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Atomic structures of an entire contractile injection system in both the extended and contracted states.

Desfosses A, Venugopal H, Joshi T, Felix J, Jessop M, Jeong H, Hyun J, Heymann JB, Hurst MRH, Gutsche I, Mitra AK.

Nat Microbiol. 2019 Aug 5. doi: 10.1038/s41564-019-0530-6. [Epub ahead of print]


Carbon replicas reveal double stranded structure of tight junctions in phase-contrast electron microscopy.

Krystofiak ES, Heymann JB, Kachar B.

Commun Biol. 2019 Mar 12;2:98. doi: 10.1038/s42003-019-0319-4. eCollection 2019.


Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina.

Heymann JB, Vijayasarathy C, Huang RK, Dearborn AD, Sieving PA, Steven AC.

J Cell Biol. 2019 Mar 4;218(3):1027-1038. doi: 10.1083/jcb.201806148. Epub 2019 Jan 10.


Single-particle reconstruction statistics: a diagnostic tool in solving biomolecular structures by cryo-EM.

Heymann JB.

Acta Crystallogr F Struct Biol Commun. 2019 Jan 1;75(Pt 1):33-44. doi: 10.1107/S2053230X18017636. Epub 2019 Jan 1. Review.


The first single particle analysis Map Challenge: A summary of the assessments.

Heymann JB, Marabini R, Kazemi M, Sorzano COS, Holmdahl M, Mendez JH, Stagg SM, Jonic S, Palovcak E, Armache JP, Zhao J, Cheng Y, Pintilie G, Chiu W, Patwardhan A, Carazo JM.

J Struct Biol. 2018 Nov;204(2):291-300. doi: 10.1016/j.jsb.2018.08.010. Epub 2018 Aug 13.


Map Challenge assessment: Fair comparison of single particle cryoEM reconstructions.

Heymann JB.

J Struct Biol. 2018 Nov;204(2):360-367. doi: 10.1016/j.jsb.2018.07.012. Epub 2018 Jul 17.


Single particle reconstruction and validation using Bsoft for the map challenge.

Heymann JB.

J Struct Biol. 2018 Oct;204(1):90-95. doi: 10.1016/j.jsb.2018.07.003. Epub 2018 Jul 5.


The Primary Enveloped Virion of Herpes Simplex Virus 1: Its Role in Nuclear Egress.

Newcomb WW, Fontana J, Winkler DC, Cheng N, Heymann JB, Steven AC.

MBio. 2017 Jun 13;8(3). pii: e00825-17. doi: 10.1128/mBio.00825-17.


The Structure of HIV-1 Rev Filaments Suggests a Bilateral Model for Rev-RRE Assembly.

DiMattia MA, Watts NR, Cheng N, Huang R, Heymann JB, Grimes JM, Wingfield PT, Stuart DI, Steven AC.

Structure. 2016 Jul 6;24(7):1068-80. doi: 10.1016/j.str.2016.04.015. Epub 2016 Jun 2.


Paired octamer rings of retinoschisin suggest a junctional model for cell-cell adhesion in the retina.

Tolun G, Vijayasarathy C, Huang R, Zeng Y, Li Y, Steven AC, Sieving PA, Heymann JB.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5287-92. doi: 10.1073/pnas.1519048113. Epub 2016 Apr 25.


The Electron Microscopy eXchange (EMX) initiative.

Marabini R, Ludtke SJ, Murray SC, Chiu W, de la Rosa-Trevín JM, Patwardhan A, Heymann JB, Carazo JM.

J Struct Biol. 2016 May;194(2):156-63. doi: 10.1016/j.jsb.2016.02.008. Epub 2016 Feb 9.


α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils.

Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC.

J Biol Chem. 2016 Jan 29;291(5):2310-8. doi: 10.1074/jbc.M115.698787. Epub 2015 Dec 7.


Subassemblies and asymmetry in assembly of herpes simplex virus procapsid.

Aksyuk AA, Newcomb WW, Cheng N, Winkler DC, Fontana J, Heymann JB, Steven AC.

MBio. 2015 Oct 6;6(5):e01525-15. doi: 10.1128/mBio.01525-15.


A virus capsid-like nanocompartment that stores iron and protects bacteria from oxidative stress.

McHugh CA, Fontana J, Nemecek D, Cheng N, Aksyuk AA, Heymann JB, Winkler DC, Lam AS, Wall JS, Steven AC, Hoiczyk E.

EMBO J. 2014 Sep 1;33(17):1896-911. doi: 10.15252/embj.201488566. Epub 2014 Jul 14.


A two-pronged structural analysis of retroviral maturation indicates that core formation proceeds by a disassembly-reassembly pathway rather than a displacive transition.

Keller PW, Huang RK, England MR, Waki K, Cheng N, Heymann JB, Craven RC, Freed EO, Steven AC.

J Virol. 2013 Dec;87(24):13655-64. doi: 10.1128/JVI.01408-13. Epub 2013 Oct 9.


One number does not fit all: mapping local variations in resolution in cryo-EM reconstructions.

Cardone G, Heymann JB, Steven AC.

J Struct Biol. 2013 Nov;184(2):226-36. doi: 10.1016/j.jsb.2013.08.002. Epub 2013 Aug 14.


Subunit folds and maturation pathway of a dsRNA virus capsid.

Nemecek D, Boura E, Wu W, Cheng N, Plevka P, Qiao J, Mindich L, Heymann JB, Hurley JH, Steven AC.

Structure. 2013 Aug 6;21(8):1374-83. doi: 10.1016/j.str.2013.06.007. Epub 2013 Jul 25.


Three-dimensional structure of the toxin-delivery particle antifeeding prophage of Serratia entomophila.

Heymann JB, Bartho JD, Rybakova D, Venugopal HP, Winkler DC, Sen A, Hurst MR, Mitra AK.

J Biol Chem. 2013 Aug 30;288(35):25276-84. doi: 10.1074/jbc.M113.456145. Epub 2013 Jul 15.


Clathrin-coated vesicles from brain have small payloads: a cryo-electron tomographic study.

Heymann JB, Winkler DC, Yim YI, Eisenberg E, Greene LE, Steven AC.

J Struct Biol. 2013 Oct;184(1):43-51. doi: 10.1016/j.jsb.2013.05.006. Epub 2013 May 18.


Data management challenges in three-dimensional EM.

Patwardhan A, Carazo JM, Carragher B, Henderson R, Heymann JB, Hill E, Jensen GJ, Lagerstedt I, Lawson CL, Ludtke SJ, Mastronarde D, Moore WJ, Roseman A, Rosenthal P, Sorzano CO, Sanz-García E, Scheres SH, Subramaniam S, Westbrook J, Winn M, Swedlow JR, Kleywegt GJ.

Nat Struct Mol Biol. 2012 Dec;19(12):1203-7. doi: 10.1038/nsmb.2426. No abstract available.


Packaging accessory protein P7 and polymerase P2 have mutually occluding binding sites inside the bacteriophage 6 procapsid.

Nemecek D, Qiao J, Mindich L, Steven AC, Heymann JB.

J Virol. 2012 Nov;86(21):11616-24. doi: 10.1128/JVI.01347-12. Epub 2012 Aug 15.


Procapsid assembly, maturation, nuclear exit: dynamic steps in the production of infectious herpesvirions.

Cardone G, Heymann JB, Cheng N, Trus BL, Steven AC.

Adv Exp Med Biol. 2012;726:423-39. doi: 10.1007/978-1-4614-0980-9_19. Review.


Structural changes in Influenza virus at low pH characterized by cryo-electron tomography.

Fontana J, Cardone G, Heymann JB, Winkler DC, Steven AC.

J Virol. 2012 Mar;86(6):2919-29. doi: 10.1128/JVI.06698-11. Epub 2012 Jan 18.


Towards an atlas of mammalian cell ultrastructure by cryo soft X-ray tomography.

Müller WG, Heymann JB, Nagashima K, Guttmann P, Werner S, Rehbein S, Schneider G, McNally JG.

J Struct Biol. 2012 Feb;177(2):179-92. doi: 10.1016/j.jsb.2011.11.025. Epub 2011 Dec 2.


Stepwise expansion of the bacteriophage ϕ6 procapsid: possible packaging intermediates.

Nemecek D, Cheng N, Qiao J, Mindich L, Steven AC, Heymann JB.

J Mol Biol. 2011 Nov 25;414(2):260-71. doi: 10.1016/j.jmb.2011.10.004. Epub 2011 Oct 12.


HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice.

Keller PW, Adamson CS, Heymann JB, Freed EO, Steven AC.

J Virol. 2011 Feb;85(4):1420-8. doi: 10.1128/JVI.01926-10. Epub 2010 Nov 24.


Three-dimensional cellular ultrastructure resolved by X-ray microscopy.

Schneider G, Guttmann P, Heim S, Rehbein S, Mueller F, Nagashima K, Heymann JB, Müller WG, McNally JG.

Nat Methods. 2010 Dec;7(12):985-7. doi: 10.1038/nmeth.1533. Epub 2010 Nov 14.


Cryo-electron tomography of bacteriophage phi6 procapsids shows random occupancy of the binding sites for RNA polymerase and packaging NTPase.

Nemecek D, Heymann JB, Qiao J, Mindich L, Steven AC.

J Struct Biol. 2010 Sep;171(3):389-96. doi: 10.1016/j.jsb.2010.06.005. Epub 2010 Jun 9.


Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex.

Grundy GJ, Ramón-Maiques S, Dimitriadis EK, Kotova S, Biertümpfel C, Heymann JB, Steven AC, Gellert M, Yang W.

Mol Cell. 2009 Jul 31;35(2):217-27. doi: 10.1016/j.molcel.2009.06.022.


Irregular and Semi-Regular Polyhedral Models for Rous Sarcoma Virus Cores.

Heymann JB, Butan C, Winkler DC, Craven RC, Steven AC.

Comput Math Methods Med. 2008;9(3-4):197-210.


Initial location of the RNA-dependent RNA polymerase in the bacteriophage Phi6 procapsid determined by cryo-electron microscopy.

Sen A, Heymann JB, Cheng N, Qiao J, Mindich L, Steven AC.

J Biol Chem. 2008 May 2;283(18):12227-31. doi: 10.1074/jbc.M710508200. Epub 2008 Feb 20.


RSV capsid polymorphism correlates with polymerization efficiency and envelope glycoprotein content: implications that nucleation controls morphogenesis.

Butan C, Winkler DC, Heymann JB, Craven RC, Steven AC.

J Mol Biol. 2008 Feb 29;376(4):1168-81. doi: 10.1016/j.jmb.2007.12.003. Epub 2007 Dec 8.


Computational resources for cryo-electron tomography in Bsoft.

Heymann JB, Cardone G, Winkler DC, Steven AC.

J Struct Biol. 2008 Mar;161(3):232-42. Epub 2007 Aug 11.


Influenza virus pleiomorphy characterized by cryoelectron tomography.

Harris A, Cardone G, Winkler DC, Heymann JB, Brecher M, White JM, Steven AC.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19123-7. Epub 2006 Dec 4.


Bsoft: image processing and molecular modeling for electron microscopy.

Heymann JB, Belnap DM.

J Struct Biol. 2007 Jan;157(1):3-18. Epub 2006 Jun 28.


A comparison of liquid nitrogen and liquid helium as cryogens for electron cryotomography.

Iancu CV, Wright ER, Heymann JB, Jensen GJ.

J Struct Biol. 2006 Mar;153(3):231-40. Epub 2006 Jan 4.


A "flip-flop" rotation stage for routine dual-axis electron cryotomography.

Iancu CV, Wright ER, Benjamin J, Tivol WF, Dias DP, Murphy GE, Morrison RC, Heymann JB, Jensen GJ.

J Struct Biol. 2005 Sep;151(3):288-97.


Common conventions for interchange and archiving of three-dimensional electron microscopy information in structural biology.

Heymann JB, Chagoyen M, Belnap DM.

J Struct Biol. 2005 Aug;151(2):196-207. Erratum in: J Struct Biol. 2006 Mar;153(3):312.


Virus maturation: dynamics and mechanism of a stabilizing structural transition that leads to infectivity.

Steven AC, Heymann JB, Cheng N, Trus BL, Conway JF.

Curr Opin Struct Biol. 2005 Apr;15(2):227-36. Review.


The axial channel of the 20S proteasome opens upon binding of the PA200 activator.

Ortega J, Heymann JB, Kajava AV, Ustrell V, Rechsteiner M, Steven AC.

J Mol Biol. 2005 Mar 11;346(5):1221-7. Epub 2005 Jan 26.


Visualization of the binding of Hsc70 ATPase to clathrin baskets: implications for an uncoating mechanism.

Heymann JB, Iwasaki K, Yim YI, Cheng N, Belnap DM, Greene LE, Eisenberg E, Steven AC.

J Biol Chem. 2005 Feb 25;280(8):7156-61. Epub 2004 Dec 13.


Molecular dynamics of protein complexes from four-dimensional cryo-electron microscopy.

Heymann JB, Conway JF, Steven AC.

J Struct Biol. 2004 Sep;147(3):291-301.


Three-dimensional structure of herpes simplex virus from cryo-electron tomography.

Grünewald K, Desai P, Winkler DC, Heymann JB, Belnap DM, Baumeister W, Steven AC.

Science. 2003 Nov 21;302(5649):1396-8.


Dynamics of herpes simplex virus capsid maturation visualized by time-lapse cryo-electron microscopy.

Heymann JB, Cheng N, Newcomb WW, Trus BL, Brown JC, Steven AC.

Nat Struct Biol. 2003 May;10(5):334-41.


Imaging streptavidin 2D crystals on biotinylated lipid monolayers at high resolution with the atomic force microscope.

Scheuring S, Muller DJ, Ringler P, Heymann JB, Engel A.

J Microsc. 1999 Jan;193(1):28-35.


Sampling effects influence heights measured with atomic force microscopy.

Heymann JB, Möller C, Müller DJ.

J Microsc. 2002 Jul;207(Pt 1):43-51.


Bsoft: image and molecular processing in electron microscopy.

Heymann JB.

J Struct Biol. 2001 Feb-Mar;133(2-3):156-69.


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