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Items: 36

1.

Decreased epileptogenesis in mice lacking the System xc - transporter occurs in association with a reduction in AMPA receptor subunit GluA1.

Sears SMS, Hewett JA, Hewett SJ.

Epilepsia Open. 2019 Feb 21;4(1):133-143. doi: 10.1002/epi4.12307. eCollection 2019 Mar.

2.

Mice lacking L-12/15-lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis.

Kanzler MA, Van Dyke AM, He Y, Hewett JA, Hewett SJ.

Epilepsia Open. 2018 May 10;3(2):255-263. doi: 10.1002/epi4.12221. eCollection 2018 Jun.

3.

Maintenance of the Innate Seizure Threshold by Cyclooxygenase-2 is Not Influenced by the Translational Silencer, T-cell Intracellular Antigen-1.

Gong Y, Hewett JA.

Neuroscience. 2018 Mar 1;373:37-51. doi: 10.1016/j.neuroscience.2018.01.004. Epub 2018 Jan 11.

4.

Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons: OPPOSING ROLES FOR THE TRANSCRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 (STIMULATORY PROTEIN-1).

Hewett SJ, Shi J, Gong Y, Dhandapani K, Pilbeam C, Hewett JA.

J Biol Chem. 2016 Dec 30;291(53):27279-27288. doi: 10.1074/jbc.M116.737353. Epub 2016 Nov 14.

5.

Interleukin 1β Regulation of the System xc- Substrate-specific Subunit, xCT, in Primary Mouse Astrocytes Involves the RNA-binding Protein HuR.

Shi J, He Y, Hewett SJ, Hewett JA.

J Biol Chem. 2016 Jan 22;291(4):1643-51. doi: 10.1074/jbc.M115.697821. Epub 2015 Nov 24.

6.

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc- Mediates Aglycemic Neuronal Cell Death.

Thorn TL, He Y, Jackman NA, Lobner D, Hewett JA, Hewett SJ.

ASN Neuro. 2015 Nov 9;7(6). pii: 1759091415614301. doi: 10.1177/1759091415614301. Print 2015 Nov-Dec.

7.

Non-cell autonomous influence of the astrocyte system xc- on hypoglycaemic neuronal cell death.

Jackman NA, Melchior SE, Hewett JA, Hewett SJ.

ASN Neuro. 2012 Feb 8;4(1). pii: e00074. doi: 10.1042/AN20110030.

8.

Induction of nitric oxide synthase-2 expression and measurement of nitric oxide production in enriched primary cortical astrocyte cultures.

Hewett JA, Hewett SJ.

Methods Mol Biol. 2012;814:251-63. doi: 10.1007/978-1-61779-452-0_17.

PMID:
22144312
9.

Generation of primary astrocyte cultures devoid of contaminating microglia.

Uliasz TF, Hamby ME, Jackman NA, Hewett JA, Hewett SJ.

Methods Mol Biol. 2012;814:61-79. doi: 10.1007/978-1-61779-452-0_5.

PMID:
22144300
10.

Neuromodulatory role of endogenous interleukin-1β in acute seizures: possible contribution of cyclooxygenase-2.

Claycomb RJ, Hewett SJ, Hewett JA.

Neurobiol Dis. 2012 Jan;45(1):234-42. doi: 10.1016/j.nbd.2011.08.007. Epub 2011 Aug 10.

11.

Prophylactic, prandial rofecoxib treatment lacks efficacy against acute PTZ-induced seizure generation and kindling acquisition.

Claycomb RJ, Hewett SJ, Hewett JA.

Epilepsia. 2011 Feb;52(2):273-83. doi: 10.1111/j.1528-1167.2010.02889.x. Epub 2011 Jan 10.

12.

Regulation of system x(c)(-)activity and expression in astrocytes by interleukin-1β: implications for hypoxic neuronal injury.

Jackman NA, Uliasz TF, Hewett JA, Hewett SJ.

Glia. 2010 Nov 15;58(15):1806-15. doi: 10.1002/glia.21050.

13.

Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression.

Hamby ME, Hewett JA, Hewett SJ.

Glia. 2010 Aug 15;58(11):1282-91. doi: 10.1002/glia.21005.

14.

Analysis and function of lipid mediators in the nervous system.

Hewett JA, Fuss B, Hewett SJ.

Prostaglandins Other Lipid Mediat. 2010 Apr;91(3-4):61-2. doi: 10.1016/j.prostaglandins.2010.02.001. Epub 2010 Feb 25. No abstract available.

PMID:
20188848
15.

Determinants of regional and local diversity within the astroglial lineage of the normal central nervous system.

Hewett JA.

J Neurochem. 2009 Sep;110(6):1717-36. doi: 10.1111/j.1471-4159.2009.06288.x. Epub 2009 Jul 17. Review.

16.

Cytosolic phospholipase A2 alpha inhibition prevents neuronal NMDA receptor-stimulated arachidonic acid mobilization and prostaglandin production but not subsequent cell death.

Taylor AL, Bonventre JV, Uliasz TF, Hewett JA, Hewett SJ.

J Neurochem. 2008 Aug;106(4):1828-40. doi: 10.1111/j.1471-4159.2008.05527.x. Epub 2008 Jun 28.

17.

TGF-beta1 reduces the heterogeneity of astrocytic cyclooxygenase-2 and nitric oxide synthase-2 gene expression in a stimulus-independent manner.

Hamby ME, Hewett JA, Hewett SJ.

Prostaglandins Other Lipid Mediat. 2008 Mar;85(3-4):115-24. doi: 10.1016/j.prostaglandins.2007.11.004. Epub 2007 Dec 8.

18.
19.

Oral treatment with rofecoxib reduces hippocampal excitotoxic neurodegeneration.

Hewett SJ, Silakova JM, Hewett JA.

J Pharmacol Exp Ther. 2006 Dec;319(3):1219-24. Epub 2006 Sep 8.

PMID:
16963621
20.
21.

Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system.

Hewett SJ, Bell SC, Hewett JA.

Pharmacol Ther. 2006 Nov;112(2):335-57. Epub 2006 Jun 5. Review.

PMID:
16750270
22.

Characterization of an improved procedure for the removal of microglia from confluent monolayers of primary astrocytes.

Hamby ME, Uliasz TF, Hewett SJ, Hewett JA.

J Neurosci Methods. 2006 Jan 15;150(1):128-37. Epub 2005 Aug 18.

PMID:
16105687
23.

Interleukin-1beta potentiates neuronal injury in a variety of injury models involving energy deprivation.

Fogal B, Hewett JA, Hewett SJ.

J Neuroimmunol. 2005 Apr;161(1-2):93-100.

PMID:
15748948
24.

Cloning and characterization of cyclooxygenase-1b (putative cyclooxygenase-3) in rat.

Snipes JA, Kis B, Shelness GS, Hewett JA, Busija DW.

J Pharmacol Exp Ther. 2005 May;313(2):668-76. Epub 2005 Jan 13.

PMID:
15650114
25.

Naproxen reduces excitotoxic neurodegeneration in vivo with an extended therapeutic window.

Silakova JM, Hewett JA, Hewett SJ.

J Pharmacol Exp Ther. 2004 Jun;309(3):1060-6. Epub 2004 Feb 9.

PMID:
14769833
26.

Differential modulation of prostaglandin H synthase-2 by nitric oxide-related species in intact cells.

Vidwans AS, Uliasz TF, Hewett JA, Hewett SJ.

Biochemistry. 2001 Sep 25;40(38):11533-42.

PMID:
11560502
27.

Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture.

Hewett SJ, Uliasz TF, Vidwans AS, Hewett JA.

J Pharmacol Exp Ther. 2000 May;293(2):417-25.

PMID:
10773011
28.

Inducible nitric oxide synthase expression in cultures enriched for mature oligodendrocytes is due to microglia.

Hewett JA, Hewett SJ, Winkler S, Pfeiffer SE.

J Neurosci Res. 1999 Apr 15;56(2):189-98. Erratum in: J Neurosci Res 1999 Aug 1;57(3):411.

PMID:
10494107
30.

Methylene dianiline hepatotoxicity is not leukocyte-dependent.

Bailie MB, Hewett JA, Schultze AE, Roth RA.

Toxicol Appl Pharmacol. 1994 Jan;124(1):25-30.

PMID:
8291058
31.

Relationship between tumor necrosis factor-alpha and neutrophils in endotoxin-induced liver injury.

Hewett JA, Jean PA, Kunkel SL, Roth RA.

Am J Physiol. 1993 Dec;265(6 Pt 1):G1011-5.

PMID:
8279551
32.

Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides.

Hewett JA, Roth RA.

Pharmacol Rev. 1993 Dec;45(4):382-411. Review. No abstract available.

PMID:
8127918
33.

Neutrophil depletion protects against liver injury from bacterial endotoxin.

Hewett JA, Schultze AE, VanCise S, Roth RA.

Lab Invest. 1992 Mar;66(3):347-61.

PMID:
1538588
34.
35.

Dieldrin activates rat neutrophils in vitro.

Hewett JA, Roth RA.

Toxicol Appl Pharmacol. 1988 Nov;96(2):269-78.

PMID:
2848335
36.

Bile and bile salts potentiate superoxide anion release from activated, rat peritoneal neutrophils.

Dahm LJ, Hewett JA, Roth RA.

Toxicol Appl Pharmacol. 1988 Aug;95(1):82-92.

PMID:
2842892

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