male and female age on Lymantria dispar (Lepidoptera: Lymantriidae) fecundity.

Tobin PC, Bolyard JL, Onufrieva KS, Hickman AD.

J Econ Entomol. 2014 Jun;107(3):1076-83.


Efficacies and Second-Year Effects of SPLAT GM™ and SPLAT GM™ Organic Formulations.

Onufrieva KS, Hickman AD, Leonard DS, Tobin PC.

Insects. 2014 Dec 23;6(1):1-12. doi: 10.3390/insects6010001.


Un Abrazo Para La Familia: an evidenced-based rehabilitation approach in providing cancer education to low-SES Hispanic co-survivors.

Marshall CA, Curran MA, Koerner SS, Kroll T, Hickman AC, García F.

J Cancer Educ. 2014 Dec;29(4):626-33. doi: 10.1007/s13187-013-0593-7.


Platinum-catalyzed C-H arylation of simple arenes.

Wagner AM, Hickman AJ, Sanford MS.

J Am Chem Soc. 2013 Oct 23;135(42):15710-3. doi: 10.1021/ja408112j. Epub 2013 Oct 15.


Breaking and joining single-stranded DNA: the HUH endonuclease superfamily.

Chandler M, de la Cruz F, Dyda F, Hickman AB, Moncalian G, Ton-Hoang B.

Nat Rev Microbiol. 2013 Aug;11(8):525-38. doi: 10.1038/nrmicro3067. Epub 2013 Jul 8. Review.


Predicting the electron requirement for carbon fixation in seas and oceans.

Lawrenz E, Silsbe G, Capuzzo E, Ylöstalo P, Forster RM, Simis SG, Prášil O, Kromkamp JC, Hickman AE, Moore CM, Forget MH, Geider RJ, Suggett DJ.

PLoS One. 2013;8(3):e58137. doi: 10.1371/journal.pone.0058137. Epub 2013 Mar 13.


IS200/IS605 family single-strand transposition: mechanism of IS608 strand transfer.

He S, Guynet C, Siguier P, Hickman AB, Dyda F, Chandler M, Ton-Hoang B.

Nucleic Acids Res. 2013 Mar 1;41(5):3302-13. doi: 10.1093/nar/gkt014. Epub 2013 Jan 23.


Persistence of the Gypsy Moth Pheromone, Disparlure, in the Environment in Various Climates.

Onufrieva KS, Thorpe KW, Hickman AD, Leonard DS, Roberts EA, Tobin PC.

Insects. 2013 Jan 14;4(1):104-16. doi: 10.3390/insects4010104.

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