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Items: 1 to 50 of 59

1.

Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome.

Coons LA, Burkholder AB, Hewitt SC, McDonnell DP, Korach KS.

iScience. 2019 May 31;15:552-591. doi: 10.1016/j.isci.2019.04.006. Epub 2019 Apr 6.

2.

A distal super enhancer mediates estrogen-dependent mouse uterine-specific gene transcription of Igf1 (insulin-like growth factor 1).

Hewitt SC, Lierz SL, Garcia M, Hamilton KJ, Gruzdev A, Grimm SA, Lydon JP, Demayo FJ, Korach KS.

J Biol Chem. 2019 Jun 21;294(25):9746-9759. doi: 10.1074/jbc.RA119.008759. Epub 2019 May 9.

PMID:
31073032
3.

Negative elongation factor is essential for endometrial function.

Hewitt SC, Li R, Adams N, Winuthayanon W, Hamilton KJ, Donoghue LJ, Lierz SL, Garcia M, Lydon JP, DeMayo FJ, Adelman K, Korach KS.

FASEB J. 2019 Feb;33(2):3010-3023. doi: 10.1096/fj.201801752. Epub 2018 Oct 17.

PMID:
30332301
4.

Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.

Xu B, Allard C, Alvarez-Mercado AI, Fuselier T, Kim JH, Coons LA, Hewitt SC, Urano F, Korach KS, Levin ER, Arvan P, Floyd ZE, Mauvais-Jarvis F.

Cell Rep. 2018 Jul 3;24(1):181-196. doi: 10.1016/j.celrep.2018.06.019.

5.

Estrogen Receptors: New Directions in the New Millennium.

Hewitt SC, Korach KS.

Endocr Rev. 2018 Oct 1;39(5):664-675. doi: 10.1210/er.2018-00087. Review.

PMID:
29901737
6.

Estrogen receptor α protects pancreatic β-cells from apoptosis by preserving mitochondrial function and suppressing endoplasmic reticulum stress.

Zhou Z, Ribas V, Rajbhandari P, Drew BG, Moore TM, Fluitt AH, Reddish BR, Whitney KA, Georgia S, Vergnes L, Reue K, Liesa M, Shirihai O, van der Bliek AM, Chi NW, Mahata SK, Tiano JP, Hewitt SC, Tontonoz P, Korach KS, Mauvais-Jarvis F, Hevener AL.

J Biol Chem. 2018 Mar 30;293(13):4735-4751. doi: 10.1074/jbc.M117.805069. Epub 2018 Jan 29.

7.

DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin.

Coons LA, Hewitt SC, Burkholder AB, McDonnell DP, Korach KS.

Endocrinology. 2017 Oct 1;158(10):3212-3234. doi: 10.1210/en.2017-00468.

8.

Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation.

Winuthayanon W, Lierz SL, Delarosa KC, Sampels SR, Donoghue LJ, Hewitt SC, Korach KS.

Sci Rep. 2017 Aug 21;7(1):8377. doi: 10.1038/s41598-017-07728-1.

9.

Role of ERα in Mediating Female Uterine Transcriptional Responses to IGF1.

Hewitt SC, Winuthayanon W, Lierz SL, Hamilton KJ, Donoghue LJ, Ramsey JT, Grimm SA, Arao Y, Korach KS.

Endocrinology. 2017 Aug 1;158(8):2427-2435. doi: 10.1210/en.2017-00349.

10.

Estrogen Hormone Biology.

Hamilton KJ, Hewitt SC, Arao Y, Korach KS.

Curr Top Dev Biol. 2017;125:109-146. doi: 10.1016/bs.ctdb.2016.12.005. Epub 2017 Feb 3. Review.

11.

Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice.

Hart-Unger S, Arao Y, Hamilton KJ, Lierz SL, Malarkey DE, Hewitt SC, Freemark M, Korach KS.

Int J Obes (Lond). 2017 Jun;41(6):945-954. doi: 10.1038/ijo.2017.50. Epub 2017 Feb 21.

12.

SCA-1 Labels a Subset of Estrogen-Responsive Bipotential Repopulating Cells within the CD24+ CD49fhi Mammary Stem Cell-Enriched Compartment.

Dall GV, Vieusseux JL, Korach KS, Arao Y, Hewitt SC, Hamilton KJ, Dzierzak E, Boon WC, Simpson ER, Ramsay RG, Stein T, Morris JS, Anderson RL, Risbridger GP, Britt KL.

Stem Cell Reports. 2017 Feb 14;8(2):417-431. doi: 10.1016/j.stemcr.2016.12.022. Epub 2017 Jan 26.

13.

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females.

Ribas V, Drew BG, Zhou Z, Phun J, Kalajian NY, Soleymani T, Daraei P, Widjaja K, Wanagat J, de Aguiar Vallim TQ, Fluitt AH, Bensinger S, Le T, Radu C, Whitelegge JP, Beaven SW, Tontonoz P, Lusis AJ, Parks BW, Vergnes L, Reue K, Singh H, Bopassa JC, Toro L, Stefani E, Watt MJ, Schenk S, Akerstrom T, Kelly M, Pedersen BK, Hewitt SC, Korach KS, Hevener AL.

Sci Transl Med. 2016 Apr 13;8(334):334ra54. doi: 10.1126/scitranslmed.aad3815.

14.

Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus.

Mehta FF, Son J, Hewitt SC, Jang E, Lydon JP, Korach KS, Chung SH.

Oncotarget. 2016 Apr 5;7(14):17455-67. doi: 10.18632/oncotarget.8159.

15.

What's new in estrogen receptor action in the female reproductive tract.

Hewitt SC, Winuthayanon W, Korach KS.

J Mol Endocrinol. 2016 Feb;56(2):R55-71. doi: 10.1530/JME-15-0254. Review.

16.

Oviductal estrogen receptor α signaling prevents protease-mediated embryo death.

Winuthayanon W, Bernhardt ML, Padilla-Banks E, Myers PH, Edin ML, Lih FB, Hewitt SC, Korach KS, Williams CJ.

Elife. 2015 Dec 1;4:e10453. doi: 10.7554/eLife.10453.

17.

Development of phenotypic and transcriptional biomarkers to evaluate relative activity of potentially estrogenic chemicals in ovariectomized mice.

Hewitt SC, Winuthayanon W, Pockette B, Kerns RT, Foley JF, Flagler N, Ney E, Suksamrarn A, Piyachaturawat P, Bushel PR, Korach KS.

Environ Health Perspect. 2015 Apr;123(4):344-52. doi: 10.1289/ehp.1307935. Epub 2015 Jan 9.

18.

Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression.

Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL.

J Biol Chem. 2015 Feb 27;290(9):5566-81. doi: 10.1074/jbc.M114.606459. Epub 2014 Dec 2.

19.

The role of genetics in estrogen responses: a critical piece of an intricate puzzle.

Wall EH, Hewitt SC, Case LK, Lin CY, Korach KS, Teuscher C.

FASEB J. 2014 Dec;28(12):5042-54. doi: 10.1096/fj.14-260307. Epub 2014 Sep 11. Review.

20.

Uterine epithelial cell estrogen receptor alpha-dependent and -independent genomic profiles that underlie estrogen responses in mice.

Winuthayanon W, Hewitt SC, Korach KS.

Biol Reprod. 2014 Nov;91(5):110. doi: 10.1095/biolreprod.114.120170. Epub 2014 Sep 10.

21.

Novel DNA motif binding activity observed in vivo with an estrogen receptor α mutant mouse.

Hewitt SC, Li L, Grimm SA, Winuthayanon W, Hamilton KJ, Pockette B, Rubel CA, Pedersen LC, Fargo D, Lanz RB, DeMayo FJ, Schütz G, Korach KS.

Mol Endocrinol. 2014 Jun;28(6):899-911. doi: 10.1210/me.2014-1051. Epub 2014 Apr 8.

22.

Genetic control of ductal morphology, estrogen-induced ductal growth, and gene expression in female mouse mammary gland.

Wall EH, Case LK, Hewitt SC, Nguyen-Vu T, Candelaria NR, Teuscher C, Lin CY.

Endocrinology. 2014 Aug;155(8):3025-35. doi: 10.1210/en.2013-1910. Epub 2014 Apr 7.

23.

The natural estrogenic compound diarylheptanoid (D3): in vitro mechanisms of action and in vivo uterine responses via estrogen receptor α.

Winuthayanon W, Piyachaturawat P, Suksamrarn A, Burns KA, Arao Y, Hewitt SC, Pedersen LC, Korach KS.

Environ Health Perspect. 2013 Apr;121(4):433-9. doi: 10.1289/ehp.1206122. Epub 2013 Jan 18.

24.

Genetic control of estrogen-regulated transcriptional and cellular responses in mouse uterus.

Wall EH, Hewitt SC, Liu L, del Rio R, Case LK, Lin CY, Korach KS, Teuscher C.

FASEB J. 2013 May;27(5):1874-86. doi: 10.1096/fj.12-213462. Epub 2013 Jan 31.

25.

Role of estrogen receptor signaling required for endometriosis-like lesion establishment in a mouse model.

Burns KA, Rodriguez KF, Hewitt SC, Janardhan KS, Young SL, Korach KS.

Endocrinology. 2012 Aug;153(8):3960-71. doi: 10.1210/en.2012-1294. Epub 2012 Jun 14.

26.

Research resource: whole-genome estrogen receptor α binding in mouse uterine tissue revealed by ChIP-seq.

Hewitt SC, Li L, Grimm SA, Chen Y, Liu L, Li Y, Bushel PR, Fargo D, Korach KS.

Mol Endocrinol. 2012 May;26(5):887-98. doi: 10.1210/me.2011-1311. Epub 2012 Mar 22.

27.

Myeloid-specific estrogen receptor alpha deficiency impairs metabolic homeostasis and accelerates atherosclerotic lesion development.

Ribas V, Drew BG, Le JA, Soleymani T, Daraei P, Sitz D, Mohammad L, Henstridge DC, Febbraio MA, Hewitt SC, Korach KS, Bensinger SJ, Hevener AL.

Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16457-62. doi: 10.1073/pnas.1104533108. Epub 2011 Sep 7. Erratum in: Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):645.

28.

Uterine gland formation in mice is a continuous process, requiring the ovary after puberty, but not after parturition.

Stewart CA, Fisher SJ, Wang Y, Stewart MD, Hewitt SC, Rodriguez KF, Korach KS, Behringer RR.

Biol Reprod. 2011 Nov;85(5):954-64. doi: 10.1095/biolreprod.111.091470. Epub 2011 Jul 6.

29.

Cell biology. A hand to support the implantation window.

Hewitt SC, Korach KS.

Science. 2011 Feb 18;331(6019):863-4. doi: 10.1126/science.1202372. No abstract available.

30.

Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses.

Winuthayanon W, Hewitt SC, Orvis GD, Behringer RR, Korach KS.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19272-7. doi: 10.1073/pnas.1013226107. Epub 2010 Oct 25.

31.

Ex3αERKO male infertility phenotype recapitulates the αERKO male phenotype.

Goulding EH, Hewitt SC, Nakamura N, Hamilton K, Korach KS, Eddy EM.

J Endocrinol. 2010 Dec;207(3):281-8. doi: 10.1677/JOE-10-0290. Epub 2010 Sep 10.

32.

Estrogenic activity of bisphenol A and 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE) demonstrated in mouse uterine gene profiles.

Hewitt SC, Korach KS.

Environ Health Perspect. 2011 Jan;119(1):63-70. doi: 10.1289/ehp.1002347. Epub 2010 Sep 8.

33.

Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene.

Hewitt SC, Kissling GE, Fieselman KE, Jayes FL, Gerrish KE, Korach KS.

FASEB J. 2010 Dec;24(12):4660-7. doi: 10.1096/fj.10-163428. Epub 2010 Jul 28.

34.

Extranuclear estrogen receptor-alpha stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis.

Wong WP, Tiano JP, Liu S, Hewitt SC, Le May C, Dalle S, Katzenellenbogen JA, Katzenellenbogen BS, Korach KS, Mauvais-Jarvis F.

Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13057-62. doi: 10.1073/pnas.0914501107. Epub 2010 Jun 29.

35.

FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis.

Bernardo GM, Lozada KL, Miedler JD, Harburg G, Hewitt SC, Mosley JD, Godwin AK, Korach KS, Visvader JE, Kaestner KH, Abdul-Karim FW, Montano MM, Keri RA.

Development. 2010 Jun;137(12):2045-54. doi: 10.1242/dev.043299.

36.

Estrogen-mediated regulation of Igf1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements.

Hewitt SC, Li Y, Li L, Korach KS.

J Biol Chem. 2010 Jan 22;285(4):2676-85. doi: 10.1074/jbc.M109.043471. Epub 2009 Nov 17.

37.

Selective disruption of ER{alpha} DNA-binding activity alters uterine responsiveness to estradiol.

Hewitt SC, O'Brien JE, Jameson JL, Kissling GE, Korach KS.

Mol Endocrinol. 2009 Dec;23(12):2111-6. doi: 10.1210/me.2009-0356. Epub 2009 Oct 7.

38.

Diarylheptanoid phytoestrogens isolated from the medicinal plant Curcuma comosa: biologic actions in vitro and in vivo indicate estrogen receptor-dependent mechanisms.

Winuthayanon W, Piyachaturawat P, Suksamrarn A, Ponglikitmongkol M, Arao Y, Hewitt SC, Korach KS.

Environ Health Perspect. 2009 Jul;117(7):1155-61. doi: 10.1289/ehp.0900613. Epub 2009 Mar 23.

39.

Profile of estrogen-responsive genes in an estrogen-specific mammary gland outgrowth model.

Deroo BJ, Hewitt SC, Collins JB, Grissom SF, Hamilton KJ, Korach KS.

Mol Reprod Dev. 2009 Aug;76(8):733-50. doi: 10.1002/mrd.21041.

40.

An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo.

Sinkevicius KW, Burdette JE, Woloszyn K, Hewitt SC, Hamilton K, Sugg SL, Temple KA, Wondisford FE, Korach KS, Woodruff TK, Greene GL.

Endocrinology. 2008 Jun;149(6):2970-9. doi: 10.1210/en.2007-1526. Epub 2008 Mar 13.

41.

The five W's of progesterone receptors A and B: now we know where and when.

Hewitt SC.

Endocrinology. 2006 Dec;147(12):5501-2. No abstract available.

PMID:
17107971
42.

Estrogen-induced proliferation of uterine epithelial cells is independent of estrogen receptor alpha binding to classical estrogen response elements.

O'Brien JE, Peterson TJ, Tong MH, Lee EJ, Pfaff LE, Hewitt SC, Korach KS, Weiss J, Jameson JL.

J Biol Chem. 2006 Sep 8;281(36):26683-92. Epub 2006 Jul 17.

43.

Estren behaves as a weak estrogen rather than a nongenomic selective activator in the mouse uterus.

Hewitt SC, Collins J, Grissom S, Hamilton K, Korach KS.

Endocrinology. 2006 May;147(5):2203-14. Epub 2006 Feb 9.

PMID:
16469803
44.

Upregulation of estrogen receptor expression in the uterus of ovariectomized B6C3F1 mice and Ishikawa cells treated with bromoethane.

Aoyama H, Couse JF, Hewitt SC, Haseman JK, He H, Zheng X, Majstoravich S, Korach KS, Dixon D.

Toxicol Appl Pharmacol. 2005 Dec 15;209(3):226-35.

PMID:
15922381
45.

Signal transduction. A new mediator for an old hormone?

Hewitt SC, Deroo BJ, Korach KS.

Science. 2005 Mar 11;307(5715):1572-3. No abstract available.

PMID:
15761144
46.

Lessons in estrogen biology from knockout and transgenic animals.

Hewitt SC, Harrell JC, Korach KS.

Annu Rev Physiol. 2005;67:285-308. Review.

PMID:
15709960
47.

Global uterine genomics in vivo: microarray evaluation of the estrogen receptor alpha-growth factor cross-talk mechanism.

Hewitt SC, Collins J, Grissom S, Deroo B, Korach KS.

Mol Endocrinol. 2005 Mar;19(3):657-68. Epub 2004 Nov 4.

PMID:
15528273
48.

Estradiol regulates the thioredoxin antioxidant system in the mouse uterus.

Deroo BJ, Hewitt SC, Peddada SD, Korach KS.

Endocrinology. 2004 Dec;145(12):5485-92. Epub 2004 Sep 2.

PMID:
15345672
49.

Update on animal models developed for analyses of estrogen receptor biological activity.

Korach KS, Emmen JM, Walker VR, Hewitt SC, Yates M, Hall JM, Swope DL, Harrell JC, Couse JF.

J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):387-91. Review.

PMID:
14623535
50.

Estrogen receptor-dependent genomic responses in the uterus mirror the biphasic physiological response to estrogen.

Hewitt SC, Deroo BJ, Hansen K, Collins J, Grissom S, Afshari CA, Korach KS.

Mol Endocrinol. 2003 Oct;17(10):2070-83. Epub 2003 Jul 31.

PMID:
12893882

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