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Items: 1 to 50 of 94

1.

Community-engaged Evidence Synthesis to Inform Public Health Policy and Clinical Practice: A Case Study.

Springs S, Rofeberg V, Brown S, Boudreau S, Hey SP, Baruch J.

Med Care. 2019 Oct;57 Suppl 10 Suppl 3:S253-S258. doi: 10.1097/MLR.0000000000001180.

PMID:
31517796
2.

Data Sharing For Research-Encouraging Signs Amid Ethical Tensions.

Hey SP.

JAMA Netw Open. 2019 Aug 2;2(8):e199732. doi: 10.1001/jamanetworkopen.2019.9732. No abstract available.

PMID:
31433476
3.

Public Approval of Exception From Informed Consent in Emergency Clinical Trials: A Systematic Review of Community Consultation Surveys.

Feldman WB, Hey SP, Franklin JM, Kesselheim AS.

JAMA Netw Open. 2019 Jul 3;2(7):e197591. doi: 10.1001/jamanetworkopen.2019.7591.

4.

A mixed methods comparative evaluation of a low cost otoscope (Arclight) with a traditional device in twenty-one clinicians.

Hey SY, Buckley JC, Shahsavari S, Kousha O, Haddow KA, Blaikie A, Walker FDL.

Clin Otolaryngol. 2019 Jul 18. doi: 10.1111/coa.13403. [Epub ahead of print] No abstract available.

PMID:
31319018
5.

Cell and Gene Therapy Trials: Are We Facing an 'Evidence Crisis'?

Abou-El-Enein M, Hey SP.

EClinicalMedicine. 2019 Feb 2;7:13-14. doi: 10.1016/j.eclinm.2019.01.015. eCollection 2019 Jan. No abstract available.

6.

Assessment of the Clinical Benefit of Cancer Drugs Receiving Accelerated Approval.

Gyawali B, Hey SP, Kesselheim AS.

JAMA Intern Med. 2019 Jul 1;179(7):906-913. doi: 10.1001/jamainternmed.2019.0462.

PMID:
31135808
7.

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.

D'Andrea E, Hey SP, Ramirez CL, Kesselheim AS.

JAMA Netw Open. 2019 Apr 5;2(4):e192224. doi: 10.1001/jamanetworkopen.2019.2224.

8.

Drainless parotidectomy and the same day discharge with routine use of topical haemostatic agent and Balaclava bandage.

Hey SY, Flach S, Shahsavari S, Manickavasagam J.

Clin Otolaryngol. 2019 Apr 9. doi: 10.1111/coa.13339. [Epub ahead of print] No abstract available.

PMID:
30965391
9.

A Framework for Assessing Scientific Merit in Ethical Review of Clinical Research.

Binik A, Hey SP.

Ethics Hum Res. 2019 Mar;41(2):2-13. doi: 10.1002/eahr.500007.

PMID:
30895755
10.

Endoscopic Sphenopalatine Artery Ligation: General Applicability in a Teaching Unit.

Hey SY, Koo Ng NKF, McGarry GW.

Ear Nose Throat J. 2019 Feb;98(2):85-88. doi: 10.1177/0145561319828675. Epub 2019 Feb 12.

PMID:
30884999
12.

A systematic review of trial-level meta-analyses measuring the strength of association between surrogate end-points and overall survival in oncology.

Haslam A, Hey SP, Gill J, Prasad V.

Eur J Cancer. 2019 Jan;106:196-211. doi: 10.1016/j.ejca.2018.11.012. Epub 2018 Dec 5. Review.

PMID:
30528804
13.

Nonhypoxic pharmacological stabilization of Hypoxia Inducible Factor 1α: Effects on dopaminergic differentiation of human neural stem cells.

Hey SM, Jensen P, Ryding M, Martínez Serrano A, Kristensen BW, Meyer M.

Eur J Neurosci. 2019 Feb;49(4):497-509. doi: 10.1111/ejn.14284. Epub 2018 Dec 8.

PMID:
30471165
14.

Stakeholder views regarding ethical issues in the design and conduct of pragmatic trials: study protocol.

Nicholls SG, Carroll K, Brehaut J, Weijer C, Hey SP, Goldstein CE, Zwarenstein M, Graham ID, McKenzie JE, McIntyre L, Jairath V, Campbell MK, Grimshaw JM, Fergusson DA, Taljaard M.

BMC Med Ethics. 2018 Nov 20;19(1):90. doi: 10.1186/s12910-018-0332-z.

15.

ZmMADS69 functions as a flowering activator through the ZmRap2.7-ZCN8 regulatory module and contributes to maize flowering time adaptation.

Liang Y, Liu Q, Wang X, Huang C, Xu G, Hey S, Lin HY, Li C, Xu D, Wu L, Wang C, Wu W, Xia J, Han X, Lu S, Lai J, Song W, Schnable PS, Tian F.

New Phytol. 2019 Mar;221(4):2335-2347. doi: 10.1111/nph.15512. Epub 2018 Oct 30.

PMID:
30288760
16.

A Systematic Review Of The Food And Drug Administration's 'Exception From Informed Consent' Pathway.

Feldman WB, Hey SP, Kesselheim AS.

Health Aff (Millwood). 2018 Oct;37(10):1605-1614. doi: 10.1377/hlthaff.2018.0501.

PMID:
30273035
17.

Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol.

Taljaard M, Weijer C, Grimshaw JM, Ali A, Brehaut JC, Campbell MK, Carroll K, Edwards S, Eldridge S, Forrest CB, Giraudeau B, Goldstein CE, Graham ID, Hemming K, Hey SP, Horn AR, Jairath V, Klassen TP, London AJ, Marlin S, Marshall JC, McIntyre L, McKenzie JE, Nicholls SG, Alison Paprica P, Zwarenstein M, Fergusson DA.

Trials. 2018 Sep 27;19(1):525. doi: 10.1186/s13063-018-2895-x.

18.

Glycine is able to induce both a motility speed in- and decrease during zebrafish neuronal migration.

Theisen U, Hey S, Hennig CD, Schnabel R, Köster RW.

Commun Integr Biol. 2018 Aug 13;11(3):1-7. doi: 10.1080/19420889.2018.1493324. eCollection 2018.

19.

Defining "True and Non-Misleading" for Pharmaceutical Promotion.

Hey SP, Kesselheim AS.

J Law Med Ethics. 2018 Jun;46(2):552-554. doi: 10.1177/1073110518782970. No abstract available.

PMID:
30146990
20.

Intracerebral hemorrhage: positive predictive value of diagnosis codes in two nationwide Danish registries.

Hald SM, Kring Sloth C, Hey SM, Madsen C, Nguyen N, García Rodríguez LA, Al-Shahi Salman R, Möller S, Poulsen FR, Pottegård A, Gaist D.

Clin Epidemiol. 2018 Aug 7;10:941-948. doi: 10.2147/CLEP.S167576. eCollection 2018.

21.

Thinking clearly about the FIRST trial: addressing ethical challenges in cluster randomised trials of policy interventions involving health providers.

Horn AR, Weijer C, Hey SP, Brehaut J, Fergusson DA, Goldstein CE, Grimshaw J, Taljaard M.

J Med Ethics. 2018 Sep;44(9):593-598. doi: 10.1136/medethics-2017-104282. Epub 2018 Apr 27.

PMID:
29703860
22.

Research ethics for emerging trial designs: does equipoise need to adapt?

Hey SP, Weijer C, Taljaard M, Kesselheim AS.

BMJ. 2018 Jan 25;360:k226. doi: 10.1136/bmj.k226. No abstract available.

PMID:
29371211
23.

Is the concept of clinical equipoise still relevant to research?

Hey SP, London AJ, Weijer C, Rid A, Miller F.

BMJ. 2017 Dec 28;359:j5787. doi: 10.1136/bmj.j5787. No abstract available. Erratum in: BMJ. 2018 Mar 5;360:k1065.

PMID:
29284666
24.

Supportive Mental Health Self-Monitoring among Smartphone Users with Psychological Distress: Protocol for a Fully Mobile Randomized Controlled Trial.

Beiwinkel T, Hey S, Bock O, Rössler W.

Front Public Health. 2017 Sep 21;5:249. doi: 10.3389/fpubh.2017.00249. eCollection 2017.

25.

Ethical Challenges in Biomarker-Driven Drug Development.

Hey SP.

Clin Pharmacol Ther. 2018 Jan;103(1):23-25. doi: 10.1002/cpt.862. Epub 2017 Sep 25.

PMID:
28944956
26.

Influence, integrity, and the FDA: An ethical framework.

Hey SP, Cohen IG, Adashi EY, Kesselheim AS.

Science. 2017 Sep 1;357(6354):876-877. doi: 10.1126/science.aao1056. No abstract available.

PMID:
28860375
27.

Success, Failure, and Transparency in Biomarker-Based Drug Development: A Case Study of Cholesteryl Ester Transfer Protein Inhibitors.

Hey SP, Franklin JM, Avorn J, Kesselheim AS.

Circ Cardiovasc Qual Outcomes. 2017 Jun;10(6). pii: e003121. doi: 10.1161/CIRCOUTCOMES.116.003121. Review.

PMID:
28611186
28.

Complexity and specificity of the maize (Zea mays L.) root hair transcriptome.

Hey S, Baldauf J, Opitz N, Lithio A, Pasha A, Provart N, Nettleton D, Hochholdinger F.

J Exp Bot. 2017 Apr 1;68(9):2175-2185. doi: 10.1093/jxb/erx104.

29.

Reprioritizing Research Activity for the Post-Antibiotic Era: Ethical, Legal, and Social Considerations.

Hey SP, Kesselheim AS.

Hastings Cent Rep. 2017 Mar;47(2):16-20. doi: 10.1002/hast.685.

PMID:
28301705
30.

Priority, prediction and the ethical research enterprise.

Hey SP.

J Med Ethics. 2017 Dec;43(12):812-813. doi: 10.1136/medethics-2016-103999. Epub 2017 Feb 6. No abstract available.

PMID:
28167632
31.

The Challenges of Validating in Precision Medicine: The Case of Excision Repair Cross-Complement Group 1 Diagnostic Testing.

Barsanti-Innes B, Hey SP, Kimmelman J.

Oncologist. 2017 Jan;22(1):89-96. doi: 10.1634/theoncologist.2016-0188. Epub 2016 Oct 24.

32.

Characterization of maize roothairless6 which encodes a D-type cellulose synthase and controls the switch from bulge formation to tip growth.

Li L, Hey S, Liu S, Liu Q, McNinch C, Hu HC, Wen TJ, Marcon C, Paschold A, Bruce W, Schnable PS, Hochholdinger F.

Sci Rep. 2016 Oct 6;6:34395. doi: 10.1038/srep34395.

33.

The contribution of wheat to human diet and health.

Shewry PR, Hey SJ.

Food Energy Secur. 2015 Oct;4(3):178-202. Epub 2015 Aug 14. Review.

34.

The FDA, Juno Therapeutics, and the ethical imperative of transparency.

Hey SP, Kesselheim AS.

BMJ. 2016 Aug 15;354:i4435. doi: 10.1136/bmj.i4435. No abstract available.

PMID:
27526698
35.

BIOMEDICAL RESEARCH. Countering imprecision in precision medicine.

Hey SP, Kesselheim AS.

Science. 2016 Jul 29;353(6298):448-9. doi: 10.1126/science.aaf5101. No abstract available.

PMID:
27471295
36.

Alpha-Fetoprotein Detection of Hepatocellular Carcinoma Leads to a Standardized Analysis of Dynamic AFP to Improve Screening Based Detection.

Bird TG, Dimitropoulou P, Turner RM, Jenks SJ, Cusack P, Hey S, Blunsum A, Kelly S, Sturgeon C, Hayes PC, Bird SM.

PLoS One. 2016 Jun 16;11(6):e0156801. doi: 10.1371/journal.pone.0156801. eCollection 2016.

37.

Do We Know Whether Researchers and Reviewers are Estimating Risk and Benefit Accurately?

Hey SP, Kimmelman J.

Bioethics. 2016 Oct;30(8):609-17. doi: 10.1111/bioe.12260. Epub 2016 May 16.

PMID:
27197044
38.

What questions can a placebo answer?

Hey SP, Weijer C.

Monash Bioeth Rev. 2016 Mar;34(1):23-36. doi: 10.1007/s40592-016-0057-z. Review.

PMID:
27188301
39.

An Uninformative Truth: The Logic of Amarin's Off-Label Promotion.

Hey SP, Kesselheim AS.

PLoS Med. 2016 Mar 15;13(3):e1001978. doi: 10.1371/journal.pmed.1001978. eCollection 2016 Mar.

40.

Do we need to worry about eating wheat?

Shewry PR, Hey SJ.

Nutr Bull. 2016 Mar;41(1):6-13. Epub 2016 Feb 16. Review.

41.

Epistemology, Ethics, and Progress in Precision Medicine.

Hey SP, Barsanti-Innes B.

Perspect Biol Med. 2016;59(3):293-310. doi: 10.1353/pbm.2016.0026.

PMID:
28479573
42.

The Question of Clinical Equipoise and Patients' Best Interests.

Hey SP, Truog RD.

AMA J Ethics. 2015 Dec 1;17(12):1108-15. doi: 10.1001/journalofethics.2015.17.12.ecas1-1512. No abstract available.

43.

Conserved and unique features of the homeologous maize Aux/IAA proteins ROOTLESS WITH UNDETECTABLE MERISTEM 1 and RUM1-like 1.

Zhang Y, Marcon C, Tai H, von Behrens I, Ludwig Y, Hey S, Berendzen KW, Hochholdinger F.

J Exp Bot. 2016 Feb;67(4):1137-47. doi: 10.1093/jxb/erv519. Epub 2015 Dec 15.

44.

Benefit, Risk, and Outcomes in Drug Development: A Systematic Review of Sunitinib.

Carlisle B, Demko N, Freeman G, Hakala A, MacKinnon N, Ramsay T, Hey S, London AJ, Kimmelman J.

J Natl Cancer Inst. 2015 Nov 7;108(1). pii: djv292. doi: 10.1093/jnci/djv292. Print 2016 Jan. Review.

45.

LATERAL ROOT PRIMORDIA 1 of maize acts as a transcriptional activator in auxin signalling downstream of the Aux/IAA gene rootless with undetectable meristem 1.

Zhang Y, von Behrens I, Zimmermann R, Ludwig Y, Hey S, Hochholdinger F.

J Exp Bot. 2015 Jul;66(13):3855-63. doi: 10.1093/jxb/erv187. Epub 2015 Apr 23.

46.

Rejoinder.

Hey SP, Kimmelman J.

Clin Trials. 2015 Apr;12(2):125-7. doi: 10.1177/1740774515569014. Epub 2015 Feb 3. No abstract available.

PMID:
25649107
47.

Are outcome-adaptive allocation trials ethical?

Hey SP, Kimmelman J.

Clin Trials. 2015 Apr;12(2):102-6. doi: 10.1177/1740774514563583. Epub 2015 Feb 3.

48.

A systematic review on skin complications of bone-anchored hearing aids in relation to surgical techniques.

Mohamad S, Khan I, Hey SY, Hussain SS.

Eur Arch Otorhinolaryngol. 2016 Mar;273(3):559-65. doi: 10.1007/s00405-014-3436-1. Epub 2014 Dec 14. Review.

PMID:
25503356
49.

Ethics and epistemology of accurate prediction in clinical research.

Hey SP.

J Med Ethics. 2015 Jul;41(7):559-62. doi: 10.1136/medethics-2013-101868. Epub 2014 Sep 23.

PMID:
25249375
50.

Oral trauma following rigid endoscopy and a novel approach to its prevention - prospective study of one hundred and thirteen patients.

Hey SY, Harrison A, MacKenzie K.

Clin Otolaryngol. 2014 Dec;39(6):389-92. doi: 10.1111/coa.12304. No abstract available.

PMID:
25142339

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