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Items: 4

1.

Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity.

Heusser SA, Lycksell M, Wang X, McComas SE, Howard RJ, Lindahl E.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10672-10677. doi: 10.1073/pnas.1809650115. Epub 2018 Oct 1.

2.

Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.

Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M.

Cell Rep. 2018 Apr 24;23(4):993-1004. doi: 10.1016/j.celrep.2018.03.108.

3.

Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.

Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ.

J Neurochem. 2016 Jul;138(2):243-53. doi: 10.1111/jnc.13644. Epub 2016 May 25.

4.

Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels.

Heusser SA, Howard RJ, Borghese CM, Cullins MA, Broemstrup T, Lee US, Lindahl E, Carlsson J, Harris RA.

Mol Pharmacol. 2013 Nov;84(5):670-8. doi: 10.1124/mol.113.087692. Epub 2013 Aug 15.

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