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Items: 1 to 50 of 146

1.

Melt-electrowriting with novel milk protein/PCL biomaterials for skin regeneration.

Hewitt E, Mros S, Mcconnell M, Cabral J, Ali A.

Biomed Mater. 2019 Jul 18. doi: 10.1088/1748-605X/ab3344. [Epub ahead of print]

PMID:
31318339
2.

Cathepsin S acts via protease-activated receptor 2 to activate sensory neurons and induce itch-like behaviour.

Chung K, Pitcher T, Grant AD, Hewitt E, Lindstrom E, Malcangio M.

Neurobiol Pain. 2019 May 2;6:100032. doi: 10.1016/j.ynpai.2019.100032. eCollection 2019 Aug-Dec.

3.

A new era for understanding amyloid structures and disease.

Iadanza MG, Jackson MP, Hewitt EW, Ranson NA, Radford SE.

Nat Rev Mol Cell Biol. 2018 Dec;19(12):755-773. doi: 10.1038/s41580-018-0060-8. Review.

4.

Why are Functional Amyloids Non-Toxic in Humans?

Jackson MP, Hewitt EW.

Biomolecules. 2017 Sep 22;7(4). pii: E71. doi: 10.3390/biom7040071. Review.

5.

Manipulation Peak Forces Across Spinal Regions for Children Using Mannequin Simulators.

Triano JJ, Lester S, Starmer D, Hewitt EG.

J Manipulative Physiol Ther. 2017 Mar - Apr;40(3):139-146. doi: 10.1016/j.jmpt.2017.01.001. Epub 2017 Mar 6.

PMID:
28274487
6.

Cellular proteostasis: degradation of misfolded proteins by lysosomes.

Jackson MP, Hewitt EW.

Essays Biochem. 2016 Oct 15;60(2):173-180. Review.

7.

Health information quality on the internet in gynecological oncology: a multilingual evaluation.

Lawrentschuk N, Abouassaly R, Hewitt E, Mulcahy A, Bolton DM, Jobling T.

Eur J Gynaecol Oncol. 2016 Aug;37(4):478-483.

PMID:
29894070
8.

Selective Cathepsin S Inhibition with MIV-247 Attenuates Mechanical Allodynia and Enhances the Antiallodynic Effects of Gabapentin and Pregabalin in a Mouse Model of Neuropathic Pain.

Hewitt E, Pitcher T, Rizoska B, Tunblad K, Henderson I, Sahlberg BL, Grabowska U, Classon B, Edenius C, Malcangio M, Lindström E.

J Pharmacol Exp Ther. 2016 Sep;358(3):387-96. doi: 10.1124/jpet.116.232926. Epub 2016 Jun 22.

PMID:
27335437
9.

Best Practices for Chiropractic Care of Children: A Consensus Update.

Hawk C, Schneider MJ, Vallone S, Hewitt EG.

J Manipulative Physiol Ther. 2016 Mar-Apr;39(3):158-68. doi: 10.1016/j.jmpt.2016.02.015. Epub 2016 Mar 31.

10.

Comparison of the aggregation of homologous β2-microglobulin variants reveals protein solubility as a key determinant of amyloid formation.

Pashley CL, Hewitt EW, Radford SE.

J Mol Biol. 2016 Feb 13;428(3):631-643. doi: 10.1016/j.jmb.2016.01.009. Epub 2016 Jan 15.

11.

Core Competencies of the Certified Pediatric Doctor of Chiropractic: Results of a Delphi Consensus Process.

Hewitt E, Hestbaek L, Pohlman KA.

J Evid Based Complementary Altern Med. 2016 Apr;21(2):110-4. doi: 10.1177/2156587215622769. Epub 2016 Jan 5.

PMID:
26739669
12.

Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?

Tipping KW, van Oosten-Hawle P, Hewitt EW, Radford SE.

Trends Biochem Sci. 2015 Dec;40(12):719-727. doi: 10.1016/j.tibs.2015.10.002. Epub 2015 Nov 2. Review.

13.

pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers.

Tipping KW, Karamanos TK, Jakhria T, Iadanza MG, Goodchild SC, Tuma R, Ranson NA, Hewitt EW, Radford SE.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5691-6. doi: 10.1073/pnas.1423174112. Epub 2015 Apr 20.

14.

β2-microglobulin amyloid fibrils are nanoparticles that disrupt lysosomal membrane protein trafficking and inhibit protein degradation by lysosomes.

Jakhria T, Hellewell AL, Porter MY, Jackson MP, Tipping KW, Xue WF, Radford SE, Hewitt EW.

J Biol Chem. 2014 Dec 26;289(52):35781-94. doi: 10.1074/jbc.M114.586222. Epub 2014 Nov 5.

15.

Neural interaction between logical reasoning and pragmatic processing in narrative discourse.

Prado J, Spotorno N, Koun E, Hewitt E, Van der Henst JB, Sperber D, Noveck IA.

J Cogn Neurosci. 2015 Apr;27(4):692-704. doi: 10.1162/jocn_a_00744. Epub 2014 Oct 16.

PMID:
25321487
16.

β2-Microglobulin amyloid fibril-induced membrane disruption is enhanced by endosomal lipids and acidic pH.

Goodchild SC, Sheynis T, Thompson R, Tipping KW, Xue WF, Ranson NA, Beales PA, Hewitt EW, Radford SE.

PLoS One. 2014 Aug 6;9(8):e104492. doi: 10.1371/journal.pone.0104492. eCollection 2014.

17.

Analysis of familial hemophagocytic lymphohistiocytosis type 4 (FHL-4) mutant proteins reveals that S-acylation is required for the function of syntaxin 11 in natural killer cells.

Hellewell AL, Foresti O, Gover N, Porter MY, Hewitt EW.

PLoS One. 2014 Jun 9;9(6):e98900. doi: 10.1371/journal.pone.0098900. eCollection 2014.

18.

Immunologic human renal allograft injury associates with an altered IL-10/TNF-α expression ratio in regulatory B cells.

Cherukuri A, Rothstein DM, Clark B, Carter CR, Davison A, Hernandez-Fuentes M, Hewitt E, Salama AD, Baker RJ.

J Am Soc Nephrol. 2014 Jul;25(7):1575-85. doi: 10.1681/ASN.2013080837. Epub 2014 Mar 7.

19.

Donors deferred for self-reported Chagas disease history: does it reduce risk?

Steele WR, Hewitt EH, Kaldun AM, Krysztof DE, Dodd RY, Stramer SL.

Transfusion. 2014 Aug;54(8):2092-7. doi: 10.1111/trf.12590. Epub 2014 Mar 6.

PMID:
24601956
20.
21.

Aggregation modulators interfere with membrane interactions of β2-microglobulin fibrils.

Sheynis T, Friediger A, Xue WF, Hellewell AL, Tipping KW, Hewitt EW, Radford SE, Jelinek R.

Biophys J. 2013 Aug 6;105(3):745-55. doi: 10.1016/j.bpj.2013.06.015.

22.

Direct three-dimensional visualization of membrane disruption by amyloid fibrils.

Milanesi L, Sheynis T, Xue WF, Orlova EV, Hellewell AL, Jelinek R, Hewitt EW, Radford SE, Saibil HR.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20455-60. doi: 10.1073/pnas.1206325109. Epub 2012 Nov 26.

23.

Lignocaine plasma levels following topical gel application in laparoscopic and hysteroscopic procedures.

Hewitt EA, Armstrong G, Beg N, Katz S, Vancaillie TG.

Anaesth Intensive Care. 2012 Mar;40(2):292-6.

24.

An analysis of lymphocyte phenotype after steroid avoidance with either alemtuzumab or basiliximab induction in renal transplantation.

Cherukuri A, Salama AD, Carter C, Smalle N, McCurtin R, Hewitt EW, Hernandez-Fuentes M, Clark B, Baker RJ.

Am J Transplant. 2012 Apr;12(4):919-31. doi: 10.1111/j.1600-6143.2011.03891.x. Epub 2012 Mar 5.

25.

Characterization of the response of primary cells relevant to dialysis-related amyloidosis to β2-microglobulin monomer and fibrils.

Porter MY, Routledge KE, Radford SE, Hewitt EW.

PLoS One. 2011;6(11):e27353. doi: 10.1371/journal.pone.0027353. Epub 2011 Nov 9.

26.

Ligand binding to distinct states diverts aggregation of an amyloid-forming protein.

Woods LA, Platt GW, Hellewell AL, Hewitt EW, Homans SW, Ashcroft AE, Radford SE.

Nat Chem Biol. 2011 Aug 28;7(10):730-9. doi: 10.1038/nchembio.635.

27.

Biomarkers and immunomodulation as a treatment option for chronic pain conditions.

Gupta A, Hewitt E, Oshinsky C.

Pain Manag. 2011 Jan;1(1):81-6. doi: 10.2217/pmt.10.3.

PMID:
24654587
28.

Fibril fragmentation in amyloid assembly and cytotoxicity: when size matters.

Xue WF, Hellewell AL, Hewitt EW, Radford SE.

Prion. 2010 Jan-Mar;4(1):20-5. Epub 2010 Jan 29.

29.

Best practices recommendations for chiropractic care for infants, children, and adolescents: results of a consensus process.

Hawk C, Schneider M, Ferrance RJ, Hewitt E, Van Loon M, Tanis L.

J Manipulative Physiol Ther. 2009 Oct;32(8):639-47. doi: 10.1016/j.jmpt.2009.08.018. Erratum in: J Manipulative Physiol Ther. 2010 Feb;33(2):164.

PMID:
19836600
30.

Fibril fragmentation enhances amyloid cytotoxicity.

Xue WF, Hellewell AL, Gosal WS, Homans SW, Hewitt EW, Radford SE.

J Biol Chem. 2009 Dec 4;284(49):34272-82. doi: 10.1074/jbc.M109.049809. Epub 2009 Oct 6.

31.

Natural killer cell cytotoxicity: how do they pull the trigger?

Topham NJ, Hewitt EW.

Immunology. 2009 Sep;128(1):7-15. doi: 10.1111/j.1365-2567.2009.03123.x. Review.

32.

Dependence of the localization and function of the human cytomegalovirus protein US6 on the transporter associated with antigen processing.

Dugan GE, Hewitt EW.

J Gen Virol. 2009 Sep;90(Pt 9):2234-8. doi: 10.1099/vir.0.012757-0. Epub 2009 May 13.

PMID:
19439551
33.

Kaposi's sarcoma-associated herpesvirus RTA promotes degradation of the Hey1 repressor protein through the ubiquitin proteasome pathway.

Gould F, Harrison SM, Hewitt EW, Whitehouse A.

J Virol. 2009 Jul;83(13):6727-38. doi: 10.1128/JVI.00351-09. Epub 2009 Apr 15.

34.

Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice.

Svelander L, Erlandsson-Harris H, Astner L, Grabowska U, Klareskog L, Lindstrom E, Hewitt E.

Eur J Pharmacol. 2009 Jun 24;613(1-3):155-62. doi: 10.1016/j.ejphar.2009.03.074. Epub 2009 Apr 7.

PMID:
19358841
35.

Solid-phase parallel synthesis and SAR of 4-amidofuran-3-one inhibitors of cathepsin S: effect of sulfonamides P3 substituents on potency and selectivity.

Ayesa S, Lindquist C, Agback T, Benkestock K, Classon B, Henderson I, Hewitt E, Jansson K, Kallin A, Sheppard D, Samuelsson B.

Bioorg Med Chem. 2009 Feb 1;17(3):1307-24. doi: 10.1016/j.bmc.2008.12.020. Epub 2008 Dec 24.

PMID:
19124252
36.

Structural and Functional Dissection of the Human Cytomegalovirus Immune Evasion Protein US6.

Dugan GE, Hewitt EW.

J Virol. 2008 Apr;82(7):3271-82. doi: 10.1128/JVI.01705-07. Epub 2008 Jan 16.

37.

Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils.

Morten IJ, Gosal WS, Radford SE, Hewitt EW.

J Biol Chem. 2007 Oct 5;282(40):29691-700. Epub 2007 Aug 8.

38.

Specific glycosaminoglycans promote unseeded amyloid formation from beta2-microglobulin under physiological conditions.

Borysik AJ, Morten IJ, Radford SE, Hewitt EW.

Kidney Int. 2007 Jul;72(2):174-81. Epub 2007 May 2.

39.

Organelle proteomics: identification of the exocytic machinery associated with the natural killer cell secretory lysosome.

Casey TM, Meade JL, Hewitt EW.

Mol Cell Proteomics. 2007 May;6(5):767-80. Epub 2007 Jan 31.

40.

Effects of oxygen tension on the establishment and lactate dehydrogenase activity of murine embryonic stem cells.

Gibbons J, Hewitt E, Gardner DK.

Cloning Stem Cells. 2006 Summer;8(2):117-22.

PMID:
16776603
41.

A systematic study of the effect of physiological factors on beta2-microglobulin amyloid formation at neutral pH.

Myers SL, Jones S, Jahn TR, Morten IJ, Tennent GA, Hewitt EW, Radford SE.

Biochemistry. 2006 Feb 21;45(7):2311-21.

PMID:
16475820
42.

Implementation of a rapid and automated high performance liquid chromatography method development strategy for pharmaceutical drug candidates.

Hewitt EF, Lukulay P, Galushko S.

J Chromatogr A. 2006 Feb 24;1107(1-2):79-87. Epub 2006 Jan 9.

PMID:
16406385
43.

River flow and associated transport of sediments and solutes through a highly urbanised catchment, Bradford, West Yorkshire.

Old GH, Leeks GJ, Packman JC, Smith BP, Lewis S, Hewitt EJ.

Sci Total Environ. 2006 May 1;360(1-3):98-108. Epub 2005 Oct 7.

PMID:
16214202
44.

Competing pathways determine fibril morphology in the self-assembly of beta2-microglobulin into amyloid.

Gosal WS, Morten IJ, Hewitt EW, Smith DA, Thomson NH, Radford SE.

J Mol Biol. 2005 Aug 26;351(4):850-64.

PMID:
16024039
45.

Virus subversion of protective immunity.

Hewitt EW, Dugan GE.

Curr Allergy Asthma Rep. 2004 Sep;4(5):365-70. Review.

PMID:
15283875
46.
47.

The impact of a convectional summer rainfall event on river flow and fine sediment transport in a highly urbanised catchment: Bradford, West Yorkshire.

Old GH, Leeks GJ, Packman JC, Smith BP, Lewis S, Hewitt EJ, Holmes M, Young A.

Sci Total Environ. 2003 Oct 1;314-316:495-512.

PMID:
14499547
48.

Phylogenetic relationships among 28 spirotrichous ciliates documented by rDNA.

Hewitt EA, Müller KM, Cannone J, Hogan DJ, Gutell R, Prescott DM.

Mol Phylogenet Evol. 2003 Nov;29(2):258-67.

PMID:
13678681
49.

Novel cell-permeable acyloxymethylketone inhibitors of asparaginyl endopeptidase.

Loak K, Li DN, Manoury B, Billson J, Morton F, Hewitt E, Watts C.

Biol Chem. 2003 Aug;384(8):1239-46.

PMID:
12974392
50.

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