Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 130


In vitro role of Rad54 in Rad51-ssDNA filament-dependent homology search and synaptic complexes formation.

Tavares EM, Wright WD, Heyer WD, Le Cam E, Dupaigne P.

Nat Commun. 2019 Sep 6;10(1):4058. doi: 10.1038/s41467-019-12082-z.


Role of the Srs2-Rad51 Interaction Domain in Crossover Control in Saccharomyces cerevisiae.

Jenkins SS, Gore S, Guo X, Liu J, Ede C, Veaute X, Jinks-Robertson S, Kowalczykowski SC, Heyer WD.

Genetics. 2019 Aug;212(4):1133-1145. doi: 10.1534/genetics.119.302337. Epub 2019 May 29.


Moving forward one step back at a time: reversibility during homologous recombination.

Piazza A, Heyer WD.

Curr Genet. 2019 May 23. doi: 10.1007/s00294-019-00995-7. [Epub ahead of print] Review.


Cooperation between non-essential DNA polymerases contributes to genome stability in Saccharomyces cerevisiae.

Meyer D, Fu BXH, Chavez M, Loeillet S, Cerqueira PG, Nicolas A, Heyer WD.

DNA Repair (Amst). 2019 Apr;76:40-49. doi: 10.1016/j.dnarep.2019.02.004. Epub 2019 Feb 6.


Dynamic Processing of Displacement Loops during Recombinational DNA Repair.

Piazza A, Shah SS, Wright WD, Gore SK, Koszul R, Heyer WD.

Mol Cell. 2019 Mar 21;73(6):1255-1266.e4. doi: 10.1016/j.molcel.2019.01.005. Epub 2019 Feb 5.


Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes.

Klein HL, Ang KKH, Arkin MR, Beckwitt EC, Chang YH, Fan J, Kwon Y, Morten MJ, Mukherjee S, Pambos OJ, El Sayyed H, Thrall ES, Vieira-da-Rocha JP, Wang Q, Wang S, Yeh HY, Biteen JS, Chi P, Heyer WD, Kapanidis AN, Loparo JJ, Strick TR, Sung P, Van Houten B, Niu H, Rothenberg E.

Microb Cell. 2019 Jan 7;6(1):65-101. doi: 10.15698/mic2019.01.665. Review.


Homologous Recombination and the Formation of Complex Genomic Rearrangements.

Piazza A, Heyer WD.

Trends Cell Biol. 2019 Feb;29(2):135-149. doi: 10.1016/j.tcb.2018.10.006. Epub 2018 Nov 26. Review.


Homologous recombination and the repair of DNA double-strand breaks.

Wright WD, Shah SS, Heyer WD.

J Biol Chem. 2018 Jul 6;293(27):10524-10535. doi: 10.1074/jbc.TM118.000372. Epub 2018 Mar 29. Review.


Multi-Invasion-Induced Rearrangements as a Pathway for Physiological and Pathological Recombination.

Piazza A, Heyer WD.

Bioessays. 2018 May;40(5):e1700249. doi: 10.1002/bies.201700249. Epub 2018 Mar 26. Review.


A Proximity Ligation-Based Method for Quantitative Measurement of D-Loop Extension in S. cerevisiae.

Piazza A, Koszul R, Heyer WD.

Methods Enzymol. 2018;601:27-44. doi: 10.1016/bs.mie.2017.11.024. Epub 2018 Feb 24.


Multi-invasions Are Recombination Byproducts that Induce Chromosomal Rearrangements.

Piazza A, Wright WD, Heyer WD.

Cell. 2017 Aug 10;170(4):760-773.e15. doi: 10.1016/j.cell.2017.06.052. Epub 2017 Aug 3.


Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops.

Liu J, Ede C, Wright WD, Gore SK, Jenkins SS, Freudenthal BD, Todd Washington M, Veaute X, Heyer WD.

Elife. 2017 May 23;6. pii: e22195. doi: 10.7554/eLife.22195.


Correction for Muñoz-Galván et al., "Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange".

Muñoz-Galván S, Tous C, Blanco MG, Schwartz EK, Ehmsen KT, West SC, Heyer WD, Aguilera A.

Mol Cell Biol. 2017 May 16;37(11). pii: e00161-17. doi: 10.1128/MCB.00161-17. Print 2017 Jun 1. No abstract available.


Eukaryotic DNA Polymerases in Homologous Recombination.

McVey M, Khodaverdian VY, Meyer D, Cerqueira PG, Heyer WD.

Annu Rev Genet. 2016 Nov 23;50:393-421. Review.


Strand displacement synthesis by yeast DNA polymerase ε.

Ganai RA, Zhang XP, Heyer WD, Johansson E.

Nucleic Acids Res. 2016 Sep 30;44(17):8229-40. doi: 10.1093/nar/gkw556. Epub 2016 Jun 20.


Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.

Spies J, Waizenegger A, Barton O, Sürder M, Wright WD, Heyer WD, Löbrich M.

Mol Cell. 2016 Jun 16;62(6):903-917. doi: 10.1016/j.molcel.2016.04.032. Epub 2016 Jun 2.


Nonsense-mediated decay regulates key components of homologous recombination.

Janke R, Kong J, Braberg H, Cantin G, Yates JR 3rd, Krogan NJ, Heyer WD.

Nucleic Acids Res. 2016 Jun 20;44(11):5218-30. doi: 10.1093/nar/gkw182. Epub 2016 Mar 21.


Autism and Cancer Share Risk Genes, Pathways, and Drug Targets.

Crawley JN, Heyer WD, LaSalle JM.

Trends Genet. 2016 Mar;32(3):139-146. doi: 10.1016/j.tig.2016.01.001. Epub 2016 Jan 29. Review.


DNA polymerases δ and λ cooperate in repairing double-strand breaks by microhomology-mediated end-joining in Saccharomyces cerevisiae.

Meyer D, Fu BX, Heyer WD.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6907-16. doi: 10.1073/pnas.1507833112. Epub 2015 Nov 25.


Regulation of recombination and genomic maintenance.

Heyer WD.

Cold Spring Harb Perspect Biol. 2015 Aug 3;7(8):a016501. doi: 10.1101/cshperspect.a016501. Review.


RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.

Mason JM, Dusad K, Wright WD, Grubb J, Budke B, Heyer WD, Connell PP, Weichselbaum RR, Bishop DK.

Nucleic Acids Res. 2015 Mar 31;43(6):3180-96. doi: 10.1093/nar/gkv175. Epub 2015 Mar 12.


Top3-Rmi1 dissolve Rad51-mediated D loops by a topoisomerase-based mechanism.

Fasching CL, Cejka P, Kowalczykowski SC, Heyer WD.

Mol Cell. 2015 Feb 19;57(4):595-606. doi: 10.1016/j.molcel.2015.01.022.


The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.

Mukherjee S, Wright WD, Ehmsen KT, Heyer WD.

Nucleic Acids Res. 2014 Jun;42(10):6511-22. doi: 10.1093/nar/gku265. Epub 2014 Apr 17.


Rad54 functions as a heteroduplex DNA pump modulated by its DNA substrates and Rad51 during D loop formation.

Wright WD, Heyer WD.

Mol Cell. 2014 Feb 6;53(3):420-32. doi: 10.1016/j.molcel.2013.12.027. Epub 2014 Jan 30.


A conserved sequence extending motif III of the motor domain in the Snf2-family DNA translocase Rad54 is critical for ATPase activity.

Zhang XP, Janke R, Kingsley J, Luo J, Fasching C, Ehmsen KT, Heyer WD.

PLoS One. 2013 Dec 16;8(12):e82184. doi: 10.1371/journal.pone.0082184. eCollection 2013. Erratum in: PLoS One. 2014;9(6):e101094.


Synthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps.

Zinovyev A, Kuperstein I, Barillot E, Heyer WD.

PLoS Comput Biol. 2013 Apr;9(4):e1003016. doi: 10.1371/journal.pcbi.1003016. Epub 2013 Apr 4.


Reconstitution of recombination-associated DNA synthesis with human proteins.

Sneeden JL, Grossi SM, Tappin I, Hurwitz J, Heyer WD.

Nucleic Acids Res. 2013 May;41(9):4913-25. doi: 10.1093/nar/gkt192. Epub 2013 Mar 27.


Mus81-Mms4 functions as a single heterodimer to cleave nicked intermediates in recombinational DNA repair.

Schwartz EK, Wright WD, Ehmsen KT, Evans JE, Stahlberg H, Heyer WD.

Mol Cell Biol. 2012 Aug;32(15):3065-80. doi: 10.1128/MCB.00547-12. Epub 2012 May 29.


Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange.

Muñoz-Galván S, Tous C, Blanco MG, Schwartz EK, Ehmsen KT, West SC, Heyer WD, Aguilera A.

Mol Cell Biol. 2012 May;32(9):1592-603. doi: 10.1128/MCB.00111-12. Epub 2012 Feb 21. Erratum in: Mol Cell Biol. 2017 May 16;37(11):.


Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation.

Liu J, Renault L, Veaute X, Fabre F, Stahlberg H, Heyer WD.

Nature. 2011 Oct 23;479(7372):245-8. doi: 10.1038/nature10522.


Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination.

Ceballos SJ, Heyer WD.

Biochim Biophys Acta. 2011 Sep;1809(9):509-23. doi: 10.1016/j.bbagrm.2011.06.006. Epub 2011 Jun 16. Review.


In vitro assays for DNA pairing and recombination-associated DNA synthesis.

Liu J, Sneeden J, Heyer WD.

Methods Mol Biol. 2011;745:363-83. doi: 10.1007/978-1-61779-129-1_21.


Assays for structure-selective DNA endonucleases.

Wright WD, Ehmsen KT, Heyer WD.

Methods Mol Biol. 2011;745:345-62. doi: 10.1007/978-1-61779-129-1_20.


Quality control of purified proteins involved in homologous recombination.

Zhang XP, Heyer WD.

Methods Mol Biol. 2011;745:329-43. doi: 10.1007/978-1-61779-129-1_19.


Presynaptic filament dynamics in homologous recombination and DNA repair.

Liu J, Ehmsen KT, Heyer WD, Morrical SW.

Crit Rev Biochem Mol Biol. 2011 Jun;46(3):240-70. doi: 10.3109/10409238.2011.576007.


Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes.

Schwartz EK, Heyer WD.

Chromosoma. 2011 Apr;120(2):109-27. doi: 10.1007/s00412-010-0304-7. Epub 2011 Jan 11. Review. Erratum in: Chromosoma. 2011 Aug;120(4):423-4.


Who's who in human recombination: BRCA2 and RAD52.

Liu J, Heyer WD.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):441-2. doi: 10.1073/pnas.1016614108. Epub 2010 Dec 28. No abstract available.


Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.

Liu J, Doty T, Gibson B, Heyer WD.

Nat Struct Mol Biol. 2010 Oct;17(10):1260-2. doi: 10.1038/nsmb.1904. Epub 2010 Aug 22.


Regulation of homologous recombination in eukaryotes.

Heyer WD, Ehmsen KT, Liu J.

Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955. Review.


A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae.

Janke R, Herzberg K, Rolfsmeier M, Mar J, Bashkirov VI, Haghnazari E, Cantin G, Yates JR 3rd, Heyer WD.

Nucleic Acids Res. 2010 Apr;38(7):2302-13. doi: 10.1093/nar/gkp1222. Epub 2010 Jan 8.


PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase delta.

Li X, Stith CM, Burgers PM, Heyer WD.

Mol Cell. 2009 Nov 25;36(4):704-13. doi: 10.1016/j.molcel.2009.09.036.


Phylogeography of the frog Leptodactylus validus (Amphibia: Anura): patterns and timing of colonization events in the Lesser Antilles.

Camargo A, Heyer WR, de Sá RO.

Mol Phylogenet Evol. 2009 Nov;53(2):571-9. doi: 10.1016/j.ympev.2009.07.004. Epub 2009 Jul 9.


A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4.

Ehmsen KT, Heyer WD.

Nucleic Acids Res. 2009 Apr;37(6):2026-36. doi: 10.1093/nar/gkp038. Epub 2009 Feb 11.


Loop 2 in Saccharomyces cerevisiae Rad51 protein regulates filament formation and ATPase activity.

Zhang XP, Galkin VE, Yu X, Egelman EH, Heyer WD.

Nucleic Acids Res. 2009 Jan;37(1):158-71. doi: 10.1093/nar/gkn914. Epub 2008 Nov 25.


Saccharomyces cerevisiae Mus81-Mms4 is a catalytic, DNA structure-selective endonuclease.

Ehmsen KT, Heyer WD.

Nucleic Acids Res. 2008 Apr;36(7):2182-95. doi: 10.1093/nar/gkm1152. Epub 2008 Feb 16.


Homologous recombination in DNA repair and DNA damage tolerance.

Li X, Heyer WD.

Cell Res. 2008 Jan;18(1):99-113. doi: 10.1038/cr.2008.1. Review.


Rad51 and Rad54 ATPase activities are both required to modulate Rad51-dsDNA filament dynamics.

Li X, Zhang XP, Solinger JA, Kiianitsa K, Yu X, Egelman EH, Heyer WD.

Nucleic Acids Res. 2007;35(12):4124-40. Epub 2007 Jun 12.


Two alternatively spliced transcripts generated from OsMUS81, a rice homolog of yeast MUS81, are up-regulated by DNA-damaging treatments.

Mimida N, Kitamoto H, Osakabe K, Nakashima M, Ito Y, Heyer WD, Toki S, Ichikawa H.

Plant Cell Physiol. 2007 Apr;48(4):648-54. Epub 2007 Feb 27.


Supplemental Content

Support Center