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Vitamin D Supplementation in Mechanically Ventilated Patients in the Medical Intensive Care Unit.

Leclair TR, Zakai N, Bunn JY, Gianni M, Heyland DK, Ardren SS, Stapleton RD.

JPEN J Parenter Enteral Nutr. 2019 Feb 12. doi: 10.1002/jpen.1520. [Epub ahead of print]


PEP uP (Enhanced Protein-Energy Provision via the Enteral Route Feeding Protocol) in Surgical Patients-A Multicenter Pilot Randomized Controlled Trial.

Yeh DD, Ortiz LA, Lee JM, Chan J, McKenzie K, Young B, Chetelat L, Collier B, Benson A, Heyland DK.

JPEN J Parenter Enteral Nutr. 2019 Feb 11. doi: 10.1002/jpen.1521. [Epub ahead of print]


Short Graphic Values History Tool for decision making during serious illness.

You JJ, Allatt P, Howard M, Robinson CA, Simon J, Sudore R, Tan A, Bernard C, Swinton M, Jiang X, Klein D, McKenzie M, Fyles G, Heyland DK.

BMJ Support Palliat Care. 2019 Feb 6. pii: bmjspcare-2018-001698. doi: 10.1136/bmjspcare-2018-001698. [Epub ahead of print]


Adaptation and Preliminary Validation of the Advance Care Planning Engagement Survey for Surrogate Decision Makers.

Van Scoy LJ, Day AG, Howard M, Sudore R, Heyland DK.

J Pain Symptom Manage. 2019 Jan 24. pii: S0885-3924(19)30041-7. doi: 10.1016/j.jpainsymman.2019.01.008. [Epub ahead of print]


Translation of the modified NUTRIC score and adaptation to the Greek ICU setting.

Chourdakis M, Grammatikopoulou MG, Poulia KA, Passakiotou M, Pafili ZK, Bouras E, Doundoulakis I, Galitsianos I, Lappa T, Karakatsanis A, Heyland DK.

Clin Nutr ESPEN. 2019 Feb;29:72-76. doi: 10.1016/j.clnesp.2018.12.003. Epub 2018 Dec 29.


The relevance of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D concentration for postoperative infections and postoperative organ dysfunctions in cardiac surgery patients: The eVIDenCe study.

Ney J, Heyland DK, Amrein K, Marx G, Grottke O, Choudrakis M, Autschbach T, Hill A, Meybohm P, Benstoem C, Goetzenich A, Fitzner C, Stoppe C.

Clin Nutr. 2018 Dec 13. pii: S0261-5614(18)32568-8. doi: 10.1016/j.clnu.2018.11.033. [Epub ahead of print]


Are all low-NUTRIC-score patients the same? Analysis of a multi-center observational study to determine the relationship between nutrition intake and outcome.

Chourdakis M, Grammatikopoulou MG, Day AG, Bouras E, Heyland DK.

Clin Nutr. 2018 Dec 8. pii: S0261-5614(18)32573-1. doi: 10.1016/j.clnu.2018.12.006. [Epub ahead of print]


Prediction of Prolonged ICU Stay in Cardiac Surgery Patients as a Useful Method to Identify Nutrition Risk in Cardiac Surgery Patients: A Post Hoc Analysis of a Prospective Observational Study.

Stoppe C, Ney J, Lomivorotov VV, Efremov SM, Benstoem C, Hill A, Nesterova E, Laaf E, Goetzenich A, McDonald B, Peine A, Marx G, Fehnle K, Heyland DK.

JPEN J Parenter Enteral Nutr. 2018 Dec 2. doi: 10.1002/jpen.1486. [Epub ahead of print]


Determination of Nutrition Risk and Status in Critically Ill Patients: What Are Our Considerations?

Lee ZY, Heyland DK.

Nutr Clin Pract. 2019 Feb;34(1):96-111. doi: 10.1002/ncp.10214. Epub 2018 Nov 23. Review.


Vitamin C Administration to the Critically Ill: A Systematic Review and Meta-Analysis.

Langlois PL, Manzanares W, Adhikari NKJ, Lamontagne F, Stoppe C, Hill A, Heyland DK.

JPEN J Parenter Enteral Nutr. 2019 Mar;43(3):335-346. doi: 10.1002/jpen.1471. Epub 2018 Nov 19. Review.


The Effect of Higher Protein Dosing in Critically Ill Patients: A Multicenter Registry-Based Randomized Trial: The EFFORT Trial.

Heyland DK, Patel J, Bear D, Sacks G, Nixdorf H, Dolan J, Aloupis M, Licastro K, Jovanovic V, Rice TW, Compher C.

JPEN J Parenter Enteral Nutr. 2019 Mar;43(3):326-334. doi: 10.1002/jpen.1449. Epub 2018 Sep 27. Review.


Unraveling Methodology to Ensure the Search for Optimal Nutrition Quantity in Acute Respiratory Distress Syndrome Remains INTACT.

Patel JJ, Martindale RG, Heyland DK.

JPEN J Parenter Enteral Nutr. 2019 Jan;43(1):8-9. doi: 10.1002/jpen.1443. Epub 2018 Sep 25. No abstract available.


Patient and family engagement in the ICU: Report from the task force of the World Federation of Societies of Intensive and Critical Care Medicine.

Kleinpell R, Heyland DK, Lipman J, Sprung CL, Levy M, Mer M, Koh Y, Davidson J, Taha A, Curtis JR; Council of the World Federation of Societies of Intensive and Critical Care Medicine.

J Crit Care. 2018 Dec;48:251-256. doi: 10.1016/j.jcrc.2018.09.006. Epub 2018 Sep 8.


Outcomes of Older Hospitalized Patients Requiring Rapid Response Team Activation for Acute Deterioration.

Fernando SM, Reardon PM, McIsaac DI, Eagles D, Murphy K, Tanuseputro P, Heyland DK, Kyeremanteng K.

Crit Care Med. 2018 Dec;46(12):1953-1960. doi: 10.1097/CCM.0000000000003442.


Implications of low muscle mass across the continuum of care: a narrative review.

Prado CM, Purcell SA, Alish C, Pereira SL, Deutz NE, Heyland DK, Goodpaster BH, Tappenden KA, Heymsfield SB.

Ann Med. 2018 Dec;50(8):675-693. doi: 10.1080/07853890.2018.1511918. Epub 2018 Sep 12.


Vitamin C to Improve Organ Dysfunction in Cardiac Surgery Patients-Review and Pragmatic Approach.

Hill A, Wendt S, Benstoem C, Neubauer C, Meybohm P, Langlois P, Adhikari NK, Heyland DK, Stoppe C.

Nutrients. 2018 Jul 27;10(8). pii: E974. doi: 10.3390/nu10080974. Review.


Greater Nutrient Intake Is Associated With Lower Mortality in Western and Eastern Critically Ill Patients With Low BMI: A Multicenter, Multinational Observational Study.

Compher C, Chittams J, Sammarco T, Higashibeppu N, Higashiguchi T, Heyland DK.

JPEN J Parenter Enteral Nutr. 2019 Jan;43(1):63-69. doi: 10.1002/jpen.1180. Epub 2018 Jun 30.


Nutrition Adequacy Therapeutic Enhancement in the Critically Ill: A Randomized Double-Blind, Placebo-Controlled Trial of the Motilin Receptor Agonist Camicinal (GSK962040): The NUTRIATE Study.

Deane AM, Lamontagne F, Dukes GE, Neil D, Vasist L, Barton ME, Hacquoil K, Ou X, Richards D, Stelfox HT, Mehta S, Day AG, Chapman MJ, Heyland DK.

JPEN J Parenter Enteral Nutr. 2018 Jul;42(5):949-959. doi: 10.1002/jpen.1038. Epub 2017 Dec 28.


A RandomizEd trial of ENtERal Glutamine to minimIZE thermal injury (The RE-ENERGIZE Trial): a clinical trial protocol.

Heyland DK, Wischmeyer P, Jeschke MG, Wibbenmeyer L, Turgeon AF, Stelfox HT, Day AG, Garrel D.

Scars Burn Heal. 2017 Dec 12;3:2059513117745241. doi: 10.1177/2059513117745241. eCollection 2017 Jan-Dec.


Older patient engagement in advance care planning in Canadian primary care practices: Results of a multisite survey.

Howard M, Bernard C, Klein D, Tan A, Slaven M, Barwich D, You JJ, Asselin G, Simon J, Heyland DK.

Can Fam Physician. 2018 May;64(5):371-377.


Prevalence, Risk Factors, and Clinical Consequences of Recurrent Activation of a Rapid Response Team: A Multicenter Observational Study.

Fernando SM, Reardon PM, Scales DC, Murphy K, Tanuseputro P, Heyland DK, Kyeremanteng K.

J Intensive Care Med. 2018 Jan 1:885066618773735. doi: 10.1177/0885066618773735. [Epub ahead of print]


Barriers to and enablers of advance care planning with patients in primary care: Survey of health care providers.

Howard M, Bernard C, Klein D, Elston D, Tan A, Slaven M, Barwich D, You JJ, Heyland DK.

Can Fam Physician. 2018 Apr;64(4):e190-e198.


Should We Prescribe More Protein to Critically Ill Patients?

Heyland DK, Stapleton R, Compher C.

Nutrients. 2018 Apr 7;10(4). pii: E462. doi: 10.3390/nu10040462. Review.


Impact of nighttime Rapid Response Team activation on outcomes of hospitalized patients with acute deterioration.

Fernando SM, Reardon PM, Bagshaw SM, Scales DC, Murphy K, Shen J, Tanuseputro P, Heyland DK, Kyeremanteng K.

Crit Care. 2018 Mar 14;22(1):67. doi: 10.1186/s13054-018-2005-1.


Development of a decision aid for cardiopulmonary resuscitation and invasive mechanical ventilation in the intensive care unit employing user-centered design and a wiki platform for rapid prototyping.

Plaisance A, Witteman HO, LeBlanc A, Kryworuchko J, Heyland DK, Ebell MH, Blair L, Tapp D, Dupuis A, Lavoie-Bérard CA, McGinn CA, Légaré F, Archambault PM.

PLoS One. 2018 Feb 15;13(2):e0191844. doi: 10.1371/journal.pone.0191844. eCollection 2018.


Clinically Practical Approach for Screening of Low Muscularity Using Electronic Linear Measures on Computed Tomography Images in Critically Ill Patients.

Avrutin E, Moisey LL, Zhang R, Khattab J, Todd E, Premji T, Kozar R, Heyland DK, Mourtzakis M.

JPEN J Parenter Enteral Nutr. 2018 Jul;42(5):885-891. doi: 10.1002/jpen.1019. Epub 2017 Dec 6.


Outcomes and Costs of Patients Admitted to the ICU Due to Spontaneous Intracranial Hemorrhage.

Fernando SM, Reardon PM, Dowlatshahi D, English SW, Thavorn K, Tanuseputro P, Perry JJ, Rosenberg E, Wijdicks EF, Heyland DK, Kyeremanteng K.

Crit Care Med. 2018 May;46(5):e395-e403. doi: 10.1097/CCM.0000000000003013.


Family members' satisfaction with care and decision-making in intensive care units and post-stay follow-up needs-a cross-sectional survey study.

Frivold G, Slettebø Å, Heyland DK, Dale B.

Nurs Open. 2017 Oct 18;5(1):6-14. doi: 10.1002/nop2.97. eCollection 2018 Jan.


Improving partnerships with family members of ICU patients: study protocol for a randomized controlled trial.

Heyland DK, Davidson J, Skrobik Y, des Ordons AR, Van Scoy LJ, Day AG, Vandall-Walker V, Marshall AP.

Trials. 2018 Jan 4;19(1):3. doi: 10.1186/s13063-017-2379-4.


Reservations about Permissive Underfeeding in Low versus High NUTRIC Patients?

Compher C, Martin ND, Heyland DK.

Am J Respir Crit Care Med. 2018 May 1;197(9):1226-1227. doi: 10.1164/rccm.201710-2064LE. No abstract available.


Intermittent versus continuous feeding in critically ill adults.

Patel JJ, Rosenthal MD, Heyland DK.

Curr Opin Clin Nutr Metab Care. 2018 Mar;21(2):116-120. doi: 10.1097/MCO.0000000000000447.


Recognizing difficult trade-offs: values and treatment preferences for end-of-life care in a multi-site survey of adult patients in family practices.

Howard M, Bansback N, Tan A, Klein D, Bernard C, Barwich D, Dodek P, Nijjar A, Heyland DK.

BMC Med Inform Decis Mak. 2017 Dec 6;17(1):164. doi: 10.1186/s12911-017-0570-x.


Bereaved family members' perceptions of the quality of end-of-life care across four types of inpatient care settings.

Stajduhar K, Sawatzky R, Robin Cohen S, Heyland DK, Allan D, Bidgood D, Norgrove L, Gadermann AM.

BMC Palliat Care. 2017 Nov 25;16(1):59. doi: 10.1186/s12904-017-0237-5.


Definition and recommendations for advance care planning: an international consensus supported by the European Association for Palliative Care.

Rietjens JAC, Sudore RL, Connolly M, van Delden JJ, Drickamer MA, Droger M, van der Heide A, Heyland DK, Houttekier D, Janssen DJA, Orsi L, Payne S, Seymour J, Jox RJ, Korfage IJ; European Association for Palliative Care.

Lancet Oncol. 2017 Sep;18(9):e543-e551. doi: 10.1016/S1470-2045(17)30582-X. Review.


Outcomes That Define Successful Advance Care Planning: A Delphi Panel Consensus.

Sudore RL, Heyland DK, Lum HD, Rietjens JAC, Korfage IJ, Ritchie CS, Hanson LC, Meier DE, Pantilat SZ, Lorenz K, Howard M, Green MJ, Simon JE, Feuz MA, You JJ.

J Pain Symptom Manage. 2018 Feb;55(2):245-255.e8. doi: 10.1016/j.jpainsymman.2017.08.025. Epub 2017 Sep 1.


Discordance between patients' stated values and treatment preferences for end-of-life care: results of a multicentre survey.

Heyland DK, Heyland R, Dodek P, You JJ, Sinuff T, Hiebert T, Jiang X, Day AG; ACCEPT Study Team and the Canadian Researchers at the End of Life Network (CARENET).

BMJ Support Palliat Care. 2017 Sep;7(3):292-299. doi: 10.1136/bmjspcare-2015-001056. Epub 2016 Oct 6.


Critical Care Nutrition Support Best Practices: Key Differences Between Canadian and American Guidelines.

Patel JJ, Lemieux M, McClave SA, Martindale RG, Hurt RT, Heyland DK.

Nutr Clin Pract. 2017 Oct;32(5):633-644. doi: 10.1177/0884533617722165. Epub 2017 Aug 18. Review.


The authors reply.

Compher C, Heyland DK.

Crit Care Med. 2017 Sep;45(9):e986. doi: 10.1097/CCM.0000000000002531. No abstract available.


Development and Psychometric Properties of a Survey to Assess Barriers to Implementing Advance Care Planning in Primary Care.

Howard M, Day AG, Bernard C, Tan A, You J, Klein D, Heyland DK.

J Pain Symptom Manage. 2018 Jan;55(1):12-21. doi: 10.1016/j.jpainsymman.2017.08.003. Epub 2017 Aug 10.


Validation of quality indicators for end-of-life communication: results of a multicentre survey.

Heyland DK, Dodek P, You JJ, Sinuff T, Hiebert T, Tayler C, Jiang X, Simon J, Downar J; ACCEPT Study Team and the Canadian Researchers at the End of Life Network (CARENET).

CMAJ. 2017 Jul 31;189(30):E980-E989. doi: 10.1503/cmaj.160515.


Intravenous fish oil in critically ill and surgical patients - Historical remarks and critical appraisal.

Kreymann KG, Heyland DK, de Heer G, Elke G.

Clin Nutr. 2018 Jun;37(3):1075-1081. doi: 10.1016/j.clnu.2017.07.006. Epub 2017 Jul 13.


Patient-family agreement on values and preferences for life-sustaining treatment: results of a multicentre observational study.

Abdul-Razzak A, Heyland DK, Simon J, Ghosh S, Day AG, You JJ.

BMJ Support Palliat Care. 2019 Mar;9(1):e20. doi: 10.1136/bmjspcare-2016-001284. Epub 2017 Jul 22.


Measuring Family Members' Satisfaction with End-of-Life Care in Long-Term Care: Adaptation of the CANHELP Lite Questionnaire.

Nadin S, Miandad MA, Kelley ML, Marcella J, Heyland DK.

Biomed Res Int. 2017;2017:4621592. doi: 10.1155/2017/4621592. Epub 2017 Jun 19.


Barriers to Goals of Care Discussions With Patients Who Have Advanced Heart Failure: Results of a Multicenter Survey of Hospital-Based Cardiology Clinicians.

You JJ, Aleksova N, Ducharme A, MacIver J, Mielniczuk L, Fowler RA, Demers C, Clarke B, Parent MC, Toma M, Strachan PH, Farand P, Isaac D, Zieroth S, Swinton M, Jiang X, Day AG, Heyland DK, Ross HJ.

J Card Fail. 2017 Nov;23(11):786-793. doi: 10.1016/j.cardfail.2017.06.003. Epub 2017 Jun 23.


The authors reply.

Compher C, Heyland DK.

Crit Care Med. 2017 Jul;45(7):e743-e744. doi: 10.1097/CCM.0000000000002471. No abstract available.


A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial.

Wischmeyer PE, Hasselmann M, Kummerlen C, Kozar R, Kutsogiannis DJ, Karvellas CJ, Besecker B, Evans DK, Preiser JC, Gramlich L, Jeejeebhoy K, Dhaliwal R, Jiang X, Day AG, Heyland DK.

Crit Care. 2017 Jun 9;21(1):142. doi: 10.1186/s13054-017-1736-8.


Role of nutrition support in adult cardiac surgery: a consensus statement from an International Multidisciplinary Expert Group on Nutrition in Cardiac Surgery.

Stoppe C, Goetzenich A, Whitman G, Ohkuma R, Brown T, Hatzakorzian R, Kristof A, Meybohm P, Mechanick J, Evans A, Yeh D, McDonald B, Chourdakis M, Jones P, Barton R, Tripathi R, Elke G, Liakopoulos O, Agarwala R, Lomivorotov V, Nesterova E, Marx G, Benstoem C, Lemieux M, Heyland DK.

Crit Care. 2017 Jun 5;21(1):131. doi: 10.1186/s13054-017-1690-5.


Vitamin D supplementation in the critically ill: A systematic review and meta-analysis.

Langlois PL, Szwec C, D'Aragon F, Heyland DK, Manzanares W.

Clin Nutr. 2018 Aug;37(4):1238-1246. doi: 10.1016/j.clnu.2017.05.006. Epub 2017 May 11.


Novel, Family-Centered Intervention to Improve Nutrition in Patients Recovering From Critical Illness: A Feasibility Study.

Marshall AP, Lemieux M, Dhaliwal R, Seyler H, MacEachern KN, Heyland DK.

Nutr Clin Pract. 2017 Jun;32(3):392-399. doi: 10.1177/0884533617695241. Epub 2017 Mar 16.


Translation and adaptation of the NUTRIC Score to identify critically ill patients who benefit the most from nutrition therapy.

Rosa M, Heyland DK, Fernandes D, Rabito EI, Oliveira ML, Marcadenti A.

Clin Nutr ESPEN. 2016 Aug;14:31-36. doi: 10.1016/j.clnesp.2016.04.030. Epub 2016 May 21.


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