Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 104

1.

Heuristics and Explanation in Translational Medicine.

Hey SP.

Perspect Biol Med. 2019;62(4):675-689. doi: 10.1353/pbm.2019.0039.

PMID:
31761800
2.

Shared genetic control of root system architecture between Zea mays and Sorghum bicolor.

Zheng Z, Hey S, Jubery T, Liu H, Yang Y, Coffey L, Miao C, Sigmon B, Schnable J, Hochholdinger F, Ganapathysubramanian B, Schnable PS.

Plant Physiol. 2019 Nov 18. pii: pp.00752.2019. doi: 10.1104/pp.19.00752. [Epub ahead of print]

3.

Comparative analysis of the accelerated aged seed transcriptome profiles of two maize chromosome segment substitution lines.

Li L, Wang F, Li X, Peng Y, Zhang H, Hey S, Wang G, Wang J, Gu R.

PLoS One. 2019 Nov 11;14(11):e0216977. doi: 10.1371/journal.pone.0216977. eCollection 2019.

4.

US Food and Drug Administration Recommendations on the Use of Surrogate Measures as End Points in New Anti-infective Drug Approvals.

Hey SP, Kesselheim AS, Patel P, Mehrotra P, Powers JH 3rd.

JAMA Intern Med. 2019 Nov 11. doi: 10.1001/jamainternmed.2019.5451. [Epub ahead of print]

PMID:
31710344
5.

Highly accelerated time-of-flight magnetic resonance angiography using spiral imaging improves conspicuity of intracranial arterial branches while reducing scan time.

Greve T, Sollmann N, Hock A, Hey S, Gnanaprakasam V, Nijenhuis M, Zimmer C, Kirschke JS.

Eur Radiol. 2019 Oct 29. doi: 10.1007/s00330-019-06442-y. [Epub ahead of print]

PMID:
31664504
6.

A Systematic Review and Meta-analysis of Bevacizumab in First-line Metastatic Breast Cancer: Lessons for the Research and Regulatory Enterprises.

Hey SP, Gyawali B, D'Andrea E, Kanagaraj M, Franklin JM, Kesselheim AS.

J Natl Cancer Inst. 2019 Oct 25. pii: djz211. doi: 10.1093/jnci/djz211. [Epub ahead of print]

PMID:
31651981
7.

Hyppo-X: A Scalable Exploratory Framework for Analyzing Complex Phenomics Data.

Kamruzzaman M, Kalyanaraman A, Krishnamoorthy B, Hey S, Schnable P.

IEEE/ACM Trans Comput Biol Bioinform. 2019 Oct 23. doi: 10.1109/TCBB.2019.2947500. [Epub ahead of print]

PMID:
31647442
8.

Adaptive trials, efficiency, and ethics.

Hey SP.

BMC Med. 2019 Oct 22;17(1):189. doi: 10.1186/s12916-019-1437-z. No abstract available.

9.

Surrogate Endpoints and Drug Regulation: What Is Needed to Clarify the Evidence.

Hey SP, Feldman WB, Jung EH, D'Andrea E, Kesselheim AS.

J Law Med Ethics. 2019 Sep;47(3):381-387. doi: 10.1177/1073110519876167.

PMID:
31560631
10.

Challenges and Opportunities for Biomarker Validation.

Hey SP, D'Andrea E, Jung EH, Tessema F, Luo J, Gyawali B, Kesselheim AS.

J Law Med Ethics. 2019 Sep;47(3):357-361. doi: 10.1177/1073110519876162.

PMID:
31560620
11.

Community-engaged Evidence Synthesis to Inform Public Health Policy and Clinical Practice: A Case Study.

Springs S, Rofeberg V, Brown S, Boudreau S, Hey SP, Baruch J.

Med Care. 2019 Oct;57 Suppl 10 Suppl 3:S253-S258. doi: 10.1097/MLR.0000000000001180.

12.

Data Sharing For Research-Encouraging Signs Amid Ethical Tensions.

Hey SP.

JAMA Netw Open. 2019 Aug 2;2(8):e199732. doi: 10.1001/jamanetworkopen.2019.9732. No abstract available.

PMID:
31433476
13.

Public Approval of Exception From Informed Consent in Emergency Clinical Trials: A Systematic Review of Community Consultation Surveys.

Feldman WB, Hey SP, Franklin JM, Kesselheim AS.

JAMA Netw Open. 2019 Jul 3;2(7):e197591. doi: 10.1001/jamanetworkopen.2019.7591.

14.

A mixed methods comparative evaluation of a low cost otoscope (Arclight) with a traditional device in twenty-one clinicians.

Hey SY, Buckley JC, Shahsavari S, Kousha O, Haddow KA, Blaikie A, Walker FDL.

Clin Otolaryngol. 2019 Nov;44(6):1101-1104. doi: 10.1111/coa.13403. Epub 2019 Aug 6. No abstract available.

PMID:
31319018
15.

Cell and Gene Therapy Trials: Are We Facing an 'Evidence Crisis'?

Abou-El-Enein M, Hey SP.

EClinicalMedicine. 2019 Feb 2;7:13-14. doi: 10.1016/j.eclinm.2019.01.015. eCollection 2019 Jan. No abstract available.

16.

Assessment of the Clinical Benefit of Cancer Drugs Receiving Accelerated Approval.

Gyawali B, Hey SP, Kesselheim AS.

JAMA Intern Med. 2019 Jul 1;179(7):906-913. doi: 10.1001/jamainternmed.2019.0462.

PMID:
31135808
17.

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis.

D'Andrea E, Hey SP, Ramirez CL, Kesselheim AS.

JAMA Netw Open. 2019 Apr 5;2(4):e192224. doi: 10.1001/jamanetworkopen.2019.2224.

18.

Drainless parotidectomy and the same day discharge with routine use of topical haemostatic agent and Balaclava bandage.

Hey SY, Flach S, Shahsavari S, Manickavasagam J.

Clin Otolaryngol. 2019 Nov;44(6):1218-1220. doi: 10.1111/coa.13339. Epub 2019 Apr 24. No abstract available.

PMID:
30965391
19.

A Framework for Assessing Scientific Merit in Ethical Review of Clinical Research.

Binik A, Hey SP.

Ethics Hum Res. 2019 Mar;41(2):2-13. doi: 10.1002/eahr.500007.

PMID:
30895755
20.

Endoscopic Sphenopalatine Artery Ligation: General Applicability in a Teaching Unit.

Hey SY, Koo Ng NKF, McGarry GW.

Ear Nose Throat J. 2019 Feb;98(2):85-88. doi: 10.1177/0145561319828675. Epub 2019 Feb 12.

PMID:
30884999
22.

A systematic review of trial-level meta-analyses measuring the strength of association between surrogate end-points and overall survival in oncology.

Haslam A, Hey SP, Gill J, Prasad V.

Eur J Cancer. 2019 Jan;106:196-211. doi: 10.1016/j.ejca.2018.11.012. Epub 2018 Dec 5. Review.

PMID:
30528804
23.

Nonhypoxic pharmacological stabilization of Hypoxia Inducible Factor 1α: Effects on dopaminergic differentiation of human neural stem cells.

Hey SM, Jensen P, Ryding M, Martínez Serrano A, Kristensen BW, Meyer M.

Eur J Neurosci. 2019 Feb;49(4):497-509. doi: 10.1111/ejn.14284. Epub 2018 Dec 8.

PMID:
30471165
24.

Stakeholder views regarding ethical issues in the design and conduct of pragmatic trials: study protocol.

Nicholls SG, Carroll K, Brehaut J, Weijer C, Hey SP, Goldstein CE, Zwarenstein M, Graham ID, McKenzie JE, McIntyre L, Jairath V, Campbell MK, Grimshaw JM, Fergusson DA, Taljaard M.

BMC Med Ethics. 2018 Nov 20;19(1):90. doi: 10.1186/s12910-018-0332-z.

25.

ZmMADS69 functions as a flowering activator through the ZmRap2.7-ZCN8 regulatory module and contributes to maize flowering time adaptation.

Liang Y, Liu Q, Wang X, Huang C, Xu G, Hey S, Lin HY, Li C, Xu D, Wu L, Wang C, Wu W, Xia J, Han X, Lu S, Lai J, Song W, Schnable PS, Tian F.

New Phytol. 2019 Mar;221(4):2335-2347. doi: 10.1111/nph.15512. Epub 2018 Oct 30.

PMID:
30288760
26.

A Systematic Review Of The Food And Drug Administration's 'Exception From Informed Consent' Pathway.

Feldman WB, Hey SP, Kesselheim AS.

Health Aff (Millwood). 2018 Oct;37(10):1605-1614. doi: 10.1377/hlthaff.2018.0501.

PMID:
30273035
27.

Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol.

Taljaard M, Weijer C, Grimshaw JM, Ali A, Brehaut JC, Campbell MK, Carroll K, Edwards S, Eldridge S, Forrest CB, Giraudeau B, Goldstein CE, Graham ID, Hemming K, Hey SP, Horn AR, Jairath V, Klassen TP, London AJ, Marlin S, Marshall JC, McIntyre L, McKenzie JE, Nicholls SG, Alison Paprica P, Zwarenstein M, Fergusson DA.

Trials. 2018 Sep 27;19(1):525. doi: 10.1186/s13063-018-2895-x.

28.

Glycine is able to induce both a motility speed in- and decrease during zebrafish neuronal migration.

Theisen U, Hey S, Hennig CD, Schnabel R, Köster RW.

Commun Integr Biol. 2018 Aug 13;11(3):1-7. doi: 10.1080/19420889.2018.1493324. eCollection 2018.

29.

Defining "True and Non-Misleading" for Pharmaceutical Promotion.

Hey SP, Kesselheim AS.

J Law Med Ethics. 2018 Jun;46(2):552-554. doi: 10.1177/1073110518782970. No abstract available.

PMID:
30146990
30.

Intracerebral hemorrhage: positive predictive value of diagnosis codes in two nationwide Danish registries.

Hald SM, Kring Sloth C, Hey SM, Madsen C, Nguyen N, García Rodríguez LA, Al-Shahi Salman R, Möller S, Poulsen FR, Pottegård A, Gaist D.

Clin Epidemiol. 2018 Aug 7;10:941-948. doi: 10.2147/CLEP.S167576. eCollection 2018.

31.

Thinking clearly about the FIRST trial: addressing ethical challenges in cluster randomised trials of policy interventions involving health providers.

Horn AR, Weijer C, Hey SP, Brehaut J, Fergusson DA, Goldstein CE, Grimshaw J, Taljaard M.

J Med Ethics. 2018 Sep;44(9):593-598. doi: 10.1136/medethics-2017-104282. Epub 2018 Apr 27.

PMID:
29703860
32.

Research ethics for emerging trial designs: does equipoise need to adapt?

Hey SP, Weijer C, Taljaard M, Kesselheim AS.

BMJ. 2018 Jan 25;360:k226. doi: 10.1136/bmj.k226. No abstract available.

PMID:
29371211
33.

Is the concept of clinical equipoise still relevant to research?

Hey SP, London AJ, Weijer C, Rid A, Miller F.

BMJ. 2017 Dec 28;359:j5787. doi: 10.1136/bmj.j5787. No abstract available. Erratum in: BMJ. 2018 Mar 5;360:k1065.

PMID:
29284666
34.

Supportive Mental Health Self-Monitoring among Smartphone Users with Psychological Distress: Protocol for a Fully Mobile Randomized Controlled Trial.

Beiwinkel T, Hey S, Bock O, Rössler W.

Front Public Health. 2017 Sep 21;5:249. doi: 10.3389/fpubh.2017.00249. eCollection 2017.

35.

Ethical Challenges in Biomarker-Driven Drug Development.

Hey SP.

Clin Pharmacol Ther. 2018 Jan;103(1):23-25. doi: 10.1002/cpt.862. Epub 2017 Sep 25.

PMID:
28944956
36.

Influence, integrity, and the FDA: An ethical framework.

Hey SP, Cohen IG, Adashi EY, Kesselheim AS.

Science. 2017 Sep 1;357(6354):876-877. doi: 10.1126/science.aao1056. No abstract available.

PMID:
28860375
37.

Success, Failure, and Transparency in Biomarker-Based Drug Development: A Case Study of Cholesteryl Ester Transfer Protein Inhibitors.

Hey SP, Franklin JM, Avorn J, Kesselheim AS.

Circ Cardiovasc Qual Outcomes. 2017 Jun;10(6). pii: e003121. doi: 10.1161/CIRCOUTCOMES.116.003121. Review.

PMID:
28611186
38.

Complexity and specificity of the maize (Zea mays L.) root hair transcriptome.

Hey S, Baldauf J, Opitz N, Lithio A, Pasha A, Provart N, Nettleton D, Hochholdinger F.

J Exp Bot. 2017 Apr 1;68(9):2175-2185. doi: 10.1093/jxb/erx104.

39.

Reprioritizing Research Activity for the Post-Antibiotic Era: Ethical, Legal, and Social Considerations.

Hey SP, Kesselheim AS.

Hastings Cent Rep. 2017 Mar;47(2):16-20. doi: 10.1002/hast.685.

PMID:
28301705
40.

Priority, prediction and the ethical research enterprise.

Hey SP.

J Med Ethics. 2017 Dec;43(12):812-813. doi: 10.1136/medethics-2016-103999. Epub 2017 Feb 6. No abstract available.

PMID:
28167632
41.

The Challenges of Validating in Precision Medicine: The Case of Excision Repair Cross-Complement Group 1 Diagnostic Testing.

Barsanti-Innes B, Hey SP, Kimmelman J.

Oncologist. 2017 Jan;22(1):89-96. doi: 10.1634/theoncologist.2016-0188. Epub 2016 Oct 24.

42.

Characterization of maize roothairless6 which encodes a D-type cellulose synthase and controls the switch from bulge formation to tip growth.

Li L, Hey S, Liu S, Liu Q, McNinch C, Hu HC, Wen TJ, Marcon C, Paschold A, Bruce W, Schnable PS, Hochholdinger F.

Sci Rep. 2016 Oct 6;6:34395. doi: 10.1038/srep34395.

43.

The contribution of wheat to human diet and health.

Shewry PR, Hey SJ.

Food Energy Secur. 2015 Oct;4(3):178-202. Epub 2015 Aug 14. Review.

44.

The FDA, Juno Therapeutics, and the ethical imperative of transparency.

Hey SP, Kesselheim AS.

BMJ. 2016 Aug 15;354:i4435. doi: 10.1136/bmj.i4435. No abstract available.

PMID:
27526698
45.

BIOMEDICAL RESEARCH. Countering imprecision in precision medicine.

Hey SP, Kesselheim AS.

Science. 2016 Jul 29;353(6298):448-9. doi: 10.1126/science.aaf5101. No abstract available.

PMID:
27471295
46.

Alpha-Fetoprotein Detection of Hepatocellular Carcinoma Leads to a Standardized Analysis of Dynamic AFP to Improve Screening Based Detection.

Bird TG, Dimitropoulou P, Turner RM, Jenks SJ, Cusack P, Hey S, Blunsum A, Kelly S, Sturgeon C, Hayes PC, Bird SM.

PLoS One. 2016 Jun 16;11(6):e0156801. doi: 10.1371/journal.pone.0156801. eCollection 2016.

47.

Do We Know Whether Researchers and Reviewers are Estimating Risk and Benefit Accurately?

Hey SP, Kimmelman J.

Bioethics. 2016 Oct;30(8):609-17. doi: 10.1111/bioe.12260. Epub 2016 May 16.

PMID:
27197044
48.

What questions can a placebo answer?

Hey SP, Weijer C.

Monash Bioeth Rev. 2016 Mar;34(1):23-36. doi: 10.1007/s40592-016-0057-z. Review.

PMID:
27188301
49.

An Uninformative Truth: The Logic of Amarin's Off-Label Promotion.

Hey SP, Kesselheim AS.

PLoS Med. 2016 Mar 15;13(3):e1001978. doi: 10.1371/journal.pmed.1001978. eCollection 2016 Mar.

50.

Do we need to worry about eating wheat?

Shewry PR, Hey SJ.

Nutr Bull. 2016 Mar;41(1):6-13. Epub 2016 Feb 16. Review.

Supplemental Content

Support Center