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Items: 47


Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice.

Blaser MC, Wei K, Adams RLE, Zhou YQ, Caruso LL, Mirzaei Z, Lam AY, Tam RKK, Zhang H, Heximer SP, Henkelman RM, Simmons CA.

Circ Res. 2018 Feb 2;122(3):405-416. doi: 10.1161/CIRCRESAHA.117.311194. Epub 2017 Dec 22.


The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice.

Baggio LL, Ussher JR, McLean BA, Cao X, Kabir MG, Mulvihill EE, Mighiu AS, Zhang H, Ludwig A, Seeley RJ, Heximer SP, Drucker DJ.

Mol Metab. 2017 Nov;6(11):1339-1349. doi: 10.1016/j.molmet.2017.08.010. Epub 2017 Sep 1.


Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure.

Kroetsch JT, Levy AS, Zhang H, Aschar-Sobbi R, Lidington D, Offermanns S, Nedospasov SA, Backx PH, Heximer SP, Bolz SS.

Nat Commun. 2017 Apr 5;8:14805. doi: 10.1038/ncomms14805.


Gαi3-Dependent Inhibition of JNK Activity on Intracellular Membranes.

Bastin G, Yang JY, Heximer SP.

Front Bioeng Biotechnol. 2015 Sep 1;3:128. doi: 10.3389/fbioe.2015.00128. eCollection 2015.


Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes.

Liu J, Kim KH, Morales MJ, Heximer SP, Hui CC, Backx PH.

PLoS One. 2015 Jul 21;10(7):e0133274. doi: 10.1371/journal.pone.0133274. eCollection 2015.


The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent.

Guo J, Breen DM, Pereira TJ, Dalvi PS, Zhang H, Mori Y, Ghanim H, Tumiati L, Fantus IG, Bendeck MP, Dandona P, Rao V, Dolinsky VW, Heximer SP, Giacca A.

Atherosclerosis. 2015 Jul;241(1):111-20. doi: 10.1016/j.atherosclerosis.2015.04.799. Epub 2015 Apr 25.


Enhanced proliferation and altered calcium handling in RGS2-deficient vascular smooth muscle cells.

Momen A, Afroze T, Sadi AM, Khoshbin A, Zhang H, Choi J, Gu S, Zaidi SH, Heximer SP, Husain M.

J Recept Signal Transduct Res. 2014 Dec;34(6):476-83. doi: 10.3109/10799893.2014.920393. Epub 2014 May 20.


Early stress prevents the potentiation of muscarinic excitation by calcium release in adult prefrontal cortex.

Proulx É, Suri D, Heximer SP, Vaidya VA, Lambe EK.

Biol Psychiatry. 2014 Aug 15;76(4):315-23. doi: 10.1016/j.biopsych.2013.10.017. Epub 2013 Oct 28.


Rab family proteins regulate the endosomal trafficking and function of RGS4.

Bastin G, Heximer SP.

J Biol Chem. 2013 Jul 26;288(30):21836-49. doi: 10.1074/jbc.M113.466888. Epub 2013 Jun 3.


A "new twist" on RGS protein selectivity.

Heximer SP.

Structure. 2013 Mar 5;21(3):319-20. doi: 10.1016/j.str.2013.02.011.


Amino-terminal cysteine residues differentially influence RGS4 protein plasma membrane targeting, intracellular trafficking, and function.

Bastin G, Singh K, Dissanayake K, Mighiu AS, Nurmohamed A, Heximer SP.

J Biol Chem. 2012 Aug 17;287(34):28966-74. doi: 10.1074/jbc.M112.345629. Epub 2012 Jun 29.


Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node.

Mighiu AS, Heximer SP.

Front Physiol. 2012 Jun 13;3:204. doi: 10.3389/fphys.2012.00204. eCollection 2012.


Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling.

Yang J, Noyan-Ashraf MH, Meissner A, Voigtlaender-Bolz J, Kroetsch JT, Foltz W, Jaffray D, Kapoor A, Momen A, Heximer SP, Zhang H, van Eede M, Henkelman RM, Matthews SG, Lidington D, Husain M, Bolz SS.

Circulation. 2012 Jul 10;126(2):196-206. doi: 10.1161/CIRCULATIONAHA.111.039644. Epub 2012 Jun 5.


Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism.

Breen DM, Dolinsky VW, Zhang H, Ghanim H, Guo J, Mroziewicz M, Tsiani EL, Bendeck MP, Dandona P, Dyck JR, Heximer SP, Giacca A.

Atherosclerosis. 2012 Jun;222(2):375-81. doi: 10.1016/j.atherosclerosis.2012.03.021. Epub 2012 Mar 27.


β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.

Holden NS, Bell MJ, Rider CF, King EM, Gaunt DD, Leigh R, Johnson M, Siderovski DP, Heximer SP, Giembycz MA, Newton R.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19713-8. doi: 10.1073/pnas.1110226108. Epub 2011 Nov 11.


Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia.

Tsui AK, Marsden PA, Mazer CD, Adamson SL, Henkelman RM, Ho JJ, Wilson DF, Heximer SP, Connelly KA, Bolz SS, Lidington D, El-Beheiry MH, Dattani ND, Chen KM, Hare GM.

Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17544-9. doi: 10.1073/pnas.1114026108. Epub 2011 Oct 5.


Origin-specific epigenetic program correlates with vascular bed-specific differences in Rgs5 expression.

Zhang H, Gu S, Al-Sabeq B, Wang S, He J, Tam A, Cifelli C, Mathalone N, Tirgari S, Boyd S, Heximer SP.

FASEB J. 2012 Jan;26(1):181-91. doi: 10.1096/fj.11-185454. Epub 2011 Sep 29.


Metoprolol impairs resistance artery function in mice.

El Beheiry MH, Heximer SP, Voigtlaender-Bolz J, Mazer CD, Connelly KA, Wilson DF, Beattie WS, Tsui AK, Zhang H, Golam K, Hu T, Liu E, Lidington D, Bolz SS, Hare GM.

J Appl Physiol (1985). 2011 Oct;111(4):1125-33. doi: 10.1152/japplphysiol.01340.2010. Epub 2011 Jul 28.


Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation.

Rose RA, Sellan M, Simpson JA, Izaddoustdar F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH.

Circ Arrhythm Electrophysiol. 2011 Oct;4(5):733-42. doi: 10.1161/CIRCEP.110.960401. Epub 2011 Jul 11.


Intracellular regulation of heterotrimeric G-protein signaling modulates vascular smooth muscle cell contraction.

Bastin G, Heximer SP.

Arch Biochem Biophys. 2011 Jun 15;510(2):182-9. doi: 10.1016/ Epub 2011 May 20. Review.


Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse.

Pacey LK, Doss L, Cifelli C, van der Kooy D, Heximer SP, Hampson DR.

Mol Cell Neurosci. 2011 Mar;46(3):563-72. doi: 10.1016/j.mcn.2010.12.005. Epub 2011 Jan 6.


Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.

Leen JL, Izzo A, Upadhyay C, Rowland KJ, Dubé PE, Gu S, Heximer SP, Rhodes CJ, Storm DR, Lund PK, Brubaker PL.

Endocrinology. 2011 Feb;152(2):436-46. doi: 10.1210/en.2010-0822. Epub 2010 Dec 15.


Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload.

Li H, He C, Feng J, Zhang Y, Tang Q, Bian Z, Bai X, Zhou H, Jiang H, Heximer SP, Qin M, Huang H, Liu PP, Huang C.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13818-23. doi: 10.1073/pnas.1008397107. Epub 2010 Jul 19. Erratum in: Proc Natl Acad Sci U S A. 2018 Apr 2;:.


Increased GABA(B) receptor-mediated signaling reduces the susceptibility of fragile X knockout mice to audiogenic seizures.

Pacey LK, Heximer SP, Hampson DR.

Mol Pharmacol. 2009 Jul;76(1):18-24. doi: 10.1124/mol.109.056127. Epub 2009 Apr 7.


RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function.

Gu S, Cifelli C, Wang S, Heximer SP.

Clin Sci (Lond). 2009 Mar;116(5):391-9. doi: 10.1042/CS20080272. Review.


RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node.

Cifelli C, Rose RA, Zhang H, Voigtlaender-Bolz J, Bolz SS, Backx PH, Heximer SP.

Circ Res. 2008 Aug 29;103(5):527-35. doi: 10.1161/CIRCRESAHA.108.180984. Epub 2008 Jul 24.


The RGS2 gene product from a candidate hypertension allele shows decreased plasma membrane association and inhibition of Gq.

Gu S, Tirgari S, Heximer SP.

Mol Pharmacol. 2008 Apr;73(4):1037-43. doi: 10.1124/mol.107.044214. Epub 2008 Jan 29.


Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins.

Gu S, Anton A, Salim S, Blumer KJ, Dessauer CW, Heximer SP.

Mol Pharmacol. 2008 Jan;73(1):1-11. Epub 2007 Sep 27.


Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members.

Gu S, He J, Ho WT, Ramineni S, Thal DM, Natesh R, Tesmer JJ, Hepler JR, Heximer SP.

J Biol Chem. 2007 Nov 9;282(45):33064-75. Epub 2007 Sep 11.


Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons.

Gong B, Wang H, Gu S, Heximer SP, Zhuo M.

Eur J Neurosci. 2007 Jul;26(2):275-88.


RGS proteins: Swiss army knives in seven-transmembrane domain receptor signaling networks.

Heximer SP, Blumer KJ.

Sci STKE. 2007 Jan 23;2007(370):pe2.


RGS2-mediated regulation of Gqalpha.

Heximer SP.

Methods Enzymol. 2004;390:65-82.


Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure.

Tang KM, Wang GR, Lu P, Karas RH, Aronovitz M, Heximer SP, Kaltenbronn KM, Blumer KJ, Siderovski DP, Zhu Y, Mendelsohn ME.

Nat Med. 2003 Dec;9(12):1506-12. Epub 2003 Nov 9. Erratum in: Nat Med. 2004 Jan;10(1):105. Tang, Mary [corrected to Tang, K Mary]; Wang, Guang [corrected to Wang, Guang-rong].


Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.

Faury G, Pezet M, Knutsen RH, Boyle WA, Heximer SP, McLean SE, Minkes RK, Blumer KJ, Kovacs A, Kelly DP, Li DY, Starcher B, Mecham RP.

J Clin Invest. 2003 Nov;112(9):1419-28.


Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ.

J Clin Invest. 2003 Apr;111(8):1259. No abstract available.


Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ.

J Clin Invest. 2003 Feb;111(4):445-52.


Mechanisms governing subcellular localization and function of human RGS2.

Heximer SP, Lim H, Bernard JL, Blumer KJ.

J Biol Chem. 2001 Apr 27;276(17):14195-203. Epub 2001 Jan 30.


G protein selectivity is a determinant of RGS2 function.

Heximer SP, Srinivasa SP, Bernstein LS, Bernard JL, Linder ME, Hepler JR, Blumer KJ.

J Biol Chem. 1999 Nov 26;274(48):34253-9.


Expression and processing of G0/G1 switch gene 24 (G0S24/TIS11/TTP/NUP475) RNA in cultured human blood mononuclear cells.

Heximer SP, Cristillo AD, Russell L, Forsdyke DR.

DNA Cell Biol. 1998 Mar;17(3):249-63.


RGS2/G0S8 is a selective inhibitor of Gqalpha function.

Heximer SP, Watson N, Linder ME, Blumer KJ, Hepler JR.

Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14389-93.


Cyclosporin A inhibits early mRNA expression of G0/G1 switch gene 2 (G0S2) in cultured human blood mononuclear cells.

Cristillo AD, Heximer SP, Russell L, Forsdyke DR.

DNA Cell Biol. 1997 Dec;16(12):1449-58.


Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3).

Heximer SP, Cristillo AD, Russell L, Forsdyke DR.

DNA Cell Biol. 1996 Dec;15(12):1025-38.


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