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Items: 1 to 50 of 168

1.

In Vivo Gene Essentiality and Metabolism in Bordetella pertussis.

Gonyar LA, Gelbach PE, McDuffie DG, Koeppel AF, Chen Q, Lee G, Temple LM, Stibitz S, Hewlett EL, Papin JA, Damron FH, Eby JC.

mSphere. 2019 May 22;4(3). pii: e00694-18. doi: 10.1128/mSphere.00694-18.

2.

Bordetella pertussis Can Be Motile and Express Flagellum-Like Structures.

Hoffman CL, Gonyar LA, Zacca F, Sisti F, Fernandez J, Wong T, Damron FH, Hewlett EL.

MBio. 2019 May 14;10(3). pii: e00787-19. doi: 10.1128/mBio.00787-19.

3.

Analysis of the In Vivo Transcriptome of Bordetella pertussis during Infection of Mice.

Wong TY, Hall JM, Nowak ES, Boehm DT, Gonyar LA, Hewlett EL, Eby JC, Barbier M, Damron FH.

mSphere. 2019 Apr 17;4(2). pii: e00154-19. doi: 10.1128/mSphereDirect.00154-19.

4.

Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice.

Boehm DT, Hall JM, Wong TY, DiVenere AM, Sen-Kilic E, Bevere JR, Bradford SD, Blackwood CB, Elkins CM, DeRoos KA, Gray MC, Cooper CG, Varney ME, Maynard JA, Hewlett EL, Barbier M, Damron FH.

Infect Immun. 2018 Sep 21;86(10). pii: e00857-17. doi: 10.1128/IAI.00857-17. Print 2018 Oct.

5.

Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin.

Gonyar LA, Gray MC, Christianson GJ, Mehrad B, Hewlett EL.

Infect Immun. 2017 May 23;85(6). pii: e00198-17. doi: 10.1128/IAI.00198-17. Print 2017 Jun.

6.

Fine Epitope Mapping of Two Antibodies Neutralizing the Bordetella Adenylate Cyclase Toxin.

Wang X, Stapleton JA, Klesmith JR, Hewlett EL, Whitehead TA, Maynard JA.

Biochemistry. 2017 Mar 7;56(9):1324-1336. doi: 10.1021/acs.biochem.6b01163. Epub 2017 Feb 23.

7.

Use of a Toxin Neutralization Assay To Characterize the Serologic Response to Adenylate Cyclase Toxin after Infection with Bordetella pertussis.

Eby JC, Gray MC, Warfel JM, Merkel TJ, Hewlett EL.

Clin Vaccine Immunol. 2017 Jan 5;24(1). pii: e00370-16. doi: 10.1128/CVI.00370-16. Print 2017 Jan.

8.

Review of the neutrophil response to Bordetella pertussis infection.

Eby JC, Hoffman CL, Gonyar LA, Hewlett EL.

Pathog Dis. 2015 Dec;73(9):ftv081. doi: 10.1093/femspd/ftv081. Epub 2015 Oct 2. Review.

9.

The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies.

Wang X, Gray MC, Hewlett EL, Maynard JA.

J Biol Chem. 2015 Sep 18;290(38):23025. doi: 10.1074/jbc.A114.585281. No abstract available.

10.

Whole-genome sequencing in outbreak analysis.

Gilchrist CA, Turner SD, Riley MF, Petri WA Jr, Hewlett EL.

Clin Microbiol Rev. 2015 Jul;28(3):541-63. doi: 10.1128/CMR.00075-13. Review.

11.

High temporal resolution of glucosyltransferase dependent and independent effects of Clostridium difficile toxins across multiple cell types.

D'Auria KM, Bloom MJ, Reyes Y, Gray MC, van Opstal EJ, Papin JA, Hewlett EL.

BMC Microbiol. 2015 Feb 4;15:7. doi: 10.1186/s12866-015-0361-4.

12.
13.

Cyclic AMP-mediated suppression of neutrophil extracellular trap formation and apoptosis by the Bordetella pertussis adenylate cyclase toxin.

Eby JC, Gray MC, Hewlett EL.

Infect Immun. 2014 Dec;82(12):5256-69. doi: 10.1128/IAI.02487-14. Epub 2014 Oct 6.

14.

Pertussis pathogenesis--what we know and what we don't know.

Hewlett EL, Burns DL, Cotter PA, Harvill ET, Merkel TJ, Quinn CP, Stibitz ES.

J Infect Dis. 2014 Apr 1;209(7):982-5. doi: 10.1093/infdis/jit639. Review.

15.

Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size.

Masin J, Fiser R, Linhartova I, Osicka R, Bumba L, Hewlett EL, Benz R, Sebo P.

Infect Immun. 2013 Dec;81(12):4571-82. doi: 10.1128/IAI.00711-13. Epub 2013 Sep 30.

16.

In vivo physiological and transcriptional profiling reveals host responses to Clostridium difficile toxin A and toxin B.

D'Auria KM, Kolling GL, Donato GM, Warren CA, Gray MC, Hewlett EL, Papin JA.

Infect Immun. 2013 Oct;81(10):3814-24. doi: 10.1128/IAI.00869-13. Epub 2013 Jul 29.

17.

Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection.

Eby JC, Gray MC, Warfel JM, Paddock CD, Jones TF, Day SR, Bowden J, Poulter MD, Donato GM, Merkel TJ, Hewlett EL.

Infect Immun. 2013 May;81(5):1390-8. doi: 10.1128/IAI.00110-13. Epub 2013 Feb 19.

18.

Contribution of Bordetella filamentous hemagglutinin and adenylate cyclase toxin to suppression and evasion of interleukin-17-mediated inflammation.

Henderson MW, Inatsuka CS, Sheets AJ, Williams CL, Benaron DJ, Donato GM, Gray MC, Hewlett EL, Cotter PA.

Infect Immun. 2012 Jun;80(6):2061-75. doi: 10.1128/IAI.00148-12. Epub 2012 Apr 2.

19.

A metabolic network approach for the identification and prioritization of antimicrobial drug targets.

Chavali AK, D'Auria KM, Hewlett EL, Pearson RD, Papin JA.

Trends Microbiol. 2012 Mar;20(3):113-23. doi: 10.1016/j.tim.2011.12.004. Epub 2012 Jan 31. Review.

20.

Delivery of Bordetella pertussis adenylate cyclase toxin to target cells via outer membrane vesicles.

Donato GM, Goldsmith CS, Paddock CD, Eby JC, Gray MC, Hewlett EL.

FEBS Lett. 2012 Feb 17;586(4):459-65. doi: 10.1016/j.febslet.2012.01.032. Epub 2012 Jan 28.

21.

Systems analysis of the transcriptional response of human ileocecal epithelial cells to Clostridium difficile toxins and effects on cell cycle control.

D'Auria KM, Donato GM, Gray MC, Kolling GL, Warren CA, Cave LM, Solga MD, Lannigan JA, Papin JA, Hewlett EL.

BMC Syst Biol. 2012 Jan 6;6:2. doi: 10.1186/1752-0509-6-2.

22.

Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis.

Eby JC, Gray MC, Mangan AR, Donato GM, Hewlett EL.

Infect Immun. 2012 Feb;80(2):850-9. doi: 10.1128/IAI.05979-11. Epub 2011 Dec 5.

23.

Cell cycle arrest induced by the bacterial adenylate cyclase toxins from Bacillus anthracis and Bordetella pertussis.

Gray MC, Hewlett EL.

Cell Microbiol. 2011 Jan;13(1):123-34. doi: 10.1111/j.1462-5822.2010.01525.x. Epub 2010 Oct 14.

24.

Selective translocation of the Bordetella pertussis adenylate cyclase toxin across the basolateral membranes of polarized epithelial cells.

Eby JC, Ciesla WP, Hamman W, Donato GM, Pickles RJ, Hewlett EL, Lencer WI.

J Biol Chem. 2010 Apr 2;285(14):10662-70. doi: 10.1074/jbc.M109.089219. Epub 2010 Feb 5.

25.

International Bordetella pertussis assay standardization and harmonization meeting report. Centers for Disease Control and Prevention, Atlanta, Georgia, United States, 19-20 July 2007.

Tondella ML, Carlone GM, Messonnier N, Quinn CP, Meade BD, Burns DL, Cherry JD, Guiso N, Hewlett EL, Edwards KM, Xing D, Giammanco A, Wirsing von K├Ânig CH, Han L, Hueston L, Robbins JB, Powell M, Mink CM, Poolman JT, Hildreth SW, Lynn F, Morris A.

Vaccine. 2009 Feb 5;27(6):803-14. doi: 10.1016/j.vaccine.2008.11.072. Epub 2008 Dec 9.

PMID:
19071179
26.
27.

A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability.

Easley CJ, Karlinsey JM, Bienvenue JM, Legendre LA, Roper MG, Feldman SH, Hughes MA, Hewlett EL, Merkel TJ, Ferrance JP, Landers JP.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19272-7. Epub 2006 Dec 11.

28.

Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte.

Mehlmann LM, Kalinowski RR, Ross LF, Parlow AF, Hewlett EL, Jaffe LA.

Dev Biol. 2006 Nov 15;299(2):345-55. Epub 2006 Aug 5.

29.
30.
31.

Oligomeric behavior of Bordetella pertussis adenylate cyclase toxin in solution.

Lee SJ, Gray MC, Zu K, Hewlett EL.

Arch Biochem Biophys. 2005 Jun 1;438(1):80-7. Epub 2005 Apr 19.

PMID:
15878155
32.

Clinical practice. Pertussis--not just for kids.

Hewlett EL, Edwards KM.

N Engl J Med. 2005 Mar 24;352(12):1215-22. Review. No abstract available.

PMID:
15788498
33.

Newly secreted adenylate cyclase toxin is responsible for intoxication of target cells by Bordetella pertussis.

Gray MC, Donato GM, Jones FR, Kim T, Hewlett EL.

Mol Microbiol. 2004 Sep;53(6):1709-19.

35.

Protein kinase A translocation and insulin secretion in pancreatic beta-cells: studies with adenylate cyclase toxin from Bordetella pertussis.

Gao Z, Young RA, Trucco MM, Greene SR, Hewlett EL, Matschinsky FM, Wolf BA.

Biochem J. 2002 Dec 1;368(Pt 2):397-404. Erratum in: Biochem J. 2003 Feb 1;369(Pt 3):739..

36.

Structural consequences of divalent metal binding by the adenylyl cyclase toxin of Bordetella pertussis.

Rhodes CR, Gray MC, Watson JM, Muratore TL, Kim SB, Hewlett EL, Grisham CM.

Arch Biochem Biophys. 2001 Nov 15;395(2):169-76.

PMID:
11697853
37.

Translocation-specific conformation of adenylate cyclase toxin from Bordetella pertussis inhibits toxin-mediated hemolysis.

Gray MC, Lee SJ, Gray LS, Zaretzky FR, Otero AS, Szabo G, Hewlett EL.

J Bacteriol. 2001 Oct;183(20):5904-10.

38.

Adenylate cyclase toxin from Bordetella pertussis: current concepts and problems in the study of toxin functions.

Hewlett EL, Kim KJ, Lee SJ, Gray MC.

Int J Med Microbiol. 2000 Oct;290(4-5):333-5.

PMID:
11111907
39.

Neutralizing antibodies to adenylate cyclase toxin promote phagocytosis of Bordetella pertussis by human neutrophils.

Weingart CL, Mobberley-Schuman PS, Hewlett EL, Gray MC, Weiss AA.

Infect Immun. 2000 Dec;68(12):7152-5.

40.

Escherichia coli alpha-hemolysin (HlyA) is heterogeneously acylated in vivo with 14-, 15-, and 17-carbon fatty acids.

Lim KB, Walker CR, Guo L, Pellett S, Shabanowitz J, Hunt DF, Hewlett EL, Ludwig A, Goebel W, Welch RA, Hackett M.

J Biol Chem. 2000 Nov 24;275(47):36698-702.

41.

Characterization of binding of adenylate cyclase toxin to target cells by flow cytometry.

Gray MC, Ross W, Kim K, Hewlett EL.

Infect Immun. 1999 Sep;67(9):4393-9.

42.

A commentary on the pathogenesis of pertussis.

Hewlett EL.

Clin Infect Dis. 1999 Jun;28 Suppl 2:S94-8. Review.

PMID:
10447025
43.

Epitope mapping of monoclonal antibodies against Bordetella pertussis adenylate cyclase toxin.

Lee SJ, Gray MC, Guo L, Sebo P, Hewlett EL.

Infect Immun. 1999 May;67(5):2090-5.

44.

Serological correlates of immunity to Bordetella pertussis.

Hewlett EL, Halperin SA.

Vaccine. 1998 Dec;16(20):1899-900. No abstract available.

PMID:
9796040
45.

Pertussis: current concepts of pathogenesis and prevention.

Hewlett EL.

Pediatr Infect Dis J. 1997 Apr;16(4 Suppl):S78-84. Review.

PMID:
9109161
46.

Role of pertussis toxin A subunit in neutrophil migration and vascular permeability.

Brito GA, Souza MH, Melo-Filho AA, Hewlett EL, Lima AA, Flores CA, Ribeiro RA.

Infect Immun. 1997 Mar;65(3):1114-8.

48.

Adenylate cyclase in striatal cholinergic interneurons regulates acetylcholine release.

Login IS, Hewlett EL.

Brain Res. 1996 Oct 7;735(2):330-4.

PMID:
8911674
49.

Acellular pertussis trial.

Hewlett EL.

Pediatrics. 1996 Oct;98(4 Pt 1):800. No abstract available.

PMID:
8885972
50.

ATP shortens atrial action potential duration in the dog: role of adenosine, the vagus nerve, and G protein.

Pelleg A, Hurt CM, Hewlett EL.

Can J Physiol Pharmacol. 1996 Jan;74(1):15-22.

PMID:
8963948

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