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Items: 39

1.

Differential Interleukin-2 Transcription Kinetics Render Mouse but Not Human T Cells Vulnerable to Splicing Inhibition Early after Activation.

Bose D, Neumann A, Timmermann B, Meinke S, Heyd F.

Mol Cell Biol. 2019 Jul 29;39(16). pii: e00035-19. doi: 10.1128/MCB.00035-19. Print 2019 Aug 15.

PMID:
31160491
2.

Increased versatility despite reduced molecular complexity: evolution, structure and function of metazoan splicing factor PRPF39.

De Bortoli F, Neumann A, Kotte A, Timmermann B, Schüler T, Wahl MC, Loll B, Heyd F.

Nucleic Acids Res. 2019 Jun 20;47(11):5867-5879. doi: 10.1093/nar/gkz243.

3.

A homozygous genome-edited Sept2-EGFP fibroblast cell line.

Banko M, Mucha-Kruczynska I, Weise C, Heyd F, Ewers H.

Cytoskeleton (Hoboken). 2019 Jan;76(1):73-82. doi: 10.1002/cm.21518. Epub 2019 Apr 19.

4.

Genome-wide identification of alternative splicing events that regulate protein transport across the secretory pathway.

Neumann A, Schindler M, Olofsson D, Wilhelmi I, Schürmann A, Heyd F.

J Cell Sci. 2019 Apr 25;132(8). pii: jcs230201. doi: 10.1242/jcs.230201.

PMID:
30890649
5.

Modulation of MKNK2 alternative splicing by splice-switching oligonucleotides as a novel approach for glioblastoma treatment.

Mogilevsky M, Shimshon O, Kumar S, Mogilevsky A, Keshet E, Yavin E, Heyd F, Karni R.

Nucleic Acids Res. 2018 Nov 30;46(21):11396-11404. doi: 10.1093/nar/gky921.

6.

Characterization of cis-acting elements that control oscillating alternative splicing.

Goldammer G, Neumann A, Strauch M, Müller-McNicoll M, Heyd F, Preußner M.

RNA Biol. 2018;15(8):1081-1092. doi: 10.1080/15476286.2018.1502587. Epub 2018 Sep 10.

7.

Temperature-controlled Rhythmic Gene Expression in Endothermic Mammals: All Diurnal Rhythms are Equal, but Some are Circadian.

Preußner M, Heyd F.

Bioessays. 2018 Jul;40(7):e1700216. doi: 10.1002/bies.201700216. Epub 2018 Jun 4. Review.

PMID:
29869389
8.

The cancer-associated U2AF35 470A>G (Q157R) mutation creates an in-frame alternative 5' splice site that impacts splicing regulation in Q157R patients.

Herdt O, Neumann A, Timmermann B, Heyd F.

RNA. 2017 Dec;23(12):1796-1806. doi: 10.1261/rna.061432.117. Epub 2017 Sep 11.

9.

Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals.

Preußner M, Goldammer G, Neumann A, Haltenhof T, Rautenstrauch P, Müller-McNicoll M, Heyd F.

Mol Cell. 2017 Aug 3;67(3):433-446.e4. doi: 10.1016/j.molcel.2017.06.006. Epub 2017 Jul 6.

10.

DDX54 regulates transcriptome dynamics during DNA damage response.

Milek M, Imami K, Mukherjee N, Bortoli F, Zinnall U, Hazapis O, Trahan C, Oeffinger M, Heyd F, Ohler U, Selbach M, Landthaler M.

Genome Res. 2017 Aug;27(8):1344-1359. doi: 10.1101/gr.218438.116. Epub 2017 Jun 8.

11.

Activation-Dependent TRAF3 Exon 8 Alternative Splicing Is Controlled by CELF2 and hnRNP C Binding to an Upstream Intronic Element.

Schultz AS, Preussner M, Bunse M, Karni R, Heyd F.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00488-16. doi: 10.1128/MCB.00488-16. Print 2017 Apr 1.

12.

The genomic basis of circadian and circalunar timing adaptations in a midge.

Kaiser TS, Poehn B, Szkiba D, Preussner M, Sedlazeck FJ, Zrim A, Neumann T, Nguyen LT, Betancourt AJ, Hummel T, Vogel H, Dorner S, Heyd F, von Haeseler A, Tessmar-Raible K.

Nature. 2016 Dec 1;540(7631):69-73. doi: 10.1038/nature20151. Epub 2016 Nov 21.

13.

Sec16 alternative splicing dynamically controls COPII transport efficiency.

Wilhelmi I, Kanski R, Neumann A, Herdt O, Hoff F, Jacob R, Preußner M, Heyd F.

Nat Commun. 2016 Aug 5;7:12347. doi: 10.1038/ncomms12347.

14.

Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells.

Gaudreau MC, Grapton D, Helness A, Vadnais C, Fraszczak J, Shooshtarizadeh P, Wilhelm B, Robert F, Heyd F, Möröy T.

Sci Rep. 2016 Jun 7;6:27379. doi: 10.1038/srep27379.

15.

Post-transcriptional control of the mammalian circadian clock: implications for health and disease.

Preußner M, Heyd F.

Pflugers Arch. 2016 Jun;468(6):983-91. doi: 10.1007/s00424-016-1820-y. Epub 2016 Apr 23. Review.

16.

Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.

Meininger I, Griesbach RA, Hu D, Gehring T, Seeholzer T, Bertossi A, Kranich J, Oeckinghaus A, Eitelhuber AC, Greczmiel U, Gewies A, Schmidt-Supprian M, Ruland J, Brocker T, Heissmeyer V, Heyd F, Krappmann D.

Nat Commun. 2016 Apr 12;7:11292. doi: 10.1038/ncomms11292.

17.

The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.

Absmeier E, Wollenhaupt J, Mozaffari-Jovin S, Becke C, Lee CT, Preussner M, Heyd F, Urlaub H, Lührmann R, Santos KF, Wahl MC.

Genes Dev. 2015 Dec 15;29(24):2576-87. doi: 10.1101/gad.271528.115. Epub 2015 Dec 4.

18.

Rhythmic U2af26 alternative splicing controls PERIOD1 stability and the circadian clock in mice.

Preußner M, Wilhelmi I, Schultz AS, Finkernagel F, Michel M, Möröy T, Heyd F.

Mol Cell. 2014 May 22;54(4):651-62. doi: 10.1016/j.molcel.2014.04.015. Epub 2014 May 15.

19.

Activation-induced tumor necrosis factor receptor-associated factor 3 (Traf3) alternative splicing controls the noncanonical nuclear factor κB pathway and chemokine expression in human T cells.

Michel M, Wilhelmi I, Schultz AS, Preussner M, Heyd F.

J Biol Chem. 2014 May 9;289(19):13651-60. doi: 10.1074/jbc.M113.526269. Epub 2014 Mar 26.

20.

[Alternative splicing--principles, functional consequences and therapeutic implications].

Heyd F.

Dtsch Med Wochenschr. 2014 Feb;139(7):339-42. doi: 10.1055/s-0033-1349570. Epub 2013 Nov 13. Review. German.

PMID:
24226838
21.

Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells.

Gaudreau MC, Heyd F, Bastien R, Wilhelm B, Möröy T.

J Immunol. 2012 Jun 1;188(11):5377-88. doi: 10.4049/jimmunol.1103142. Epub 2012 Apr 20.

22.

Alternative splicing networks regulated by signaling in human T cells.

Martinez NM, Pan Q, Cole BS, Yarosh CA, Babcock GA, Heyd F, Zhu W, Ajith S, Blencowe BJ, Lynch KW.

RNA. 2012 May;18(5):1029-40. doi: 10.1261/rna.032243.112. Epub 2012 Mar 27.

23.

PSF controls expression of histone variants and cellular viability in thymocytes.

Heyd F, Lynch KW.

Biochem Biophys Res Commun. 2011 Nov 4;414(4):743-9. doi: 10.1016/j.bbrc.2011.09.149. Epub 2011 Oct 6.

24.

Degrade, move, regroup: signaling control of splicing proteins.

Heyd F, Lynch KW.

Trends Biochem Sci. 2011 Aug;36(8):397-404. doi: 10.1016/j.tibs.2011.04.003. Epub 2011 May 17. Review.

25.

The p150 subunit of the histone chaperone Caf-1 interacts with the transcriptional repressor Gfi1.

Heyd F, Chen R, Afshar K, Saba I, Lazure C, Fiolka K, Möröy T.

Biochim Biophys Acta. 2011 Apr-Jun;1809(4-6):255-61. doi: 10.1016/j.bbagrm.2011.04.009. Epub 2011 May 1.

PMID:
21570500
26.

Signal- and development-dependent alternative splicing of LEF1 in T cells is controlled by CELF2.

Mallory MJ, Jackson J, Weber B, Chi A, Heyd F, Lynch KW.

Mol Cell Biol. 2011 Jun;31(11):2184-95. doi: 10.1128/MCB.05170-11. Epub 2011 Mar 28.

27.

Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.

Heyd F, Lynch KW.

Mol Cell. 2010 Oct 8;40(1):126-37. doi: 10.1016/j.molcel.2010.09.013.

28.

Zinc finger protein Gfi1 controls the endotoxin-mediated Toll-like receptor inflammatory response by antagonizing NF-kappaB p65.

Sharif-Askari E, Vassen L, Kosan C, Khandanpour C, Gaudreau MC, Heyd F, Okayama T, Jin J, Rojas ME, Grimes HL, Zeng H, Möröy T.

Mol Cell Biol. 2010 Aug;30(16):3929-42. doi: 10.1128/MCB.00087-10. Epub 2010 Jun 14.

29.

Context-dependent regulatory mechanism of the splicing factor hnRNP L.

Motta-Mena LB, Heyd F, Lynch KW.

Mol Cell. 2010 Jan 29;37(2):223-34. doi: 10.1016/j.molcel.2009.12.027.

30.

Getting under the skin of alternative splicing: identification of epithelial-specific splicing factors.

Heyd F, Lynch KW.

Mol Cell. 2009 Mar 27;33(6):674-6. doi: 10.1016/j.molcel.2009.03.001.

31.

Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.

Kirjavainen A, Sulg M, Heyd F, Alitalo K, Ylä-Herttuala S, Möröy T, Petrova TV, Pirvola U.

Dev Biol. 2008 Oct 1;322(1):33-45. doi: 10.1016/j.ydbio.2008.07.004. Epub 2008 Jul 9.

32.

Differential isoform expression and interaction with the P32 regulatory protein controls the subcellular localization of the splicing factor U2AF26.

Heyd F, Carmo-Fonseca M, Möröy T.

J Biol Chem. 2008 Jul 11;283(28):19636-45. doi: 10.1074/jbc.M801014200. Epub 2008 May 6.

33.

Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function.

Pargmann D, Yücel R, Kosan C, Saba I, Klein-Hitpass L, Schimmer S, Heyd F, Dittmer U, Möröy T.

Eur J Immunol. 2007 Dec;37(12):3551-63.

34.

The impact of alternative splicing in vivo: mouse models show the way.

Möröy T, Heyd F.

RNA. 2007 Aug;13(8):1155-71. Epub 2007 Jun 11. Review.

35.

Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway.

Cawthorn WP, Heyd F, Hegyi K, Sethi JK.

Cell Death Differ. 2007 Jul;14(7):1361-73. Epub 2007 Apr 20.

36.

Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing.

Heyd F, ten Dam G, Möröy T.

Nat Immunol. 2006 Aug;7(8):859-67. Epub 2006 Jul 2.

PMID:
16819553
37.

Quantitative real-time PCR for titration of infectious recombinant AAV-2 particles.

Rohr UP, Heyd F, Neukirchen J, Wulf MA, Queitsch I, Kroener-Lux G, Steidl U, Fenk R, Haas R, Kronenwett R.

J Virol Methods. 2005 Jul;127(1):40-5. Epub 2005 Apr 12.

PMID:
15893564
38.
39.

Non-small lung cancer cells are prime targets for p53 gene transfer mediated by a recombinant adeno-associated virus type-2 vector.

Rohr UP, Wulf MA, Stahn S, Heyd F, Steidl U, Fenk R, Opalka B, Pitschke G, Prisack HB, Bojar H, Haas R, Kronenwett R.

Cancer Gene Ther. 2003 Dec;10(12):898-906.

PMID:
14712316

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