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Items: 1 to 50 of 126

1.

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis.

Chow BSM, Kocan M, Shen M, Wang Y, Han L, Chew JY, Wang C, Bosnyak S, Mirabito-Colafella KM, Barsha G, Wigg B, Johnstone EKM, Hossain MA, Pfleger KDG, Denton KM, Widdop RE, Summers RJ, Bathgate RAD, Hewitson TD, Samuel CS.

J Am Soc Nephrol. 2019 Sep 11. pii: ASN.2019060597. doi: 10.1681/ASN.2019060597. [Epub ahead of print]

PMID:
31511361
2.

αKlotho-FGF23 interactions and their role in kidney disease: a molecular insight.

Smith ER, Holt SG, Hewitson TD.

Cell Mol Life Sci. 2019 Jul 26. doi: 10.1007/s00018-019-03241-y. [Epub ahead of print] Review.

PMID:
31350618
3.

Profiling histone modifications in the normal mouse kidney and after unilateral ureteric obstruction.

Hewitson TD, Holt SG, Samuel CS, Wigg B, Smith ER.

Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F606-F615. doi: 10.1152/ajprenal.00262.2019. Epub 2019 Jul 3.

PMID:
31268352
4.

The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities.

Roman J, Barnes TR, Kervitsky DJ, Cosgrove GP, Doherty DE, Tager AM, Richeldi L, White ES, Brenner DA, Schnapp LM, Hewitson TD, Jugdutt BI, McKinsey TA, Tosi JD, Crane S, Brown KK; Fibrosis Across Organs Symposium Working Group.

Am J Med Sci. 2019 May;357(5):405-410. doi: 10.1016/j.amjms.2019.02.014. No abstract available.

5.

TGF-β1 modifies histone acetylation and acetyl-coenzyme A metabolism in renal myofibroblasts.

Smith ER, Wigg B, Holt S, Hewitson TD.

Am J Physiol Renal Physiol. 2019 Jan 9. doi: 10.1152/ajprenal.00513.2018. [Epub ahead of print]

PMID:
30623724
6.

High-intensity physical exercise increases serum α-klotho levels in healthy volunteers.

Tan SJ, Chu MM, Toussaint ND, Cai MM, Hewitson TD, Holt SG.

J Circ Biomark. 2018 Aug 16;7:1849454418794582. doi: 10.1177/1849454418794582. eCollection 2018 Jan-Dec.

7.

Calciprotein Particle Formation in Peritoneal Dialysis Effluent Is Dependent on Dialysate Calcium Concentration.

Cai MMX, Smith ER, Kent A, Huang L, Hewitson TD, McMahon LP, Holt SG.

Perit Dial Int. 2018 Jul-Aug;38(4):286-292. doi: 10.3747/pdi.2017.00163. Epub 2018 May 23.

PMID:
29793980
8.

Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism.

Ruderman I, Smith ER, Toussaint ND, Hewitson TD, Holt SG.

BMC Nephrol. 2018 May 15;19(1):113. doi: 10.1186/s12882-018-0910-9.

9.

Current and potential therapeutic strategies for the management of vascular calcification in patients with chronic kidney disease including those on dialysis.

Ruderman I, Holt SG, Hewitson TD, Smith ER, Toussaint ND.

Semin Dial. 2018 Sep;31(5):487-499. doi: 10.1111/sdi.12710. Epub 2018 May 7. Review.

PMID:
29733462
10.

Biochemical transformation of calciprotein particles in uraemia.

Smith ER, Hewitson TD, Hanssen E, Holt SG.

Bone. 2018 May;110:355-367. doi: 10.1016/j.bone.2018.02.023. Epub 2018 Feb 27.

PMID:
29499417
11.

Editorial: Novel Therapeutic Targets and Emerging Treatments for Fibrosis.

Samuel CS, Hewitson TD.

Front Pharmacol. 2017 Nov 14;8:824. doi: 10.3389/fphar.2017.00824. eCollection 2017. No abstract available.

12.

Fetuin-A in the peritoneal effluent of patients with encapsulating peritoneal sclerosis-more than a protein?

Smith ER, Hewitson TD, Cai MMX, Holt SG.

Kidney Int. 2017 Nov;92(5):1289-1290. doi: 10.1016/j.kint.2017.07.028. No abstract available.

PMID:
29055430
13.

FGF23 activates injury-primed renal fibroblasts via FGFR4-dependent signalling and enhancement of TGF-β autoinduction.

Smith ER, Holt SG, Hewitson TD.

Int J Biochem Cell Biol. 2017 Nov;92:63-78. doi: 10.1016/j.biocel.2017.09.009. Epub 2017 Sep 15.

14.

The Role of Secondary Calciprotein Particles in the Mineralisation Paradox of Chronic Kidney Disease.

Cai MMX, Smith ER, Tan SJ, Hewitson TD, Holt SG.

Calcif Tissue Int. 2017 Dec;101(6):570-580. doi: 10.1007/s00223-017-0313-0. Epub 2017 Aug 31.

PMID:
28861648
15.

Progression of Tubulointerstitial Fibrosis and the Chronic Kidney Disease Phenotype - Role of Risk Factors and Epigenetics.

Hewitson TD, Holt SG, Smith ER.

Front Pharmacol. 2017 Aug 8;8:520. doi: 10.3389/fphar.2017.00520. eCollection 2017.

16.

A novel fluorescent probe-based flow cytometric assay for mineral-containing nanoparticles in serum.

Smith ER, Hewitson TD, Cai MMX, Aghagolzadeh P, Bachtler M, Pasch A, Holt SG.

Sci Rep. 2017 Jul 18;7(1):5686. doi: 10.1038/s41598-017-05474-y.

17.

Soluble klotho may be a marker of phosphate reabsorption.

Tan SJ, Smith ER, Holt SG, Hewitson TD, Toussaint ND.

Clin Kidney J. 2017 Jun;10(3):397-404. doi: 10.1093/ckj/sfw146. Epub 2017 Feb 28.

18.

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-β1 Stimulation.

Hewitson TD, Holt SG, Tan SJ, Wigg B, Samuel CS, Smith ER.

Front Pharmacol. 2017 May 29;8:307. doi: 10.3389/fphar.2017.00307. eCollection 2017.

19.

FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts.

Smith ER, Tan SJ, Holt SG, Hewitson TD.

Sci Rep. 2017 Jun 13;7(1):3345. doi: 10.1038/s41598-017-02709-w.

20.

Changes in Markers of Mineral Metabolism After Living Kidney Donation.

Tan SJ, Hewitson TD, Hughes PD, Holt SG, Toussaint ND.

Transplant Direct. 2017 Mar 28;3(4):e150. doi: 10.1097/TXD.0000000000000660. eCollection 2017 Apr.

21.

Mineral adaptations following kidney transplantation.

Tan SJ, Crosthwaite A, Langsford D, Obeysekere V, Ierino FL, Roberts MA, Hughes PD, Hewitson TD, Dwyer KM, Toussaint ND.

Transpl Int. 2017 May;30(5):463-473. doi: 10.1111/tri.12925. Epub 2017 Mar 5.

22.

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension.

Ling YH, Krishnan SM, Chan CT, Diep H, Ferens D, Chin-Dusting J, Kemp-Harper BK, Samuel CS, Hewitson TD, Latz E, Mansell A, Sobey CG, Drummond GR.

Pharmacol Res. 2017 Feb;116:77-86. doi: 10.1016/j.phrs.2016.12.015. Epub 2016 Dec 13.

23.

Parenteral iron polymaltose changes i:c-terminal FGF23 ratios in iron deficiency, but not in dialysis patients.

Tan SJ, Satake S, Smith ER, Toussaint ND, Hewitson TD, Holt SG.

Eur J Clin Nutr. 2017 Feb;71(2):180-184. doi: 10.1038/ejcn.2016.217. Epub 2016 Nov 16.

PMID:
27848940
24.

Hypoxia in tissue repair and fibrosis.

Darby IA, Hewitson TD.

Cell Tissue Res. 2016 Sep;365(3):553-62. doi: 10.1007/s00441-016-2461-3. Epub 2016 Jul 16. Review.

PMID:
27423661
25.

Estrogens do not protect, but androgens exacerbate, collagen accumulation in the female mouse kidney after ureteric obstruction.

Hewitson TD, Boon WC, Simpson ER, Smith ER, Samuel CS.

Life Sci. 2016 Aug 1;158:130-6. doi: 10.1016/j.lfs.2016.06.022. Epub 2016 Jun 29.

PMID:
27373424
26.

Anti-fibrotic actions of relaxin.

Samuel CS, Royce SG, Hewitson TD, Denton KM, Cooney TE, Bennett RG.

Br J Pharmacol. 2017 May;174(10):962-976. doi: 10.1111/bph.13529. Epub 2016 Jul 7. Review. Erratum in: Br J Pharmacol. 2017 Dec;174(24):4836.

27.

The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate.

Wang C, Kemp-Harper BK, Kocan M, Ang SY, Hewitson TD, Samuel CS.

Front Pharmacol. 2016 Mar 31;7:91. doi: 10.3389/fphar.2016.00091. eCollection 2016.

28.

Antifibrotic Actions of Serelaxin - New Roles for an Old Player.

Samuel CS, Summers RJ, Hewitson TD.

Trends Pharmacol Sci. 2016 Jun;37(6):485-497. doi: 10.1016/j.tips.2016.02.007. Epub 2016 Mar 17. Review.

PMID:
26996448
29.

Qualitative and Quantitative Analysis of Histone Deacetylases in Kidney Tissue Sections.

Ververis K, Marzully S, Samuel CS, Hewitson TD, Karagiannis TC.

Methods Mol Biol. 2016;1397:279-289. doi: 10.1007/978-1-4939-3353-2_19.

PMID:
26676140
30.

Laser Capture Microdissection of Archival Kidney Tissue for qRT-PCR.

Hewitson TD, Christie M, Smith ER.

Methods Mol Biol. 2016;1397:251-265. doi: 10.1007/978-1-4939-3353-2_17.

PMID:
26676138
31.

Propagation and Culture of Human Renal Fibroblasts.

Tan SJ, Hewitson TD.

Methods Mol Biol. 2016;1397:11-23. doi: 10.1007/978-1-4939-3353-2_2.

PMID:
26676123
32.

Relationship between timed and spot urine collections for measuring phosphate excretion.

Tan SJ, Smith ER, Cai MM, Holt SG, Hewitson TD, Toussaint ND.

Int Urol Nephrol. 2016 Jan;48(1):115-24. doi: 10.1007/s11255-015-1149-z. Epub 2015 Nov 14.

PMID:
26568386
33.

Animal Models to Study Links between Cardiovascular Disease and Renal Failure and Their Relevance to Human Pathology.

Hewitson TD, Holt SG, Smith ER.

Front Immunol. 2015 Sep 17;6:465. doi: 10.3389/fimmu.2015.00465. eCollection 2015. Review.

34.

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice.

Krishnan SM, Dowling JK, Ling YH, Diep H, Chan CT, Ferens D, Kett MM, Pinar A, Samuel CS, Vinh A, Arumugam TV, Hewitson TD, Kemp-Harper BK, Robertson AA, Cooper MA, Latz E, Mansell A, Sobey CG, Drummond GR.

Br J Pharmacol. 2016 Feb;173(4):752-65. doi: 10.1111/bph.13230. Epub 2015 Jul 31.

35.

Diurnal variation and short-term pre-analytical stability of serum soluble α-klotho in healthy volunteers: a pilot study.

Tan SJ, Smith ER, Hewitson TD, Holt SG, Toussaint ND.

Ann Clin Biochem. 2015 Jul;52(Pt 4):506-9. doi: 10.1177/0004563214563415. Epub 2014 Nov 21.

PMID:
25416731
36.

Development of second generation peptides modulating cellular adiponectin receptor responses.

Otvos L Jr, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S.

Front Chem. 2014 Oct 17;2:93. doi: 10.3389/fchem.2014.00093. eCollection 2014.

37.

Relative abundance of fetuin- A in peritoneal dialysis effluent and its association with in situ formation of calciprotein particles: an observational pilot study.

Cai MM, Wigg B, Smith ER, Hewitson TD, McMahon LP, Holt SG.

Nephrology (Carlton). 2015 Jan;20(1):6-10. doi: 10.1111/nep.12350.

PMID:
25307355
38.

Qualitative and quantitative analysis of fibrosis in the kidney.

Hewitson TD, Smith ER, Samuel CS.

Nephrology (Carlton). 2014 Nov;19(11):721-6. doi: 10.1111/nep.12321.

PMID:
25196487
39.

Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease.

Samuel CS, Bodaragama H, Chew JY, Widdop RE, Royce SG, Hewitson TD.

Hypertension. 2014 Aug;64(2):315-22. doi: 10.1161/HYPERTENSIONAHA.114.03594.

PMID:
24866131
40.

The importance of klotho in phosphate metabolism and kidney disease.

Tan SJ, Smith ER, Hewitson TD, Holt SG, Toussaint ND.

Nephrology (Carlton). 2014 Aug;19(8):439-49. doi: 10.1111/nep.12268. Review.

PMID:
24750549
41.

Therapeutic effects of serelaxin in acute heart failure.

Du XJ, Hewitson TD, Nguyen MN, Samuel CS.

Circ J. 2014;78(3):542-52. Epub 2014 Jan 23.

42.

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis.

Chow BS, Kocan M, Bosnyak S, Sarwar M, Wigg B, Jones ES, Widdop RE, Summers RJ, Bathgate RA, Hewitson TD, Samuel CS.

Kidney Int. 2014 Jul;86(1):75-85. doi: 10.1038/ki.2013.518. Epub 2014 Jan 15.

43.

Animal models of chronic kidney disease: useful but not perfect.

Becker GJ, Hewitson TD.

Nephrol Dial Transplant. 2013 Oct;28(10):2432-8. doi: 10.1093/ndt/gft071. Epub 2013 Jun 30. Review.

PMID:
23817139
44.

The anti-fibrotic hormone relaxin is not reno-protective, despite being active, in an experimental model of type 1 diabetes.

Wong SE, Samuel CS, Kelly DJ, Zhang Y, Becker GJ, Hewitson TD.

Protein Pept Lett. 2013 Sep;20(9):1029-38.

PMID:
23343143
45.

Fibrosis in the kidney: is a problem shared a problem halved?

Hewitson TD.

Fibrogenesis Tissue Repair. 2012 Jun 6;5(Suppl 1):S14. doi: 10.1186/1755-1536-5-S1-S14. eCollection 2012.

46.

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS.

Chow BS, Chew EG, Zhao C, Bathgate RA, Hewitson TD, Samuel CS.

PLoS One. 2012;7(8):e42714. doi: 10.1371/journal.pone.0042714. Epub 2012 Aug 22.

47.

Hypoxia and hypoxia signaling in tissue repair and fibrosis.

Lokmic Z, Musyoka J, Hewitson TD, Darby IA.

Int Rev Cell Mol Biol. 2012;296:139-85. doi: 10.1016/B978-0-12-394307-1.00003-5. Review.

PMID:
22559939
48.

Glomerular density and progression.

Hewitson TD, Becker GJ.

Nephrol Dial Transplant. 2012 May;27(5):2131-2; author reply 2132. doi: 10.1093/ndt/gfs009. No abstract available.

PMID:
22547752
49.

Explanting is an ex vivo model of renal epithelial-mesenchymal transition.

Winbanks CE, Darby IA, Kelynack KJ, Pouniotis D, Becker GJ, Hewitson TD.

J Biomed Biotechnol. 2011;2011:212819. doi: 10.1155/2011/212819. Epub 2011 Nov 24.

50.

Relaxin and castration in male mice protect from, but testosterone exacerbates, age-related cardiac and renal fibrosis, whereas estrogens are an independent determinant of organ size.

Hewitson TD, Zhao C, Wigg B, Lee SW, Simpson ER, Boon WC, Samuel CS.

Endocrinology. 2012 Jan;153(1):188-99. doi: 10.1210/en.2011-1311. Epub 2011 Oct 25.

PMID:
22028442

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