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Epigenetic re-wiring of breast cancer by pharmacological targeting of C-terminal binding protein.

Byun JS, Park S, Yi DI, Shin JH, Hernandez SG, Hewitt SM, Nicklaus MC, Peach ML, Guasch L, Tang B, Wakefield LM, Yan T, Caban A, Jones A, Kabbout M, Vohra N, Nápoles AM, Singhal S, Yancey R, De Siervi A, Gardner K.

Cell Death Dis. 2019 Sep 18;10(10):689. doi: 10.1038/s41419-019-1892-7.


Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer.

Shin S, Kim K, Kim HR, Ylaya K, Do SI, Hewitt SM, Park HS, Roe JS, Chung JY, Song J.

Cell Death Differ. 2019 Sep 17. doi: 10.1038/s41418-019-0419-1. [Epub ahead of print]


A dataset describing a suite of novel antibody reagents for the RAS signaling network.

Schoenherr RM, Huang D, Voytovich UJ, Ivey RG, Kennedy JJ, Saul RG, Colantonio S, Roberts RR, Knotts JG, Kaczmarczyk JA, Perry C, Hewitt SM, Bocik W, Whiteley GR, Hiltke T, Boja ES, Rodriguez H, Whiteaker JR, Paulovich AG.

Sci Data. 2019 Aug 29;6(1):160. doi: 10.1038/s41597-019-0166-7.


Renal Fibrosis: Common Enemy of Many Origins.

Hewitt SM, Schaefer L.

J Histochem Cytochem. 2019 Sep;67(9):621. doi: 10.1369/0022155419865531. No abstract available.


T-Cell Receptor Gene Therapy for Human Papillomavirus-Associated Epithelial Cancers: A First-in-Human, Phase I/II Study.

Doran SL, Stevanović S, Adhikary S, Gartner JJ, Jia L, Kwong MLM, Faquin WC, Hewitt SM, Sherry RM, Yang JC, Rosenberg SA, Hinrichs CS.

J Clin Oncol. 2019 Aug 13:JCO1802424. doi: 10.1200/JCO.18.02424. [Epub ahead of print]


A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN.

Komiya T, Blumenthal GM, DeChowdhury R, Fioravanti S, Ballas MS, Morris J, Hornyak TJ, Wank S, Hewitt SM, Morrow B, Memmott RM, Rajan A, Dennis PA.

Oncologist. 2019 Jul 26. pii: theoncologist.2019-0514. doi: 10.1634/theoncologist.2019-0514. [Epub ahead of print]


Bone metabolism, bone mineral density and low-energy fractures 10 years after Roux-en-Y gastric bypass.

Blom-Høgestøl IK, Hewitt S, Chahal-Kummen M, Brunborg C, Gulseth HL, Kristinsson JA, Eriksen EF, Mala T.

Bone. 2019 Oct;127:436-445. doi: 10.1016/j.bone.2019.07.014. Epub 2019 Jul 16.


Agreement in Histological Assessment of Mitotic Activity Between Microscopy and Digital Whole Slide Images Informs Conversion for Clinical Diagnosis.

Wei BR, Halsey CH, Hoover SB, Puri M, Yang HH, Gallas BD, Lee MP, Chen W, Durham AC, Dwyer JE, Sánchez MD, Traslavina RP, Frank C, Bradley C, McGill LD, Esplin DG, Schaffer PA, Cramer SD, Lyle LT, Beck J, Buza E, Gong Q, Hewitt SM, Simpson RM.

Acad Pathol. 2019 Jul 11;6:2374289519859841. doi: 10.1177/2374289519859841. eCollection 2019 Jan-Dec.


Forkhead box protein O1 (FOXO1) and paired box gene 3 (PAX3) overexpression is associated with poor prognosis in patients with cervical cancer.

Chay DB, Han GH, Nam S, Cho H, Chung JY, Hewitt SM.

Int J Clin Oncol. 2019 Jul 13. doi: 10.1007/s10147-019-01507-w. [Epub ahead of print]


Cas9-based enrichment and single-molecule sequencing for precise characterization of genomic duplications.

Watson CM, Crinnion LA, Hewitt S, Bates J, Robinson R, Carr IM, Sheridan E, Adlard J, Bonthron DT.

Lab Invest. 2019 Jul 4. doi: 10.1038/s41374-019-0283-0. [Epub ahead of print]


A mouse model of Proteus syndrome.

Lindhurst MJ, Brinster LR, Kondolf HC, Shwetar JJ, Yourick MR, Shiferaw H, Keppler-Noreuil KM, Elliot G, Rivas C, Garrett L, Gomez-Rodriguez J, Sebire NJ, Hewitt SM, Schwartzberg PL, Biesecker LG.

Hum Mol Genet. 2019 Sep 1;28(17):2920-2936. doi: 10.1093/hmg/ddz116.


A simple, robust, universal assay for real-time enzyme monitoring by signalling changes in nucleoside phosphate anion concentration using a europium(iii)-based anion receptor.

Hewitt SH, Ali R, Mailhot R, Antonen CR, Dodson CA, Butler SJ.

Chem Sci. 2019 May 1;10(20):5373-5381. doi: 10.1039/c9sc01552c. eCollection 2019 May 28.


Decoding the Inversion Symmetry Underlying Transcription Factor DNA-Binding Specificity and Functionality in the Genome.

Coons LA, Burkholder AB, Hewitt SC, McDonnell DP, Korach KS.

iScience. 2019 May 31;15:552-591. doi: 10.1016/j.isci.2019.04.006. Epub 2019 Apr 6.


A distal super enhancer mediates estrogen-dependent mouse uterine-specific gene transcription of Igf1 (insulin-like growth factor 1).

Hewitt SC, Lierz SL, Garcia M, Hamilton KJ, Gruzdev A, Grimm SA, Lydon JP, Demayo FJ, Korach KS.

J Biol Chem. 2019 Jun 21;294(25):9746-9759. doi: 10.1074/jbc.RA119.008759. Epub 2019 May 9.


Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study.

Thomas A, Vilimas R, Trindade C, Erwin-Cohen R, Roper N, Xi L, Krishnasamy V, Levy E, Mammen A, Nichols S, Chen Y, Velcheti V, Yin F, Szabo E, Pommier Y, Steinberg SM, Trepel JB, Raffeld M, Young HA, Khan J, Hewitt S, Lee JM.

J Thorac Oncol. 2019 Aug;14(8):1447-1457. doi: 10.1016/j.jtho.2019.04.026. Epub 2019 May 4.


Hepatitis B Surface Antigen Activates Unfolded Protein Response in Forming Ground Glass Hepatocytes of Chronic Hepatitis B.

Li Y, Xia Y, Cheng X, Kleiner DE, Hewitt SM, Sproch J, Li T, Zhuang H, Liang TJ.

Viruses. 2019 Apr 25;11(4). pii: E386. doi: 10.3390/v11040386.


Automated Computational Detection, Quantitation, and Mapping of Mitosis in Whole-Slide Images for Clinically Actionable Surgical Pathology Decision Support.

Puri M, Hoover SB, Hewitt SM, Wei BR, Adissu HA, Halsey CHC, Beck J, Bradley C, Cramer SD, Durham AC, Esplin DG, Frank C, Lyle LT, McGill LD, Sánchez MD, Schaffer PA, Traslavina RP, Buza E, Yang HH, Lee MP, Dwyer JE, Simpson RM.

J Pathol Inform. 2019 Feb 7;10:4. doi: 10.4103/jpi.jpi_59_18. eCollection 2019.


Data, Information, and Knowledge.

Hewitt SM.

J Histochem Cytochem. 2019 Apr;67(4):227-228. doi: 10.1369/0022155419836995. No abstract available.


Understanding the measurement properties of the incremental shuttle walk test in patients with severe asthma.

Majd S, Hewitt SM, Apps LD, Murphy AC, Bradding P, Singh SJ, Green RH, Evans RA.

Respirology. 2019 Aug;24(8):752-757. doi: 10.1111/resp.13519. Epub 2019 Mar 18.


An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.

Lee TK, Murthy SR, Cawley NX, Dhanvantari S, Hewitt SM, Lou H, Lau T, Ma S, Huynh T, Wesley RA, Ng IO, Pacak K, Poon RT, Loh YP.

J Clin Invest. 2019 Mar 18;130:1804. doi: 10.1172/JCI128836. eCollection 2019 Mar 18. No abstract available.


Combination immunotherapy with IL-4 Pseudomonas exotoxin and IFN-α and IFN-γ mediate antitumor effects in vitro and in a mouse model of human ovarian cancer.

Green DS, Husain SR, Johnson CL, Sato Y, Han J, Joshi B, Hewitt SM, Puri RK, Zoon KC.

Immunotherapy. 2019 Apr;11(6):483-496. doi: 10.2217/imt-2018-0158.


APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors.

Roper N, Gao S, Maity TK, Banday AR, Zhang X, Venugopalan A, Cultraro CM, Patidar R, Sindiri S, Brown AL, Goncearenco A, Panchenko AR, Biswas R, Thomas A, Rajan A, Carter CA, Kleiner DE, Hewitt SM, Khan J, Prokunina-Olsson L, Guha U.

Cell Rep. 2019 Mar 5;26(10):2651-2666.e6. doi: 10.1016/j.celrep.2019.02.028.


Associations of CDH1 germline variant location and cancer phenotype in families with hereditary diffuse gastric cancer (HDGC).

Lo W, Zhu B, Sabesan A, Wu HH, Powers A, Sorber RA, Ravichandran S, Chen I, McDuffie LA, Quadri HS, Beane JD, Calzone K, Miettinen MM, Hewitt SM, Koh C, Heller T, Wacholder S, Rudloff U.

J Med Genet. 2019 Jun;56(6):370-379. doi: 10.1136/jmedgenet-2018-105361. Epub 2019 Feb 11.


Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells.

Simon N, Antignani A, Hewitt SM, Gadina M, Alewine C, FitzGerald D.

JCI Insight. 2019 Mar 7;4(5). pii: 123281. doi: 10.1172/jci.insight.123281. eCollection 2019 Mar 7.


An alternative to array-based diagnostics: a prospectively recruited cohort, comparing arrayCGH to next-generation sequencing to evaluate foetal structural abnormalities.

Walker L, Watson CM, Hewitt S, Crinnion LA, Bonthron DT, Cohen KE.

J Obstet Gynaecol. 2019 Apr;39(3):328-334. doi: 10.1080/01443615.2018.1522529. Epub 2019 Feb 3.


Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs.

Hewitt SL, Bai A, Bailey D, Ichikawa K, Zielinski J, Karp R, Apte A, Arnold K, Zacharek SJ, Iliou MS, Bhatt K, Garnaas M, Musenge F, Davis A, Khatwani N, Su SV, MacLean G, Farlow SJ, Burke K, Frederick JP.

Sci Transl Med. 2019 Jan 30;11(477). pii: eaat9143. doi: 10.1126/scitranslmed.aat9143.


Immunophenotypic Characterization of Canine Splenic Follicular-Derived B-Cell Lymphoma.

Stein L, Bacmeister C, Ylaya K, Fetsch P, Wang Z, Hewitt SM, Kiupel M.

Vet Pathol. 2019 May;56(3):350-357. doi: 10.1177/0300985818823668. Epub 2019 Jan 13.


Relationship of DNA methylation to mutational changes and transcriptional organization in fusion-positive and fusion-negative rhabdomyosarcoma.

Sun W, Chatterjee B, Shern JF, Patidar R, Song Y, Wang Y, Walker RL, Pawel BR, Linardic CM, Houghton P, Hewitt SM, Edelman DC, Khan J, Meltzer PS, Barr FG.

Int J Cancer. 2019 Jun 1;144(11):2707-2717. doi: 10.1002/ijc.32006. Epub 2019 Jan 15.


Correction: Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF.

Han SY, Ko A, Kitano H, Choi CH, Lee MS, Seo J, Fukuoka J, Kim SY, Hewitt SM, Chung JY, Song J.

Cancer Res. 2018 Dec 15;78(24):6903. doi: 10.1158/0008-5472.CAN-18-3311. No abstract available.


Let's 'cut to the chase' on malaria elimination in the Greater Mekong Subregion.

Hewitt SE.

Trans R Soc Trop Med Hyg. 2019 Apr 1;113(4):161-162. doi: 10.1093/trstmh/try125.


Building a Digital Wind Farm.

Hewitt S, Margetts L, Revell A.

Arch Comput Methods Eng. 2018;25(4):879-899. doi: 10.1007/s11831-017-9222-7. Epub 2017 Apr 18.


APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R.

Okamoto K, Rausch JW, Wakashin H, Fu Y, Chung JY, Dummer PD, Shin MK, Chandra P, Suzuki K, Shrivastav S, Rosenberg AZ, Hewitt SM, Ray PE, Noiri E, Le Grice SFJ, Hoek M, Han Z, Winkler CA, Kopp JB.

Commun Biol. 2018 Nov 7;1:188. doi: 10.1038/s42003-018-0188-2. eCollection 2018.


Genomic Network-Based Analysis Reveals Pancreatic Adenocarcinoma Up-Regulating Factor-Related Prognostic Markers in Cervical Carcinoma.

Kim J, Chung JY, Kim TJ, Lee JW, Kim BG, Bae DS, Choi CH, Hewitt SM.

Front Oncol. 2018 Oct 23;8:465. doi: 10.3389/fonc.2018.00465. eCollection 2018.


Microvascular inflammation in renal allograft biopsies assessed by endothelial and leukocyte co-immunostain: a retrospective study on reproducibility and clinical/prognostic correlates.

Delsante M, Maggiore U, Levi J, Kleiner DE, Jackson AM, Arend LJ, Hewitt SM, Carter-Monroe N, Bagnasco SM, Rosenberg AZ.

Transpl Int. 2019 Mar;32(3):300-312. doi: 10.1111/tri.13371. Epub 2018 Dec 11.


Patients with learning disabilities should be considered at high risk of cervical spine injury.

Byrne C, Johnson GD, Tabner AJ, Hewitt SM.

Emerg Med J. 2019 Jan;36(1):54. doi: 10.1136/emermed-2018-208117. Epub 2018 Oct 20. No abstract available.


Negative elongation factor is essential for endometrial function.

Hewitt SC, Li R, Adams N, Winuthayanon W, Hamilton KJ, Donoghue LJ, Lierz SL, Garcia M, Lydon JP, DeMayo FJ, Adelman K, Korach KS.

FASEB J. 2019 Feb;33(2):3010-3023. doi: 10.1096/fj.201801752. Epub 2018 Oct 17.


Identification of water use efficiency related genes in 'Garnem' almond-peach rootstock using time-course transcriptome analysis.

Bielsa B, Hewitt S, Reyes-Chin-Wo S, Dhingra A, Rubio-Cabetas MJ.

PLoS One. 2018 Oct 11;13(10):e0205493. doi: 10.1371/journal.pone.0205493. eCollection 2018.


Anemia following Roux-en-Y gastric bypass for morbid obesity; a 5-year follow-up study.

Engebretsen KV, Blom-Høgestøl IK, Hewitt S, Risstad H, Moum B, Kristinsson JA, Mala T.

Scand J Gastroenterol. 2018 Aug;53(8):917-922. doi: 10.1080/00365521.2018.1489892.


Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance.

Song KH, Kim JH, Lee YH, Bae HC, Lee HJ, Woo SR, Oh SJ, Lee KM, Yee C, Kim BW, Cho H, Chung EJ, Chung JY, Hewitt SM, Chung TW, Ha KT, Bae YK, Mao CP, Yang A, Wu TC, Kim TW.

J Clin Invest. 2018 Aug 31;128(9):4098-4114. doi: 10.1172/JCI96804. Epub 2018 Aug 20.


Elevated expression of pancreatic adenocarcinoma upregulated factor (PAUF) is associated with poor prognosis and chemoresistance in epithelial ovarian cancer.

Choi CH, Kang TH, Song JS, Kim YS, Chung EJ, Ylaya K, Kim S, Koh SS, Chung JY, Kim JH, Hewitt SM.

Sci Rep. 2018 Aug 15;8(1):12161. doi: 10.1038/s41598-018-30582-8.


Scoring of tumor-infiltrating lymphocytes: From visual estimation to machine learning.

Klauschen F, Müller KR, Binder A, Bockmayr M, Hägele M, Seegerer P, Wienert S, Pruneri G, de Maria S, Badve S, Michiels S, Nielsen TO, Adams S, Savas P, Symmans F, Willis S, Gruosso T, Park M, Haibe-Kains B, Gallas B, Thompson AM, Cree I, Sotiriou C, Solinas C, Preusser M, Hewitt SM, Rimm D, Viale G, Loi S, Loibl S, Salgado R, Denkert C; International Immuno-Oncology Biomarker Working Group.

Semin Cancer Biol. 2018 Oct;52(Pt 2):151-157. doi: 10.1016/j.semcancer.2018.07.001. Epub 2018 Jul 7. Review.


Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes.

Xu B, Allard C, Alvarez-Mercado AI, Fuselier T, Kim JH, Coons LA, Hewitt SC, Urano F, Korach KS, Levin ER, Arvan P, Floyd ZE, Mauvais-Jarvis F.

Cell Rep. 2018 Jul 3;24(1):181-196. doi: 10.1016/j.celrep.2018.06.019.


Increased High Molecular Weight FGF2 in Endocrine-Resistant Breast Cancer.

Sahores A, Figueroa V, May M, Liguori M, Rubstein A, Fuentes C, Jacobsen BM, Elía A, Rojas P, Sequeira GR, Álvarez MM, González P, Gass H, Hewitt S, Molinolo A, Lanari C, Lamb CA.

Horm Cancer. 2018 Oct;9(5):338-348. doi: 10.1007/s12672-018-0339-4. Epub 2018 Jun 28.


A multiprotein supercomplex controlling oncogenic signalling in lymphoma.

Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL 3rd, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM.

Nature. 2018 Aug;560(7718):387-391. doi: 10.1038/s41586-018-0290-0. Epub 2018 Jun 20.


Estrogen Receptors: New Directions in the New Millennium.

Hewitt SC, Korach KS.

Endocr Rev. 2018 Oct 1;39(5):664-675. doi: 10.1210/er.2018-00087. Review.


Application of lanthanide luminescence in probing enzyme activity.

Hewitt SH, Butler SJ.

Chem Commun (Camb). 2018 Jun 19;54(50):6635-6647. doi: 10.1039/c8cc02824a.


Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T-Cell Receptors in High-Risk MYCN-Not-Amplified Human Neuroblastoma.

Wei JS, Kuznetsov IB, Zhang S, Song YK, Asgharzadeh S, Sindiri S, Wen X, Patidar R, Najaraj S, Walton A, Auvil JMG, Gerhard DS, Yuksel A, Catchpoole D, Hewitt SM, Sondel PM, Seeger R, Maris JM, Khan J.

Clin Cancer Res. 2018 Nov 15;24(22):5673-5684. doi: 10.1158/1078-0432.CCR-18-0599. Epub 2018 May 21.


Generation of Dynamic Combinatorial Libraries Using Hydrazone-Functionalized Surface Mimetics.

Hewitt SH, Wilson AJ.

European J Org Chem. 2018 Apr 30;2018(16):1872-1879. doi: 10.1002/ejoc.201800022. Epub 2018 Apr 25.


E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.

Horne HN, Oh H, Sherman ME, Palakal M, Hewitt SM, Schmidt MK, Milne RL, Hardisson D, Benitez J, Blomqvist C, Bolla MK, Brenner H, Chang-Claude J, Cora R, Couch FJ, Cuk K, Devilee P, Easton DF, Eccles DM, Eilber U, Hartikainen JM, Heikkilä P, Holleczek B, Hooning MJ, Jones M, Keeman R, Mannermaa A, Martens JWM, Muranen TA, Nevanlinna H, Olson JE, Orr N, Perez JIA, Pharoah PDP, Ruddy KJ, Saum KU, Schoemaker MJ, Seynaeve C, Sironen R, Smit VTHBM, Swerdlow AJ, Tengström M, Thomas AS, Timmermans AM, Tollenaar RAEM, Troester MA, van Asperen CJ, van Deurzen CHM, Van Leeuwen FF, Van't Veer LJ, García-Closas M, Figueroa JD.

Sci Rep. 2018 Apr 26;8(1):6574. doi: 10.1038/s41598-018-23733-4.


Assessing consumers' preferences and willingness to pay for novel sliced packed fresh pears: A latent class approach.

Ikiz D, Gallardo RK, Dhingra A, Hewitt S.

Agribusiness (N Y N Y). 2018 Spring;34(2):321-337. doi: 10.1002/agr.21532. Epub 2017 Nov 19.

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