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Items: 1 to 50 of 704

1.

Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice.

Li D, Li N, Zhang YF, Fu H, Feng M, Schneider D, Su L, Wu X, Zhou J, Mackay S, Kramer J, Duan Z, Yang H, Kolluri A, Hummer AM, Torres MB, Zhu H, Hall MD, Luo X, Chen J, Wang Q, Abate-Daga D, Dropublic B, Hewitt SM, Orentas RJ, Greten TF, Ho M.

Gastroenterology. 2020 Feb 11. pii: S0016-5085(20)30211-0. doi: 10.1053/j.gastro.2020.02.011. [Epub ahead of print]

PMID:
32060001
2.

Health benefits and risks during 10 years after Roux-en-Y gastric bypass.

Chahal-Kummen M, Salte OBK, Hewitt S, Blom-Høgestøl IK, Risstad H, Kristinsson J, Mala T.

Surg Endosc. 2020 Jan 28. doi: 10.1007/s00464-019-07328-2. [Epub ahead of print]

PMID:
31993812
3.

HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors.

Song KH, Oh SJ, Kim S, Cho H, Lee HJ, Song JS, Chung JY, Cho E, Lee J, Jeon S, Yee C, Lee KM, Hewitt SM, Kim JH, Woo SR, Kim TW.

Nat Commun. 2020 Jan 28;11(1):562. doi: 10.1038/s41467-019-14259-y.

4.

Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis.

Marie KL, Sassano A, Yang HH, Michalowski AM, Michael HT, Guo T, Tsai YC, Weissman AM, Lee MP, Jenkins LM, Zaidi MR, Pérez-Guijarro E, Day CP, Ylaya K, Hewitt SM, Patel NL, Arnheiter H, Davis S, Meltzer PS, Merlino G, Mishra PJ.

Nat Commun. 2020 Jan 16;11(1):333. doi: 10.1038/s41467-019-14085-2.

5.

Concomitant phytonutrient and transcriptome analysis of mature fruit and leaf tissues of tomato (Solanum lycopersicum L. cv. Oregon Spring) grown using organic and conventional fertilizer.

Sharpe RM, Gustafson L, Hewitt S, Kilian B, Crabb J, Hendrickson C, Jiwan D, Andrews P, Dhingra A.

PLoS One. 2020 Jan 13;15(1):e0227429. doi: 10.1371/journal.pone.0227429. eCollection 2020.

6.

Racial Differences in the Association between Luminal Master Regulator Gene Expression Levels and Breast Cancer Survival.

Byun JS, Singhal S, Park S, Yi DI, Yan T, Caban A, Jones A, Mukhopadhyay P, Gil SM, Hewitt SM, Newman L, Davis MB, Jenkins BD, Sepulveda JL, De Siervi A, Nápoles AM, Vohra NA, Gardner K.

Clin Cancer Res. 2020 Jan 7. pii: clincanres.0875.2019. doi: 10.1158/1078-0432.CCR-19-0875. [Epub ahead of print]

7.

Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor α in the Isthmus and the Uterus.

Herrera GGB, Lierz SL, Harris EA, Donoghue LJ, Hewitt SC, Rodriguez KF, Jefferson WN, Lydon JP, DeMayo FJ, Williams CJ, Korach KS, Winuthayanon W.

Endocrinology. 2020 Feb 1;161(2). pii: bqz033. doi: 10.1210/endocr/bqz033.

PMID:
31883000
8.

Introducing: Capstone Articles.

Hewitt SM.

J Histochem Cytochem. 2020 Jan;68(1):73. doi: 10.1369/0022155419896341. No abstract available.

PMID:
31870240
9.

Diesel exhaust and bladder cancer risk by pathologic stage and grade subtypes.

Koutros S, Kogevinas M, Friesen MC, Stewart PA, Baris D, Karagas MR, Schwenn M, Johnson A, Monawar Hosain GM, Serra C, Tardon A, Carrato A, Garcia-Closas R, Moore LE, Nickerson ML, Hewitt SM, Lenz P, Schned AR, Lloreta J, Allory Y, Zhang H, Chatterjee N, Garcia-Closas M, Rothman N, Malats N, Silverman DT.

Environ Int. 2020 Feb;135:105346. doi: 10.1016/j.envint.2019.105346. Epub 2019 Dec 18.

10.

Evidence for pre-climacteric activation of AOX transcription during cold-induced conditioning to ripen in European pear (Pyrus communis L.).

Hendrickson C, Hewitt S, Swanson ME, Einhorn T, Dhingra A.

PLoS One. 2019 Dec 4;14(12):e0225886. doi: 10.1371/journal.pone.0225886. eCollection 2019.

11.

CDK7 is a reliable prognostic factor and novel therapeutic target in epithelial ovarian cancer.

Kim J, Cho YJ, Ryu JY, Hwang I, Han HD, Ahn HJ, Kim WY, Cho H, Chung JY, Hewitt SM, Kim JH, Kim BG, Bae DS, Choi CH, Lee JW.

Gynecol Oncol. 2020 Jan;156(1):211-221. doi: 10.1016/j.ygyno.2019.11.004. Epub 2019 Nov 24.

PMID:
31776040
12.

A functionalized hydroxydopamine quinone links thiol modification to neuronal cell death.

Farzam A, Chohan K, Strmiskova M, Hewitt SJ, Park DS, Pezacki JP, Özcelik D.

Redox Biol. 2020 Jan;28:101377. doi: 10.1016/j.redox.2019.101377. Epub 2019 Nov 9.

13.

Application of convolutional neural networks to breast biopsies to delineate tissue correlates of mammographic breast density.

Mullooly M, Ehteshami Bejnordi B, Pfeiffer RM, Fan S, Palakal M, Hada M, Vacek PM, Weaver DL, Shepherd JA, Fan B, Mahmoudzadeh AP, Wang J, Malkov S, Johnson JM, Herschorn SD, Sprague BL, Hewitt S, Brinton LA, Karssemeijer N, van der Laak J, Beck A, Sherman ME, Gierach GL.

NPJ Breast Cancer. 2019 Nov 19;5:43. doi: 10.1038/s41523-019-0134-6. eCollection 2019.

14.

Associations of tobacco smoking with body mass distribution; a population-based study of 65,875 men and women in midlife.

Graff-Iversen S, Hewitt S, Forsén L, Grøtvedt L, Ariansen I.

BMC Public Health. 2019 Nov 1;19(1):1439. doi: 10.1186/s12889-019-7807-9.

15.

Using Digital Pathology to Understand Epithelial Characteristics of Benign Breast Disease among Women Undergoing Diagnostic Image-Guided Breast Biopsy.

Mullooly M, Puvanesarajah S, Fan S, Pfeiffer RM, Olsson LT, Hada M, Kirk EL, Vacek PM, Weaver DL, Shepherd J, Mahmoudzadeh A, Wang J, Malkov S, Johnson JM, Hewitt SM, Herschorn SD, Sherman ME, Troester MA, Gierach GL.

Cancer Prev Res (Phila). 2019 Dec;12(12):861-870. doi: 10.1158/1940-6207.CAPR-19-0120. Epub 2019 Oct 23.

PMID:
31645342
16.

Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (Avelumab) treatment in advanced thymoma.

Rajan A, Heery CR, Thomas A, Mammen AL, Perry S, O'Sullivan Coyne G, Guha U, Berman A, Szabo E, Madan RA, Ballester LY, Pittaluga S, Donahue RN, Tsai YT, Lepone LM, Chin K, Ginty F, Sood A, Hewitt SM, Schlom J, Hassan R, Gulley JL.

J Immunother Cancer. 2019 Oct 21;7(1):269. doi: 10.1186/s40425-019-0723-9.

17.

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.

Wong JB, Hewitt SL, Heltemes-Harris LM, Mandal M, Johnson K, Rajewsky K, Koralov SB, Clark MR, Farrar MA, Skok JA.

Nat Commun. 2019 Oct 18;10(1):4768. doi: 10.1038/s41467-019-12824-z.

18.

ALDH1A2 Is a Candidate Tumor Suppressor Gene in Ovarian Cancer.

Choi JA, Kwon H, Cho H, Chung JY, Hewitt SM, Kim JH.

Cancers (Basel). 2019 Oct 14;11(10). pii: E1553. doi: 10.3390/cancers11101553.

19.

Fatal encephalopathy with wild-type JC virus and ruxolitinib therapy.

Reoma LB, Trindade CJ, Monaco MC, Solis J, Montojo MG, Vu P, Johnson K, Beck E, Nair G, Khan OI, Quezado M, Hewitt SM, Reich DS, Childs R, Nath A.

Ann Neurol. 2019 Dec;86(6):878-884. doi: 10.1002/ana.25608. Epub 2019 Oct 16.

PMID:
31600832
20.

Tumor Cell Biodiversity Drives Microenvironmental Reprogramming in Liver Cancer.

Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, Kleiner DE, Hewitt SM, Ylaya K, Wood BJ, Greten TF, Wang XW.

Cancer Cell. 2019 Oct 14;36(4):418-430.e6. doi: 10.1016/j.ccell.2019.08.007. Epub 2019 Oct 3.

21.

No evidence of ongoing HIV replication or compartmentalization in tissues during combination antiretroviral therapy: Implications for HIV eradication.

Bozzi G, Simonetti FR, Watters SA, Anderson EM, Gouzoulis M, Kearney MF, Rote P, Lange C, Shao W, Gorelick R, Fullmer B, Kumar S, Wank S, Hewitt S, Kleiner DE, Hattori J, Bale MJ, Hill S, Bell J, Rehm C, Grossman Z, Yarchoan R, Uldrick T, Maldarelli F.

Sci Adv. 2019 Sep 25;5(9):eaav2045. doi: 10.1126/sciadv.aav2045. eCollection 2019 Sep.

22.

Enlightening kidney pathophysiology.

Hewitt SM, Star RA.

Nat Mater. 2019 Oct;18(10):1034-1035. doi: 10.1038/s41563-019-0490-5. No abstract available.

PMID:
31537941
23.

Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein.

Byun JS, Park S, Yi DI, Shin JH, Hernandez SG, Hewitt SM, Nicklaus MC, Peach ML, Guasch L, Tang B, Wakefield LM, Yan T, Caban A, Jones A, Kabbout M, Vohra N, Nápoles AM, Singhal S, Yancey R, De Siervi A, Gardner K.

Cell Death Dis. 2019 Sep 18;10(10):689. doi: 10.1038/s41419-019-1892-7.

24.

Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer.

Shin S, Kim K, Kim HR, Ylaya K, Do SI, Hewitt SM, Park HS, Roe JS, Chung JY, Song J.

Cell Death Differ. 2019 Sep 17. doi: 10.1038/s41418-019-0419-1. [Epub ahead of print]

PMID:
31527799
25.

A dataset describing a suite of novel antibody reagents for the RAS signaling network.

Schoenherr RM, Huang D, Voytovich UJ, Ivey RG, Kennedy JJ, Saul RG, Colantonio S, Roberts RR, Knotts JG, Kaczmarczyk JA, Perry C, Hewitt SM, Bocik W, Whiteley GR, Hiltke T, Boja ES, Rodriguez H, Whiteaker JR, Paulovich AG.

Sci Data. 2019 Aug 29;6(1):160. doi: 10.1038/s41597-019-0166-7.

26.

Renal Fibrosis: Common Enemy of Many Origins.

Hewitt SM, Schaefer L.

J Histochem Cytochem. 2019 Sep;67(9):621. doi: 10.1369/0022155419865531. No abstract available.

PMID:
31451045
27.

T-Cell Receptor Gene Therapy for Human Papillomavirus-Associated Epithelial Cancers: A First-in-Human, Phase I/II Study.

Doran SL, Stevanović S, Adhikary S, Gartner JJ, Jia L, Kwong MLM, Faquin WC, Hewitt SM, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS.

J Clin Oncol. 2019 Oct 20;37(30):2759-2768. doi: 10.1200/JCO.18.02424. Epub 2019 Aug 13.

28.

A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN.

Komiya T, Blumenthal GM, DeChowdhury R, Fioravanti S, Ballas MS, Morris J, Hornyak TJ, Wank S, Hewitt SM, Morrow B, Memmott RM, Rajan A, Dennis PA.

Oncologist. 2019 Dec;24(12):1510-e1265. doi: 10.1634/theoncologist.2019-0514. Epub 2019 Jul 26.

29.

Bone metabolism, bone mineral density and low-energy fractures 10 years after Roux-en-Y gastric bypass.

Blom-Høgestøl IK, Hewitt S, Chahal-Kummen M, Brunborg C, Gulseth HL, Kristinsson JA, Eriksen EF, Mala T.

Bone. 2019 Oct;127:436-445. doi: 10.1016/j.bone.2019.07.014. Epub 2019 Jul 16.

PMID:
31323430
30.

Agreement in Histological Assessment of Mitotic Activity Between Microscopy and Digital Whole Slide Images Informs Conversion for Clinical Diagnosis.

Wei BR, Halsey CH, Hoover SB, Puri M, Yang HH, Gallas BD, Lee MP, Chen W, Durham AC, Dwyer JE, Sánchez MD, Traslavina RP, Frank C, Bradley C, McGill LD, Esplin DG, Schaffer PA, Cramer SD, Lyle LT, Beck J, Buza E, Gong Q, Hewitt SM, Simpson RM.

Acad Pathol. 2019 Jul 11;6:2374289519859841. doi: 10.1177/2374289519859841. eCollection 2019 Jan-Dec.

31.

Forkhead box protein O1 (FOXO1) and paired box gene 3 (PAX3) overexpression is associated with poor prognosis in patients with cervical cancer.

Chay DB, Han GH, Nam S, Cho H, Chung JY, Hewitt SM.

Int J Clin Oncol. 2019 Nov;24(11):1429-1439. doi: 10.1007/s10147-019-01507-w. Epub 2019 Jul 13.

PMID:
31302815
32.

Cas9-based enrichment and single-molecule sequencing for precise characterization of genomic duplications.

Watson CM, Crinnion LA, Hewitt S, Bates J, Robinson R, Carr IM, Sheridan E, Adlard J, Bonthron DT.

Lab Invest. 2020 Jan;100(1):135-146. doi: 10.1038/s41374-019-0283-0. Epub 2019 Jul 4.

33.

A mouse model of Proteus syndrome.

Lindhurst MJ, Brinster LR, Kondolf HC, Shwetar JJ, Yourick MR, Shiferaw H, Keppler-Noreuil KM, Elliot G, Rivas C, Garrett L, Gomez-Rodriguez J, Sebire NJ, Hewitt SM, Schwartzberg PL, Biesecker LG.

Hum Mol Genet. 2019 Sep 1;28(17):2920-2936. doi: 10.1093/hmg/ddz116.

PMID:
31194862
34.

A simple, robust, universal assay for real-time enzyme monitoring by signalling changes in nucleoside phosphate anion concentration using a europium(iii)-based anion receptor.

Hewitt SH, Ali R, Mailhot R, Antonen CR, Dodson CA, Butler SJ.

Chem Sci. 2019 May 1;10(20):5373-5381. doi: 10.1039/c9sc01552c. eCollection 2019 May 28.

35.

Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome.

Coons LA, Burkholder AB, Hewitt SC, McDonnell DP, Korach KS.

iScience. 2019 May 31;15:552-591. doi: 10.1016/j.isci.2019.04.006. Epub 2019 Apr 6.

36.

A distal super enhancer mediates estrogen-dependent mouse uterine-specific gene transcription of Igf1 (insulin-like growth factor 1).

Hewitt SC, Lierz SL, Garcia M, Hamilton KJ, Gruzdev A, Grimm SA, Lydon JP, Demayo FJ, Korach KS.

J Biol Chem. 2019 Jun 21;294(25):9746-9759. doi: 10.1074/jbc.RA119.008759. Epub 2019 May 9.

PMID:
31073032
37.

Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study.

Thomas A, Vilimas R, Trindade C, Erwin-Cohen R, Roper N, Xi L, Krishnasamy V, Levy E, Mammen A, Nichols S, Chen Y, Velcheti V, Yin F, Szabo E, Pommier Y, Steinberg SM, Trepel JB, Raffeld M, Young HA, Khan J, Hewitt S, Lee JM.

J Thorac Oncol. 2019 Aug;14(8):1447-1457. doi: 10.1016/j.jtho.2019.04.026. Epub 2019 May 4.

PMID:
31063862
38.

Hepatitis B Surface Antigen Activates Unfolded Protein Response in Forming Ground Glass Hepatocytes of Chronic Hepatitis B.

Li Y, Xia Y, Cheng X, Kleiner DE, Hewitt SM, Sproch J, Li T, Zhuang H, Liang TJ.

Viruses. 2019 Apr 25;11(4). pii: E386. doi: 10.3390/v11040386.

39.

Automated Computational Detection, Quantitation, and Mapping of Mitosis in Whole-Slide Images for Clinically Actionable Surgical Pathology Decision Support.

Puri M, Hoover SB, Hewitt SM, Wei BR, Adissu HA, Halsey CHC, Beck J, Bradley C, Cramer SD, Durham AC, Esplin DG, Frank C, Lyle LT, McGill LD, Sánchez MD, Schaffer PA, Traslavina RP, Buza E, Yang HH, Lee MP, Dwyer JE, Simpson RM.

J Pathol Inform. 2019 Feb 7;10:4. doi: 10.4103/jpi.jpi_59_18. eCollection 2019.

40.

Data, Information, and Knowledge.

Hewitt SM.

J Histochem Cytochem. 2019 Apr;67(4):227-228. doi: 10.1369/0022155419836995. No abstract available.

PMID:
30909851
41.

Understanding the measurement properties of the incremental shuttle walk test in patients with severe asthma.

Majd S, Hewitt SM, Apps LD, Murphy AC, Bradding P, Singh SJ, Green RH, Evans RA.

Respirology. 2019 Aug;24(8):752-757. doi: 10.1111/resp.13519. Epub 2019 Mar 18.

PMID:
30887627
42.

An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.

Lee TK, Murthy SR, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau T, Ma S, Huynh T, Wesley RA, Ng IO, Pacak K, Poon RT, Loh YP.

J Clin Invest. 2019 Mar 18;130:1804. doi: 10.1172/JCI128836. eCollection 2019 Mar 18. No abstract available.

43.

Combination immunotherapy with IL-4 Pseudomonas exotoxin and IFN-α and IFN-γ mediate antitumor effects in vitro and in a mouse model of human ovarian cancer.

Green DS, Husain SR, Johnson CL, Sato Y, Han J, Joshi B, Hewitt SM, Puri RK, Zoon KC.

Immunotherapy. 2019 Apr;11(6):483-496. doi: 10.2217/imt-2018-0158.

PMID:
30860437
44.

APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors.

Roper N, Gao S, Maity TK, Banday AR, Zhang X, Venugopalan A, Cultraro CM, Patidar R, Sindiri S, Brown AL, Goncearenco A, Panchenko AR, Biswas R, Thomas A, Rajan A, Carter CA, Kleiner DE, Hewitt SM, Khan J, Prokunina-Olsson L, Guha U.

Cell Rep. 2019 Mar 5;26(10):2651-2666.e6. doi: 10.1016/j.celrep.2019.02.028.

45.

Associations of CDH1 germline variant location and cancer phenotype in families with hereditary diffuse gastric cancer (HDGC).

Lo W, Zhu B, Sabesan A, Wu HH, Powers A, Sorber RA, Ravichandran S, Chen I, McDuffie LA, Quadri HS, Beane JD, Calzone K, Miettinen MM, Hewitt SM, Koh C, Heller T, Wacholder S, Rudloff U.

J Med Genet. 2019 Jun;56(6):370-379. doi: 10.1136/jmedgenet-2018-105361. Epub 2019 Feb 11.

46.

Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells.

Simon N, Antignani A, Hewitt SM, Gadina M, Alewine C, FitzGerald D.

JCI Insight. 2019 Mar 7;4(5). pii: 123281. doi: 10.1172/jci.insight.123281. eCollection 2019 Mar 7.

47.

An alternative to array-based diagnostics: a prospectively recruited cohort, comparing arrayCGH to next-generation sequencing to evaluate foetal structural abnormalities.

Walker L, Watson CM, Hewitt S, Crinnion LA, Bonthron DT, Cohen KE.

J Obstet Gynaecol. 2019 Apr;39(3):328-334. doi: 10.1080/01443615.2018.1522529. Epub 2019 Feb 3.

48.

Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs.

Hewitt SL, Bai A, Bailey D, Ichikawa K, Zielinski J, Karp R, Apte A, Arnold K, Zacharek SJ, Iliou MS, Bhatt K, Garnaas M, Musenge F, Davis A, Khatwani N, Su SV, MacLean G, Farlow SJ, Burke K, Frederick JP.

Sci Transl Med. 2019 Jan 30;11(477). pii: eaat9143. doi: 10.1126/scitranslmed.aat9143.

PMID:
30700577
49.

Immunophenotypic Characterization of Canine Splenic Follicular-Derived B-Cell Lymphoma.

Stein L, Bacmeister C, Ylaya K, Fetsch P, Wang Z, Hewitt SM, Kiupel M.

Vet Pathol. 2019 May;56(3):350-357. doi: 10.1177/0300985818823668. Epub 2019 Jan 13.

PMID:
30636524
50.

Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma.

Sun W, Chatterjee B, Shern JF, Patidar R, Song Y, Wang Y, Walker RL, Pawel BR, Linardic CM, Houghton P, Hewitt SM, Edelman DC, Khan J, Meltzer PS, Barr FG.

Int J Cancer. 2019 Jun 1;144(11):2707-2717. doi: 10.1002/ijc.32006. Epub 2019 Jan 15.

PMID:
30565669

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