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Items: 1 to 50 of 90

1.

Acetylcholine receptor antagonists in acute respiratory distress syndrome: much more than muscle relaxants.

Jansen D, de Vries H, Heunks LMA.

Crit Care. 2018 May 22;22(1):132. doi: 10.1186/s13054-018-1979-z.

2.

Respiratory Muscle Effort during Expiration in Successful and Failed Weaning from Mechanical Ventilation.

Doorduin J, Roesthuis LH, Jansen D, van der Hoeven JG, van Hees HWH, Heunks LMA.

Anesthesiology. 2018 May 16. doi: 10.1097/ALN.0000000000002256. [Epub ahead of print]

PMID:
29771711
3.

Highlights in acute respiratory failure.

Scala R, Heunks L.

Eur Respir Rev. 2018 Mar 28;27(147). pii: 180008. doi: 10.1183/16000617.0008-2018. Print 2018 Mar 31. No abstract available.

4.

Positive End-expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers.

Lindqvist J, van den Berg M, van der Pijl R, Hooijman PE, Beishuizen A, Elshof J, de Waard M, Girbes A, Spoelstra-de Man A, Shi ZH, van den Brom C, Bogaards S, Shen S, Strom J, Granzier H, Kole J, Musters RJP, Paul MA, Heunks LMA, Ottenheijm CAC.

Am J Respir Crit Care Med. 2018 Mar 26. doi: 10.1164/rccm.201709-1917OC. [Epub ahead of print]

PMID:
29578749
5.

The effect of metabolic alkalosis on the ventilatory response in healthy subjects.

Oppersma E, Doorduin J, van der Hoeven JG, Veltink PH, van Hees HWH, Heunks LMA.

Respir Physiol Neurobiol. 2018 Feb;249:47-53. doi: 10.1016/j.resp.2018.01.002. Epub 2018 Jan 4.

6.

Efficacy of ventilator waveform observation for detection of patient-ventilator asynchrony during NIV: a multicentre study.

Longhini F, Colombo D, Pisani L, Idone F, Chun P, Doorduin J, Ling L, Alemani M, Bruni A, Zhaochen J, Tao Y, Lu W, Garofalo E, Carenzo L, Maggiore SM, Qiu H, Heunks L, Antonelli M, Nava S, Navalesi P.

ERJ Open Res. 2017 Oct 4;3(4). pii: 00075-2017. doi: 10.1183/23120541.00075-2017. eCollection 2017 Oct.

7.

Diaphragm-Protective Mechanical Ventilation to Improve Outcomes in ICU Patients?

Heunks L, Ottenheijm C.

Am J Respir Crit Care Med. 2018 Jan 15;197(2):150-152. doi: 10.1164/rccm.201710-2002ED. No abstract available.

PMID:
29182892
8.

Correction to: Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators; ESICM Trials Group.

Intensive Care Med. 2018 Jan;44(1):157-165. doi: 10.1007/s00134-017-4981-z.

PMID:
29138899
9.

Critical illness-associated diaphragm weakness.

Dres M, Goligher EC, Heunks LMA, Brochard LJ.

Intensive Care Med. 2017 Oct;43(10):1441-1452. doi: 10.1007/s00134-017-4928-4. Epub 2017 Sep 15. Review.

PMID:
28917004
10.

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.

van den Berg M, Hooijman PE, Beishuizen A, de Waard MC, Paul MA, Hartemink KJ, van Hees HWH, Lawlor MW, Brocca L, Bottinelli R, Pellegrino MA, Stienen GJM, Heunks LMA, Wüst RCI, Ottenheijm CAC.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1544-1558. doi: 10.1164/rccm.201703-0501OC.

PMID:
28787181
11.

Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study.

Laffey JG, Madotto F, Bellani G, Pham T, Fan E, Brochard L, Amin P, Arabi Y, Bajwa EK, Bruhn A, Cerny V, Clarkson K, Heunks L, Kurahashi K, Laake JH, Lorente JA, McNamee L, Nin N, Palo JE, Piquilloud L, Qiu H, Jiménez JIS, Esteban A, McAuley DF, van Haren F, Ranieri M, Rubenfeld G, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators and the ESICM Trials Group.

Lancet Respir Med. 2017 Aug;5(8):627-638. doi: 10.1016/S2213-2600(17)30213-8. Epub 2017 Jun 15.

PMID:
28624388
12.

Assembly 2: respiratory intensive care.

Scala R, Heunks L, Gregoretti C, Schultz MJ, Dreher M, Winck J.

Breathe (Sheff). 2017 Jun;13(2):147-148. doi: 10.1183/20734735.018616.

13.

Update in Critical Care 2016.

Dos Santos C, Heunks L, Wunsch H.

Am J Respir Crit Care Med. 2017 Jul 1;196(1):11-17. doi: 10.1164/rccm.201701-0164UP. Review. No abstract available.

PMID:
28530111
14.

Functional assessment of the diaphragm by speckle tracking ultrasound during inspiratory loading.

Oppersma E, Hatam N, Doorduin J, van der Hoeven JG, Marx G, Goetzenich A, Fritsch S, Heunks LMA, Bruells CS.

J Appl Physiol (1985). 2017 Nov 1;123(5):1063-1070. doi: 10.1152/japplphysiol.00095.2017. Epub 2017 May 18.

PMID:
28522757
15.

Ultrasound to assess diaphragmatic function in the critically ill-a critical perspective.

Haaksma M, Tuinman PR, Heunks L.

Ann Transl Med. 2017 Mar;5(5):114. doi: 10.21037/atm.2017.01.37.

16.

Compliance and statistics : Discussion on "Severe hypercapnia and outcomes of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome".

Elbers PW, Heunks L, Peñuelas O, Muriel A, Nin N, Esteban A.

Intensive Care Med. 2017 May;43(5):724-725. doi: 10.1007/s00134-017-4747-7. Epub 2017 Mar 23. No abstract available.

PMID:
28337508
17.

Novel insights in ICU-acquired respiratory muscle dysfunction: implications for clinical care.

Jonkman AH, Jansen D, Heunks LM.

Crit Care. 2017 Mar 21;21(1):64. doi: 10.1186/s13054-017-1642-0. Review.

18.

The role of calpains in ventilator-induced diaphragm atrophy.

Zhu X, van Hees HWH, Heunks L, Wang F, Shao L, Huang J, Shi L, Ma S.

Intensive Care Med Exp. 2017 Dec;5(1):14. doi: 10.1186/s40635-017-0127-4. Epub 2017 Mar 14.

19.

Respiratory Muscles and Ventilator-induced Lung Injury Critical Care.

Schellekens WM, Jansen D, Dorresteijn MJ, Heunks LM.

Am J Respir Crit Care Med. 2017 Jan 15;195(2):258-260. doi: 10.1164/rccm.201608-1627RR. No abstract available.

PMID:
27898224
20.

Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.

Laffey JG, Bellani G, Pham T, Fan E, Madotto F, Bajwa EK, Brochard L, Clarkson K, Esteban A, Gattinoni L, van Haren F, Heunks LM, Kurahashi K, Laake JH, Larsson A, McAuley DF, McNamee L, Nin N, Qiu H, Ranieri M, Rubenfeld GD, Thompson BT, Wrigge H, Slutsky AS, Pesenti A; LUNG SAFE Investigators and the ESICM Trials Group.

Intensive Care Med. 2016 Dec;42(12):1865-1876. doi: 10.1007/s00134-016-4571-5. Epub 2016 Oct 18. Erratum in: Intensive Care Med. 2017 Nov 14;:.

PMID:
27757516
21.

Partial Neuromuscular Blockade during Partial Ventilatory Support in Sedated Patients with High Tidal Volumes.

Doorduin J, Nollet JL, Roesthuis LH, van Hees HW, Brochard LJ, Sinderby CA, van der Hoeven JG, Heunks LM.

Am J Respir Crit Care Med. 2017 Apr 15;195(8):1033-1042. doi: 10.1164/rccm.201605-1016OC.

PMID:
27748627
22.

Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper.

Farmakis D, Alvarez J, Gal TB, Brito D, Fedele F, Fonseca C, Gordon AC, Gotsman I, Grossini E, Guarracino F, Harjola VP, Hellman Y, Heunks L, Ivancan V, Karavidas A, Kivikko M, Lomivorotov V, Longrois D, Masip J, Metra M, Morelli A, Nikolaou M, Papp Z, Parkhomenko A, Poelzl G, Pollesello P, Ravn HB, Rex S, Riha H, Ricksten SE, Schwinger RHG, Vrtovec B, Yilmaz MB, Zielinska M, Parissis J.

Int J Cardiol. 2016 Nov 1;222:303-312. doi: 10.1016/j.ijcard.2016.07.202. Epub 2016 Jul 29. Review.

23.

Assessment of dead-space ventilation in patients with acute respiratory distress syndrome: a prospective observational study.

Doorduin J, Nollet JL, Vugts MP, Roesthuis LH, Akankan F, van der Hoeven JG, van Hees HW, Heunks LM.

Crit Care. 2016 May 5;20(1):121. doi: 10.1186/s13054-016-1311-8.

24.

Strategies to optimize respiratory muscle function in ICU patients.

Schellekens WJ, van Hees HW, Doorduin J, Roesthuis LH, Scheffer GJ, van der Hoeven JG, Heunks LM.

Crit Care. 2016 Apr 19;20(1):103. doi: 10.1186/s13054-016-1280-y. Review.

25.

The differential diagnosis for failure to wean from mechanical ventilation.

Doorduin J, van der Hoeven JG, Heunks LM.

Curr Opin Anaesthesiol. 2016 Apr;29(2):150-7. doi: 10.1097/ACO.0000000000000297. Review.

PMID:
26854883
26.

Appropriate positioning of the NAVA catheter.

Schellekens WM, Heunks LMA.

Intensive Care Med. 2016 Apr;42(4):633-634. doi: 10.1007/s00134-016-4213-y. Epub 2016 Feb 5. No abstract available.

PMID:
26850329
27.

Comparison Between Neurally Adjusted Ventilatory Assist and Pressure Support Ventilation Levels in Terms of Respiratory Effort.

Carteaux G, Córdoba-Izquierdo A, Lyazidi A, Heunks L, Thille AW, Brochard L.

Crit Care Med. 2016 Mar;44(3):503-11. doi: 10.1097/CCM.0000000000001418.

PMID:
26540399
28.

Letter to the Editor.

Schellekens WJ, van Hees HW, Heunks LM.

J Physiol. 2015 Aug 1;593(15):3389. doi: 10.1113/JP270385. No abstract available.

29.

EFFECTS OF EXPERIMENTAL HUMAN ENDOTOXEMIA ON DIAPHRAGM FUNCTION.

Doorduin J, Leentjens J, Kox M, van Hees HW, van der Hoeven JG, Pickkers P, Heunks LM.

Shock. 2015 Oct;44(4):316-22. doi: 10.1097/SHK.0000000000000435.

PMID:
26196838
30.

Assisted Ventilation in Patients with Acute Respiratory Distress Syndrome: Lung-distending Pressure and Patient-Ventilator Interaction.

Doorduin J, Sinderby CA, Beck J, van der Hoeven JG, Heunks LM.

Anesthesiology. 2015 Jul;123(1):181-90. doi: 10.1097/ALN.0000000000000694.

PMID:
25955983
31.

Levosimendan affects oxidative and inflammatory pathways in the diaphragm of ventilated endotoxemic mice.

Schellekens WJ, van Hees HW, Linkels M, Dekhuijzen PN, Scheffer GJ, van der Hoeven JG, Heunks LM.

Crit Care. 2015 Mar 2;19:69. doi: 10.1186/s13054-015-0798-8.

32.

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.

Hooijman PE, Beishuizen A, Witt CC, de Waard MC, Girbes AR, Spoelstra-de Man AM, Niessen HW, Manders E, van Hees HW, van den Brom CE, Silderhuis V, Lawlor MW, Labeit S, Stienen GJ, Hartemink KJ, Paul MA, Heunks LM, Ottenheijm CA.

Am J Respir Crit Care Med. 2015 May 15;191(10):1126-38. doi: 10.1164/rccm.201412-2214OC.

33.

Feasibility and safety of hydrotherapy in critically ill ventilated patients.

Felten-Barentsz KM, Haans AJ, Slutsky AS, Heunks LM, van der Hoeven JG.

Am J Respir Crit Care Med. 2015 Feb 15;191(4):476-7. doi: 10.1164/rccm.201408-1559LE. No abstract available.

PMID:
25679106
34.

Monitoring and preventing diaphragm injury.

Heunks LM, Doorduin J, van der Hoeven JG.

Curr Opin Crit Care. 2015 Feb;21(1):34-41. doi: 10.1097/MCC.0000000000000168.

35.

Automated patient-ventilator interaction analysis during neurally adjusted non-invasive ventilation and pressure support ventilation in chronic obstructive pulmonary disease.

Doorduin J, Sinderby CA, Beck J, van der Hoeven JG, Heunks LM.

Crit Care. 2014 Oct 13;18(5):550. doi: 10.1186/s13054-014-0550-9.

36.

Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.

Hooijman PE, Beishuizen A, de Waard MC, de Man FS, Vermeijden JW, Steenvoorde P, Bouwman RA, Lommen W, van Hees HW, Heunks LM, Dickhoff C, van der Peet DL, Girbes AR, Jasper JR, Malik FI, Stienen GJ, Hartemink KJ, Paul MA, Ottenheijm CA.

Am J Respir Crit Care Med. 2014 Apr 1;189(7):863-5. doi: 10.1164/rccm.201312-2260LE. No abstract available.

37.

Resveratrol attenuates NF-κB-binding activity but not cytokine production in mechanically ventilated mice.

Van der Wal SE, Vaneker M, Kox M, Braak G, Van Hees HW, Van den Brink IA, Van de Pol FM, Heunks LM, Van der Hoeven JG, Joosten LA, Vissers KC, Scheffer GJ.

Acta Anaesthesiol Scand. 2014 Apr;58(4):487-94. doi: 10.1111/aas.12276. Epub 2014 Feb 24.

PMID:
24571360
38.

Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction.

Schellekens WJ, van Hees HW, Kox M, Linkels M, Acuña GL, Dekhuijzen PN, Scheffer GJ, van der Hoeven JG, Heunks LM.

Crit Care. 2014 Feb 9;18(1):R28. doi: 10.1186/cc13719.

39.

Levosimendan: current data, clinical use and future development.

Nieminen MS, Fruhwald S, Heunks LM, Suominen PK, Gordon AC, Kivikko M, Pollesello P.

Heart Lung Vessel. 2013;5(4):227-45. Review.

40.

Noninvasive ventilation and the upper airway: should we pay more attention?

Oppersma E, Doorduin J, van der Heijden EH, van der Hoeven JG, Heunks LM.

Crit Care. 2013 Dec 5;17(6):245. doi: 10.1186/cc13141. Review.

41.

Time course of diaphragm function recovery after controlled mechanical ventilation in rats.

Thomas D, Maes K, Agten A, Heunks L, Dekhuijzen R, Decramer M, Van Hees H, Gayan-Ramirez G.

J Appl Physiol (1985). 2013 Sep;115(6):775-84. doi: 10.1152/japplphysiol.00302.2012. Epub 2013 Jul 11.

42.

Oxygen-induced hypercapnia in COPD: myths and facts.

Abdo WF, Heunks LM.

Crit Care. 2012 Oct 29;16(5):323. doi: 10.1186/cc11475. Review.

43.

Monitoring of the respiratory muscles in the critically ill.

Doorduin J, van Hees HW, van der Hoeven JG, Heunks LM.

Am J Respir Crit Care Med. 2013 Jan 1;187(1):20-7. doi: 10.1164/rccm.201206-1117CP. Epub 2012 Oct 26.

PMID:
23103733
44.

Toll-like receptor 4 signaling in ventilator-induced diaphragm atrophy.

Schellekens WJ, van Hees HW, Vaneker M, Linkels M, Dekhuijzen PN, Scheffer GJ, van der Hoeven JG, Heunks LM.

Anesthesiology. 2012 Aug;117(2):329-38.

PMID:
22722577
45.

Titin and diaphragm dysfunction in mechanically ventilated rats.

van Hees HW, Schellekens WJ, Andrade Acuña GL, Linkels M, Hafmans T, Ottenheijm CA, Granzier HL, Scheffer GJ, van der Hoeven JG, Dekhuijzen PN, Heunks LM.

Intensive Care Med. 2012 Apr;38(4):702-9. doi: 10.1007/s00134-012-2504-5. Epub 2012 Feb 11.

46.

Effect of do-not-resuscitate orders on the penumbra of care.

Spoelstra-de Man AM, van der Hoeven JG, Heunks LM.

Intensive Care Med. 2012 Apr;38(4):726-7. doi: 10.1007/s00134-011-2461-4. Epub 2012 Jan 19. No abstract available.

PMID:
22258565
47.

How can you mend a broken heart?.

Doorduin J, Heunks LM, Pickkers P.

Crit Care Med. 2012 Feb;40(2):702-3. doi: 10.1097/CCM.0b013e318236ec67. No abstract available.

PMID:
22249064
48.

The calcium sensitizer levosimendan improves human diaphragm function.

Doorduin J, Sinderby CA, Beck J, Stegeman DF, van Hees HW, van der Hoeven JG, Heunks LM.

Am J Respir Crit Care Med. 2012 Jan 1;185(1):90-5. doi: 10.1164/rccm.201107-1268OC.

PMID:
21960535
49.

Plasma from septic shock patients induces loss of muscle protein.

van Hees HW, Schellekens WJ, Linkels M, Leenders F, Zoll J, Donders R, Dekhuijzen PN, van der Hoeven JG, Heunks LM.

Crit Care. 2011;15(5):R233. doi: 10.1186/cc10475. Epub 2011 Sep 29.

50.

Proteasome inhibition improves diaphragm function in an animal model for COPD.

van Hees H, Ottenheijm C, Ennen L, Linkels M, Dekhuijzen R, Heunks L.

Am J Physiol Lung Cell Mol Physiol. 2011 Jul;301(1):L110-6. doi: 10.1152/ajplung.00396.2010. Epub 2011 Apr 1.

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