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Items: 1 to 50 of 110


In silico simulation of future hybrid performance to evaluate heterotic pool formation in a self-pollinating crop.

Cowling WA, Gaynor RC, Antolín R, Gorjanc G, Edwards SM, Powell O, Hickey JM.

Sci Rep. 2020 Mar 4;10(1):4037. doi: 10.1038/s41598-020-61031-0.


Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed-batch fermentation.

Velez-Suberbie ML, Morris SA, Kaur K, Hickey JM, Joshi SB, Volkin DB, Bracewell DG, Mukhopadhyay TK.

Biotechnol Prog. 2020 Jan 20:e2966. doi: 10.1002/btpr.2966. [Epub ahead of print]


A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system.

Lee SM, Hickey JM, Miura K, Joshi SB, Volkin DB, King CR, Plieskatt JL.

Sci Rep. 2020 Jan 15;10(1):395. doi: 10.1038/s41598-019-57384-w.


The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate.

Lee SM, Wu Y, Hickey JM, Miura K, Whitaker N, Joshi SB, Volkin DB, Richter King C, Plieskatt J.

Malar J. 2019 Nov 8;18(1):356. doi: 10.1186/s12936-019-2989-2.


Genetic dissection of complex behaviour traits in German Shepherd dogs.

Friedrich J, Strandberg E, Arvelius P, Sánchez-Molano E, Pong-Wong R, Hickey JM, Haskell MJ, Wiener P.

Heredity (Edinb). 2019 Dec;123(6):746-758. doi: 10.1038/s41437-019-0275-2. Epub 2019 Oct 14.


Effect of Aluminum Adjuvant and Preservatives on Structural Integrity and Physicochemical Stability Profiles of Three Recombinant Subunit Rotavirus Vaccine Antigens.

Agarwal S, Hickey JM, McAdams D, White JA, Sitrin R, Khandke L, Cryz S, Joshi SB, Volkin DB.

J Pharm Sci. 2020 Jan;109(1):476-487. doi: 10.1016/j.xphs.2019.10.004. Epub 2019 Oct 4.


Flexible modelling of spatial variation in agricultural field trials with the R package INLA.

Selle ML, Steinsland I, Hickey JM, Gorjanc G.

Theor Appl Genet. 2019 Dec;132(12):3277-3293. doi: 10.1007/s00122-019-03424-y. Epub 2019 Sep 18.


Efficient use of genomic information for sustainable genetic improvement in small cattle populations.

Obšteter J, Jenko J, Hickey JM, Gorjanc G.

J Dairy Sci. 2019 Nov;102(11):9971-9982. doi: 10.3168/jds.2019-16853. Epub 2019 Aug 30.


Recombinant Subunit Rotavirus Trivalent Vaccine Candidate: Physicochemical Comparisons and Stability Evaluations of Three Protein Antigens.

Agarwal S, Hickey JM, Sahni N, Toth RT 4th, Robertson GA, Sitrin R, Cryz S, Joshi SB, Volkin DB.

J Pharm Sci. 2020 Jan;109(1):380-393. doi: 10.1016/j.xphs.2019.08.002. Epub 2019 Aug 7.


Characterizing and Minimizing Aggregation and Particle Formation of Three Recombinant Fusion-Protein Bulk Antigens for Use in a Candidate Trivalent Rotavirus Vaccine.

Agarwal S, Sahni N, Hickey JM, Robertson GA, Sitrin R, Cryz S, Joshi SB, Volkin DB.

J Pharm Sci. 2020 Jan;109(1):394-406. doi: 10.1016/j.xphs.2019.08.001. Epub 2019 Aug 7.


Family-specific genotype arrays increase the accuracy of pedigree-based imputation at very low marker densities.

Whalen A, Gorjanc G, Hickey JM.

Genet Sel Evol. 2019 Jun 26;51(1):33. doi: 10.1186/s12711-019-0478-2.


The role of genetics in mainstreaming the production of new and orphan crops to diversify food systems and support human nutrition.

Dawson IK, Powell W, Hendre P, Bančič J, Hickey JM, Kindt R, Hoad S, Hale I, Jamnadass R.

New Phytol. 2019 Oct;224(1):37-54. doi: 10.1111/nph.15895. Epub 2019 Jun 28. Review.


Removal of alleles by genome editing (RAGE) against deleterious load.

Johnsson M, Gaynor RC, Jenko J, Gorjanc G, de Koning DJ, Hickey JM.

Genet Sel Evol. 2019 Apr 17;51(1):14. doi: 10.1186/s12711-019-0456-8.


The effects of training population design on genomic prediction accuracy in wheat.

Edwards SM, Buntjer JB, Jackson R, Bentley AR, Lage J, Byrne E, Burt C, Jack P, Berry S, Flatman E, Poupard B, Smith S, Hayes C, Gaynor RC, Gorjanc G, Howell P, Ober E, Mackay IJ, Hickey JM.

Theor Appl Genet. 2019 Jul;132(7):1943-1952. doi: 10.1007/s00122-019-03327-y. Epub 2019 Mar 19.


Analysis of a large dataset reveals haplotypes carrying putatively recessive lethal and semi-lethal alleles with pleiotropic effects on economically important traits in beef cattle.

Jenko J, McClure MC, Matthews D, McClure J, Johnsson M, Gorjanc G, Hickey JM.

Genet Sel Evol. 2019 Mar 5;51(1):9. doi: 10.1186/s12711-019-0452-z.


A large-scale pedigree resource of wheat reveals evidence for adaptation and selection by breeders.

Fradgley N, Gardner KA, Cockram J, Elderfield J, Hickey JM, Howell P, Jackson R, Mackay IJ.

PLoS Biol. 2019 Feb 28;17(2):e3000071. doi: 10.1371/journal.pbio.3000071. eCollection 2019 Feb.


Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens.

Whitaker N, Hickey JM, Kaur K, Xiong J, Sawant N, Cupo A, Lee WH, Ozorowski G, Medina-Ramírez M, Ward AB, Sanders RW, Moore JP, Joshi SB, Volkin DB, Dey AK.

J Pharm Sci. 2019 Jul;108(7):2264-2277. doi: 10.1016/j.xphs.2019.01.033. Epub 2019 Feb 15.


Sequence variation, evolutionary constraint, and selection at the CD163 gene in pigs.

Johnsson M, Ros-Freixedes R, Gorjanc G, Campbell MA, Naswa S, Kelly K, Lightner J, Rounsley S, Hickey JM.

Genet Sel Evol. 2018 Dec 20;50(1):69. doi: 10.1186/s12711-018-0440-8.


A Strategy To Exploit Surrogate Sire Technology in Livestock Breeding Programs.

Gottardo P, Gorjanc G, Battagin M, Gaynor RC, Jenko J, Ros-Freixedes R, Bruce A Whitelaw C, Mileham AJ, Herring WO, Hickey JM.

G3 (Bethesda). 2019 Jan 9;9(1):203-215. doi: 10.1534/g3.118.200890.


Hybrid peeling for fast and accurate calling, phasing, and imputation with sequence data of any coverage in pedigrees.

Whalen A, Ros-Freixedes R, Wilson DL, Gorjanc G, Hickey JM.

Genet Sel Evol. 2018 Dec 18;50(1):67. doi: 10.1186/s12711-018-0438-2.


Parentage assignment with genotyping-by-sequencing data.

Whalen A, Gorjanc G, Hickey JM.

J Anim Breed Genet. 2019 Mar;136(2):102-112. doi: 10.1111/jbg.12370. Epub 2018 Dec 13.


Impact of index hopping and bias towards the reference allele on accuracy of genotype calls from low-coverage sequencing.

Ros-Freixedes R, Battagin M, Johnsson M, Gorjanc G, Mileham AJ, Rounsley SD, Hickey JM.

Genet Sel Evol. 2018 Dec 13;50(1):64. doi: 10.1186/s12711-018-0436-4.


Assessment of the performance of hidden Markov models for imputation in animal breeding.

Whalen A, Gorjanc G, Ros-Freixedes R, Hickey JM.

Genet Sel Evol. 2018 Sep 17;50(1):44. doi: 10.1186/s12711-018-0416-8.


A heuristic method for fast and accurate phasing and imputation of single-nucleotide polymorphism data in bi-parental plant populations.

Gonen S, Wimmer V, Gaynor RC, Byrne E, Gorjanc G, Hickey JM.

Theor Appl Genet. 2018 Nov;131(11):2345-2357. doi: 10.1007/s00122-018-3156-9. Epub 2018 Aug 4.


Accuracy of genotype imputation in Labrador Retrievers.

Friedrich J, Antolín R, Edwards SM, Sánchez-Molano E, Haskell MJ, Hickey JM, Wiener P.

Anim Genet. 2018 Aug;49(4):303-311. doi: 10.1111/age.12677. Epub 2018 Jul 5.


Optimal cross selection for long-term genetic gain in two-part programs with rapid recurrent genomic selection.

Gorjanc G, Gaynor RC, Hickey JM.

Theor Appl Genet. 2018 Sep;131(9):1953-1966. doi: 10.1007/s00122-018-3125-3. Epub 2018 Jun 6.


AlphaMate: a program for optimizing selection, maintenance of diversity and mate allocation in breeding programs.

Gorjanc G, Hickey JM.

Bioinformatics. 2018 Oct 1;34(19):3408-3411. doi: 10.1093/bioinformatics/bty375.


Joint Genomic Prediction of Canine Hip Dysplasia in UK and US Labrador Retrievers.

Edwards SM, Woolliams JA, Hickey JM, Blott SC, Clements DN, Sánchez-Molano E, Todhunter RJ, Wiener P.

Front Genet. 2018 Mar 28;9:101. doi: 10.3389/fgene.2018.00101. eCollection 2018.


Analytical Comparability Assessments of 5 Recombinant CRM197 Proteins From Different Manufacturers and Expression Systems.

Hickey JM, Toprani VM, Kaur K, Mishra RPN, Goel A, Oganesyan N, Lees A, Sitrin R, Joshi SB, Volkin DB.

J Pharm Sci. 2018 Jul;107(7):1806-1819. doi: 10.1016/j.xphs.2018.03.002. Epub 2018 Mar 8.


Development of Stabilizing Formulations of a Trivalent Inactivated Poliovirus Vaccine in a Dried State for Delivery in the Nanopatch™ Microprojection Array.

Wan Y, Hickey JM, Bird C, Witham K, Fahey P, Forster A, Joshi SB, Volkin DB.

J Pharm Sci. 2018 Jun;107(6):1540-1551. doi: 10.1016/j.xphs.2018.01.027. Epub 2018 Feb 6.


A method for allocating low-coverage sequencing resources by targeting haplotypes rather than individuals.

Ros-Freixedes R, Gonen S, Gorjanc G, Hickey JM.

Genet Sel Evol. 2017 Oct 25;49(1):78. doi: 10.1186/s12711-017-0353-y.


High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine.

Toth RT 4th, Angalakurthi SK, Van Slyke G, Vance DJ, Hickey JM, Joshi SB, Middaugh CR, Volkin DB, Weis DD, Mantis NJ.

Clin Vaccine Immunol. 2017 Dec 5;24(12). pii: e00237-17. doi: 10.1128/CVI.00237-17. Print 2017 Dec.


Genomic prediction unifies animal and plant breeding programs to form platforms for biological discovery.

Hickey JM, Chiurugwi T, Mackay I, Powell W; Implementing Genomic Selection in CGIAR Breeding Programs Workshop Participants.

Nat Genet. 2017 Aug 30;49(9):1297-1303. doi: 10.1038/ng.3920.


Structural Characterization and Physicochemical Stability Profile of a Double Mutant Heat Labile Toxin Protein Based Adjuvant.

Toprani VM, Hickey JM, Sahni N, Toth RT 4th, Robertson GA, Middaugh CR, Joshi SB, Volkin DB.

J Pharm Sci. 2017 Dec;106(12):3474-3485. doi: 10.1016/j.xphs.2017.07.019. Epub 2017 Aug 2.


N-Terminal Pfs230 Domain Produced in Baculovirus as a Biological Active Transmission-Blocking Vaccine Candidate.

Lee SM, Wu CK, Plieskatt JL, Miura K, Hickey JM, King CR.

Clin Vaccine Immunol. 2017 Oct 5;24(10). pii: e00140-17. doi: 10.1128/CVI.00140-17. Print 2017 Oct.


The potential of shifting recombination hotspots to increase genetic gain in livestock breeding.

Gonen S, Battagin M, Johnston SE, Gorjanc G, Hickey JM.

Genet Sel Evol. 2017 Jul 4;49(1):55. doi: 10.1186/s12711-017-0330-5.


Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant.

Toprani VM, Sahni N, Hickey JM, Robertson GA, Middaugh CR, Joshi SB, Volkin DB.

Vaccine. 2017 Oct 4;35(41):5471-5480. doi: 10.1016/j.vaccine.2017.03.101. Epub 2017 May 24.


A method for the allocation of sequencing resources in genotyped livestock populations.

Gonen S, Ros-Freixedes R, Battagin M, Gorjanc G, Hickey JM.

Genet Sel Evol. 2017 May 18;49(1):47. doi: 10.1186/s12711-017-0322-5.


A hybrid method for the imputation of genomic data in livestock populations.

Antolín R, Nettelblad C, Gorjanc G, Money D, Hickey JM.

Genet Sel Evol. 2017 Mar 3;49(1):30. doi: 10.1186/s12711-017-0300-y.


Genotype Imputation To Improve the Cost-Efficiency of Genomic Selection in Farmed Atlantic Salmon.

Tsai HY, Matika O, Edwards SM, Antolín-Sánchez R, Hamilton A, Guy DR, Tinch AE, Gharbi K, Stear MJ, Taggart JB, Bron JE, Hickey JM, Houston RD.

G3 (Bethesda). 2017 Apr 3;7(4):1377-1383. doi: 10.1534/g3.117.040717.


Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs.

Gonen S, Jenko J, Gorjanc G, Mileham AJ, Whitelaw CB, Hickey JM.

Genet Sel Evol. 2017 Jan 4;49(1):3. doi: 10.1186/s12711-016-0280-3.


Preformulation Characterization, Stabilization, and Formulation Design for the Acrylodan-Labeled Glucose-Binding Protein SM4-AC.

Sahni N, Chaudhuri R, Hickey JM, Manikwar P, D'Souza A, Metters A, Joshi SB, Middaugh CR, Volkin DB.

J Pharm Sci. 2017 May;106(5):1197-1210. doi: 10.1016/j.xphs.2017.01.004. Epub 2017 Jan 11.


Effect of acrylodan conjugation and forced oxidation on the structural integrity, conformational stability, and binding activity of a glucose binding protein SM4 used in a prototype continuous glucose monitor.

Hickey JM, Sahni N, Chaudhuri R, D'Souza A, Metters A, Joshi SB, Russell Middaugh C, Volkin DB.

Protein Sci. 2017 Mar;26(3):527-535. doi: 10.1002/pro.3102. Epub 2017 Feb 12.


Sequence Type 631 Vibrio parahaemolyticus, an Emerging Foodborne Pathogen in North America.

Xu F, Gonzalez-Escalona N, Haendiges J, Myers RA, Ferguson J, Stiles T, Hickey E, Moore M, Hickey JM, Schillaci C, Mank L, DeRosia-Banick K, Matluk N, Robbins A, Sebra RP, Cooper VS, Jones SH, Whistler CA.

J Clin Microbiol. 2017 Feb;55(2):645-648. doi: 10.1128/JCM.02162-16. Epub 2016 Dec 14. No abstract available.


Genome-Enabled Prediction Models for Yield Related Traits in Chickpea.

Roorkiwal M, Rathore A, Das RR, Singh MK, Jain A, Srinivasan S, Gaur PM, Chellapilla B, Tripathi S, Li Y, Hickey JM, Lorenz A, Sutton T, Crossa J, Jannink JL, Varshney RK.

Front Plant Sci. 2016 Nov 22;7:1666. eCollection 2016.


AlphaSim: Software for Breeding Program Simulation.

Faux AM, Gorjanc G, Gaynor RC, Battagin M, Edwards SM, Wilson DL, Hearne SJ, Gonen S, Hickey JM.

Plant Genome. 2016 Nov;9(3). doi: 10.3835/plantgenome2016.02.0013.


What Is Your Diagnosis?

Le Roux AB, Hickey JM, Noel PG.

J Am Vet Med Assoc. 2016 Dec 15;249(12):1353-1355. No abstract available.


Effect of manipulating recombination rates on response to selection in livestock breeding programs.

Battagin M, Gorjanc G, Faux AM, Johnston SE, Hickey JM.

Genet Sel Evol. 2016 Jun 22;48(1):44. doi: 10.1186/s12711-016-0221-1.


What Is Your Diagnosis?

Hickey JM, Le Roux AB.

J Am Vet Med Assoc. 2016 Jul 1;249(1):51-3. doi: 10.2460/javma.249.1.51. No abstract available.


Formulation Studies During Preclinical Development of Influenza Hemagglutinin and Virus-Like Particle Vaccine Candidates.

Wahome N, Hickey JM, Volkin DB, Middaugh CR.

Methods Mol Biol. 2016;1404:393-421. doi: 10.1007/978-1-4939-3389-1_27.


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