Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 72

1.

Effect of LX4211 on glucose homeostasis and body composition in preclinical models.

Powell DR, DaCosta CM, Smith M, Doree D, Harris A, Buhring L, Heydorn W, Nouraldeen A, Xiong W, Yalamanchili P, Mseeh F, Wilson A, Shadoan M, Zambrowicz B, Ding ZM.

J Pharmacol Exp Ther. 2014 Aug;350(2):232-42. doi: 10.1124/jpet.114.214304. Epub 2014 May 21.

PMID:
24849925
2.

Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).

Bagdanoff JT, Donoviel MS, Nouraldeen A, Carlsen M, Jessop TC, Tarver J, Aleem S, Dong L, Zhang H, Boteju L, Hazelwood J, Yan J, Bednarz M, Layek S, Owusu IB, Gopinathan S, Moran L, Lai Z, Kramer J, Kimball SD, Yalamanchili P, Heydorn WE, Frazier KS, Brooks B, Brown P, Wilson A, Sonnenburg WK, Main A, Carson KG, Oravecz T, Augeri DJ.

J Med Chem. 2010 Dec 23;53(24):8650-62. doi: 10.1021/jm101183p. Epub 2010 Nov 22.

PMID:
21090716
3.

Early toxicology signal generation in the mouse.

Kramer JA, O'Neill E, Phillips ME, Bruce D, Smith T, Albright MM, Bellum S, Gopinathan S, Heydorn WE, Liu X, Nouraldeen A, Payne BJ, Read R, Vogel P, Yu XQ, Wilson AG.

Toxicol Pathol. 2010 Apr;38(3):452-71. doi: 10.1177/0192623310364025. Epub 2010 Mar 19.

PMID:
20305093
4.

Discovery and characterization of novel tryptophan hydroxylase inhibitors that selectively inhibit serotonin synthesis in the gastrointestinal tract.

Liu Q, Yang Q, Sun W, Vogel P, Heydorn W, Yu XQ, Hu Z, Yu W, Jonas B, Pineda R, Calderon-Gay V, Germann M, O'Neill E, Brommage R, Cullinan E, Platt K, Wilson A, Powell D, Sands A, Zambrowicz B, Shi ZC.

J Pharmacol Exp Ther. 2008 Apr;325(1):47-55. doi: 10.1124/jpet.107.132670. Epub 2008 Jan 11.

PMID:
18192499
5.

Summary from the 152nd meeting of the American Psychiatric Association.

Heydorn WE.

Expert Opin Investig Drugs. 1999 Jul;8(7):1113-6.

PMID:
15992111
6.
7.

Summary of the 34th annual meeting of the Drug Information Association.

Heydorn WE.

Expert Opin Investig Drugs. 1998 Aug;7(8):1331-4.

PMID:
15992035
9.

A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescents.

Wagner KD, Robb AS, Findling RL, Jin J, Gutierrez MM, Heydorn WE.

Am J Psychiatry. 2004 Jun;161(6):1079-83.

PMID:
15169696
10.

Naturalistic study of the early psychiatric use of citalopram in the United States.

Rush AJ, Bose A, Heydorn WE.

Depress Anxiety. 2002;16(3):121-7.

PMID:
12415537
11.

Zaleplon - a review of a novel sedative hypnotic used in the treatment of insomnia.

Heydorn WE.

Expert Opin Investig Drugs. 2000 Apr;9(4):841-58. Review.

PMID:
11060714
12.

Design and synthesis of novel alpha1a adrenoceptor-selective dihydropyridine antagonists for the treatment of benign prostatic hyperplasia.

Nagarathnam D, Wetzel JM, Miao SW, Marzabadi MR, Chiu G, Wong WC, Hong X, Fang J, Forray C, Branchek TA, Heydorn WE, Chang RS, Broten T, Schorn TW, Gluchowski C.

J Med Chem. 1998 Dec 17;41(26):5320-33.

PMID:
9857099
13.

The 98th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics.

Heydorn WE.

Expert Opin Investig Drugs. 1997 Apr;6(4):453-7.

PMID:
15989613
14.

Use of ex vivo magnetic resonance imaging to detect onset of vigabatrin-induced intramyelinic edema in canine brain.

Peyster RG, Sussman NM, Hershey BL, Heydorn WE, Meyerson LR, Yarrington JT, Gibson JP.

Epilepsia. 1995 Jan;36(1):93-100.

PMID:
8001516
15.

MRI monitoring of vigabatrin-induced intramyelinic edema in dogs.

Weiss KL, Schroeder CE, Kastin SJ, Gibson JP, Yarrington JT, Heydorn WE, McBride RG, Sussman NM, Arezzo JC.

Neurology. 1994 Oct;44(10):1944-9.

PMID:
7936252
16.

Sequential neuropathology of dogs treated with vigabatrin, a GABA-transaminase inhibitor.

Yarrington JT, Gibson JP, Dillberger JE, Hurst G, Lippert B, Sussman NM, Heydorn WE, Marler RJ.

Toxicol Pathol. 1993 Sep-Oct;21(5):480-9.

PMID:
8115824
17.

Simultaneous reconstruction of the abdominal aorta and cholecystectomy. A peer review perspective.

Heydorn WH, Moncrief WH Jr.

West J Med. 1992 Nov;157(5):569-71. No abstract available.

18.

Effects of high-dose gamma-vinyl GABA (vigabatrin) administration on visual and somatosensory evoked potentials in dogs.

Schroeder CE, Gibson JP, Yarrington J, Heydorn WE, Sussman NM, Arezzo JC.

Epilepsia. 1992;33 Suppl 5:S13-25.

PMID:
1425496
19.

A five-year U.S. Army experience with 36,250 abdominal hernia repairs.

Heydorn WH, Velanovich V.

Am Surg. 1990 Oct;56(10):596-600.

PMID:
2221607
20.

Basic and advanced combat casualty care: a military problem.

Heydorn WH.

Mil Med. 1990 May;155(5):229-31.

PMID:
2114589
21.

Quantification of proteins in discrete brain regions of androgen-insensitive testicular feminized Tfm mice.

Olsen KL, Heydorn WE, Rodriguez-Sierra JF, Jacobowitz DM.

Neuroendocrinology. 1989 Oct;50(4):392-9.

PMID:
2812273
22.

Pericardial substitutes: a survey.

Heydorn WH, Ferraris VA, Berry WR.

Ann Thorac Surg. 1988 Nov;46(5):567-9.

PMID:
3190332
23.
24.
25.

A new look at pericardial substitutes.

Heydorn WH, Daniel JS, Wade CE.

J Thorac Cardiovasc Surg. 1987 Aug;94(2):291-6.

PMID:
3613629
26.

Incorporation of amino acids into proteins of the hypothalamus of prepuberal female rats after estradiol treatment.

Rodriguez-Sierra JF, Heydorn WE, Creed GJ, Jacobowitz DM.

Neuroendocrinology. 1987 Jun;45(6):459-64.

PMID:
3614550
27.

Isolation of specific proteins affected by estradiol in the arcuate-median eminence of prepuberal female rats.

Rodriguez-Sierra JF, Heydorn WE, Creed GJ, Jacobowitz DM.

Brain Res. 1986 Dec 10;399(2):379-82.

PMID:
3828772
28.

Protein patterns in various malignant human brain tumors by two-dimensional gel electrophoresis.

Narayan RK, Heydorn WE, Creed GJ, Jacobowitz DM.

Cancer Res. 1986 Sep;46(9):4685-94.

29.

Iron deficiency alters discrete proteins in rat caudate nucleus and nucleus accumbens.

Youdim MB, Sills MA, Heydorn WE, Creed GJ, Jacobowitz DM.

J Neurochem. 1986 Sep;47(3):794-9.

PMID:
2942640
30.

Subfornical organ: effects of salt loading and water deprivation on in vitro radioamino acid incorporation into individual proteins.

Santer DM, Heydorn WE, Creed GJ, Klein DC, Jacobowitz DM.

Brain Res. 1986 Apr 30;372(1):107-14.

PMID:
3708350
31.

Effect of 5,7-dihydroxytryptamine on the concentration of individual proteins in different areas of the rat brain.

Heydorn WE, Creed GJ, Nguyen KQ, Jacobowitz DM.

Brain Res. 1986 Mar 12;368(1):193-6.

PMID:
3006866
32.
33.

Effect of chronic treatment with clorgyline on the relative concentration of specific proteins in the hippocampus and parietal cortex of the rat.

Sills MA, Heydorn WE, Cohen RM, Creed GJ, Jacobowitz DM.

Neuropharmacology. 1986 Feb;25(2):143-50.

PMID:
3703169
34.

Distribution of proteins in different subcellular fractions of rat brain studied by two-dimensional gel electrophoresis.

Heydorn WE, Joseph Creed G, Patel J, Jacobowitz DM.

Neurochem Int. 1986;9(3):357-70.

PMID:
20493135
35.

Studies on catechol-O-methyltransferase in rat brain using two-dimensional gel electrophoresis.

Heydorn WE, Joseph Creed G, Creveling CR, Jacobowitz DM.

Neurochem Int. 1986;8(4):581-6.

PMID:
20493092
36.
37.

Quantitative evaluation of the myocardial preservative characteristics of nifedipine during hypothermic myocardial ischemia.

Moores WY, Mack JW, Dembitsky WP, Heydorn WH, Daily PO.

J Thorac Cardiovasc Surg. 1985 Dec;90(6):912-20.

PMID:
4068742
38.

Proteins regulated by gonadal steroids in the medial preoptic and ventromedial hypothalamic nucleic of male and female rats.

Scouten CW, Heydorn WE, Creed GJ, Malsbury CW, Jacobowitz DM.

Neuroendocrinology. 1985 Sep;41(3):237-45.

PMID:
4047339
39.

Effect of reduction of cholinergic input on the concentration of specific proteins in different cortical regions of the rat brain.

Heydorn WE, Nguyen KQ, Creed GJ, Jacobowitz DM.

Brain Res. 1985 Jul 29;339(2):209-18.

PMID:
4027621
40.

An apparent genetic polymorphism for a protein present in the hypothalamus of Sprague-Dawley rats.

Scouten CW, Heydorn WE, Creed GJ, Malsbury CW, Jacobowitz DM.

Brain Res. 1985 Mar 18;330(1):170-3.

PMID:
3986539
41.

Immunological evidence for existence of two subforms of soluble glutamic oxaloacetic transminase (sGOT) in human and rat brain.

Heydorn WE, Joseph Creed G, Wada H, Jacobowitz DM.

Neurochem Int. 1985;7(5):833-41.

PMID:
20492994
42.

Identification of neuron-specific enolase and nonneuronal enolase in human and rat brain on two-dimensional polyacrylamide gels.

Heydorn WE, Creed GJ, Marangos PJ, Jacobowitz DM.

J Neurochem. 1985 Jan;44(1):201-9.

PMID:
3964828
43.

Naloxone: ineffective in improving cardiac performance after hypoperfusion in swine.

Heydorn WH, Moores WY, Bellamy RF, O'Benar JD.

Circ Shock. 1985;17(1):35-43.

PMID:
2932263
44.
45.

Proteins in normal, irradiated, and postmortem human brain quantitatively compared by using two-dimensional gel electrophoresis.

Narayan RK, Heydorn WE, Creed GJ, Kornblith PL, Jacobowitz DM.

Clin Chem. 1984 Dec;30(12 Pt 1):1989-95.

46.

Amiodarone-digoxin interaction. Clinical and experimental observations.

Oetgen WJ, Sobol SM, Tri TB, Heydorn WH, Rakita L.

Chest. 1984 Jul;86(1):75-9.

PMID:
6734297
48.

Sex differences in specific proteins in the preoptic medial nucleus of the rat hypothalamus.

Gold MA, Heydorn WE, Creed GJ, Jacobowitz DM.

Neuroendocrinology. 1983 Dec;37(6):470-2.

PMID:
6657004
49.

Mapping and quantitation of proteins from discrete nuclei and other areas of the rat brain by two-dimensional gel electrophoresis.

Heydorn WE, Creed GJ, Goldman D, Kanter D, Merril CR, Jacobowitz DM.

J Neurosci. 1983 Dec;3(12):2597-606.

50.

S-100-mediated inhibition of brain protein phosphorylation.

Patel J, Marangos PJ, Heydorn WE, Chang G, Verma A, Jacobowitz D.

J Neurochem. 1983 Oct;41(4):1040-5.

PMID:
6619843

Supplemental Content

Loading ...
Support Center