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Items: 1 to 50 of 85

1.

Peptide ligand-based ELISA reagents for antibody detection.

Heyduk E, Hickey R, Pozzi N, Heyduk T.

Anal Biochem. 2018 Oct 15;559:55-61. doi: 10.1016/j.ab.2018.08.012. Epub 2018 Aug 18.

PMID:
30130491
2.

DNA template sequence control of bacterial RNA polymerase escape from the promoter.

Heyduk E, Heyduk T.

Nucleic Acids Res. 2018 May 18;46(9):4469-4486. doi: 10.1093/nar/gky172.

3.

RNA polymerase motions during promoter melting.

Feklistov A, Bae B, Hauver J, Lass-Napiorkowska A, Kalesse M, Glaus F, Altmann KH, Heyduk T, Landick R, Darst SA.

Science. 2017 May 26;356(6340):863-866. doi: 10.1126/science.aam7858.

4.

Real-Time Observation of Backtracking by Bacterial RNA Polymerase.

Lass-Napiorkowska A, Heyduk T.

Biochemistry. 2016 Feb 2;55(4):647-58. doi: 10.1021/acs.biochem.5b01184. Epub 2016 Jan 21.

5.

Next Generation Sequencing-based analysis of RNA polymerase functions.

Heyduk T, Heyduk E.

Methods. 2015 Sep 15;86:37-44. doi: 10.1016/j.ymeth.2015.04.030. Epub 2015 May 1. Review.

PMID:
25937393
6.

Ribosome display enhanced by next generation sequencing: a tool to identify antibody-specific peptide ligands.

Heyduk E, Heyduk T.

Anal Biochem. 2014 Nov 1;464:73-82. doi: 10.1016/j.ab.2014.07.014. Epub 2014 Jul 21.

PMID:
25058925
7.

Kinetics of promoter escape by bacterial RNA polymerase: effects of promoter contacts and transcription bubble collapse.

Ko J, Heyduk T.

Biochem J. 2014 Oct 1;463(1):135-44. doi: 10.1042/BJ20140179.

PMID:
24995916
8.

Next generation sequencing-based parallel analysis of melting kinetics of 4096 variants of a bacterial promoter.

Heyduk E, Heyduk T.

Biochemistry. 2014 Jan 21;53(2):282-92. doi: 10.1021/bi401277w. Epub 2014 Jan 7.

9.

Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation.

Pozzi N, Chen Z, Gohara DW, Niu W, Heyduk T, Di Cera E.

J Biol Chem. 2013 Aug 2;288(31):22734-44. doi: 10.1074/jbc.M113.466946. Epub 2013 Jun 17.

10.

Detection methodology based on target molecule-induced sequence-specific binding to a single-stranded oligonucleotide.

Lass-Napiorkowska A, Heyduk E, Tian L, Heyduk T.

Anal Chem. 2012 Apr 3;84(7):3382-9. doi: 10.1021/ac3001034. Epub 2012 Mar 22.

PMID:
22401560
11.

Promoter spacer DNA plays an active role in integrating the functional consequences of RNA polymerase contacts with -10 and -35 promoter elements.

Sztiller-Sikorska M, Heyduk E, Heyduk T.

Biophys Chem. 2011 Nov;159(1):73-81. doi: 10.1016/j.bpc.2011.05.008. Epub 2011 May 13.

12.

Homogeneous insulin and C-Peptide sensors for rapid assessment of insulin and C-peptide secretion by the islets.

Heyduk E, Moxley MM, Salvatori A, Corbett JA, Heyduk T.

Diabetes. 2010 Oct;59(10):2360-5. doi: 10.2337/db10-0088. Epub 2010 Jul 9.

13.

Practical biophysics: Sensors for rapid detection of biological targets utilizing target-induced oligonucleotide annealing.

Heyduk T.

Biophys Chem. 2010 Oct;151(3):91-5. doi: 10.1016/j.bpc.2010.05.008. Epub 2010 May 23. Review.

14.

Fluorescent homogeneous immunosensors for detecting pathogenic bacteria.

Heyduk E, Heyduk T.

Anal Biochem. 2010 Jan 15;396(2):298-303. doi: 10.1016/j.ab.2009.09.039. Epub 2009 Sep 24.

15.

Antigen peptide-based immunosensors for rapid detection of antibodies and antigens.

Tian L, Heyduk T.

Anal Chem. 2009 Jul 1;81(13):5218-25. doi: 10.1021/ac900845a.

16.

Transcription regulation of restriction-modification system Esp1396I.

Bogdanova E, Zakharova M, Streeter S, Taylor J, Heyduk T, Kneale G, Severinov K.

Nucleic Acids Res. 2009 Jun;37(10):3354-66. doi: 10.1093/nar/gkp210. Epub 2009 Mar 30.

17.

Bivalent ligands with long nanometer-scale flexible linkers.

Tian L, Heyduk T.

Biochemistry. 2009 Jan 20;48(2):264-75. doi: 10.1021/bi801630b.

PMID:
19113836
18.

Molecular pincers: antibody-based homogeneous protein sensors.

Heyduk E, Dummit B, Chang YH, Heyduk T.

Anal Chem. 2008 Jul 1;80(13):5152-9. doi: 10.1021/ac8004154. Epub 2008 May 21.

19.

Transcription regulation of the type II restriction-modification system AhdI.

Bogdanova E, Djordjevic M, Papapanagiotou I, Heyduk T, Kneale G, Severinov K.

Nucleic Acids Res. 2008 Mar;36(5):1429-42. doi: 10.1093/nar/gkm1116. Epub 2008 Jan 18.

20.

Specific recognition of the -10 promoter element by the free RNA polymerase sigma subunit.

Sevostyanova A, Feklistov A, Barinova N, Heyduk E, Bass I, Klimasauskas S, Heyduk T, Kulbachinskiy A.

J Biol Chem. 2007 Jul 27;282(30):22033-9. Epub 2007 May 29.

21.

A basal promoter element recognized by free RNA polymerase sigma subunit determines promoter recognition by RNA polymerase holoenzyme.

Feklistov A, Barinova N, Sevostyanova A, Heyduk E, Bass I, Vvedenskaya I, Kuznedelov K, Merkiene E, Stavrovskaya E, Klimasauskas S, Nikiforov V, Heyduk T, Severinov K, Kulbachinskiy A.

Mol Cell. 2006 Jul 7;23(1):97-107. Epub 2006 Jun 22.

22.

A consensus adenine at position -11 of the nontemplate strand of bacterial promoter is important for nucleation of promoter melting.

Heyduk E, Kuznedelov K, Severinov K, Heyduk T.

J Biol Chem. 2006 May 5;281(18):12362-9. Epub 2006 Mar 9.

23.

Transcription regulation of the EcoRV restriction-modification system.

Semenova E, Minakhin L, Bogdanova E, Nagornykh M, Vasilov A, Heyduk T, Solonin A, Zakharova M, Severinov K.

Nucleic Acids Res. 2005 Dec 6;33(21):6942-51. Print 2005.

24.

Synaptic complex formation of two retrovirus DNA attachment sites by integrase: a fluorescence energy transfer study.

Bera S, Vora AC, Chiu R, Heyduk T, Grandgenett DP.

Biochemistry. 2005 Nov 22;44(46):15106-14.

PMID:
16285714
25.

Escherichia coli RNA polymerase contacts outside the -10 promoter element are not essential for promoter melting.

Niedziela-Majka A, Heyduk T.

J Biol Chem. 2005 Nov 18;280(46):38219-27. Epub 2005 Sep 15.

26.

Nucleic acid-based fluorescence sensors for detecting proteins.

Heyduk E, Heyduk T.

Anal Chem. 2005 Feb 15;77(4):1147-56.

PMID:
15858998
27.

Zinc inhibition of adenylyl cyclase correlates with conformational changes in the enzyme.

Klein C, Heyduk T, Sunahara RK.

Cell Signal. 2004 Oct;16(10):1177-85.

PMID:
15240012
28.

A regulator that inhibits transcription by targeting an intersubunit interaction of the RNA polymerase holoenzyme.

Gregory BD, Nickels BE, Garrity SJ, Severinova E, Minakhin L, Urbauer RJ, Urbauer JL, Heyduk T, Severinov K, Hochschild A.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4554-9. Epub 2004 Mar 22.

29.

Unimolecular beacons for the detection of DNA-binding proteins.

Knoll E, Heyduk T.

Anal Chem. 2004 Feb 15;76(4):1156-64.

PMID:
14961750
30.

High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity.

Borrmann L, Schwanbeck R, Heyduk T, Seebeck B, Rogalla P, Bullerdiek J, Wisniewski JR.

Nucleic Acids Res. 2003 Dec 1;31(23):6841-51.

31.

Characterization of the interactions between the bacteriophage T4 AsiA protein and RNA polymerase.

Simeonov MF, Bieber Urbauer RJ, Gilmore JM, Adelman K, Brody EN, Niedziela-Majka A, Minakhin L, Heyduk T, Urbauer JL.

Biochemistry. 2003 Jul 1;42(25):7717-26.

PMID:
12820881
32.

Homogeneous fluorescence assay for cyclic AMP.

Heyduk E, Fei Y, Heyduk T.

Comb Chem High Throughput Screen. 2003 Jun;6(4):347-54.

PMID:
12769678
33.

Molecular beacons for detecting DNA binding proteins: mechanism of action.

Heyduk E, Knoll E, Heyduk T.

Anal Biochem. 2003 May 1;316(1):1-10.

PMID:
12694720
35.

Interaction of T4 AsiA with its target sites in the RNA polymerase sigma70 subunit leads to distinct and opposite effects on transcription.

Minakhin L, Niedziela-Majka A, Kuznedelov K, Adelman K, Urbauer JL, Heyduk T, Severinov K.

J Mol Biol. 2003 Feb 21;326(3):679-90.

PMID:
12581632
36.

Measuring protein conformational changes by FRET/LRET.

Heyduk T.

Curr Opin Biotechnol. 2002 Aug;13(4):292-6. Review.

PMID:
12323348
37.
38.

A novel bacteriophage-encoded RNA polymerase binding protein inhibits transcription initiation and abolishes transcription termination by host RNA polymerase.

Nechaev S, Yuzenkova Y, Niedziela-Majka A, Heyduk T, Severinov K.

J Mol Biol. 2002 Jun 28;320(1):11-22.

PMID:
12079331
39.

Fluorescence resonance energy transfer analysis of escherichia coli RNA polymerase and polymerase-DNA complexes.

Heyduk T, Niedziela-Majka A.

Biopolymers. 2001-2002;61(3):201-13. Review.

PMID:
11987181
40.

Conformation of fork junction DNA in a complex with Escherichia coli RNA polymerase.

Heyduk E, Heyduk T.

Biochemistry. 2002 Feb 26;41(8):2876-83.

PMID:
11851436
41.

A role for interaction of the RNA polymerase flap domain with the sigma subunit in promoter recognition.

Kuznedelov K, Minakhin L, Niedziela-Majka A, Dove SL, Rogulja D, Nickels BE, Hochschild A, Heyduk T, Severinov K.

Science. 2002 Feb 1;295(5556):855-7.

42.

Molecular beacons for detecting DNA binding proteins.

Heyduk T, Heyduk E.

Nat Biotechnol. 2002 Feb;20(2):171-6.

PMID:
11821863
43.

Zinc inhibition of cAMP signaling.

Klein C, Sunahara RK, Hudson TY, Heyduk T, Howlett AC.

J Biol Chem. 2002 Apr 5;277(14):11859-65. Epub 2002 Jan 22.

44.

Interaction of the alpha-subunit of Escherichia coli RNA polymerase with DNA: rigid body nature of the protein-DNA contact.

Heyduk E, Baichoo N, Heyduk T.

J Biol Chem. 2001 Nov 30;276(48):44598-603. Epub 2001 Sep 24.

45.

Luminescence resonance energy transfer analysis of RNA polymerase complexes.

Heyduk T.

Methods. 2001 Sep;25(1):44-53. Review.

PMID:
11558996
46.

A coiled-coil from the RNA polymerase beta' subunit allosterically induces selective nontemplate strand binding by sigma(70).

Young BA, Anthony LC, Gruber TM, Arthur TM, Heyduk E, Lu CZ, Sharp MM, Heyduk T, Burgess RR, Gross CA.

Cell. 2001 Jun 29;105(7):935-44.

47.

Consecutive steps of phosphorylation affect conformation and DNA binding of the chironomus high mobility group A protein.

Schwanbeck R, Gymnopoulos M, Petry I, Piekiełko A, Szewczuk Z, Heyduk T, Zechel K, Wiśniewski JR.

J Biol Chem. 2001 Jul 13;276(28):26012-21. Epub 2001 May 2.

48.

Hydroxyl radical footprinting of proteins using metal ion complexes.

Heyduk T, Baichoo N, Heyduk E.

Met Ions Biol Syst. 2001;38:255-87. Review. No abstract available.

PMID:
11219012
49.
50.

Phosphorylation site mutations in heterochromatin protein 1 (HP1) reduce or eliminate silencing activity.

Zhao T, Heyduk T, Eissenberg JC.

J Biol Chem. 2001 Mar 23;276(12):9512-8. Epub 2000 Dec 19.

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