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Items: 1 to 50 of 142

1.

Novel Tools towards Magnetic Guidance of Neurite Growth: (I) Guidance of Magnetic Nanoparticles into Neurite Extensions of Induced Human Neurons and In Vitro Functionalization with RAS Regulating Proteins.

Schöneborn H, Raudzus F, Secret E, Otten N, Michel A, Fresnais J, Ménager C, Siaugue JM, Zaehres H, Dietzel ID, Heumann R.

J Funct Biomater. 2019 Jul 16;10(3). pii: E32. doi: 10.3390/jfb10030032.

2.

The binding affinity of PTPN13's tandem PDZ2/3 domain is allosterically modulated.

Dicks M, Kock G, Kohl B, Zhong X, Pütz S, Heumann R, Erdmann KS, Stoll R.

BMC Mol Cell Biol. 2019 Jul 8;20(1):23. doi: 10.1186/s12860-019-0203-6.

3.

Differential expression patterns of sodium potassium ATPase alpha and beta subunit isoforms in mouse brain during postnatal development.

Sundaram SM, Safina D, Ehrkamp A, Faissner A, Heumann R, Dietzel ID.

Neurochem Int. 2019 Sep;128:163-174. doi: 10.1016/j.neuint.2019.04.009. Epub 2019 Apr 19.

PMID:
31009649
4.

Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons.

Schöneborn H, Raudzus F, Coppey M, Neumann S, Heumann R.

Int J Mol Sci. 2018 Dec 14;19(12). pii: E4052. doi: 10.3390/ijms19124052. Review.

5.

Molecular Basis of Class III Ligand Recognition by PDZ3 in Murine Protein Tyrosine Phosphatase PTPN13.

Kock G, Dicks M, Yip KT, Kohl B, Pütz S, Heumann R, Erdmann KS, Stoll R.

J Mol Biol. 2018 Oct 19;430(21):4275-4292. doi: 10.1016/j.jmb.2018.08.023. Epub 2018 Sep 3.

PMID:
30189200
6.

Lethal Factor Domain-Mediated Delivery of Nurr1 Transcription Factor Enhances Tyrosine Hydroxylase Activity and Protects from Neurotoxin-Induced Degeneration of Dopaminergic Cells.

Paliga D, Raudzus F, Leppla SH, Heumann R, Neumann S.

Mol Neurobiol. 2019 May;56(5):3393-3403. doi: 10.1007/s12035-018-1311-6. Epub 2018 Aug 18.

7.

Highlight Issue 'Molecular Basis of Life 2017'.

Heumann R.

Biol Chem. 2018 Jun 27;399(7):621-622. doi: 10.1515/hsz-2018-0248. No abstract available.

PMID:
29894290
8.

Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury.

Serdar M, Herz J, Kempe K, Winterhager E, Jastrow H, Heumann R, Felderhoff-Müser U, Bendix I.

Front Neurol. 2018 Mar 21;9:175. doi: 10.3389/fneur.2018.00175. eCollection 2018.

9.

The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2.

Athanasopoulos PS, Heumann R, Kortholt A.

Biol Chem. 2018 Jun 27;399(7):643-647. doi: 10.1515/hsz-2017-0332. Review.

PMID:
29537215
10.

Ras Activity Tunes the Period and Modulates the Entrainment of the Suprachiasmatic Clock.

Serchov T, Heumann R.

Front Neurol. 2017 Jun 9;8:264. doi: 10.3389/fneur.2017.00264. eCollection 2017. Review.

11.

The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function.

Schöpel M, Potheraveedu VN, Al-Harthy T, Abdel-Jalil R, Heumann R, Stoll R.

Biol Chem. 2017 May 1;398(5-6):577-588. doi: 10.1515/hsz-2016-0276. Review.

PMID:
28475102
12.

Rheb in neuronal degeneration, regeneration, and connectivity.

Potheraveedu VN, Schöpel M, Stoll R, Heumann R.

Biol Chem. 2017 May 1;398(5-6):589-606. doi: 10.1515/hsz-2016-0312. Review.

PMID:
28212107
13.

Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.

Islam MS, Nolte H, Jacob W, Ziegler AB, Pütz S, Grosjean Y, Szczepanowska K, Trifunovic A, Braun T, Heumann H, Heumann R, Hovemann B, Moore DJ, Krüger M.

Hum Mol Genet. 2016 Dec 15;25(24):5365-5382. doi: 10.1093/hmg/ddw352.

14.

Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2.

Athanasopoulos PS, Jacob W, Neumann S, Kutsch M, Wolters D, Tan EK, Bichler Z, Herrmann C, Heumann R.

Biol Chem. 2016 Jun 1;397(6):541-54. doi: 10.1515/hsz-2015-0189.

PMID:
26894577
15.

Highlight: Perspectives of molecular neuroscience in health and disease.

Heumann R.

Biol Chem. 2016 Mar;397(3):175. doi: 10.1515/hsz-2016-0110. No abstract available.

PMID:
26812788
16.

Signaling pathways regulating Homer1a expression: implications for antidepressant therapy.

Serchov T, Heumann R, van Calker D, Biber K.

Biol Chem. 2016 Mar;397(3):207-14. doi: 10.1515/hsz-2015-0267. Review.

PMID:
26641965
17.

Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia.

Serdar M, Herz J, Kempe K, Lumpe K, Reinboth BS, Sizonenko SV, Hou X, Herrmann R, Hadamitzky M, Heumann R, Hansen W, Sifringer M, van de Looij Y, Felderhoff-Müser U, Bendix I.

Brain Behav Immun. 2016 Feb;52:106-119. doi: 10.1016/j.bbi.2015.10.004. Epub 2015 Oct 21.

18.

Ras does not contribute to the facilitation of hippocampal synaptic plasticity enabled by environmental enrichment.

Novkovic T, Heumann R, Manahan-Vaughan D.

Neuroscience. 2015 Nov 19;309:214-23. doi: 10.1016/j.neuroscience.2015.04.052. Epub 2015 Apr 29.

PMID:
25934042
19.

Ras Activity Oscillates in the Mouse Suprachiasmatic Nucleus and Modulates Circadian Clock Dynamics.

Serchov T, Jilg A, Wolf CT, Radtke I, Stehle JH, Heumann R.

Mol Neurobiol. 2016 Apr;53(3):1843-1855. doi: 10.1007/s12035-015-9135-0. Epub 2015 Mar 12.

PMID:
25762011
20.

Dyskinesia in Parkinson's disease: mechanisms and current non-pharmacological interventions.

Heumann R, Moratalla R, Herrero MT, Chakrabarty K, Drucker-Colín R, Garcia-Montes JR, Simola N, Morelli M.

J Neurochem. 2014 Aug;130(4):472-89. doi: 10.1111/jnc.12751. Epub 2014 Jun 7. Review.

21.

Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists.

Schöpel M, Jockers KF, Düppe PM, Autzen J, Potheraveedu VN, Ince S, Yip KT, Heumann R, Herrmann C, Scherkenbeck J, Stoll R.

J Med Chem. 2013 Dec 12;56(23):9664-72. doi: 10.1021/jm401291q. Epub 2013 Nov 22.

PMID:
24266771
22.

Ras and rheb signaling in survival and cell death.

Ehrkamp A, Herrmann C, Stoll R, Heumann R.

Cancers (Basel). 2013 May 28;5(2):639-61. doi: 10.3390/cancers5020639.

23.

Highlight: perspectives in molecular neurobiology.

Heumann R.

Biol Chem. 2013 Dec;394(12):1551. doi: 10.1515/hsz-2013-0266. No abstract available.

PMID:
24129105
24.

MeCP2 phosphorylation in the brain: from transcription to behavior.

Damen D, Heumann R.

Biol Chem. 2013 Dec;394(12):1595-605. doi: 10.1515/hsz-2013-0193. Review.

PMID:
23912219
25.

Thrombin has biphasic effects on the nitric oxide-cGMP pathway in endothelial cells and contributes to experimental pulmonary hypertension.

Nickel KF, Laux V, Heumann R, von Degenfeld G.

PLoS One. 2013 Jun 13;8(6):e63504. doi: 10.1371/journal.pone.0063504. Print 2013.

26.

Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling.

Drost J, Nonis D, Eich F, Leske O, Damrath E, Brunt ER, Lastres-Becker I, Heumann R, Nowock J, Auburger G.

J Mol Neurosci. 2013 Sep;51(1):68-81. doi: 10.1007/s12031-012-9949-4. Epub 2013 Jan 19.

27.

Erythropoietin modulates autophagy signaling in the developing rat brain in an in vivo model of oxygen-toxicity.

Bendix I, Schulze C, Haefen Cv, Gellhaus A, Endesfelder S, Heumann R, Felderhoff-Mueser U, Sifringer M.

Int J Mol Sci. 2012 Oct 10;13(10):12939-51. doi: 10.3390/ijms131012939.

28.

Hyperoxia changes the balance of the thioredoxin/peroxiredoxin system in the neonatal rat brain.

Bendix I, Weichelt U, Strasser K, Serdar M, Endesfelder S, von Haefen C, Heumann R, Ehrkamp A, Felderhoff-Mueser U, Sifringer M.

Brain Res. 2012 Nov 12;1484:68-75. doi: 10.1016/j.brainres.2012.09.024. Epub 2012 Sep 21.

PMID:
23006780
29.

Nanoparticle-mediated gene transfer from electrophoretically coated metal surfaces.

Kovtun A, Neumann S, Neumeier M, Urch H, Heumann R, Gepp MM, Wallat K, Koeller M, Zimmermann H, Epple M.

J Phys Chem B. 2013 Feb 14;117(6):1550-5. doi: 10.1021/jp303448v. Epub 2012 Jul 13.

PMID:
22746541
30.

Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus.

Imielski Y, Schwamborn JC, Lüningschrör P, Heimann P, Holzberg M, Werner H, Leske O, Püschel AW, Memet S, Heumann R, Israel A, Kaltschmidt C, Kaltschmidt B.

PLoS One. 2012;7(2):e30838. doi: 10.1371/journal.pone.0030838. Epub 2012 Feb 1.

31.

Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate.

Gasser G, Pinto A, Neumann S, Sosniak AM, Seitz M, Merz K, Heumann R, Metzler-Nolte N.

Dalton Trans. 2012 Feb 28;41(8):2304-13. doi: 10.1039/c2dt12114j. Epub 2011 Dec 20.

PMID:
22183093
32.

The beneficial effects of physical activity on impaired adult neurogenesis and cognitive performance.

Lafenetre P, Leske O, Wahle P, Heumann R.

Front Neurosci. 2011 Apr 12;5:51. doi: 10.3389/fnins.2011.00051. eCollection 2011.

33.

Role of neuronal ras activity in adult hippocampal neurogenesis and cognition.

Manns M, Leske O, Gottfried S, Bichler Z, Lafenêtre P, Wahle P, Heumann R.

Front Neurosci. 2011 Feb 14;5:18. doi: 10.3389/fnins.2011.00018. eCollection 2011.

34.

Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.

Karassek S, Berghaus C, Schwarten M, Goemans CG, Ohse N, Kock G, Jockers K, Neumann S, Gottfried S, Herrmann C, Heumann R, Stoll R.

J Biol Chem. 2010 Oct 29;285(44):33979-91. doi: 10.1074/jbc.M109.095968. Epub 2010 Aug 4.

35.

Sequence-specific 1H, 13C, and 15N assignment of the extended PDZ3 domain of the protein tyrosine phosphatase basophil-like PTP-BL.

Kock G, Dicks M, Heumann R, Erdmann KS, Stoll R.

Biomol NMR Assign. 2010 Oct;4(2):199-202. doi: 10.1007/s12104-010-9242-9. Epub 2010 Jun 19.

PMID:
20563762
36.

Neuronal Ras activation inhibits adult hippocampal progenitor cell division and impairs spatial short-term memory.

Manns M, Bichler Z, Leske O, Heumann R.

Genes Brain Behav. 2010 Jul;9(5):525-36. doi: 10.1111/j.1601-183X.2010.00584.x. Epub 2010 Apr 6.

37.

Exercise can rescue recognition memory impairment in a model with reduced adult hippocampal neurogenesis.

Lafenêtre P, Leske O, Ma-Högemeie Z, Haghikia A, Bichler Z, Wahle P, Heumann R.

Front Behav Neurosci. 2010 Feb 22;3:34. doi: 10.3389/neuro.08.034.2009. eCollection 2010.

38.

The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfection.

Neumann S, Kovtun A, Dietzel ID, Epple M, Heumann R.

Biomaterials. 2009 Dec;30(35):6794-802. doi: 10.1016/j.biomaterials.2009.08.043. Epub 2009 Sep 18.

PMID:
19766304
39.

PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells.

Stenzel N, Fetzer CP, Heumann R, Erdmann KS.

J Cell Sci. 2009 Sep 15;122(Pt 18):3374-84. doi: 10.1242/jcs.046854. Epub 2009 Aug 25.

40.

Calcium phosphate nanoparticles for the transfection of cells.

Kovtun A, Heumann R, Epple M.

Biomed Mater Eng. 2009;19(2-3):241-7. doi: 10.3233/BME-2009-0586. Review.

PMID:
19581719
41.

Regulation and function of neuronal GTP-Ras in facial motor nerve regeneration.

Makwana M, Serchov T, Hristova M, Bohatschek M, Gschwendtner A, Kalla R, Liu Z, Heumann R, Raivich G.

J Neurochem. 2009 Mar;108(6):1453-63. doi: 10.1111/j.1471-4159.2009.05890.x.

42.

Interneuronal growth and expression of interneuronal markers in visual cortex of mice with transgenic activation of Ras.

Patz S, Colovic C, Wawro S, Lafenetre P, Leske O, Heumann R, Schönfelder S, Tomaschewski J, Räk A, Wahle P.

Exp Brain Res. 2009 Dec;199(3-4):265-78. doi: 10.1007/s00221-008-1688-y.

PMID:
19139860
43.

Corticosteroids reverse cytokine-induced block of survival and differentiation of oligodendrocyte progenitor cells from rats.

Mann SA, Versmold B, Marx R, Stahlhofen S, Dietzel ID, Heumann R, Berger R.

J Neuroinflammation. 2008 Sep 22;5:39. doi: 10.1186/1742-2094-5-39.

44.

Prospective of Ras signaling in stem cells.

Chakrabarty K, Heumann R.

Biol Chem. 2008 Jul;389(7):791-8. doi: 10.1515/BC.2008.104. Review.

PMID:
18627319
45.

Sequence-specific (1)H, (13)C, and (15)N backbone assignment of the 28 kDa PDZ2/PDZ3 tandem domain of the protein tyrosine phosphatase PTP-BL.

Fetzer CP, Sauvageau J, Kock G, Berghaus C, Bangert JA, Dicks M, Heumann R, Erdmann KS, Stoll R.

Biomol NMR Assign. 2007 Dec;1(2):151-3. doi: 10.1007/s12104-007-9043-y. Epub 2007 Aug 3.

PMID:
19636852
46.

Sequence-specific 1H, 13C, and 15N backbone assignment of the activated 21 kDa GTPase rRheb.

Schwarten M, Berghaus C, Heumann R, Stoll R.

Biomol NMR Assign. 2007 Jul;1(1):105-8. doi: 10.1007/s12104-007-9030-3. Epub 2007 Jul 11.

PMID:
19636840
47.

Sequence-specific 1H, 13C, and 15N backbone assignment of the GTPase rRheb in its GDP-bound form.

Berghaus C, Schwarten M, Heumann R, Stoll R.

Biomol NMR Assign. 2007 Jul;1(1):45-7. doi: 10.1007/s12104-007-9013-4. Epub 2007 May 22.

PMID:
19636822
48.

Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones.

Chakrabarty K, Serchov T, Mann SA, Dietzel ID, Heumann R.

Eur J Neurosci. 2007 Apr;25(7):1971-81.

PMID:
17439485
49.

Antagonistic effects of TrkB and p75(NTR) on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes.

Sandoval M, Sandoval R, Thomas U, Spilker C, Smalla KH, Falcon R, Marengo JJ, Calderón R, Saavedra V, Heumann R, Bronfman F, Garner CC, Gundelfinger ED, Wyneken U.

J Neurochem. 2007 Jun;101(6):1672-84. Epub 2007 Mar 23.

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