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Items: 36


miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity.

Hewitson JP, Shah KM, Brown N, Grevitt P, Hain S, Newling K, Sharp TV, Kaye PM, Lagos D.

EMBO Rep. 2019 Apr;20(4). pii: e46620. doi: 10.15252/embr.201846620. Epub 2019 Mar 4.


TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus.

Smyth DJ, Harcus Y, White MPJ, Gregory WF, Nahler J, Stephens I, Toke-Bjolgerud E, Hewitson JP, Ivens A, McSorley HJ, Maizels RM.

Int J Parasitol. 2018 Apr;48(5):379-385. doi: 10.1016/j.ijpara.2017.12.004. Epub 2018 Mar 3.


A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells.

Johnston CJC, Smyth DJ, Kodali RB, White MPJ, Harcus Y, Filbey KJ, Hewitson JP, Hinck CS, Ivens A, Kemter AM, Kildemoes AO, Le Bihan T, Soares DC, Anderton SM, Brenn T, Wigmore SJ, Woodcock HV, Chambers RC, Hinck AP, McSorley HJ, Maizels RM.

Nat Commun. 2017 Nov 23;8(1):1741. doi: 10.1038/s41467-017-01886-6.


HpARI Protein Secreted by a Helminth Parasite Suppresses Interleukin-33.

Osbourn M, Soares DC, Vacca F, Cohen ES, Scott IC, Gregory WF, Smyth DJ, Toivakka M, Kemter AM, le Bihan T, Wear M, Hoving D, Filbey KJ, Hewitson JP, Henderson H, Gonzàlez-Cìscar A, Errington C, Vermeren S, Astier AL, Wallace WA, Schwarze J, Ivens AC, Maizels RM, McSorley HJ.

Immunity. 2017 Oct 17;47(4):739-751.e5. doi: 10.1016/j.immuni.2017.09.015.


Macrophage origin limits functional plasticity in helminth-bacterial co-infection.

Rückerl D, Campbell SM, Duncan S, Sutherland TE, Jenkins SJ, Hewitson JP, Barr TA, Jackson-Jones LH, Maizels RM, Allen JE.

PLoS Pathog. 2017 Mar 23;13(3):e1006233. doi: 10.1371/journal.ppat.1006233. eCollection 2017 Mar.


Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections.

Maizels RM, Hewitson JP.

Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.MCHD-0043-2016. Review.


S6K2-mediated regulation of TRBP as a determinant of miRNA expression in human primary lymphatic endothelial cells.

Warner MJ, Bridge KS, Hewitson JP, Hodgkinson MR, Heyam A, Massa BC, Haslam JC, Chatzifrangkeskou M, Evans GJ, Plevin MJ, Sharp TV, Lagos D.

Nucleic Acids Res. 2016 Nov 16;44(20):9942-9955. Epub 2016 Jul 12.


Chronic Gastrointestinal Nematode Infection Mutes Immune Responses to Mycobacterial Infection Distal to the Gut.

Obieglo K, Feng X, Bollampalli VP, Dellacasa-Lindberg I, Classon C, Österblad M, Helmby H, Hewitson JP, Maizels RM, Gigliotti Rothfuchs A, Nylén S.

J Immunol. 2016 Mar 1;196(5):2262-71. doi: 10.4049/jimmunol.1500970. Epub 2016 Jan 27.


Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus.

Hewitson JP, Nguyen DL, van Diepen A, Smit CH, Koeleman CA, McSorley HJ, Murray J, Maizels RM, Hokke CH.

Int J Parasitol. 2016 Mar;46(3):157-170. doi: 10.1016/j.ijpara.2015.10.004. Epub 2015 Dec 12.


Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths.

Smith KA, Filbey KJ, Reynolds LA, Hewitson JP, Harcus Y, Boon L, Sparwasser T, Hämmerling G, Maizels RM.

Mucosal Immunol. 2016 Mar;9(2):428-43. doi: 10.1038/mi.2015.73. Epub 2015 Aug 19.


Concerted activity of IgG1 antibodies and IL-4/IL-25-dependent effector cells trap helminth larvae in the tissues following vaccination with defined secreted antigens, providing sterile immunity to challenge infection.

Hewitson JP, Filbey KJ, Esser-von Bieren J, Camberis M, Schwartz C, Murray J, Reynolds LA, Blair N, Robertson E, Harcus Y, Boon L, Huang SC, Yang L, Tu Y, Miller MJ, Voehringer D, Le Gros G, Harris N, Maizels RM.

PLoS Pathog. 2015 Mar 27;11(3):e1004676. doi: 10.1371/journal.ppat.1004676. eCollection 2015 Mar.


The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an 'M2' phenotype in response to Th2 immunologic challenge.

Mylonas KJ, Jenkins SJ, Castellan RF, Ruckerl D, McGregor K, Phythian-Adams AT, Hewitson JP, Campbell SM, MacDonald AS, Allen JE, Gray GA.

Immunobiology. 2015 Jul;220(7):924-33. doi: 10.1016/j.imbio.2015.01.013. Epub 2015 Feb 7.


Commensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasites.

Reynolds LA, Smith KA, Filbey KJ, Harcus Y, Hewitson JP, Redpath SA, Valdez Y, Yebra MJ, Finlay BB, Maizels RM.

Gut Microbes. 2014 Jul 1;5(4):522-32. doi: 10.4161/gmic.32155. Epub 2014 Aug 5.


MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus.

Reynolds LA, Harcus Y, Smith KA, Webb LM, Hewitson JP, Ross EA, Brown S, Uematsu S, Akira S, Gray D, Gray M, MacDonald AS, Cunningham AF, Maizels RM.

J Immunol. 2014 Sep 15;193(6):2984-93. doi: 10.4049/jimmunol.1401056. Epub 2014 Aug 11.


Vaccination against helminth parasite infections.

Hewitson JP, Maizels RM.

Expert Rev Vaccines. 2014 Apr;13(4):473-87. Review.


The secreted triose phosphate isomerase of Brugia malayi is required to sustain microfilaria production in vivo.

Hewitson JP, Rückerl D, Harcus Y, Murray J, Webb LM, Babayan SA, Allen JE, Kurniawan A, Maizels RM.

PLoS Pathog. 2014 Feb 27;10(2):e1003930. doi: 10.1371/journal.ppat.1003930. eCollection 2014 Feb. Erratum in: PLoS Pathog. 2014 Apr;10(4):e1004133.


Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection.

Filbey KJ, Grainger JR, Smith KA, Boon L, van Rooijen N, Harcus Y, Jenkins S, Hewitson JP, Maizels RM.

Immunol Cell Biol. 2014 May-Jun;92(5):436-48. doi: 10.1038/icb.2013.109. Epub 2014 Feb 4.


IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1.

Jenkins SJ, Ruckerl D, Thomas GD, Hewitson JP, Duncan S, Brombacher F, Maizels RM, Hume DA, Allen JE.

J Exp Med. 2013 Oct 21;210(11):2477-91. doi: 10.1084/jem.20121999. Epub 2013 Oct 7.


Secretion of protective antigens by tissue-stage nematode larvae revealed by proteomic analysis and vaccination-induced sterile immunity.

Hewitson JP, Ivens AC, Harcus Y, Filbey KJ, McSorley HJ, Murray J, Bridgett S, Ashford D, Dowle AA, Maizels RM.

PLoS Pathog. 2013 Aug;9(8):e1003492. doi: 10.1371/journal.ppat.1003492. Epub 2013 Aug 15.


Immunomodulation by helminth parasites: defining mechanisms and mediators.

McSorley HJ, Hewitson JP, Maizels RM.

Int J Parasitol. 2013 Mar;43(3-4):301-10. doi: 10.1016/j.ijpara.2012.11.011. Epub 2013 Jan 3. Review.


Antibodies and IL-3 support helminth-induced basophil expansion.

Herbst T, Esser J, Prati M, Kulagin M, Stettler R, Zaiss MM, Hewitson JP, Merky P, Verbeek JS, Bourquin C, Camberis M, Prout M, Maizels RM, Le Gros G, Harris NL.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14954-9. doi: 10.1073/pnas.1117584109. Epub 2012 Aug 28.


Susceptibility and immunity to helminth parasites.

Maizels RM, Hewitson JP, Smith KA.

Curr Opin Immunol. 2012 Aug;24(4):459-66. doi: 10.1016/j.coi.2012.06.003. Epub 2012 Jul 12. Review.


Heligmosomoides polygyrus elicits a dominant nonprotective antibody response directed against restricted glycan and peptide epitopes.

Hewitson JP, Filbey KJ, Grainger JR, Dowle AA, Pearson M, Murray J, Harcus Y, Maizels RM.

J Immunol. 2011 Nov 1;187(9):4764-77. doi: 10.4049/jimmunol.1004140. Epub 2011 Sep 30.


Immune modulation and modulators in Heligmosomoides polygyrus infection.

Maizels RM, Hewitson JP, Murray J, Harcus YM, Dayer B, Filbey KJ, Grainger JR, McSorley HJ, Reynolds LA, Smith KA.

Exp Parasitol. 2012 Sep;132(1):76-89. doi: 10.1016/j.exppara.2011.08.011. Epub 2011 Aug 22. Review.


Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins.

Hewitson JP, Harcus Y, Murray J, van Agtmaal M, Filbey KJ, Grainger JR, Bridgett S, Blaxter ML, Ashton PD, Ashford DA, Curwen RS, Wilson RA, Dowle AA, Maizels RM.

J Proteomics. 2011 Aug 24;74(9):1573-94. doi: 10.1016/j.jprot.2011.06.002. Epub 2011 Jun 29.


Heligmosomoides polygyrus: one species still.

Maizels RM, Hewitson JP, Gause WC.

Trends Parasitol. 2011 Mar;27(3):100-1. doi: 10.1016/ Epub 2010 Dec 14. No abstract available.


Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-β pathway.

Grainger JR, Smith KA, Hewitson JP, McSorley HJ, Harcus Y, Filbey KJ, Finney CA, Greenwood EJ, Knox DP, Wilson MS, Belkaid Y, Rudensky AY, Maizels RM.

J Exp Med. 2010 Oct 25;207(11):2331-41. doi: 10.1084/jem.20101074. Epub 2010 Sep 27.


Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity.

Hewitson JP, Grainger JR, Maizels RM.

Mol Biochem Parasitol. 2009 Sep;167(1):1-11. doi: 10.1016/j.molbiopara.2009.04.008. Epub 2009 May 3. Review.


The secretome of the filarial parasite, Brugia malayi: proteomic profile of adult excretory-secretory products.

Hewitson JP, Harcus YM, Curwen RS, Dowle AA, Atmadja AK, Ashton PD, Wilson A, Maizels RM.

Mol Biochem Parasitol. 2008 Jul;160(1):8-21. doi: 10.1016/j.molbiopara.2008.02.007. Epub 2008 Feb 16.


Four decades of conjoined twins at Red Cross Children's Hospital--lessons learned.

Rode H, Fieggen AG, Brown RA, Cywes S, Davies MR, Hewitson JP, Hoffman EB, Jee LD, Lawrenson J, Mann MD, Matthews LS, Millar AJ, Numanoglu A, Peter JC, Thomas J, Wainwright H.

S Afr Med J. 2006 Sep;96(9 Pt 2):931-40.


Schistosome larvae stimulate macrophage cytokine production through TLR4-dependent and -independent pathways.

Jenkins SJ, Hewitson JP, Ferret-Bernard S, Mountford AP.

Int Immunol. 2005 Nov;17(11):1409-18. Epub 2005 Sep 26.


Modulation of the host's immune response by schistosome larvae.

Jenkins SJ, Hewitson JP, Jenkins GR, Mountford AP.

Parasite Immunol. 2005 Oct-Nov;27(10-11):385-93. Review.


Immunity induced by the radiation-attenuated schistosome vaccine.

Hewitson JP, Hamblin PA, Mountford AP.

Parasite Immunol. 2005 Jul-Aug;27(7-8):271-80. Review.


Role of thoracic surgery for childhood tuberculosis.

Hewitson JP, Von Oppell UO.

World J Surg. 1997 Jun;21(5):468-74.


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