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Items: 24


Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor.

Li L, Welch MA, Li Z, Mackowiak B, Heyward S, Swaan PW, Wang H.

Mol Pharmacol. 2019 Sep;96(3):345-354. doi: 10.1124/mol.119.116616. Epub 2019 Jul 10.


High-content analysis of constitutive androstane receptor (CAR) translocation identifies mosapride citrate as a CAR agonist that represses gluconeogenesis.

Mackowiak B, Li L, Lynch C, Ziman A, Heyward S, Xia M, Wang H.

Biochem Pharmacol. 2019 Oct;168:224-236. doi: 10.1016/j.bcp.2019.07.013. Epub 2019 Jul 12.


Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies.

Liang D, Li L, Lynch C, Mackowiak B, Hedrich WD, Ai Y, Yin Y, Heyward S, Xia M, Wang H, Xue F.

Eur J Med Chem. 2019 Oct 1;179:84-99. doi: 10.1016/j.ejmech.2019.06.031. Epub 2019 Jun 15.


A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.

Kumar V, Salphati L, Hop CECA, Xiao G, Lai Y, Mathias A, Chu X, Humphreys WG, Liao M, Heyward S, Unadkat JD.

Drug Metab Dispos. 2019 Apr;47(4):350-357. doi: 10.1124/dmd.118.084988. Epub 2019 Jan 8.


Identification of Modulators That Activate the Constitutive Androstane Receptor From the Tox21 10K Compound Library.

Lynch C, Mackowiak B, Huang R, Li L, Heyward S, Sakamuru S, Wang H, Xia M.

Toxicol Sci. 2019 Jan 1;167(1):282-292. doi: 10.1093/toxsci/kfy242.


Targeted LC-MS/MS Proteomics-Based Strategy To Characterize in Vitro Models Used in Drug Metabolism and Transport Studies.

Xu M, Saxena N, Vrana M, Zhang H, Kumar V, Billington S, Khojasteh C, Heyward S, Unadkat JD, Prasad B.

Anal Chem. 2018 Oct 16;90(20):11873-11882. doi: 10.1021/acs.analchem.8b01913. Epub 2018 Sep 28.


Molecular Basis of Metabolism-Mediated Conversion of PK11195 from an Antagonist to an Agonist of the Constitutive Androstane Receptor.

Mackowiak B, Li L, Welch MA, Li D, Jones JW, Heyward S, Kane MA, Swaan PW, Wang H.

Mol Pharmacol. 2017 Jul;92(1):75-87. doi: 10.1124/mol.117.108621. Epub 2017 Apr 25.


Transcriptional Regulation of CYP2B6 Expression by Hepatocyte Nuclear Factor 3β in Human Liver Cells.

Li L, Li D, Heyward S, Wang H.

PLoS One. 2016 Mar 1;11(3):e0150587. doi: 10.1371/journal.pone.0150587. eCollection 2016.


Activation of the Constitutive Androstane Receptor Increases the Therapeutic Index of CHOP in Lymphoma Treatment.

Hedrich WD, Xiao J, Heyward S, Zhang Y, Zhang J, Baer MR, Hassan HE, Wang H.

Mol Cancer Ther. 2016 Mar;15(3):392-401. doi: 10.1158/1535-7163.MCT-15-0667. Epub 2016 Jan 28.


Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.

Lynch C, Zhao J, Huang R, Xiao J, Li L, Heyward S, Xia M, Wang H.

Sci Rep. 2015 May 20;5:10405. doi: 10.1038/srep10405.


SLC13A5 is a novel transcriptional target of the pregnane X receptor and sensitizes drug-induced steatosis in human liver.

Li L, Li H, Garzel B, Yang H, Sueyoshi T, Li Q, Shu Y, Zhang J, Hu B, Heyward S, Moeller T, Xie W, Negishi M, Wang H.

Mol Pharmacol. 2015 Apr;87(4):674-82. doi: 10.1124/mol.114.097287. Epub 2015 Jan 27.


Activation of the constitutive androstane receptor inhibits gluconeogenesis without affecting lipogenesis or fatty acid synthesis in human hepatocytes.

Lynch C, Pan Y, Li L, Heyward S, Moeller T, Swaan PW, Wang H.

Toxicol Appl Pharmacol. 2014 Aug 15;279(1):33-42. doi: 10.1016/j.taap.2014.05.009. Epub 2014 May 27.


Aldehyde oxidase activity in donor-matched fresh and cryopreserved human hepatocytes and assessment of variability in 75 donors.

Hutzler JM, Yang YS, Brown C, Heyward S, Moeller T.

Drug Metab Dispos. 2014 Jun;42(6):1090-7. doi: 10.1124/dmd.114.057984. Epub 2014 Apr 8.


Characterization of T-5 N-oxide formation as the first highly selective measure of CYP3A5 activity.

Li X, Jeso V, Heyward S, Walker GS, Sharma R, Micalizio GC, Cameron MD.

Drug Metab Dispos. 2014 Mar;42(3):334-42. doi: 10.1124/dmd.113.054726. Epub 2013 Dec 11.


Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling.

Yang H, Garzel B, Heyward S, Moeller T, Shapiro P, Wang H.

Mol Pharmacol. 2014 Feb;85(2):249-60. doi: 10.1124/mol.113.089763. Epub 2013 Nov 19.


Multicentre survey of radiologically inserted gastrostomy feeding tube (RIG) in the UK.

Lowe AS, Laasch HU, Stephenson S, Butterfield C, Goodwin M, Kay CL, Glancy S, Jackson S, Brown D, McLean P, Keanie J, Thrower A, Briggs R, Punekar S, Krishnan S, Thomas B, Yap K, Mullan D, Maskell G, Hancock J, Edwards A, Dodds N, Philips A, Heyward S, Tolan D, Harris K, Moss E, Hussain F, Lopez AJ, Kennedy P, Ellis P, Collins A, Doyle T, Thompson P, Johnston M, Richenberg J, Vallance K, Dyer J, Higginson T, Atchley J, Corr C, Robinson M, Fleming D, McBride K, Bhat R, Docherty S, Chowdury P.

Clin Radiol. 2012 Sep;67(9):843-54. doi: 10.1016/j.crad.2012.01.014. Epub 2012 Jun 8.


Prospective cohort study of mother-to-infant infection and clearance of hepatitis C in rural Egyptian villages.

Shebl FM, El-Kamary SS, Saleh DA, Abdel-Hamid M, Mikhail N, Allam A, El-Arabi H, Elhenawy I, El-Kafrawy S, El-Daly M, Selim S, El-Wahab AA, Mostafa M, Sharaf S, Hashem M, Heyward S, Stine OC, Magder LS, Stoszek S, Strickland GT.

J Med Virol. 2009 Jun;81(6):1024-31. doi: 10.1002/jmv.21480.


Neutralizing antibody response during acute and chronic hepatitis C virus infection.

Logvinoff C, Major ME, Oldach D, Heyward S, Talal A, Balfe P, Feinstone SM, Alter H, Rice CM, McKeating JA.

Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10149-54. Epub 2004 Jun 25.


Differential engraftment of genetically modified CD34(+) and CD34(-) hematopoietic cell subsets in lethally irradiated baboons.

Andrews RG, Peterson LJ, Morris J, Potter J, Heyward S, Gough M, Bryant E, Kiem HP.

Exp Hematol. 2000 May;28(5):508-18.


Expression and inducibility of vascular adhesion receptors in development.

Heyward SA, Dubois-Stringfellow N, Rapoport R, Bautch VL.

FASEB J. 1995 Jul;9(10):956-62.


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