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Items: 1 to 50 of 252

1.

Why Wait? The Case for Treating Tuberculosis with Inhaled Drugs.

Braunstein M, Hickey AJ, Ekins S.

Pharm Res. 2019 Oct 24;36(12):166. doi: 10.1007/s11095-019-2704-6.

PMID:
31650321
2.

Sterilization of Mycobacterium tuberculosis infected samples using methanol preserves anti-tuberculosis drugs for subsequent pharmacological testing studies.

Walz A, Lukka PB, Pearce C, Creissen E, Braunstein M, Hickey AJ, Meibohm B, Gonzalez-Juarrero M.

Tuberculosis (Edinb). 2019 Jul;117:52-55. doi: 10.1016/j.tube.2019.06.002. Epub 2019 Jun 6.

PMID:
31378268
3.

Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599.

Stewart IE, Lukka PB, Liu J, Meibohm B, Gonzalez-Juarrero M, Braunstein MS, Lee RE, Hickey AJ.

Pharm Res. 2019 Jul 18;36(9):136. doi: 10.1007/s11095-019-2666-8.

PMID:
31321552
4.

Muscle mass drives cost in sexually selected arthropod weapons.

O'Brien DM, Boisseau RP, Duell M, McCullough E, Powell EC, Somjee U, Solie S, Hickey AJ, Holwell GI, Painting CJ, Emlen DJ.

Proc Biol Sci. 2019 Jun 26;286(1905):20191063. doi: 10.1098/rspb.2019.1063. Epub 2019 Jun 26.

PMID:
31238851
5.

A Spray-Dried Combination of Capreomycin and CPZEN-45 for Inhaled Tuberculosis Therapy.

Pitner RA, Durham PG, Stewart IE, Reed SG, Cassell GH, Hickey AJ, Carter D.

J Pharm Sci. 2019 Oct;108(10):3302-3311. doi: 10.1016/j.xphs.2019.05.024. Epub 2019 May 29.

PMID:
31152746
6.

Exploiting machine learning for end-to-end drug discovery and development.

Ekins S, Puhl AC, Zorn KM, Lane TR, Russo DP, Klein JJ, Hickey AJ, Clark AM.

Nat Mater. 2019 May;18(5):435-441. doi: 10.1038/s41563-019-0338-z. Epub 2019 Apr 18.

PMID:
31000803
7.

Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide.

Hunter FW, Devaux JBL, Meng F, Hong CR, Khan A, Tsai P, Ketela TW, Sharma I, Kakadia PM, Marastoni S, Shalev Z, Hickey AJR, Print CG, Bohlander SK, Hart CP, Wouters BG, Wilson WR.

Mol Pharmacol. 2019 Jun;95(6):638-651. doi: 10.1124/mol.118.115196. Epub 2019 Apr 12.

PMID:
30979813
8.

Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment.

Power AS, Norman R, Jones TLM, Hickey AJ, Ward ML.

PLoS One. 2019 Apr 9;14(4):e0214740. doi: 10.1371/journal.pone.0214740. eCollection 2019.

9.

Intertidal triplefin fishes have a lower critical oxygen tension (Pcrit), higher maximal aerobic capacity, and higher tissue glycogen stores than their subtidal counterparts.

McArley TJ, Hickey AJR, Wallace L, Kunzmann A, Herbert NA.

J Comp Physiol B. 2019 Aug;189(3-4):399-411. doi: 10.1007/s00360-019-01216-w. Epub 2019 Apr 2.

PMID:
30941501
10.

Extracellular RNA Profile in Mesenteric Lymph from Exemplar Rat Models of Acute and Critical Illness.

Hong J, Blenkiron C, Tsai P, Premkumar R, Nachkebia S, Tun SM, Petzer A, Windsor JA, Hickey AJ, Phillips AR.

Lymphat Res Biol. 2019 Oct;17(5):512-517. doi: 10.1089/lrb.2018.0044. Epub 2019 Mar 12.

PMID:
30864890
11.

Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia/re-oxygenation.

Devaux JBL, Hickey AJR, Renshaw GMC.

J Exp Biol. 2019 Mar 18;222(Pt 6). pii: jeb191353. doi: 10.1242/jeb.191353.

12.

Acidosis Maintains the Function of Brain Mitochondria in Hypoxia-Tolerant Triplefin Fish: A Strategy to Survive Acute Hypoxic Exposure?

Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR.

Front Physiol. 2019 Jan 18;9:1941. doi: 10.3389/fphys.2018.01941. eCollection 2018.

13.

Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress.

Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR.

Comp Biochem Physiol A Mol Integr Physiol. 2019 Apr;230:115-121. doi: 10.1016/j.cbpa.2019.01.002. Epub 2019 Jan 22.

PMID:
30677507
14.

Voluntary wheel running prevents the acidosis-induced decrease in skeletal muscle mitochondrial reactive oxygen species emission.

Hedges CP, Bishop DJ, Hickey AJR.

FASEB J. 2019 Apr;33(4):4996-5004. doi: 10.1096/fj.201801870R. Epub 2018 Dec 31.

PMID:
30596520
15.

Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men.

Hedges CP, Woodhead JST, Wang HW, Mitchell CJ, Cameron-Smith D, Hickey AJR, Merry TL.

J Appl Physiol (1985). 2019 Feb 1;126(2):454-461. doi: 10.1152/japplphysiol.00777.2018. Epub 2018 Dec 20.

PMID:
30571281
16.

Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture.

Ghosh S, Tran K, Delbridge LMD, Hickey AJR, Hanssen E, Crampin EJ, Rajagopal V.

PLoS Comput Biol. 2018 Dec 5;14(12):e1006640. doi: 10.1371/journal.pcbi.1006640. eCollection 2018 Dec.

17.

Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis.

Montgomery SA, Young EF, Durham PG, Zulauf KE, Rank L, Miller BK, Hayden JD, Lin FC, Welch JT, Hickey AJ, Braunstein M.

PLoS One. 2018 Sep 27;13(9):e0204495. doi: 10.1371/journal.pone.0204495. eCollection 2018. Erratum in: PLoS One. 2018 Nov 5;13(11):e0207257.

18.

Hyperoxia increases maximum oxygen consumption and aerobic scope of intertidal fish facing acutely high temperatures.

McArley TJ, Hickey AJR, Herbert NA.

J Exp Biol. 2018 Nov 12;221(Pt 22). pii: jeb189993. doi: 10.1242/jeb.189993.

19.

Altered Metabolic Profile of Triglyceride-Rich Lipoproteins in Gut-Lymph of Rodent Models of Sepsis and Gut Ischemia-Reperfusion Injury.

Hong J, Nachkebia S, Tun SM, Petzer A, Windsor JA, Hickey AJ, Phillips AR.

Dig Dis Sci. 2018 Dec;63(12):3317-3328. doi: 10.1007/s10620-018-5270-6. Epub 2018 Sep 4.

PMID:
30182310
20.

Spatiotemporal and demographic variation in the diet of New Zealand lesser short-tailed bats (Mystacina tuberculata).

Czenze ZJ, Tucker JL, Clare EL, Littlefair JE, Hemprich-Bennett D, Oliveira HFM, Brigham RM, Hickey AJR, Parsons S.

Ecol Evol. 2018 Jul 9;8(15):7599-7610. doi: 10.1002/ece3.4268. eCollection 2018 Aug.

21.

Pharmacokinetics and pharmacodynamics of high doses of inhaled dry powder drugs.

Kukut Hatipoglu M, Hickey AJ, Garcia-Contreras L.

Int J Pharm. 2018 Oct 5;549(1-2):306-316. doi: 10.1016/j.ijpharm.2018.07.050. Epub 2018 Aug 2. Review.

PMID:
30077761
22.

Exercise recovery increases skeletal muscle H2O2 emission and mitochondrial respiratory capacity following two-weeks of limb immobilization.

Pileggi CA, Hedges CP, D'Souza RF, Durainayagam BR, Markworth JF, Hickey AJR, Mitchell CJ, Cameron-Smith D.

Free Radic Biol Med. 2018 Aug 20;124:241-248. doi: 10.1016/j.freeradbiomed.2018.06.012. Epub 2018 Jun 15.

PMID:
29909291
23.

Effects of Formulation Variables on Lung Dosimetry of Albuterol Sulfate Suspension and Beclomethasone Dipropionate Solution Metered Dose Inhalers.

Schroeter JD, Sheth P, Hickey AJ, Asgharian B, Price OT, Holt JT, Conti DS, Saluja B.

AAPS PharmSciTech. 2018 Jul;19(5):2335-2345. doi: 10.1208/s12249-018-1071-7. Epub 2018 Jun 1.

PMID:
29858973
24.

Calcium mishandling impairs contraction in right ventricular hypertrophy prior to overt heart failure.

Power AS, Hickey AJ, Crossman DJ, Loiselle DS, Ward ML.

Pflugers Arch. 2018 Jul;470(7):1115-1126. doi: 10.1007/s00424-018-2125-0. Epub 2018 Mar 10.

PMID:
29525825
25.

Co-suspension delivery technology in pressurized metered-dose inhalers for multi-drug dosing in the treatment of respiratory diseases.

Ferguson GT, Hickey AJ, Dwivedi S.

Respir Med. 2018 Jan;134:16-23. doi: 10.1016/j.rmed.2017.09.012. Epub 2017 Sep 25. Review.

PMID:
29413503
26.

Oxygen- and capacity-limited thermal tolerance: blurring ecology and physiology.

Jutfelt F, Norin T, Ern R, Overgaard J, Wang T, McKenzie DJ, Lefevre S, Nilsson GE, Metcalfe NB, Hickey AJR, Brijs J, Speers-Roesch B, Roche DG, Gamperl AK, Raby GD, Morgan R, Esbaugh AJ, Gräns A, Axelsson M, Ekström A, Sandblom E, Binning SA, Hicks JW, Seebacher F, Jørgensen C, Killen SS, Schulte PM, Clark TD.

J Exp Biol. 2018 Jan 10;221(Pt 1). pii: jeb169615. doi: 10.1242/jeb.169615. No abstract available.

27.

Reproducibility, sharing and progress in nanomaterial databases.

Tropsha A, Mills KC, Hickey AJ.

Nat Nanotechnol. 2017 Dec 6;12(12):1111-1114. doi: 10.1038/nnano.2017.233. Review. No abstract available.

PMID:
29209007
28.

Density and Shape Factor Terms in Stokes' Equation for Aerodynamic Behavior of Aerosols.

Hickey AJ, Edwards DA.

J Pharm Sci. 2018 Mar;107(3):794-796. doi: 10.1016/j.xphs.2017.11.005. Epub 2017 Nov 14.

PMID:
29154770
29.

Mitochondrial glycerol 3-phosphate facilitates bumblebee pre-flight thermogenesis.

Masson SWC, Hedges CP, Devaux JBL, James CS, Hickey AJR.

Sci Rep. 2017 Oct 12;7(1):13107. doi: 10.1038/s41598-017-13454-5.

30.

Changes in mitochondrial respiration in the human placenta over gestation.

Holland OJ, Hickey AJR, Alvsaker A, Moran S, Hedges C, Chamley LW, Perkins AV.

Placenta. 2017 Sep;57:102-112. doi: 10.1016/j.placenta.2017.06.011. Epub 2017 Jun 15.

PMID:
28863998
31.

Reductive Metabolism Influences the Toxicity and Pharmacokinetics of the Hypoxia-Targeted Benzotriazine Di-Oxide Anticancer Agent SN30000 in Mice.

Gu Y, Chang TT, Wang J, Jaiswal JK, Edwards D, Downes NJ, Liyanage HDS, Lynch CRH, Pruijn FB, Hickey AJR, Hay MP, Wilson WR, Hicks KO.

Front Pharmacol. 2017 Aug 11;8:531. doi: 10.3389/fphar.2017.00531. eCollection 2017.

32.

Chronic warm exposure impairs growth performance and reduces thermal safety margins in the common triplefin fish (Forsterygion lapillum).

McArley TJ, Hickey AJR, Herbert NA.

J Exp Biol. 2017 Oct 1;220(Pt 19):3527-3535. doi: 10.1242/jeb.162099. Epub 2017 Jul 31.

33.

Influence of Formulation Factors on the Aerosol Performance of Suspension and Solution Metered Dose Inhalers: A Systematic Approach.

Sheth P, Sandell D, Conti DS, Holt JT, Hickey AJ, Saluja B.

AAPS J. 2017 Sep;19(5):1396-1410. doi: 10.1208/s12248-017-0095-3. Epub 2017 Jun 7.

PMID:
28593514
34.

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals.

Durham PG, Hanif SN, Contreras LG, Young EF, Braunstein MS, Hickey AJ.

J Vis Exp. 2017 Mar 30;(121). doi: 10.3791/55356.

35.

Hepatic tuberculosis in human immunodeficiency virus co-infected adults: a case series of South African adults.

Gounder L, Moodley P, Drain PK, Hickey AJ, Moosa MS.

BMC Infect Dis. 2017 Feb 1;17(1):115. doi: 10.1186/s12879-017-2222-2.

36.

Maternal High Fat Diet Alters Skeletal Muscle Mitochondrial Catalytic Activity in Adult Male Rat Offspring.

Pileggi CA, Hedges CP, Segovia SA, Markworth JF, Durainayagam BR, Gray C, Zhang XD, Barnett MP, Vickers MH, Hickey AJ, Reynolds CM, Cameron-Smith D.

Front Physiol. 2016 Nov 18;7:546. eCollection 2016.

37.

Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy.

Jarosz J, Ghosh S, Delbridge LM, Petzer A, Hickey AJ, Crampin EJ, Hanssen E, Rajagopal V.

Am J Physiol Cell Physiol. 2017 Feb 1;312(2):C190-C197. doi: 10.1152/ajpcell.00298.2016. Epub 2016 Nov 30.

38.

Systems biology for organotypic cell cultures.

Grego S, Dougherty ER, Alexander FJ, Auerbach SS, Berridge BR, Bittner ML, Casey W, Cooley PC, Dash A, Ferguson SS, Fennell TR, Hawkins BT, Hickey AJ, Kleensang A, Liebman MNJ, Martin F, Maull EA, Paragas J, Qiao GG, Ramaiahgari S, Sumner SJ, Yoon M.

ALTEX. 2017;34(2):301-310. doi: 10.14573/altex.1608221. Epub 2016 Nov 14.

39.

Nanomaterial Drug Products: Manufacturing and Analytical Perspectives.

Sayes CM, Aquino GV, Hickey AJ.

AAPS J. 2017 Jan;19(1):18-25. doi: 10.1208/s12248-016-0008-x. Epub 2016 Nov 7. Review.

PMID:
27822601
40.

Thermodynamic analysis questions claims of improved cardiac efficiency by dietary fish oil.

Loiselle DS, Han JC, Goo E, Chapman B, Barclay CJ, Hickey AJ, Taberner AJ.

J Gen Physiol. 2016 Sep;148(3):183-93. doi: 10.1085/jgp.201611620.

41.

Cold and alone? Roost choice and season affect torpor patterns in lesser short-tailed bats.

Czenze ZJ, Brigham RM, Hickey AJ, Parsons S.

Oecologia. 2017 Jan;183(1):1-8. doi: 10.1007/s00442-016-3707-1. Epub 2016 Aug 25.

PMID:
27561779
42.

Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis.

Chakraborty M, Hickey AJ, Petrov MS, Macdonald JR, Thompson N, Newby L, Sim D, Windsor JA, Phillips AR.

Pancreatology. 2016 Sep-Oct;16(5):739-47. doi: 10.1016/j.pan.2016.06.659. Epub 2016 Jun 27.

PMID:
27473495
43.

Inhaled Pyrazinoic Acid Esters for the Treatment of Tuberculosis.

Young EF, Perkowski E, Malik S, Hayden JD, Durham PG, Zhong L, Welch JT, Braunstein MS, Hickey AJ.

Pharm Res. 2016 Oct;33(10):2495-505. doi: 10.1007/s11095-016-1974-5. Epub 2016 Jun 28.

PMID:
27351427
44.

Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-I dysfunction.

Chu MJ, Premkumar R, Hickey AJ, Jiang Y, Delahunt B, Phillips AR, Bartlett AS.

World J Gastroenterol. 2016 May 21;22(19):4673-84. doi: 10.3748/wjg.v22.i19.4673.

45.

A dry powder combination of pyrazinoic acid and its n-propyl ester for aerosol administration to animals.

Durham PG, Young EF, Braunstein MS, Welch JT, Hickey AJ.

Int J Pharm. 2016 Dec 5;514(2):384-391. doi: 10.1016/j.ijpharm.2016.04.063. Epub 2016 Apr 26.

PMID:
27130363
46.

Impaired ADP channeling to mitochondria and elevated reactive oxygen species in hypertensive hearts.

Power AS, Pham T, Loiselle DS, Crossman DH, Ward ML, Hickey AJ.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1649-57. doi: 10.1152/ajpheart.00050.2016. Epub 2016 Apr 15.

47.

Real-Time Investigation of Tuberculosis Transmission: Developing the Respiratory Aerosol Sampling Chamber (RASC).

Wood R, Morrow C, Barry CE 3rd, Bryden WA, Call CJ, Hickey AJ, Rodes CE, Scriba TJ, Blackburn J, Issarow C, Mulder N, Woodward J, Moosa A, Singh V, Mizrahi V, Warner DF.

PLoS One. 2016 Jan 25;11(1):e0146658. doi: 10.1371/journal.pone.0146658. eCollection 2016.

48.

Impact of Patient Preparation on the Diagnostic Performance of 18F-FDG PET in Cardiac Sarcoidosis: A Systematic Review and Meta-analysis.

Tang R, Wang JT, Wang L, Le K, Huang Y, Hickey AJ, Emmett L.

Clin Nucl Med. 2016 Jul;41(7):e327-39. doi: 10.1097/RLU.0000000000001063. Review.

PMID:
26646995
49.

Inhaled drug treatment for tuberculosis: Past progress and future prospects.

Hickey AJ, Durham PG, Dharmadhikari A, Nardell EA.

J Control Release. 2016 Oct 28;240:127-134. doi: 10.1016/j.jconrel.2015.11.018. Epub 2015 Nov 18. Review.

PMID:
26596254
50.

Correction for Spray Dried Aerosol Particles of Pyrazinoic Acid Salts for Tuberculosis Therapy.

Durham PG, Zhang Y, German N, Mortensen N, Dhillon J, Mitchison DA, Fourie PB, Hickey AJ.

Mol Pharm. 2015 Oct 5;12(10):3782. doi: 10.1021/acs.molpharmaceut.5b00673. Epub 2015 Sep 22. No abstract available.

PMID:
26394135

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