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Items: 1 to 50 of 69

1.

Down syndrome mouse models have an abnormal enteric nervous system.

Schill EM, Wright CM, Jamil A, LaCombe JM, Roper RJ, Heuckeroth RO.

JCI Insight. 2019 Apr 18;5. pii: 124510. doi: 10.1172/jci.insight.124510.

2.

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Taylor DM, Aronow BJ, Tan K, Bernt K, Salomonis N, Greene CS, Frolova A, Henrickson SE, Wells A, Pei L, Jaiswal JK, Whitsett J, Hamilton KE, MacParland SA, Kelsen J, Heuckeroth RO, Potter SS, Vella LA, Terry NA, Ghanem LR, Kennedy BC, Helbig I, Sullivan KE, Castelo-Soccio L, Kreigstein A, Herse F, Nawijn MC, Koppelman GH, Haendel M, Harris NL, Rokita JL, Zhang Y, Regev A, Rozenblatt-Rosen O, Rood JE, Tickle TL, Vento-Tormo R, Alimohamed S, Lek M, Mar JC, Loomes KM, Barrett DM, Uapinyoying P, Beggs AH, Agrawal PB, Chen YW, Muir AB, Garmire LX, Snapper SB, Nazarian J, Seeholzer SH, Fazelinia H, Singh LN, Faryabi RB, Raman P, Dawany N, Xie HM, Devkota B, Diskin SJ, Anderson SA, Rappaport EF, Peranteau W, Wikenheiser-Brokamp KA, Teichmann S, Wallace D, Peng T, Ding YY, Kim MS, Xing Y, Kong SW, Bönnemann CG, Mandl KD, White PS.

Dev Cell. 2019 Apr 8;49(1):10-29. doi: 10.1016/j.devcel.2019.03.001. Epub 2019 Mar 28. Review.

3.

Even When You Know Everything, There Is Still More to Learn About Hirschsprung Disease.

Heuckeroth RO.

Gastroenterology. 2018 Dec;155(6):1681-1684. doi: 10.1053/j.gastro.2018.11.006. Epub 2018 Nov 9. No abstract available.

PMID:
30419210
4.

Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function.

Schneider S, Wright CM, Heuckeroth RO.

Annu Rev Physiol. 2019 Feb 10;81:235-259. doi: 10.1146/annurev-physiol-021317-121515. Epub 2018 Oct 31.

PMID:
30379617
5.

Intestinal Dysmotility Syndromes following Systemic Infection by Flaviviruses.

White JP, Xiong S, Malvin NP, Khoury-Hanold W, Heuckeroth RO, Stappenbeck TS, Diamond MS.

Cell. 2018 Nov 15;175(5):1198-1212.e12. doi: 10.1016/j.cell.2018.08.069. Epub 2018 Oct 4.

PMID:
30293866
6.

Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit.

López SH, Avetisyan M, Wright CM, Mesbah K, Kelly RG, Moon AM, Heuckeroth RO.

Dev Biol. 2018 Dec 1;444 Suppl 1:S337-S351. doi: 10.1016/j.ydbio.2018.09.017. Epub 2018 Oct 5.

PMID:
30292786
7.

Muscularis macrophage development in the absence of an enteric nervous system.

Avetisyan M, Rood JE, Huerta Lopez S, Sengupta R, Wright-Jin E, Dougherty JD, Behrens EM, Heuckeroth RO.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4696-4701. doi: 10.1073/pnas.1802490115. Epub 2018 Apr 17.

8.

Hirschsprung disease - integrating basic science and clinical medicine to improve outcomes.

Heuckeroth RO.

Nat Rev Gastroenterol Hepatol. 2018 Mar;15(3):152-167. doi: 10.1038/nrgastro.2017.149. Epub 2018 Jan 4. Review.

PMID:
29300049
9.

MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts.

Abernathy DG, Kim WK, McCoy MJ, Lake AM, Ouwenga R, Lee SW, Xing X, Li D, Lee HJ, Heuckeroth RO, Dougherty JD, Wang T, Yoo AS.

Cell Stem Cell. 2017 Sep 7;21(3):332-348.e9. doi: 10.1016/j.stem.2017.08.002.

10.

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.

Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schäfer KH, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N, Belkind-Gerson J, Bondurand N, Bornstein JC, Chan WY, Cheah K, Gershon MD, Heuckeroth RO, Hofstra RM, Just L, Kapur RP, King SK, McCann CJ, Nagy N, Ngan E, Obermayr F, Pachnis V, Pasricha PJ, Sham MH, Tam P, Vanden Berghe P.

Dev Biol. 2016 Sep 15;417(2):229-51. doi: 10.1016/j.ydbio.2016.04.001. Epub 2016 Apr 5. Review.

11.

Gene-environment interactions and the enteric nervous system: Neural plasticity and Hirschsprung disease prevention.

Heuckeroth RO, Schäfer KH.

Dev Biol. 2016 Sep 15;417(2):188-97. doi: 10.1016/j.ydbio.2016.03.017. Epub 2016 Mar 17. Review.

12.

Regeneration: Stem cells make the bowel nervous.

Heuckeroth RO.

Nature. 2016 Mar 3;531(7592):44-5. doi: 10.1038/nature16877. Epub 2016 Feb 10. No abstract available.

PMID:
26863191
13.

Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse.

Schill EM, Lake JI, Tusheva OA, Nagy N, Bery SK, Foster L, Avetisyan M, Johnson SL, Stenson WF, Goldstein AM, Heuckeroth RO.

Dev Biol. 2016 Jan 15;409(2):473-88. doi: 10.1016/j.ydbio.2015.09.023. Epub 2015 Nov 14.

14.

Hirschsprung's disease, Down syndrome, and missing heritability: too much collagen slows migration.

Heuckeroth RO.

J Clin Invest. 2015 Dec;125(12):4323-6. doi: 10.1172/JCI85003. Epub 2015 Nov 16.

15.

Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton.

Lake JI, Avetisyan M, Zimmermann AG, Heuckeroth RO.

Dev Biol. 2016 Jan 1;409(1):152-165. doi: 10.1016/j.ydbio.2015.11.004. Epub 2015 Nov 10.

16.

Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury.

Avetisyan M, Wang H, Schill EM, Bery S, Grider JR, Hassell JA, Stappenbeck T, Heuckeroth RO.

J Neurosci. 2015 Aug 19;35(33):11543-58. doi: 10.1523/JNEUROSCI.5267-14.2015.

17.

Building a second brain in the bowel.

Avetisyan M, Schill EM, Heuckeroth RO.

J Clin Invest. 2015 Mar 2;125(3):899-907. doi: 10.1172/JCI76307. Epub 2015 Feb 9. Review.

18.

Vascular and neural stem cells in the gut: do they need each other?

Schrenk S, Schuster A, Klotz M, Schleser F, Lake J, Heuckeroth RO, Kim YJ, Laschke MW, Menger MD, Schäfer KH.

Histochem Cell Biol. 2015 Apr;143(4):397-410. doi: 10.1007/s00418-014-1288-9. Epub 2014 Nov 5.

PMID:
25371326
19.

Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis.

Lake JI, Tusheva OA, Graham BL, Heuckeroth RO.

J Clin Invest. 2013 Nov;123(11):4875-87.

20.

Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction.

Fu M, Landreville S, Agapova OA, Wiley LA, Shoykhet M, Harbour JW, Heuckeroth RO.

J Clin Invest. 2013 Dec;123(12):5152-64. doi: 10.1172/JCI67653. Epub 2013 Nov 1.

21.

Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function.

Wright-Jin EC, Grider JR, Duester G, Heuckeroth RO.

Dev Biol. 2013 Sep 1;381(1):28-37. doi: 10.1016/j.ydbio.2013.06.021. Epub 2013 Jun 24.

22.

Enteric nervous system development: migration, differentiation, and disease.

Lake JI, Heuckeroth RO.

Am J Physiol Gastrointest Liver Physiol. 2013 Jul 1;305(1):G1-24. doi: 10.1152/ajpgi.00452.2012. Epub 2013 May 2. Review.

23.

Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection.

Hitch MC, Leinicke JA, Wakeman D, Guo J, Erwin CR, Rowland KJ, Merrick EC, Heuckeroth RO, Warner BW.

Am J Physiol Gastrointest Liver Physiol. 2012 May 15;302(10):G1143-50. doi: 10.1152/ajpgi.00296.2011. Epub 2012 Mar 15.

24.

Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction.

Viader A, Wright-Jin EC, Vohra BP, Heuckeroth RO, Milbrandt J.

PLoS One. 2011;6(11):e27727. doi: 10.1371/journal.pone.0027727. Epub 2011 Nov 16.

25.

Hypothyroidism is a rare cause of isolated constipation.

Bennett WE Jr, Heuckeroth RO.

J Pediatr Gastroenterol Nutr. 2012 Feb;54(2):285-7. doi: 10.1097/MPG.0b013e318239714f.

26.

Augmentation of the ascending component of the peristaltic reflex and substance P release by glial cell line-derived neurotrophic factor.

Grider JR, Heuckeroth RO, Kuemmerle JF, Murthy KS.

Neurogastroenterol Motil. 2010 Jul;22(7):779-86. doi: 10.1111/j.1365-2982.2010.01489.x. Epub 2010 Mar 19.

27.

Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis.

Wang H, Malone JP, Gilmore PE, Davis AE, Magee JC, Townsend RR, Heuckeroth RO.

J Pediatr Gastroenterol Nutr. 2010 Apr;50(4):411-6. doi: 10.1097/MPG.0b013e3181cb42ee.

28.

Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice.

Jain S, Knoten A, Hoshi M, Wang H, Vohra B, Heuckeroth RO, Milbrandt J.

J Clin Invest. 2010 Mar;120(3):778-90. doi: 10.1172/JCI41619. Epub 2010 Feb 15.

29.

Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation.

Fu M, Sato Y, Lyons-Warren A, Zhang B, Kane MA, Napoli JL, Heuckeroth RO.

Development. 2010 Feb;137(4):631-40. doi: 10.1242/dev.040550.

30.

The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function.

Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BP, Keller-Peck C, Heuckeroth RO.

J Neurosci. 2010 Jan 27;30(4):1523-38. doi: 10.1523/JNEUROSCI.3861-09.2010.

31.

Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.

Zhang B, Chang J, Fu M, Huang J, Kashyap R, Salavaggione E, Jain S, Kulkarni S, Deardorff MA, Uzielli ML, Dorsett D, Beebe DC, Jay PY, Heuckeroth RO, Krantz I, Milbrandt J.

PLoS One. 2009;4(5):e5232. doi: 10.1371/journal.pone.0005232. Epub 2009 May 1. Erratum in: PLoS One. 2009;4(5). doi: 10.1371/annotation/ea5b7eb5-5087-448a-8325-c8efff1f54d9. Shashikant, Kulkarni [corrected to Kulkarni, Shashikant].

32.
34.

Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.

Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY, Milbrandt J.

Development. 2007 Sep;134(17):3191-201. Epub 2007 Jul 25.

35.

PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA.

Wang H, Zhang Y, Heuckeroth RO.

FEBS Lett. 2007 Jun 26;581(16):3098-104. Epub 2007 May 29.

36.

Tissue-type plasminogen activator deficiency exacerbates cholestatic liver injury in mice.

Wang H, Zhang Y, Heuckeroth RO.

Hepatology. 2007 Jun;45(6):1527-37.

PMID:
17538930
38.
39.

Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis.

Vohra BP, Tsuji K, Nagashimada M, Uesaka T, Wind D, Fu M, Armon J, Enomoto H, Heuckeroth RO.

Dev Biol. 2006 Oct 1;298(1):259-71. Epub 2006 Jun 27.

40.

Getting to the guts of enteric nervous system development.

Heuckeroth RO, Pachnis V.

Development. 2006 Jun;133(12):2287-90.

41.

Transcriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice.

Wang H, Vohra BP, Zhang Y, Heuckeroth RO.

Hepatology. 2005 Nov;42(5):1099-108.

PMID:
16250054
42.

Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival.

Srinivasan S, Anitha M, Mwangi S, Heuckeroth RO.

Mol Cell Neurosci. 2005 May;29(1):107-19.

PMID:
15866051
43.
44.

GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration.

Enomoto H, Hughes I, Golden J, Baloh RH, Yonemura S, Heuckeroth RO, Johnson EM Jr, Milbrandt J.

Neuron. 2004 Nov 18;44(4):623-36.

45.

Neurturin signalling via GFRalpha2 is essential for innervation of glandular but not muscle targets of sacral parasympathetic ganglion neurons.

Wanigasekara Y, Airaksinen MS, Heuckeroth RO, Milbrandt J, Keast JR.

Mol Cell Neurosci. 2004 Feb;25(2):288-300.

PMID:
15019945
46.

Finding your way to the end: a tale of GDNF and endothelin-3.

Heuckeroth RO.

Neuron. 2003 Dec 4;40(5):871-3. Review. No abstract available.

47.

Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca.

Song XJ, Li DQ, Farley W, Luo LH, Heuckeroth RO, Milbrandt J, Pflugfelder SC.

Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4223-9.

PMID:
14507865
48.

GDNF availability determines enteric neuron number by controlling precursor proliferation.

Gianino S, Grider JR, Cresswell J, Enomoto H, Heuckeroth RO.

Development. 2003 May;130(10):2187-98.

49.

RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons.

Enomoto H, Crawford PA, Gorodinsky A, Heuckeroth RO, Johnson EM Jr, Milbrandt J.

Development. 2001 Oct;128(20):3963-74.

50.

Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin.

Enomoto H, Heuckeroth RO, Golden JP, Johnson EM, Milbrandt J.

Development. 2000 Nov;127(22):4877-89.

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