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Items: 1 to 50 of 300

1.

Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance.

Song KH, Kim JH, Lee YH, Bae HC, Lee HJ, Woo SR, Oh SJ, Lee KM, Yee C, Kim BW, Cho H, Chung EJ, Chung JY, Hewitt SM, Chung TW, Ha KT, Bae YK, Mao CP, Yang A, Wu TC, Kim TW.

J Clin Invest. 2018 Aug 31;128(9):4098-4114. doi: 10.1172/JCI96804. Epub 2018 Aug 20.

2.

Elevated expression of pancreatic adenocarcinoma upregulated factor (PAUF) is associated with poor prognosis and chemoresistance in epithelial ovarian cancer.

Choi CH, Kang TH, Song JS, Kim YS, Chung EJ, Ylaya K, Kim S, Koh SS, Chung JY, Kim JH, Hewitt SM.

Sci Rep. 2018 Aug 15;8(1):12161. doi: 10.1038/s41598-018-30582-8.

3.

Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning.

Klauschen F, Müller KR, Binder A, Bockmayr M, Hägele M, Seegerer P, Wienert S, Pruneri G, de Maria S, Badve S, Michiels S, Nielsen TO, Adams S, Savas P, Symmans F, Willis S, Gruosso T, Park M, Haibe-Kains B, Gallas B, Thompson AM, Cree I, Sotiriou C, Solinas C, Preusser M, Hewitt SM, Rimm D, Viale G, Loi S, Loibl S, Salgado R, Denkert C; International Immuno-Oncology Biomarker Working Group.

Semin Cancer Biol. 2018 Oct;52(Pt 2):151-157. doi: 10.1016/j.semcancer.2018.07.001. Epub 2018 Jul 7. Review.

PMID:
29990622
4.

A multiprotein supercomplex controlling oncogenic signalling in lymphoma.

Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM.

Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20.

PMID:
29925955
5.

Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T-Cell Receptors in High-Risk MYCN-Not-Amplified Human Neuroblastoma.

Wei JS, Kuznetsov IB, Zhang S, Song YK, Asgharzadeh S, Sindiri S, Wen X, Patidar R, Najaraj S, Walton A, Auvil JMG, Gerhard DS, Yuksel A, Catchpoole D, Hewitt SM, Sondel PM, Seeger R, Maris JM, Khan J.

Clin Cancer Res. 2018 May 21. doi: 10.1158/1078-0432.CCR-18-0599. [Epub ahead of print]

PMID:
29784674
6.

E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.

Horne HN, Oh H, Sherman ME, Palakal M, Hewitt SM, Schmidt MK, Milne RL, Hardisson D, Benitez J, Blomqvist C, Bolla MK, Brenner H, Chang-Claude J, Cora R, Couch FJ, Cuk K, Devilee P, Easton DF, Eccles DM, Eilber U, Hartikainen JM, Heikkilä P, Holleczek B, Hooning MJ, Jones M, Keeman R, Mannermaa A, Martens JWM, Muranen TA, Nevanlinna H, Olson JE, Orr N, Perez JIA, Pharoah PDP, Ruddy KJ, Saum KU, Schoemaker MJ, Seynaeve C, Sironen R, Smit VTHBM, Swerdlow AJ, Tengström M, Thomas AS, Timmermans AM, Tollenaar RAEM, Troester MA, van Asperen CJ, van Deurzen CHM, Van Leeuwen FF, Van't Veer LJ, García-Closas M, Figueroa JD.

Sci Rep. 2018 Apr 26;8(1):6574. doi: 10.1038/s41598-018-23733-4.

7.

RE: Elevated Bladder Cancer in Northern New England: The Role of Drinking Water and Arsenic.

Koutros S, Lenz P, Hewitt SM, Kida M, Jones M, Schned AR, Baris D, Pfeiffer R, Schwenn M, Johnson A, Karagas MR, Garcia-Closas M, Rothman N, Moore LE, Silverman DT.

J Natl Cancer Inst. 2018 Mar 14. doi: 10.1093/jnci/djy045. [Epub ahead of print] No abstract available.

PMID:
29548022
8.

Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF.

Ko A, Han SY, Choi CH, Cho H, Lee MS, Kim SY, Song JS, Hong KM, Lee HW, Hewitt SM, Chung JY, Song J.

Cell Death Differ. 2018 Jun;25(6):1050-1062. doi: 10.1038/s41418-018-0072-0. Epub 2018 Feb 22.

PMID:
29472714
9.

Reproducibility and Feasibility of Strategies for Morphologic Assessment of Renal Biopsies Using the Nephrotic Syndrome Study Network Digital Pathology Scoring System.

Zee J, Hodgin JB, Mariani LH, Gaut JP, Palmer MB, Bagnasco SM, Rosenberg AZ, Hewitt SM, Holzman LB, Gillespie BW, Barisoni L.

Arch Pathol Lab Med. 2018 May;142(5):613-625. doi: 10.5858/arpa.2017-0181-OA. Epub 2018 Feb 19.

PMID:
29457738
10.

The Role of Extracellular Matrix in Innate Immunity, Fugues of Evolution.

Hewitt SM.

J Histochem Cytochem. 2018 Apr;66(4):211. doi: 10.1369/0022155418761352. Epub 2018 Feb 14. No abstract available.

PMID:
29443622
11.

Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3-NANOG Axis.

Oh SJ, Cho H, Kim S, Noh KH, Song KH, Lee HJ, Woo SR, Kim S, Choi CH, Chung JY, Hewitt SM, Kim JH, Baek S, Lee KM, Yee C, Park HC, Kim TW.

Cancer Res. 2018 May 15;78(10):2638-2653. doi: 10.1158/0008-5472.CAN-17-2325. Epub 2018 Feb 6. Erratum in: Cancer Res. 2018 Jul 15;78(14):4098.

PMID:
29437706
12.

Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors.

Giannelou A, Wang H, Zhou Q, Park YH, Abu-Asab MS, Ylaya K, Stone DL, Sediva A, Sleiman R, Sramkova L, Bhatla D, Serti E, Tsai WL, Yang D, Bishop K, Carrington B, Pei W, Deuitch N, Brooks S, Edwan JH, Joshi S, Prader S, Kaiser D, Owen WC, Sonbul AA, Zhang Y, Niemela JE, Burgess SM, Boehm M, Rehermann B, Chae J, Quezado MM, Ombrello AK, Buckley RH, Grom AA, Remmers EF, Pachlopnik JM, Su HC, Gutierrez-Cruz G, Hewitt SM, Sood R, Risma K, Calvo KR, Rosenzweig SD, Gadina M, Hafner M, Sun HW, Kastner DL, Aksentijevich I.

Ann Rheum Dis. 2018 Apr;77(4):612-619. doi: 10.1136/annrheumdis-2017-212401. Epub 2018 Jan 22.

13.

A transatlantic perspective on the integration of immuno-oncology prognostic and predictive biomarkers in innovative clinical trial design.

Morfouace M, Hewitt SM, Salgado R, Hartmann K, Litiere S, Tejpar S, Golfinopoulos V, Lively T, Thurin M, Conley B, Lacombe D.

Semin Cancer Biol. 2018 Oct;52(Pt 2):158-165. doi: 10.1016/j.semcancer.2018.01.003. Epub 2018 Jan 5. Review.

PMID:
29307568
14.

Nonalcoholic fatty liver disease in spinal and bulbar muscular atrophy.

Guber RD, Takyar V, Kokkinis A, Fox DA, Alao H, Kats I, Bakar D, Remaley AT, Hewitt SM, Kleiner DE, Liu CY, Hadigan C, Fischbeck KH, Rotman Y, Grunseich C.

Neurology. 2017 Dec 12;89(24):2481-2490. doi: 10.1212/WNL.0000000000004748. Epub 2017 Nov 15.

15.

Histomorphological and Molecular Assessments of the Fixation Times Comparing Formalin and Ethanol-Based Fixatives.

Chung JY, Song JS, Ylaya K, Sears JD, Choi L, Cho H, Rosenberg AZ, Hewitt SM.

J Histochem Cytochem. 2018 Feb;66(2):121-135. doi: 10.1369/0022155417741467. Epub 2017 Nov 10.

PMID:
29125916
16.

Bcl-2-like Protein 11 (BIM) Expression Is Associated with Favorable Prognosis for Patients with Cervical Cancer.

Kim BW, Cho H, Ylaya K, Kitano H, Chung JY, Hewitt SM, Kim JH.

Anticancer Res. 2017 Sep;37(9):4873-4879.

PMID:
28870908
17.

The anti-cancer effects of itraconazole in epithelial ovarian cancer.

Choi CH, Ryu JY, Cho YJ, Jeon HK, Choi JJ, Ylaya K, Lee YY, Kim TJ, Chung JY, Hewitt SM, Kim BG, Bae DS, Lee JW.

Sci Rep. 2017 Jul 26;7(1):6552. doi: 10.1038/s41598-017-06510-7.

18.

Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma.

Li N, Fu H, Hewitt SM, Dimitrov DS, Ho M.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6623-E6631. doi: 10.1073/pnas.1706055114. Epub 2017 Jul 24.

19.

Expression of the scaffold connector enhancer of kinase suppressor of Ras 1 (CNKSR1) is correlated with clinical outcome in pancreatic cancer.

Quadri HS, Aiken TJ, Allgaeuer M, Moravec R, Altekruse S, Hussain SP, Miettinen MM, Hewitt SM, Rudloff U.

BMC Cancer. 2017 Jul 21;17(1):495. doi: 10.1186/s12885-017-3481-4.

20.

HDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells.

Song KH, Choi CH, Lee HJ, Oh SJ, Woo SR, Hong SO, Noh KH, Cho H, Chung EJ, Kim JH, Chung JY, Hewitt SM, Baek S, Lee KM, Yee C, Son M, Mao CP, Wu TC, Kim TW.

Cancer Res. 2017 Sep 15;77(18):5039-5053. doi: 10.1158/0008-5472.CAN-17-0072. Epub 2017 Jul 17.

21.

The Impact Factor Is a 20th-Century Relic in an Electronic Journal World of Instant Citation Counts.

Hewitt SM.

J Histochem Cytochem. 2017 Jul;65(7):387-388. doi: 10.1369/0022155417712485. No abstract available.

22.

Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma.

Chaisaingmongkol J, Budhu A, Dang H, Rabibhadana S, Pupacdi B, Kwon SM, Forgues M, Pomyen Y, Bhudhisawasdi V, Lertprasertsuke N, Chotirosniramit A, Pairojkul C, Auewarakul CU, Sricharunrat T, Phornphutkul K, Sangrajrang S, Cam M, He P, Hewitt SM, Ylaya K, Wu X, Andersen JB, Thorgeirsson SS, Waterfall JJ, Zhu YJ, Walling J, Stevenson HS, Edelman D, Meltzer PS, Loffredo CA, Hama N, Shibata T, Wiltrout RH, Harris CC, Mahidol C, Ruchirawat M, Wang XW; TIGER-LC Consortium.

Cancer Cell. 2017 Jul 10;32(1):57-70.e3. doi: 10.1016/j.ccell.2017.05.009. Epub 2017 Jun 22.

23.

Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis.

Kitano H, Chung JY, Noh KH, Lee YH, Kim TW, Lee SH, Eo SH, Cho HJ, Choi CH, Inoue S, Hanaoka J, Fukuoka J, Hewitt SM.

J Transl Med. 2017 Jun 17;15(1):138. doi: 10.1186/s12967-017-1241-5.

24.

Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology.

Barisoni L, Gimpel C, Kain R, Laurinavicius A, Bueno G, Zeng C, Liu Z, Schaefer F, Kretzler M, Holzman LB, Hewitt SM.

Clin Kidney J. 2017 Apr;10(2):176-187. doi: 10.1093/ckj/sfw129. Epub 2017 Feb 18.

25.

Formulation and pH of the Buffered Ethanol Fixative BE70.

Hewitt SM.

J Histochem Cytochem. 2017 Apr;65(4):251-252. doi: 10.1369/0022155416687279. No abstract available.

26.

Editor's Note.

Hewitt SM.

J Histochem Cytochem. 2017 Apr;65(4):254. doi: 10.1369/0022155416688260. No abstract available.

27.

Interstitial fibrosis scored on whole-slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies.

Mariani LH, Martini S, Barisoni L, Canetta PA, Troost JP, Hodgin JB, Palmer M, Rosenberg AZ, Lemley KV, Chien HP, Zee J, Smith A, Appel GB, Trachtman H, Hewitt SM, Kretzler M, Bagnasco SM.

Nephrol Dial Transplant. 2018 Feb 1;33(2):310-318. doi: 10.1093/ndt/gfw443.

PMID:
28339906
28.

Multiview boosting digital pathology analysis of prostate cancer.

Kwak JT, Hewitt SM.

Comput Methods Programs Biomed. 2017 Apr;142:91-99. doi: 10.1016/j.cmpb.2017.02.023. Epub 2017 Feb 22.

PMID:
28325451
29.

Computational analysis of the mesenchymal signature landscape in gliomas.

Celiku O, Tandle A, Chung JY, Hewitt SM, Camphausen K, Shankavaram U.

BMC Med Genomics. 2017 Mar 9;10(1):13. doi: 10.1186/s12920-017-0252-7.

30.

PAX3-FOXO1 is essential for tumour initiation and maintenance but not recurrence in a human myoblast model of rhabdomyosarcoma.

Pandey PR, Chatterjee B, Olanich ME, Khan J, Miettinen MM, Hewitt SM, Barr FG.

J Pathol. 2017 Apr;241(5):626-637. doi: 10.1002/path.4867. Epub 2017 Mar 1.

31.

Relationship between crown-like structures and sex-steroid hormones in breast adipose tissue and serum among postmenopausal breast cancer patients.

Mullooly M, Yang HP, Falk RT, Nyante SJ, Cora R, Pfeiffer RM, Radisky DC, Visscher DW, Hartmann LC, Carter JM, Degnim AC, Stanczyk FZ, Figueroa JD, Garcia-Closas M, Lissowska J, Troester MA, Hewitt SM, Brinton LA, Sherman ME, Gierach GL.

Breast Cancer Res. 2017 Jan 19;19(1):8. doi: 10.1186/s13058-016-0791-4.

32.

API5 confers cancer stem cell-like properties through the FGF2-NANOG axis.

Song KH, Cho H, Kim S, Lee HJ, Oh SJ, Woo SR, Hong SO, Jang HS, Noh KH, Choi CH, Chung JY, Hewitt SM, Kim JH, Son M, Kim SH, Lee BI, Park HC, Bae YK, Kim TW.

Oncogenesis. 2017 Jan 16;6(1):e285. doi: 10.1038/oncsis.2016.87.

33.

Association between breast cancer genetic susceptibility variants and terminal duct lobular unit involution of the breast.

Bodelon C, Oh H, Chatterjee N, Garcia-Closas M, Palakal M, Sherman ME, Pfeiffer RM, Geller B, Vacek P, Weaver DL, Chicoine R, Papathomas D, Xiang J, Patel DA, Khodr ZG, Linville L, Clare SE, Visscher DW, Mies C, Hewitt SM, Brinton LA, Storniolo AMV, He C, Chanock SJ, Gierach GL, Figueroa JD.

Int J Cancer. 2017 Feb 15;140(4):825-832. doi: 10.1002/ijc.30512. Epub 2016 Nov 18.

34.

Relation of Serum Estrogen Metabolites with Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy.

Oh H, Khodr ZG, Sherman ME, Palakal M, Pfeiffer RM, Linville L, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Falk RT, Horne HN, Papathomas D, Patel DA, Xiang J, Xu X, Veenstra T, Hewitt SM, Shepherd JA, Brinton LA, Figueroa JD, Gierach GL.

Horm Cancer. 2016 Dec;7(5-6):305-315. Epub 2016 May 2.

35.

Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF.

Han SY, Ko A, Kitano H, Choi CH, Lee MS, Seo J, Fukuoka J, Kim SY, Hewitt SM, Chung JY, Song J.

Cancer Res. 2017 Jan 15;77(2):343-354. doi: 10.1158/0008-5472.CAN-16-0613. Epub 2016 Oct 28.

36.

Reduced expression of FILIP1L, a novel WNT pathway inhibitor, is associated with poor survival, progression and chemoresistance in ovarian cancer.

Kwon M, Kim JH, Rybak Y, Luna A, Choi CH, Chung JY, Hewitt SM, Adem A, Tubridy E, Lin J, Libutti SK.

Oncotarget. 2016 Nov 22;7(47):77052-77070. doi: 10.18632/oncotarget.12784.

37.

Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis.

Felix AS, Lenz P, Pfeiffer RM, Hewitt SM, Morris J, Patel DA, Geller B, Vacek PM, Weaver DL, Chicoine RE, Shepherd J, Mahmoudzadeh AP, Wang J, Fan B, Malkov S, Herschorn SD, Johnson JM, Cora RL, Brinton LA, Sherman ME, Gierach GL.

Breast Cancer Res. 2016 Aug 23;18(1):88. doi: 10.1186/s13058-016-0746-9.

38.

A melanin-bleaching methodology for molecular and histopathological analysis of formalin-fixed paraffin-embedded tissue.

Chung JY, Choi J, Sears JD, Ylaya K, Perry C, Choi CH, Hong SM, Cho H, Brown KM, Hewitt SM.

Lab Invest. 2016 Oct;96(10):1116-27. doi: 10.1038/labinvest.2016.90. Epub 2016 Aug 22.

39.

Standardized measures of lobular involution and subsequent breast cancer risk among women with benign breast disease: a nested case-control study.

Figueroa JD, Pfeiffer RM, Brinton LA, Palakal MM, Degnim AC, Radisky D, Hartmann LC, Frost MH, Stallings Mann ML, Papathomas D, Gierach GL, Hewitt SM, Duggan MA, Visscher D, Sherman ME.

Breast Cancer Res Treat. 2016 Aug;159(1):163-72. doi: 10.1007/s10549-016-3908-7. Epub 2016 Aug 3.

40.

Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer.

Choi CH, Chung JY, Chung EJ, Sears JD, Lee JW, Bae DS, Hewitt SM.

BMC Cancer. 2016 Jul 11;16:448. doi: 10.1186/s12885-016-2459-y.

41.

Ages at menarche- and menopause-related genetic variants in relation to terminal duct lobular unit involution in normal breast tissue.

Oh H, Bodelon C, Palakal M, Chatterjee N, Sherman ME, Linville L, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Papathomas D, Patel DA, Xiang J, Clare SE, Visscher DW, Mies C, Hewitt SM, Brinton LA, Storniolo AM, He C, Garcia-Closas M, Chanock SJ, Gierach GL, Figueroa JD.

Breast Cancer Res Treat. 2016 Jul;158(2):341-50. doi: 10.1007/s10549-016-3859-z. Epub 2016 Jun 24.

42.

The Application of Digital Pathology to Improve Accuracy in Glomerular Enumeration in Renal Biopsies.

Rosenberg AZ, Palmer M, Merlino L, Troost JP, Gasim A, Bagnasco S, Avila-Casado C, Johnstone D, Hodgin JB, Conway C, Gillespie BW, Nast CC, Barisoni L, Hewitt SM.

PLoS One. 2016 Jun 16;11(6):e0156441. doi: 10.1371/journal.pone.0156441. eCollection 2016.

43.

Morphometry Predicts Early GFR Change in Primary Proteinuric Glomerulopathies: A Longitudinal Cohort Study Using Generalized Estimating Equations.

Lemley KV, Bagnasco SM, Nast CC, Barisoni L, Conway CM, Hewitt SM, Song PX.

PLoS One. 2016 Jun 10;11(6):e0157148. doi: 10.1371/journal.pone.0157148. eCollection 2016.

44.

Decreased Expression of Retinoid X Receptors During Human and Azoxymethane-induced Colorectal Carcinogenesis in the Rat.

Hao X, Xiao H, Ju J, Hewitt SM, Morse HC 3rd.

Anticancer Res. 2016 Jun;36(6):2659-64.

PMID:
27272774
45.

Automated prostate tissue referencing for cancer detection and diagnosis.

Kwak JT, Hewitt SM, Kajdacsy-Balla AA, Sinha S, Bhargava R.

BMC Bioinformatics. 2016 Jun 1;17(1):227. doi: 10.1186/s12859-016-1086-6.

46.

A Buffered Alcohol-Based Fixative for Histomorphologic and Molecular Applications.

Perry C, Chung JY, Ylaya K, Choi CH, Simpson A, Matsumoto KT, Smith WA, Hewitt SM.

J Histochem Cytochem. 2016 Jul;64(7):425-40. doi: 10.1369/0022155416649579. Epub 2016 May 24.

47.

The paraffin-embedded RNA metric (PERM) for RNA isolated from formalin-fixed, paraffin-embedded tissue.

Chung JY, Cho H, Hewitt SM.

Biotechniques. 2016 May 1;60(5):239-44. doi: 10.2144/000114415. eCollection 2016.

48.

Expression of fibroblast growth factor receptor family members is associated with prognosis in early stage cervical cancer patients.

Choi CH, Chung JY, Kim JH, Kim BG, Hewitt SM.

J Transl Med. 2016 May 6;14(1):124. doi: 10.1186/s12967-016-0874-0.

49.

Reproducibility of the NEPTUNE descriptor-based scoring system on whole-slide images and histologic and ultrastructural digital images.

Barisoni L, Troost JP, Nast C, Bagnasco S, Avila-Casado C, Hodgin J, Palmer M, Rosenberg A, Gasim A, Liensziewski C, Merlino L, Chien HP, Chang A, Meehan SM, Gaut J, Song P, Holzman L, Gibson D, Kretzler M, Gillespie BW, Hewitt SM.

Mod Pathol. 2016 Jul;29(7):671-84. doi: 10.1038/modpathol.2016.58. Epub 2016 Apr 22.

50.

Targeting a Cancer-Specific Epitope of the Epidermal Growth Factor Receptor in Triple-Negative Breast Cancer.

Simon N, Antignani A, Sarnovsky R, Hewitt SM, FitzGerald D.

J Natl Cancer Inst. 2016 Apr 13;108(8). doi: 10.1093/jnci/djw028. Print 2016 Aug.

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