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Items: 11


Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.

Zaytseva YY, Rychahou PG, Le AT, Scott TL, Flight RM, Kim JT, Harris J, Liu J, Wang C, Morris AJ, Sivakumaran TA, Fan T, Moseley H, Gao T, Lee EY, Weiss HL, Heuer TS, Kemble G, Evers M.

Oncotarget. 2018 May 15;9(37):24787-24800. doi: 10.18632/oncotarget.25361. eCollection 2018 May 15.


Fatty acid synthase - Modern tumor cell biology insights into a classical oncology target.

Buckley D, Duke G, Heuer TS, O'Farrell M, Wagman AS, McCulloch W, Kemble G.

Pharmacol Ther. 2017 Sep;177:23-31. doi: 10.1016/j.pharmthera.2017.02.021. Epub 2017 Feb 12. Review.


Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.

Ventura R, Mordec K, Waszczuk J, Wang Z, Lai J, Fridlib M, Buckley D, Kemble G, Heuer TS.

EBioMedicine. 2015 Jul 2;2(8):808-24. doi: 10.1016/j.ebiom.2015.06.020. eCollection 2015 Aug.


Discovery of XL888: a novel tropane-derived small molecule inhibitor of HSP90.

Bussenius J, Blazey CM, Aay N, Anand NK, Arcalas A, Baik T, Bowles OJ, Buhr CA, Costanzo S, Curtis JK, DeFina SC, Dubenko L, Heuer TS, Huang P, Jaeger C, Joshi A, Kennedy AR, Kim AI, Lara K, Lee J, Li J, Lougheed JC, Ma S, Malek S, Manalo JC, Martini JF, McGrath G, Nicoll M, Nuss JM, Pack M, Peto CJ, Tsang TH, Wang L, Womble SW, Yakes M, Zhang W, Rice KD.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5396-404. doi: 10.1016/j.bmcl.2012.07.052. Epub 2012 Jul 21.


EXEL-7647 inhibits mutant forms of ErbB2 associated with lapatinib resistance and neoplastic transformation.

Trowe T, Boukouvala S, Calkins K, Cutler RE Jr, Fong R, Funke R, Gendreau SB, Kim YD, Miller N, Woolfrey JR, Vysotskaia V, Yang JP, Gerritsen ME, Matthews DJ, Lamb P, Heuer TS.

Clin Cancer Res. 2008 Apr 15;14(8):2465-75. doi: 10.1158/1078-0432.CCR-07-4367.


A genome-wide analysis of immune responses in Drosophila.

Irving P, Troxler L, Heuer TS, Belvin M, Kopczynski C, Reichhart JM, Hoffmann JA, Hetru C.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15119-24. Epub 2001 Dec 11.


Characterization of recombinant murine leukemia virus integrase.

Dotan I, Scottoline BP, Heuer TS, Brown PO.

J Virol. 1995 Jan;69(1):456-68.


Folding of group I introns from bacteriophage T4 involves internalization of the catalytic core.

Heuer TS, Chandry PS, Belfort M, Celander DW, Cech TR.

Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11105-9.

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