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A defined antigen skin test for the diagnosis of bovine tuberculosis.

Srinivasan S, Jones G, Veerasami M, Steinbach S, Holder T, Zewude A, Fromsa A, Ameni G, Easterling L, Bakker D, Juleff N, Gifford G, Hewinson RG, Vordermeier HM, Kapur V.

Sci Adv. 2019 Jul 17;5(7):eaax4899. doi: 10.1126/sciadv.aax4899. eCollection 2019 Jul.


Tuberculin Skin Testing Boosts Interferon Gamma Responses to DIVA Reagents in Mycobacterium bovis-Infected Cattle.

Jones GJ, Coad M, Khatri B, Bezos J, Parlane NA, Buddle BM, Villarreal-Ramos B, Hewinson RG, Vordermeier HM.

Clin Vaccine Immunol. 2017 May 5;24(5). pii: e00551-16. doi: 10.1128/CVI.00551-16. Print 2017 May.


Vaccination of calves with Mycobacterium bovis Bacillus Calmette-Guerin reduces the frequency and severity of lesions of bovine tuberculosis under a natural transmission setting in Ethiopia.

Ameni G, Tafess K, Zewde A, Eguale T, Tilahun M, Hailu T, Sirak A, Salguero FJ, Berg S, Aseffa A, Hewinson RG, Vordermeier HM.

Transbound Emerg Dis. 2018 Feb;65(1):96-104. doi: 10.1111/tbed.12618. Epub 2017 Feb 6.


Experimental Infection Models of Tuberculosis in Domestic Livestock.

Buddle BM, Vordermeier HM, Hewinson RG.

Microbiol Spectr. 2016 Aug;4(4). doi: 10.1128/microbiolspec.TBTB2-0017-2016. Review.


Vaccination of cattle with a high dose of BCG vaccine 3 weeks after experimental infection with Mycobacterium bovis increased the inflammatory response, but not tuberculous pathology.

Buddle BM, Shu D, Parlane NA, Subharat S, Heiser A, Hewinson RG, Vordermeier HM, Wedlock DN.

Tuberculosis (Edinb). 2016 Jul;99:120-7. doi: 10.1016/ Epub 2016 May 27.


Development of immune-diagnostic reagents to diagnose bovine tuberculosis in cattle.

Vordermeier HM, Jones GJ, Buddle BM, Hewinson RG.

Vet Immunol Immunopathol. 2016 Nov 15;181:10-14. doi: 10.1016/j.vetimm.2016.02.003. Epub 2016 Feb 10. Review.


Bovine Tuberculosis in Cattle: Vaccines, DIVA Tests, and Host Biomarker Discovery.

Vordermeier HM, Jones GJ, Buddle BM, Hewinson RG, Villarreal-Ramos B.

Annu Rev Anim Biosci. 2016;4:87-109. doi: 10.1146/annurev-animal-021815-111311. Review.


Population Genomics of Mycobacterium tuberculosis in Ethiopia Contradicts the Virgin Soil Hypothesis for Human Tuberculosis in Sub-Saharan Africa.

Comas I, Hailu E, Kiros T, Bekele S, Mekonnen W, Gumi B, Tschopp R, Ameni G, Hewinson RG, Robertson BD, Goig GA, Stucki D, Gagneux S, Aseffa A, Young D, Berg S.

Curr Biol. 2015 Dec 21;25(24):3260-6. doi: 10.1016/j.cub.2015.10.061. Epub 2015 Dec 10.


Admixture mapping of tuberculosis and pigmentation-related traits in an African-European hybrid cattle population.

Kassahun Y, Mattiangeli V, Ameni G, Hailu E, Aseffa A, Young DB, Hewinson RG, Vordermeier HM, Bradley DG.

Front Genet. 2015 Jun 15;6:210. doi: 10.3389/fgene.2015.00210. eCollection 2015.


Development of a BCG challenge model for the testing of vaccine candidates against tuberculosis in cattle.

Villarreal-Ramos B, Berg S, Chamberlain L, McShane H, Hewinson RG, Clifford D, Vordermeier M.

Vaccine. 2014 Sep 29;32(43):5645-9. doi: 10.1016/j.vaccine.2014.08.009. Epub 2014 Aug 17.


Vaccination against tuberculosis in badgers and cattle: an overview of the challenges, developments and current research priorities in Great Britain.

Chambers MA, Carter SP, Wilson GJ, Jones G, Brown E, Hewinson RG, Vordermeier M.

Vet Rec. 2014 Jul 26;175(4):90-6. doi: 10.1136/vr.102581. Review.


Vaccination of domestic animals against tuberculosis: review of progress and contributions to the field of the TBSTEP project.

Vordermeier HM, Pérez de Val B, Buddle BM, Villarreal-Ramos B, Jones GJ, Hewinson RG, Domingo M.

Res Vet Sci. 2014 Oct;97 Suppl:S53-60. doi: 10.1016/j.rvsc.2014.04.015. Epub 2014 May 6. Review.


Effect of dose and route of immunisation on the immune response induced in cattle by heterologous Bacille Calmette-Guerin priming and recombinant adenoviral vector boosting.

Dean G, Clifford D, Gilbert S, McShane H, Hewinson RG, Vordermeier HM, Villarreal-Ramos B.

Vet Immunol Immunopathol. 2014 Apr 15;158(3-4):208-13. doi: 10.1016/j.vetimm.2014.01.010. Epub 2014 Jan 28.


Comparison of the immunogenicity and protection against bovine tuberculosis following immunization by BCG-priming and boosting with adenovirus or protein based vaccines.

Dean G, Whelan A, Clifford D, Salguero FJ, Xing Z, Gilbert S, McShane H, Hewinson RG, Vordermeier M, Villarreal-Ramos B.

Vaccine. 2014 Mar 5;32(11):1304-10. doi: 10.1016/j.vaccine.2013.11.045. Epub 2013 Nov 19.


Genome-level analyses of Mycobacterium bovis lineages reveal the role of SNPs and antisense transcription in differential gene expression.

Golby P, Nunez J, Witney A, Hinds J, Quail MA, Bentley S, Harris S, Smith N, Hewinson RG, Gordon SV.

BMC Genomics. 2013 Oct 17;14:710. doi: 10.1186/1471-2164-14-710.


The phylogeny and population structure of Mycobacterium bovis in the British Isles.

Allen AR, Dale J, McCormick C, Mallon TR, Costello E, Gordon SV, Hewinson RG, Skuce RA, Smith NH.

Infect Genet Evol. 2013 Dec;20:8-15. doi: 10.1016/j.meegid.2013.08.003. Epub 2013 Aug 9.


High prevalence of bovine tuberculosis in dairy cattle in central ethiopia: implications for the dairy industry and public health.

Firdessa R, Tschopp R, Wubete A, Sombo M, Hailu E, Erenso G, Kiros T, Yamuah L, Vordermeier M, Hewinson RG, Young D, Gordon SV, Sahile M, Aseffa A, Berg S.

PLoS One. 2012;7(12):e52851. doi: 10.1371/journal.pone.0052851. Epub 2012 Dec 28.


BCG vaccination reduces risk of tuberculosis infection in vaccinated badgers and unvaccinated badger cubs.

Carter SP, Chambers MA, Rushton SP, Shirley MD, Schuchert P, Pietravalle S, Murray A, Rogers F, Gettinby G, Smith GC, Delahay RJ, Hewinson RG, McDonald RA.

PLoS One. 2012;7(12):e49833. doi: 10.1371/journal.pone.0049833. Epub 2012 Dec 12.


A natural-transmission model of bovine tuberculosis provides novel disease insights.

Khatri BL, Coad M, Clifford DJ, Hewinson RG, Whelan AO, Vordermeier HM.

Vet Rec. 2012 Nov 3;171(18):448. doi: 10.1136/vr.101072. Epub 2012 Aug 30. No abstract available.


Estimation of the relative sensitivity of the comparative tuberculin skin test in tuberculous cattle herds subjected to depopulation.

Karolemeas K, de la Rua-Domenech R, Cooper R, Goodchild AV, Clifton-Hadley RS, Conlan AJ, Mitchell AP, Hewinson RG, Donnelly CA, Wood JL, McKinley TJ.

PLoS One. 2012;7(8):e43217. doi: 10.1371/journal.pone.0043217. Epub 2012 Aug 21.


Conserved immune recognition hierarchy of mycobacterial PE/PPE proteins during infection in natural hosts.

Vordermeier HM, Hewinson RG, Wilkinson RJ, Wilkinson KA, Gideon HP, Young DB, Sampson SL.

PLoS One. 2012;7(8):e40890. doi: 10.1371/journal.pone.0040890. Epub 2012 Aug 1.


Duration of immunity against Mycobacterium bovis following neonatal vaccination with bacillus Calmette-Guérin Danish: significant protection against infection at 12, but not 24, months.

Thom ML, McAulay M, Vordermeier HM, Clifford D, Hewinson RG, Villarreal-Ramos B, Hope JC.

Clin Vaccine Immunol. 2012 Aug;19(8):1254-60. doi: 10.1128/CVI.00301-12. Epub 2012 Jun 20.


Evaluation of two cocktails containing ESAT-6, CFP-10 and Rv-3615c in the intradermal test and the interferon-γ assay for diagnosis of bovine tuberculosis.

Casal C, Bezos J, Díez-Guerrier A, Álvarez J, Romero B, de Juan L, Rodriguez-Campos S, Vordermeier M, Whelan A, Hewinson RG, Mateos A, Domínguez L, Aranaz A.

Prev Vet Med. 2012 Jun 1;105(1-2):149-54. doi: 10.1016/j.prevetmed.2012.02.007. Epub 2012 Mar 3.


The influence of cattle breed on susceptibility to bovine tuberculosis in Ethiopia.

Vordermeier M, Ameni G, Berg S, Bishop R, Robertson BD, Aseffa A, Hewinson RG, Young DB.

Comp Immunol Microbiol Infect Dis. 2012 May;35(3):227-32. doi: 10.1016/j.cimid.2012.01.003. Epub 2012 Feb 1. Review.


An inter-laboratory validation of a real time PCR assay to measure host excretion of bacterial pathogens, particularly of Mycobacterium bovis.

Travis ER, Gaze WH, Pontiroli A, Sweeney FP, Porter D, Mason S, Keeling MJ, Jones RM, Sawyer J, Aranaz A, Rizaldos EC, Cork J, Delahay RJ, Wilson GJ, Hewinson RG, Courtenay O, Wellington EM.

PLoS One. 2011;6(11):e27369. doi: 10.1371/journal.pone.0027369. Epub 2011 Nov 14.


Protection against bovine tuberculosis induced by oral vaccination of cattle with Mycobacterium bovis BCG is not enhanced by co-administration of mycobacterial protein vaccines.

Wedlock DN, Aldwell FE, Vordermeier HM, Hewinson RG, Buddle BM.

Vet Immunol Immunopathol. 2011 Dec 15;144(3-4):220-7. doi: 10.1016/j.vetimm.2011.09.005. Epub 2011 Sep 29.


European 2--a clonal complex of Mycobacterium bovis dominant in the Iberian Peninsula.

Rodriguez-Campos S, Schürch AC, Dale J, Lohan AJ, Cunha MV, Botelho A, De Cruz K, Boschiroli ML, Boniotti MB, Pacciarini M, Garcia-Pelayo MC, Romero B, de Juan L, Domínguez L, Gordon SV, van Soolingen D, Loftus B, Berg S, Hewinson RG, Aranaz A, Smith NH.

Infect Genet Evol. 2012 Jun;12(4):866-72. doi: 10.1016/j.meegid.2011.09.004. Epub 2011 Sep 14.


Low oral BCG doses fail to protect cattle against an experimental challenge with Mycobacterium bovis.

Buddle BM, Aldwell FE, de Lisle GW, Vordermeier HM, Hewinson RG, Wedlock DN.

Tuberculosis (Edinb). 2011 Sep;91(5):400-5. doi: 10.1016/ Epub 2011 Jul 31.


Systemic BCG immunization induces persistent lung mucosal multifunctional CD4 T(EM) cells which expand following virulent mycobacterial challenge.

Kaveh DA, Bachy VS, Hewinson RG, Hogarth PJ.

PLoS One. 2011;6(6):e21566. doi: 10.1371/journal.pone.0021566. Epub 2011 Jun 24.


Immune responses to the enduring hypoxic response antigen Rv0188 are preferentially detected in Mycobacterium bovis infected cattle with low pathology.

Jones GJ, Pirson C, Gideon HP, Wilkinson KA, Sherman DR, Wilkinson RJ, Hewinson RG, Vordermeier HM.

PLoS One. 2011;6(6):e21371. doi: 10.1371/journal.pone.0021371. Epub 2011 Jun 21.


Lack of correlation between BCG-induced tuberculin skin test sensitisation and protective immunity in cattle.

Whelan AO, Coad M, Upadhyay BL, Clifford DJ, Hewinson RG, Vordermeier HM.

Vaccine. 2011 Jul 26;29(33):5453-8. doi: 10.1016/j.vaccine.2011.05.057. Epub 2011 Jun 2.


European 1: a globally important clonal complex of Mycobacterium bovis.

Smith NH, Berg S, Dale J, Allen A, Rodriguez S, Romero B, Matos F, Ghebremichael S, Karoui C, Donati C, Machado Ada C, Mucavele C, Kazwala RR, Hilty M, Cadmus S, Ngandolo BN, Habtamu M, Oloya J, Muller A, Milian-Suazo F, Andrievskaia O, Projahn M, Barandiarán S, Macías A, Müller B, Zanini MS, Ikuta CY, Rodriguez CA, Pinheiro SR, Figueroa A, Cho SN, Mosavari N, Chuang PC, Jou R, Zinsstag J, van Soolingen D, Costello E, Aseffa A, Proaño-Perez F, Portaels F, Rigouts L, Cataldi AA, Collins DM, Boschiroli ML, Hewinson RG, Ferreira Neto JS, Surujballi O, Tadyon K, Botelho A, Zárraga AM, Buller N, Skuce R, Michel A, Aranaz A, Gordon SV, Jeon BY, Källenius G, Niemann S, Boniotti MB, van Helden PD, Harris B, Zumárraga MJ, Kremer K.

Infect Genet Evol. 2011 Aug;11(6):1340-51. doi: 10.1016/j.meegid.2011.04.027. Epub 2011 May 6.


Assessment of in vivo and in vitro tuberculosis diagnostic tests in Mycobacterium caprae naturally infected caprine flocks.

Bezos J, Alvarez J, de Juan L, Romero B, Rodríguez S, Fernández-de-Mera IG, Hewinson RG, Vordermeier M, Mateos A, Domínguez L, Aranaz A.

Prev Vet Med. 2011 Jul 1;100(3-4):187-92. doi: 10.1016/j.prevetmed.2011.03.012. Epub 2011 May 4.


The use of binding-prediction models to identify M. bovis-specific antigenic peptides for screening assays in bovine tuberculosis.

Jones GJ, Bagaini F, Hewinson RG, Vordermeier HM.

Vet Immunol Immunopathol. 2011 Jun 15;141(3-4):239-45. doi: 10.1016/j.vetimm.2011.03.006. Epub 2011 Mar 9.


Protection of Eurasian badgers (Meles meles) from tuberculosis after intra-muscular vaccination with different doses of BCG.

Lesellier S, Palmer S, Gowtage-Sequiera S, Ashford R, Dalley D, Davé D, Weyer U, Salguero FJ, Nunez A, Crawshaw T, Corner LA, Hewinson RG, Chambers MA.

Vaccine. 2011 May 12;29(21):3782-90. doi: 10.1016/j.vaccine.2011.03.028. Epub 2011 Apr 7.


Update on vaccination of cattle and wildlife populations against tuberculosis.

Buddle BM, Wedlock DN, Denis M, Vordermeier HM, Hewinson RG.

Vet Microbiol. 2011 Jul 5;151(1-2):14-22. doi: 10.1016/j.vetmic.2011.02.021. Epub 2011 Feb 24. Review.


Exploring the use of molecular epidemiology to track bovine tuberculosis in Nigeria: an overview from 2002 to 2004.

Cadmus SI, Gordon SV, Hewinson RG, Smith NH.

Vet Microbiol. 2011 Jul 5;151(1-2):133-8. doi: 10.1016/j.vetmic.2011.02.036. Epub 2011 Feb 24.


Mycobacterium bovis antigens for the differential diagnosis of vaccinated and infected cattle.

Vordermeier M, Gordon SV, Hewinson RG.

Vet Microbiol. 2011 Jul 5;151(1-2):8-13. doi: 10.1016/j.vetmic.2011.02.020. Epub 2011 Feb 24.


Identification of surrogates and correlates of protection in protective immunity against Mycobacterium bovis infection induced in neonatal calves by vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish.

Hope JC, Thom ML, McAulay M, Mead E, Vordermeier HM, Clifford D, Hewinson RG, Villarreal-Ramos B.

Clin Vaccine Immunol. 2011 Mar;18(3):373-9. doi: 10.1128/CVI.00543-10. Epub 2011 Jan 12.


Bacillus Calmette-Guérin vaccination reduces the severity and progression of tuberculosis in badgers.

Chambers MA, Rogers F, Delahay RJ, Lesellier S, Ashford R, Dalley D, Gowtage S, Davé D, Palmer S, Brewer J, Crawshaw T, Clifton-Hadley R, Carter S, Cheeseman C, Hanks C, Murray A, Palphramand K, Pietravalle S, Smith GC, Tomlinson A, Walker NJ, Wilson GJ, Corner LA, Rushton SP, Shirley MD, Gettinby G, McDonald RA, Hewinson RG.

Proc Biol Sci. 2011 Jun 22;278(1713):1913-20. doi: 10.1098/rspb.2010.1953. Epub 2010 Dec 1.


African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa.

Berg S, Garcia-Pelayo MC, Müller B, Hailu E, Asiimwe B, Kremer K, Dale J, Boniotti MB, Rodriguez S, Hilty M, Rigouts L, Firdessa R, Machado A, Mucavele C, Ngandolo BN, Bruchfeld J, Boschiroli L, Müller A, Sahraoui N, Pacciarini M, Cadmus S, Joloba M, van Soolingen D, Michel AL, Djønne B, Aranaz A, Zinsstag J, van Helden P, Portaels F, Kazwala R, Källenius G, Hewinson RG, Aseffa A, Gordon SV, Smith NH.

J Bacteriol. 2011 Feb;193(3):670-8. doi: 10.1128/JB.00750-10. Epub 2010 Nov 19. Erratum in: J Bacteriol. 2012 Mar;194(6):1641.


Simultaneous measurement of antigen-stimulated interleukin-1 beta and gamma interferon production enhances test sensitivity for the detection of Mycobacterium bovis infection in cattle.

Jones GJ, Pirson C, Hewinson RG, Vordermeier HM.

Clin Vaccine Immunol. 2010 Dec;17(12):1946-51. doi: 10.1128/CVI.00377-10. Epub 2010 Oct 6.


Field evaluation of the efficacy of Mycobacterium bovis bacillus Calmette-Guerin against bovine tuberculosis in neonatal calves in Ethiopia.

Ameni G, Vordermeier M, Aseffa A, Young DB, Hewinson RG.

Clin Vaccine Immunol. 2010 Oct;17(10):1533-8. doi: 10.1128/CVI.00222-10. Epub 2010 Aug 18.


Screening of predicted secreted antigens from Mycobacterium bovis identifies potential novel differential diagnostic reagents.

Jones GJ, Hewinson RG, Vordermeier HM.

Clin Vaccine Immunol. 2010 Sep;17(9):1344-8. doi: 10.1128/CVI.00261-10. Epub 2010 Jul 28.


Oral vaccination of badgers (Meles meles) with BCG and protective immunity against endobronchial challenge with Mycobacterium bovis.

Corner LA, Costello E, O'Meara D, Lesellier S, Aldwell FE, Singh M, Hewinson RG, Chambers MA, Gormley E.

Vaccine. 2010 Aug 31;28(38):6265-72. doi: 10.1016/j.vaccine.2010.06.120. Epub 2010 Jul 15.


Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue.

Mendoza Lopez P, Golby P, Wooff E, Garcia JN, Garcia Pelayo MC, Conlon K, Gema Camacho A, Hewinson RG, Polaina J, Suárez García A, Gordon SV.

Microbiology. 2010 Jul;156(Pt 7):2112-2123. doi: 10.1099/mic.0.037200-0. Epub 2010 Apr 8.


Bovine tuberculosis: effect of the tuberculin skin test on in vitro interferon gamma responses.

Schiller I, Vordermeier HM, Waters WR, Whelan AO, Coad M, Gormley E, Buddle BM, Palmer M, Thacker T, McNair J, Welsh M, Hewinson RG, Oesch B.

Vet Immunol Immunopathol. 2010 Jul;136(1-2):1-11. doi: 10.1016/j.vetimm.2010.02.007. Epub 2010 Feb 13. Review.


Screening of predicted secreted antigens from Mycobacterium bovis reveals the immunodominance of the ESAT-6 protein family.

Jones GJ, Gordon SV, Hewinson RG, Vordermeier HM.

Infect Immun. 2010 Mar;78(3):1326-32. doi: 10.1128/IAI.01246-09. Epub 2010 Jan 19.


Immune responses in cattle inoculated with Mycobacterium bovis, Mycobacterium tuberculosis, or Mycobacterium kansasii.

Waters WR, Whelan AO, Lyashchenko KP, Greenwald R, Palmer MV, Harris BN, Hewinson RG, Vordermeier HM.

Clin Vaccine Immunol. 2010 Feb;17(2):247-52. doi: 10.1128/CVI.00442-09. Epub 2009 Dec 9.

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