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Items: 37


Combining genomics and epidemiology to analyse bi-directional transmission of Mycobacterium bovis in a multi-host system.

Crispell J, Benton CH, Balaz D, De Maio N, Ahkmetova A, Allen A, Biek R, Presho EL, Dale J, Hewinson G, Lycett SJ, Nunez-Garcia J, Skuce RA, Trewby H, Wilson DJ, Zadoks RN, Delahay RJ, Kao RR.

Elife. 2019 Dec 17;8. pii: e45833. doi: 10.7554/eLife.45833.


Response to: Systematic review: animal studies of TB vaccines.

Williams A, Sharpe S, Verreck F, Vordermeier M, Hewinson G.

Int J Epidemiol. 2016 Apr;45(2):583-4. doi: 10.1093/ije/dyw059. No abstract available.


Investigation of the high rates of extrapulmonary tuberculosis in Ethiopia reveals no single driving factor and minimal evidence for zoonotic transmission of Mycobacterium bovis infection.

Berg S, Schelling E, Hailu E, Firdessa R, Gumi B, Erenso G, Gadisa E, Mengistu A, Habtamu M, Hussein J, Kiros T, Bekele S, Mekonnen W, Derese Y, Zinsstag J, Ameni G, Gagneux S, Robertson BD, Tschopp R, Hewinson G, Yamuah L, Gordon SV, Aseffa A.

BMC Infect Dis. 2015 Mar 3;15:112. doi: 10.1186/s12879-015-0846-7.


Transmission of Mycobacterium tuberculosis between farmers and cattle in central Ethiopia.

Ameni G, Tadesse K, Hailu E, Deresse Y, Medhin G, Aseffa A, Hewinson G, Vordermeier M, Berg S.

PLoS One. 2013 Oct 10;8(10):e76891. doi: 10.1371/journal.pone.0076891. eCollection 2013.


Splitting of a prevalent Mycobacterium bovis spoligotype by variable-number tandem-repeat typing reveals high heterogeneity in an evolving clonal group.

Rodriguez-Campos S, Navarro Y, Romero B, de Juan L, Bezos J, Mateos A, Golby P, Smith NH, Hewinson GR, Domínguez L, García-de-Viedma D, Aranaz A.

J Clin Microbiol. 2013 Nov;51(11):3658-65. doi: 10.1128/JCM.01271-13. Epub 2013 Aug 28.


Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia.

Firdessa R, Berg S, Hailu E, Schelling E, Gumi B, Erenso G, Gadisa E, Kiros T, Habtamu M, Hussein J, Zinsstag J, Robertson BD, Ameni G, Lohan AJ, Loftus B, Comas I, Gagneux S, Tschopp R, Yamuah L, Hewinson G, Gordon SV, Young DB, Aseffa A.

Emerg Infect Dis. 2013 Mar;19(3):460-3. doi: 10.3201/eid1903.120256.


Mycobacterium tuberculosis infection in grazing cattle in central Ethiopia.

Ameni G, Vordermeier M, Firdessa R, Aseffa A, Hewinson G, Gordon SV, Berg S.

Vet J. 2011 Jun;188(3):359-61. doi: 10.1016/j.tvjl.2010.05.005. Epub 2010 Jun 8.


Development of a skin test for bovine tuberculosis for differentiating infected from vaccinated animals.

Whelan AO, Clifford D, Upadhyay B, Breadon EL, McNair J, Hewinson GR, Vordermeier MH.

J Clin Microbiol. 2010 Sep;48(9):3176-81. doi: 10.1128/JCM.00420-10. Epub 2010 Jun 30.


Performance of the Enferplex TB assay with cattle in Great Britain and assessment of its suitability as a test to distinguish infected and vaccinated animals.

Whelan C, Whelan AO, Shuralev E, Kwok HF, Hewinson G, Clarke J, Vordermeier HM.

Clin Vaccine Immunol. 2010 May;17(5):813-7. doi: 10.1128/CVI.00489-09. Epub 2010 Mar 10.


Revisiting host preference in the Mycobacterium tuberculosis complex: experimental infection shows M. tuberculosis H37Rv to be avirulent in cattle.

Whelan AO, Coad M, Cockle PJ, Hewinson G, Vordermeier M, Gordon SV.

PLoS One. 2010 Jan 1;5(1):e8527. doi: 10.1371/journal.pone.0008527.


Comparison of different testing schemes to increase the detection Mycobacterium bovis infection in Ethiopian cattle.

Ameni G, Aseffa A, Hewinson G, Vordermeier M.

Trop Anim Health Prod. 2010 Mar;42(3):375-83. doi: 10.1007/s11250-009-9429-1. Epub 2009 Sep 13.


Development of a simple, sensitive, rapid test which discriminates BCG-vaccinated from Mycobacterium bovis-infected cattle.

Sopp P, Coad M, Hewinson G, Howard CJ, Cheallaigh CN, Keane J, Harris J, Hope JC.

Vaccine. 2008 Oct 9;26(43):5470-6. doi: 10.1016/j.vaccine.2008.07.059. Epub 2008 Aug 8.


Appraisal of interpretation criteria for the comparative intradermal tuberculin test for diagnosis of tuberculosis in cattle in central Ethiopia.

Ameni G, Hewinson G, Aseffa A, Young D, Vordermeier M.

Clin Vaccine Immunol. 2008 Aug;15(8):1272-6. doi: 10.1128/CVI.00114-08. Epub 2008 May 21.


High prevalence and increased severity of pathology of bovine tuberculosis in Holsteins compared to zebu breeds under field cattle husbandry in central Ethiopia.

Ameni G, Aseffa A, Engers H, Young D, Gordon S, Hewinson G, Vordermeier M.

Clin Vaccine Immunol. 2007 Oct;14(10):1356-61. Epub 2007 Aug 29.


Distribution and activation of T-lymphocyte subsets in tuberculous bovine lymph-node granulomas.

Liebana E, Marsh S, Gough J, Nunez A, Vordermeier HM, Whelan A, Spencer Y, Clifton-Hardley R, Hewinson G, Johnson L.

Vet Pathol. 2007 May;44(3):366-72.


Introduction of bovine tuberculosis to north-east England by bought-in cattle.

Gopal R, Goodchild A, Hewinson G, de la Rua Domenech R, Clifton-Hadley R.

Vet Rec. 2006 Aug 26;159(9):265-71.


Low-dose Mycobacterium bovis infection in cattle results in pathology indistinguishable from that of high-dose infection.

Johnson L, Dean G, Rhodes S, Hewinson G, Vordermeier M, Wangoo A.

Tuberculosis (Edinb). 2007 Jan;87(1):71-6. Epub 2006 May 24.


Mycobacterium bovis isolates from tuberculous lesions in Chadian zebu carcasses.

Diguimbaye-Djaibé C, Hilty M, Ngandolo R, Mahamat HH, Pfyffer GE, Baggi F, Hewinson G, Tanner M, Zinsstag J, Schelling E.

Emerg Infect Dis. 2006 May;12(5):769-71.


Bovine tuberculosis (Mycobacterium bovis) in British farmland wildlife: the importance to agriculture.

Mathews F, Macdonald DW, Taylor GM, Gelling M, Norman RA, Honess PE, Foster R, Gower CM, Varley S, Harris A, Palmer S, Hewinson G, Webster JP.

Proc Biol Sci. 2006 Feb 7;273(1584):357-65.


Immunohistochemical markers augment evaluation of vaccine efficacy and disease severity in bacillus Calmette-Guerin (BCG) vaccinated cattle challenged with Mycobacterium bovis.

Johnson L, Gough J, Spencer Y, Hewinson G, Vordermeier M, Wangoo A.

Vet Immunol Immunopathol. 2006 Jun 15;111(3-4):219-29. Epub 2006 Mar 15.


Antigen mining with iterative genome screens identifies novel diagnostics for the Mycobacterium tuberculosis complex.

Ewer K, Cockle P, Gordon S, Mansoor H, Govaerts M, Walravens K, Marché S, Hewinson G, Vordermeier M.

Clin Vaccine Immunol. 2006 Jan;13(1):90-7.


Advanced granulomatous lesions in Mycobacterium bovis-infected cattle are associated with increased expression of type I procollagen, gammadelta (WC1+) T cells and CD 68+ cells.

Wangoo A, Johnson L, Gough J, Ackbar R, Inglut S, Hicks D, Spencer Y, Hewinson G, Vordermeier M.

J Comp Pathol. 2005 Nov;133(4):223-34. Epub 2005 Sep 8.


First isolation of Mycobacterium microti (Llama-type) from a dog.

Deforges L, Boulouis HJ, Thibaud JL, Boulouha L, Sougakoff W, Blot S, Hewinson G, Truffot-Pernot C, Haddad N.

Vet Microbiol. 2004 Nov 15;103(3-4):249-53.


RNA encoding the MPT83 antigen induces protective immune responses against Mycobacterium tuberculosis infection.

Xue T, Stavropoulos E, Yang M, Ragno S, Vordermeier M, Chambers M, Hewinson G, Lowrie DB, Colston MJ, Tascon RE.

Infect Immun. 2004 Nov;72(11):6324-9.


Mycobacterium bovis infection, United Kingdom.

Smith RM, Drobniewski F, Gibson A, Montague JD, Logan MN, Hunt D, Hewinson G, Salmon RL, O'Neill B.

Emerg Infect Dis. 2004 Mar;10(3):539-41.


Molecular epidemiology of disease due to Mycobacterium bovis in humans in the United Kingdom.

Gibson AL, Hewinson G, Goodchild T, Watt B, Story A, Inwald J, Drobniewski FA.

J Clin Microbiol. 2004 Jan;42(1):431-4.


Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-vaccinated Malawian young adults.

Black GF, Weir RE, Chaguluka SD, Warndorff D, Crampin AC, Mwaungulu L, Sichali L, Floyd S, Bliss L, Jarman E, Donovan L, Andersen P, Britton W, Hewinson G, Huygen K, Paulsen J, Singh M, Prestidge R, Fine PE, Dockrell HM.

Clin Diagn Lab Immunol. 2003 Jul;10(4):602-11.


DNA injection in combination with electroporation: a novel method for vaccination of farmed ruminants.

Tollefsen S, Vordermeier M, Olsen I, Storset AK, Reitan LJ, Clifford D, Lowrie DB, Wiker HG, Huygen K, Hewinson G, Mathiesen I, Tjelle TE.

Scand J Immunol. 2003 Mar;57(3):229-38.


Improved cellular and humoral immune responses against Mycobacterium tuberculosis antigens after intramuscular DNA immunisation combined with muscle electroporation.

Tollefsen S, Tjelle T, Schneider J, Harboe M, Wiker H, Hewinson G, Huygen K, Mathiesen I.

Vaccine. 2002 Sep 10;20(27-28):3370-8.


A new evolutionary scenario for the Mycobacterium tuberculosis complex.

Brosch R, Gordon SV, Marmiesse M, Brodin P, Buchrieser C, Eiglmeier K, Garnier T, Gutierrez C, Hewinson G, Kremer K, Parsons LM, Pym AS, Samper S, van Soolingen D, Cole ST.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3684-9. Epub 2002 Mar 12.


Genetic diversity among Mycobacterium bovis isolates: a preliminary study of strains from animal and human sources.

Sales MP, Taylor GM, Hughes S, Yates M, Hewinson G, Young DB, Shaw RJ.

J Clin Microbiol. 2001 Dec;39(12):4558-62.


Sequence-specific assignment and determination of the secondary structure of the 163-residue M. tuberculosis and M. bovis antigenic protein mpb70.

Bloemink MJ, Kemmink J, Dentten E, Muskett FW, Whelan A, Sheikh A, Hewinson G, Williamson RA, Carr MD.

J Biomol NMR. 2001 Jun;20(2):185-6. No abstract available.


Molecular typing of Mycobacterium bovis isolates from Cameroon.

Njanpop-Lafourcade BM, Inwald J, Ostyn A, Durand B, Hughes S, Thorel MF, Hewinson G, Haddad N.

J Clin Microbiol. 2001 Jan;39(1):222-7.


Mycobacterium microti: more widespread than previously thought.

Kremer K, van Soolingen D, van Embden J, Hughes S, Inwald J, Hewinson G.

J Clin Microbiol. 1998 Sep;36(9):2793-4. No abstract available.


Mutagenesis of an immunodominant T cell epitope can affect recognition of different T and B determinants within the same antigen.

Harris DP, Hill M, Vordermeier HM, Jones M, Hewinson G, Thangaraj H, Ivanyi J.

Mol Immunol. 1997 Mar;34(4):315-22.


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