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CDK7 is a reliable prognostic factor and novel therapeutic target in epithelial ovarian cancer.

Kim J, Cho YJ, Ryu JY, Hwang I, Han HD, Ahn HJ, Kim WY, Cho H, Chung JY, Hewitt SM, Kim JH, Kim BG, Bae DS, Choi CH, Lee JW.

Gynecol Oncol. 2019 Nov 24. pii: S0090-8258(19)31625-7. doi: 10.1016/j.ygyno.2019.11.004. [Epub ahead of print]


Using Digital Pathology to Understand Epithelial Characteristics of Benign Breast Disease among Women Undergoing Diagnostic Image-Guided Breast Biopsy.

Mullooly M, Puvanesarajah S, Fan S, Pfeiffer RM, Olsson LT, Hada M, Kirk EL, Vacek PM, Weaver DL, Shepherd J, Mahmoudzadeh A, Wang J, Malkov S, Johnson JM, Hewitt SM, Herschorn SD, Sherman ME, Troester MA, Gierach GL.

Cancer Prev Res (Phila). 2019 Dec;12(12):861-870. doi: 10.1158/1940-6207.CAPR-19-0120. Epub 2019 Oct 23.


Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (Avelumab) treatment in advanced thymoma.

Rajan A, Heery CR, Thomas A, Mammen AL, Perry S, O'Sullivan Coyne G, Guha U, Berman A, Szabo E, Madan RA, Ballester LY, Pittaluga S, Donahue RN, Tsai YT, Lepone LM, Chin K, Ginty F, Sood A, Hewitt SM, Schlom J, Hassan R, Gulley JL.

J Immunother Cancer. 2019 Oct 21;7(1):269. doi: 10.1186/s40425-019-0723-9.


ALDH1A2 Is a Candidate Tumor Suppressor Gene in Ovarian Cancer.

Choi JA, Kwon H, Cho H, Chung JY, Hewitt SM, Kim JH.

Cancers (Basel). 2019 Oct 14;11(10). pii: E1553. doi: 10.3390/cancers11101553.


Fatal encephalopathy with wild-type JC virus and ruxolitinib therapy.

Reoma LB, Trindade CJ, Monaco MC, Solis J, Montojo MG, Vu P, Johnson K, Beck E, Nair G, Khan OI, Quezado M, Hewitt SM, Reich DS, Childs R, Nath A.

Ann Neurol. 2019 Dec;86(6):878-884. doi: 10.1002/ana.25608. Epub 2019 Oct 16.


Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer.

Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, Kleiner DE, Hewitt SM, Ylaya K, Wood BJ, Greten TF, Wang XW.

Cancer Cell. 2019 Oct 14;36(4):418-430.e6. doi: 10.1016/j.ccell.2019.08.007. Epub 2019 Oct 3.


Enlightening kidney pathophysiology.

Hewitt SM, Star RA.

Nat Mater. 2019 Oct;18(10):1034-1035. doi: 10.1038/s41563-019-0490-5. No abstract available.


Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein.

Byun JS, Park S, Yi DI, Shin JH, Hernandez SG, Hewitt SM, Nicklaus MC, Peach ML, Guasch L, Tang B, Wakefield LM, Yan T, Caban A, Jones A, Kabbout M, Vohra N, Nápoles AM, Singhal S, Yancey R, De Siervi A, Gardner K.

Cell Death Dis. 2019 Sep 18;10(10):689. doi: 10.1038/s41419-019-1892-7.


Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer.

Shin S, Kim K, Kim HR, Ylaya K, Do SI, Hewitt SM, Park HS, Roe JS, Chung JY, Song J.

Cell Death Differ. 2019 Sep 17. doi: 10.1038/s41418-019-0419-1. [Epub ahead of print]


A dataset describing a suite of novel antibody reagents for the RAS signaling network.

Schoenherr RM, Huang D, Voytovich UJ, Ivey RG, Kennedy JJ, Saul RG, Colantonio S, Roberts RR, Knotts JG, Kaczmarczyk JA, Perry C, Hewitt SM, Bocik W, Whiteley GR, Hiltke T, Boja ES, Rodriguez H, Whiteaker JR, Paulovich AG.

Sci Data. 2019 Aug 29;6(1):160. doi: 10.1038/s41597-019-0166-7.


Renal Fibrosis: Common Enemy of Many Origins.

Hewitt SM, Schaefer L.

J Histochem Cytochem. 2019 Sep;67(9):621. doi: 10.1369/0022155419865531. No abstract available.


T-Cell Receptor Gene Therapy for Human Papillomavirus-Associated Epithelial Cancers: A First-in-Human, Phase I/II Study.

Doran SL, Stevanović S, Adhikary S, Gartner JJ, Jia L, Kwong MLM, Faquin WC, Hewitt SM, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS.

J Clin Oncol. 2019 Oct 20;37(30):2759-2768. doi: 10.1200/JCO.18.02424. Epub 2019 Aug 13.


A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN.

Komiya T, Blumenthal GM, DeChowdhury R, Fioravanti S, Ballas MS, Morris J, Hornyak TJ, Wank S, Hewitt SM, Morrow B, Memmott RM, Rajan A, Dennis PA.

Oncologist. 2019 Jul 26. pii: theoncologist.2019-0514. doi: 10.1634/theoncologist.2019-0514. [Epub ahead of print]


Agreement in Histological Assessment of Mitotic Activity Between Microscopy and Digital Whole Slide Images Informs Conversion for Clinical Diagnosis.

Wei BR, Halsey CH, Hoover SB, Puri M, Yang HH, Gallas BD, Lee MP, Chen W, Durham AC, Dwyer JE, Sánchez MD, Traslavina RP, Frank C, Bradley C, McGill LD, Esplin DG, Schaffer PA, Cramer SD, Lyle LT, Beck J, Buza E, Gong Q, Hewitt SM, Simpson RM.

Acad Pathol. 2019 Jul 11;6:2374289519859841. doi: 10.1177/2374289519859841. eCollection 2019 Jan-Dec.


Forkhead box protein O1 (FOXO1) and paired box gene 3 (PAX3) overexpression is associated with poor prognosis in patients with cervical cancer.

Chay DB, Han GH, Nam S, Cho H, Chung JY, Hewitt SM.

Int J Clin Oncol. 2019 Nov;24(11):1429-1439. doi: 10.1007/s10147-019-01507-w. Epub 2019 Jul 13.


A mouse model of Proteus syndrome.

Lindhurst MJ, Brinster LR, Kondolf HC, Shwetar JJ, Yourick MR, Shiferaw H, Keppler-Noreuil KM, Elliot G, Rivas C, Garrett L, Gomez-Rodriguez J, Sebire NJ, Hewitt SM, Schwartzberg PL, Biesecker LG.

Hum Mol Genet. 2019 Sep 1;28(17):2920-2936. doi: 10.1093/hmg/ddz116.


Hepatitis B Surface Antigen Activates Unfolded Protein Response in Forming Ground Glass Hepatocytes of Chronic Hepatitis B.

Li Y, Xia Y, Cheng X, Kleiner DE, Hewitt SM, Sproch J, Li T, Zhuang H, Liang TJ.

Viruses. 2019 Apr 25;11(4). pii: E386. doi: 10.3390/v11040386.


Automated Computational Detection, Quantitation, and Mapping of Mitosis in Whole-Slide Images for Clinically Actionable Surgical Pathology Decision Support.

Puri M, Hoover SB, Hewitt SM, Wei BR, Adissu HA, Halsey CHC, Beck J, Bradley C, Cramer SD, Durham AC, Esplin DG, Frank C, Lyle LT, McGill LD, Sánchez MD, Schaffer PA, Traslavina RP, Buza E, Yang HH, Lee MP, Dwyer JE, Simpson RM.

J Pathol Inform. 2019 Feb 7;10:4. doi: 10.4103/jpi.jpi_59_18. eCollection 2019.


Data, Information, and Knowledge.

Hewitt SM.

J Histochem Cytochem. 2019 Apr;67(4):227-228. doi: 10.1369/0022155419836995. No abstract available.


Understanding the measurement properties of the incremental shuttle walk test in patients with severe asthma.

Majd S, Hewitt SM, Apps LD, Murphy AC, Bradding P, Singh SJ, Green RH, Evans RA.

Respirology. 2019 Aug;24(8):752-757. doi: 10.1111/resp.13519. Epub 2019 Mar 18.


An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.

Lee TK, Murthy SR, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau T, Ma S, Huynh T, Wesley RA, Ng IO, Pacak K, Poon RT, Loh YP.

J Clin Invest. 2019 Mar 18;130:1804. doi: 10.1172/JCI128836. eCollection 2019 Mar 18. No abstract available.


Combination immunotherapy with IL-4 Pseudomonas exotoxin and IFN-α and IFN-γ mediate antitumor effects in vitro and in a mouse model of human ovarian cancer.

Green DS, Husain SR, Johnson CL, Sato Y, Han J, Joshi B, Hewitt SM, Puri RK, Zoon KC.

Immunotherapy. 2019 Apr;11(6):483-496. doi: 10.2217/imt-2018-0158.


APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors.

Roper N, Gao S, Maity TK, Banday AR, Zhang X, Venugopalan A, Cultraro CM, Patidar R, Sindiri S, Brown AL, Goncearenco A, Panchenko AR, Biswas R, Thomas A, Rajan A, Carter CA, Kleiner DE, Hewitt SM, Khan J, Prokunina-Olsson L, Guha U.

Cell Rep. 2019 Mar 5;26(10):2651-2666.e6. doi: 10.1016/j.celrep.2019.02.028.


Associations of CDH1 germline variant location and cancer phenotype in families with hereditary diffuse gastric cancer (HDGC).

Lo W, Zhu B, Sabesan A, Wu HH, Powers A, Sorber RA, Ravichandran S, Chen I, McDuffie LA, Quadri HS, Beane JD, Calzone K, Miettinen MM, Hewitt SM, Koh C, Heller T, Wacholder S, Rudloff U.

J Med Genet. 2019 Jun;56(6):370-379. doi: 10.1136/jmedgenet-2018-105361. Epub 2019 Feb 11.


Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells.

Simon N, Antignani A, Hewitt SM, Gadina M, Alewine C, FitzGerald D.

JCI Insight. 2019 Mar 7;4(5). pii: 123281. doi: 10.1172/jci.insight.123281. eCollection 2019 Mar 7.


Immunophenotypic Characterization of Canine Splenic Follicular-Derived B-Cell Lymphoma.

Stein L, Bacmeister C, Ylaya K, Fetsch P, Wang Z, Hewitt SM, Kiupel M.

Vet Pathol. 2019 May;56(3):350-357. doi: 10.1177/0300985818823668. Epub 2019 Jan 13.


Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma.

Sun W, Chatterjee B, Shern JF, Patidar R, Song Y, Wang Y, Walker RL, Pawel BR, Linardic CM, Houghton P, Hewitt SM, Edelman DC, Khan J, Meltzer PS, Barr FG.

Int J Cancer. 2019 Jun 1;144(11):2707-2717. doi: 10.1002/ijc.32006. Epub 2019 Jan 15.


Correction: Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF.

Han SY, Ko A, Kitano H, Choi CH, Lee MS, Seo J, Fukuoka J, Kim SY, Hewitt SM, Chung JY, Song J.

Cancer Res. 2018 Dec 15;78(24):6903. doi: 10.1158/0008-5472.CAN-18-3311. No abstract available.


APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R.

Okamoto K, Rausch JW, Wakashin H, Fu Y, Chung JY, Dummer PD, Shin MK, Chandra P, Suzuki K, Shrivastav S, Rosenberg AZ, Hewitt SM, Ray PE, Noiri E, Le Grice SFJ, Hoek M, Han Z, Winkler CA, Kopp JB.

Commun Biol. 2018 Nov 7;1:188. doi: 10.1038/s42003-018-0188-2. eCollection 2018.


Genomic Network-Based Analysis Reveals Pancreatic Adenocarcinoma Up-Regulating Factor-Related Prognostic Markers in Cervical Carcinoma.

Kim J, Chung JY, Kim TJ, Lee JW, Kim BG, Bae DS, Choi CH, Hewitt SM.

Front Oncol. 2018 Oct 23;8:465. doi: 10.3389/fonc.2018.00465. eCollection 2018.


Microvascular inflammation in renal allograft biopsies assessed by endothelial and leukocyte co-immunostain: a retrospective study on reproducibility and clinical/prognostic correlates.

Delsante M, Maggiore U, Levi J, Kleiner DE, Jackson AM, Arend LJ, Hewitt SM, Carter-Monroe N, Bagnasco SM, Rosenberg AZ.

Transpl Int. 2019 Mar;32(3):300-312. doi: 10.1111/tri.13371. Epub 2018 Dec 11.


Patients with learning disabilities should be considered at high risk of cervical spine injury.

Byrne C, Johnson GD, Tabner AJ, Hewitt SM.

Emerg Med J. 2019 Jan;36(1):54. doi: 10.1136/emermed-2018-208117. Epub 2018 Oct 20. No abstract available.


Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance.

Song KH, Kim JH, Lee YH, Bae HC, Lee HJ, Woo SR, Oh SJ, Lee KM, Yee C, Kim BW, Cho H, Chung EJ, Chung JY, Hewitt SM, Chung TW, Ha KT, Bae YK, Mao CP, Yang A, Wu TC, Kim TW.

J Clin Invest. 2018 Aug 31;128(9):4098-4114. doi: 10.1172/JCI96804. Epub 2018 Aug 20.


Elevated expression of pancreatic adenocarcinoma upregulated factor (PAUF) is associated with poor prognosis and chemoresistance in epithelial ovarian cancer.

Choi CH, Kang TH, Song JS, Kim YS, Chung EJ, Ylaya K, Kim S, Koh SS, Chung JY, Kim JH, Hewitt SM.

Sci Rep. 2018 Aug 15;8(1):12161. doi: 10.1038/s41598-018-30582-8.


Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning.

Klauschen F, Müller KR, Binder A, Bockmayr M, Hägele M, Seegerer P, Wienert S, Pruneri G, de Maria S, Badve S, Michiels S, Nielsen TO, Adams S, Savas P, Symmans F, Willis S, Gruosso T, Park M, Haibe-Kains B, Gallas B, Thompson AM, Cree I, Sotiriou C, Solinas C, Preusser M, Hewitt SM, Rimm D, Viale G, Loi S, Loibl S, Salgado R, Denkert C; International Immuno-Oncology Biomarker Working Group.

Semin Cancer Biol. 2018 Oct;52(Pt 2):151-157. doi: 10.1016/j.semcancer.2018.07.001. Epub 2018 Jul 7. Review.


A multiprotein supercomplex controlling oncogenic signalling in lymphoma.

Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM.

Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20.


Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T-Cell Receptors in High-Risk MYCN-Not-Amplified Human Neuroblastoma.

Wei JS, Kuznetsov IB, Zhang S, Song YK, Asgharzadeh S, Sindiri S, Wen X, Patidar R, Najaraj S, Walton A, Auvil JMG, Gerhard DS, Yuksel A, Catchpoole D, Hewitt SM, Sondel PM, Seeger R, Maris JM, Khan J.

Clin Cancer Res. 2018 Nov 15;24(22):5673-5684. doi: 10.1158/1078-0432.CCR-18-0599. Epub 2018 May 21.


E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.

Horne HN, Oh H, Sherman ME, Palakal M, Hewitt SM, Schmidt MK, Milne RL, Hardisson D, Benitez J, Blomqvist C, Bolla MK, Brenner H, Chang-Claude J, Cora R, Couch FJ, Cuk K, Devilee P, Easton DF, Eccles DM, Eilber U, Hartikainen JM, Heikkilä P, Holleczek B, Hooning MJ, Jones M, Keeman R, Mannermaa A, Martens JWM, Muranen TA, Nevanlinna H, Olson JE, Orr N, Perez JIA, Pharoah PDP, Ruddy KJ, Saum KU, Schoemaker MJ, Seynaeve C, Sironen R, Smit VTHBM, Swerdlow AJ, Tengström M, Thomas AS, Timmermans AM, Tollenaar RAEM, Troester MA, van Asperen CJ, van Deurzen CHM, Van Leeuwen FF, Van't Veer LJ, García-Closas M, Figueroa JD.

Sci Rep. 2018 Apr 26;8(1):6574. doi: 10.1038/s41598-018-23733-4.


RE: Elevated Bladder Cancer in Northern New England: The Role of Drinking Water and Arsenic.

Koutros S, Lenz P, Hewitt SM, Kida M, Jones M, Schned AR, Baris D, Pfeiffer R, Schwenn M, Johnson A, Karagas MR, Garcia-Closas M, Rothman N, Moore LE, Silverman DT.

J Natl Cancer Inst. 2018 Nov 1;110(11):1273-1274. doi: 10.1093/jnci/djy045. No abstract available.


Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF.

Ko A, Han SY, Choi CH, Cho H, Lee MS, Kim SY, Song JS, Hong KM, Lee HW, Hewitt SM, Chung JY, Song J.

Cell Death Differ. 2018 Jun;25(6):1050-1062. doi: 10.1038/s41418-018-0072-0. Epub 2018 Feb 22.


Reproducibility and Feasibility of Strategies for Morphologic Assessment of Renal Biopsies Using the Nephrotic Syndrome Study Network Digital Pathology Scoring System.

Zee J, Hodgin JB, Mariani LH, Gaut JP, Palmer MB, Bagnasco SM, Rosenberg AZ, Hewitt SM, Holzman LB, Gillespie BW, Barisoni L.

Arch Pathol Lab Med. 2018 May;142(5):613-625. doi: 10.5858/arpa.2017-0181-OA. Epub 2018 Feb 19.


The Role of Extracellular Matrix in Innate Immunity, Fugues of Evolution.

Hewitt SM.

J Histochem Cytochem. 2018 Apr;66(4):211. doi: 10.1369/0022155418761352. Epub 2018 Feb 14. No abstract available.


Targeting Cyclin D-CDK4/6 Sensitizes Immune-Refractory Cancer by Blocking the SCP3-NANOG Axis.

Oh SJ, Cho H, Kim S, Noh KH, Song KH, Lee HJ, Woo SR, Kim S, Choi CH, Chung JY, Hewitt SM, Kim JH, Baek S, Lee KM, Yee C, Park HC, Kim TW.

Cancer Res. 2018 May 15;78(10):2638-2653. doi: 10.1158/0008-5472.CAN-17-2325. Epub 2018 Feb 6. Erratum in: Cancer Res. 2018 Jul 15;78(14):4098.


Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors.

Giannelou A, Wang H, Zhou Q, Park YH, Abu-Asab MS, Ylaya K, Stone DL, Sediva A, Sleiman R, Sramkova L, Bhatla D, Serti E, Tsai WL, Yang D, Bishop K, Carrington B, Pei W, Deuitch N, Brooks S, Edwan JH, Joshi S, Prader S, Kaiser D, Owen WC, Sonbul AA, Zhang Y, Niemela JE, Burgess SM, Boehm M, Rehermann B, Chae J, Quezado MM, Ombrello AK, Buckley RH, Grom AA, Remmers EF, Pachlopnik JM, Su HC, Gutierrez-Cruz G, Hewitt SM, Sood R, Risma K, Calvo KR, Rosenzweig SD, Gadina M, Hafner M, Sun HW, Kastner DL, Aksentijevich I.

Ann Rheum Dis. 2018 Apr;77(4):612-619. doi: 10.1136/annrheumdis-2017-212401. Epub 2018 Jan 22.


A transatlantic perspective on the integration of immuno-oncology prognostic and predictive biomarkers in innovative clinical trial design.

Morfouace M, Hewitt SM, Salgado R, Hartmann K, Litiere S, Tejpar S, Golfinopoulos V, Lively T, Thurin M, Conley B, Lacombe D.

Semin Cancer Biol. 2018 Oct;52(Pt 2):158-165. doi: 10.1016/j.semcancer.2018.01.003. Epub 2018 Jan 5. Review.


Nonalcoholic fatty liver disease in spinal and bulbar muscular atrophy.

Guber RD, Takyar V, Kokkinis A, Fox DA, Alao H, Kats I, Bakar D, Remaley AT, Hewitt SM, Kleiner DE, Liu CY, Hadigan C, Fischbeck KH, Rotman Y, Grunseich C.

Neurology. 2017 Dec 12;89(24):2481-2490. doi: 10.1212/WNL.0000000000004748. Epub 2017 Nov 15.


Histomorphological and Molecular Assessments of the Fixation Times Comparing Formalin and Ethanol-Based Fixatives.

Chung JY, Song JS, Ylaya K, Sears JD, Choi L, Cho H, Rosenberg AZ, Hewitt SM.

J Histochem Cytochem. 2018 Feb;66(2):121-135. doi: 10.1369/0022155417741467. Epub 2017 Nov 10.


Bcl-2-like Protein 11 (BIM) Expression Is Associated with Favorable Prognosis for Patients with Cervical Cancer.

Kim BW, Cho H, Ylaya K, Kitano H, Chung JY, Hewitt SM, Kim JH.

Anticancer Res. 2017 Sep;37(9):4873-4879.


The anti-cancer effects of itraconazole in epithelial ovarian cancer.

Choi CH, Ryu JY, Cho YJ, Jeon HK, Choi JJ, Ylaya K, Lee YY, Kim TJ, Chung JY, Hewitt SM, Kim BG, Bae DS, Lee JW.

Sci Rep. 2017 Jul 26;7(1):6552. doi: 10.1038/s41598-017-06510-7.


Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma.

Li N, Fu H, Hewitt SM, Dimitrov DS, Ho M.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6623-E6631. doi: 10.1073/pnas.1706055114. Epub 2017 Jul 24.

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