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Items: 1 to 50 of 62

1.

RCAN1 is a marker of oxidative stress, induced in acute pancreatitis.

Norberg KJ, Nania S, Li X, Gao H, Szatmary P, Segersvärd R, Haas S, Wagman A, Arnelo U, Sutton R, Heuchel RL, Löhr JM.

Pancreatology. 2018 Oct;18(7):734-741. doi: 10.1016/j.pan.2018.08.005. Epub 2018 Aug 16.

PMID:
30139658
2.

Publisher Correction: Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.

Sjöqvist S, Jungebluth P, Lim ML, Haag JC, Gustafsson Y, Lemon G, Baiguera S, Burguillos MA, Del Gaudio C, Rodríguez AB, Sotnichenko A, Kublickiene K, Ullman H, Kielstein H, Damberg P, Bianco A, Heuchel R, Zhao Y, Ribatti D, Ibarra C, Joseph B, Taylor DA, Macchiarini P.

Nat Commun. 2018 Apr 10;9:16208. doi: 10.1038/ncomms16208.

3.

Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development.

Zhao M, Rabieifar P, Costa TDF, Zhuang T, Minden A, Löhr M, Heuchel R, Strömblad S.

Sci Rep. 2017 Aug 1;7(1):7031. doi: 10.1038/s41598-017-07322-5.

4.

Bioinformatory-assisted analysis of next-generation sequencing data for precision medicine in pancreatic cancer.

Malgerud L, Lindberg J, Wirta V, Gustafsson-Liljefors M, Karimi M, Moro CF, Stecker K, Picker A, Huelsewig C, Stein M, Bohnert R, Del Chiaro M, Haas SL, Heuchel RL, Permert J, Maeurer MJ, Brock S, Verbeke CS, Engstrand L, Jackson DB, Grönberg H, Löhr JM.

Mol Oncol. 2017 Oct;11(10):1413-1429. doi: 10.1002/1878-0261.12108. Epub 2017 Aug 8.

5.

Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC.

Strell C, Norberg KJ, Mezheyeuski A, Schnittert J, Kuninty PR, Moro CF, Paulsson J, Schultz NA, Calatayud D, Löhr JM, Frings O, Verbeke CS, Heuchel RL, Prakash J, Johansen JS, Östman A.

Br J Cancer. 2017 Jun 27;117(1):65-77. doi: 10.1038/bjc.2017.140. Epub 2017 May 18.

6.

Discrimination of pancreatic cancer and pancreatitis by LC-MS metabolomics.

Lindahl A, Heuchel R, Forshed J, Lehtiö J, Löhr M, Nordström A.

Metabolomics. 2017;13(5):61. doi: 10.1007/s11306-017-1199-6. Epub 2017 Apr 1.

7.

A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer.

Omazic B, Ayoglu B, Löhr M, Segersvärd R, Verbeke C, Magalhaes I, Potacova Z, Mattsson J, Terman A, Ghazi S, Albiin N, Kartalis N, Nilsson P, Poiret T, Zhenjiang L, Heuchel R, Schwenk JM, Permert J, Maeurer MJ, Ringden O.

J Immunother. 2017 Mar 23. doi: 10.1097/CJI.0000000000000164. [Epub ahead of print]

PMID:
28338506
8.

Retraction: Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.

Sjöqvist S, Jungebluth P, Lim ML, Haag JC, Gustafsson Y, Lemon G, Baiguera S, Burguillos MA, Del Gaudio C, Rodríguez AB, Sotnichenko A, Kublickiene K, Ullman H, Kielstein H, Damberg P, Bianco A, Heuchel R, Zhao Y, Ribatti D, Ibarra C, Joseph B, Taylor DA, Macchiarini P.

Nat Commun. 2017 Mar 21;8:15077. doi: 10.1038/ncomms15077. No abstract available.

9.

Peptide microarray-based characterization of antibody responses to host proteins after bacille Calmette-Guérin vaccination.

Valentini D, Rao M, Rane L, Rahman S, Axelsson-Robertson R, Heuchel R, Löhr M, Hoft D, Brighenti S, Zumla A, Maeurer M.

Int J Infect Dis. 2017 Mar;56:140-154. doi: 10.1016/j.ijid.2017.01.027. Epub 2017 Feb 2.

10.

Correction: Immunohistochemical Typing of Adenocarcinomas of the Pancreatobiliary System Improves Diagnosis and Prognostic Stratification.

Fernández Moro C, Fernandez-Woodbridge A, Alistair D'souza M, Zhang Q, Bozoky B, Vasan SK, Catalano P, Heuchel R, Shtembari S, Del Chiaro M, Danielsson O, Björnstedt M, Löhr JM, Isaksson B, Verbeke C, Bozóky B.

PLoS One. 2017 Jan 26;12(1):e0171283. doi: 10.1371/journal.pone.0171283. eCollection 2017.

11.

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.

Hessmann E, Patzak MS, Klein L, Chen N, Kari V, Ramu I, Bapiro TE, Frese KK, Gopinathan A, Richards FM, Jodrell DI, Verbeke C, Li X, Heuchel R, Löhr JM, Johnsen SA, Gress TM, Ellenrieder V, Neesse A.

Gut. 2018 Mar;67(3):497-507. doi: 10.1136/gutjnl-2016-311954. Epub 2017 Jan 10.

12.

Immunohistochemical Typing of Adenocarcinomas of the Pancreatobiliary System Improves Diagnosis and Prognostic Stratification.

Fernández Moro C, Fernandez-Woodbridge A, Alistair D'souza M, Zhang Q, Bozoky B, Kandaswamy SV, Catalano P, Heuchel R, Shtembari S, Del Chiaro M, Danielsson O, Björnstedt M, Löhr JM, Isaksson B, Verbeke C, Bozóky B.

PLoS One. 2016 Nov 9;11(11):e0166067. doi: 10.1371/journal.pone.0166067. eCollection 2016. Erratum in: PLoS One. 2017 Jan 26;12 (1):e0171283.

13.

Editorial Expression of Concern: Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.

Sjöqvist S, Jungebluth P, Lim ML, Haag JC, Gustafsson Y, Lemon G, Baiguera S, Burguillos MA, Del Gaudio C, Rodriguez AB, Sotnichenko A, Kublickiene K, Ullman H, Kielstein H, Damberg P, Bianco A, Heuchel R, Zhao Y, Ribatti D, Ibarra C, Joseph B, Taylor DA, Macchiarini P.

Nat Commun. 2016 Oct 14;7:13310. doi: 10.1038/ncomms13310. No abstract available. Retraction in: Nat Commun. 2017 Mar 21;8:15077.

14.

Cerulein-induced pancreatic fibrosis is modulated by Smad7, the major negative regulator of transforming growth factor-β signaling.

Li X, Nania S, Fejzibegovic N, Moro CF, Klopp-Schulze L, Verbeke C, Löhr JM, Heuchel RL.

Biochim Biophys Acta. 2016 Sep;1862(9):1839-46. doi: 10.1016/j.bbadis.2016.06.017. Epub 2016 Jun 25.

15.

Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma.

Huang J, Löhr JM, Nilsson M, Segersvärd R, Matsson H, Verbeke C, Heuchel R, Kere J, Iafrate AJ, Zheng Z, Ye W.

Clin Chem. 2015 Nov;61(11):1408-16. doi: 10.1373/clinchem.2015.238543. Epub 2015 Sep 16.

16.

Fluorescence labeled microbubbles for multimodal imaging.

Barrefelt Å, Zhao Y, Larsson MK, Egri G, Kuiper RV, Hamm J, Saghafian M, Caidahl K, Brismar TB, Aspelin P, Heuchel R, Muhammed M, Dähne L, Hassan M.

Biochem Biophys Res Commun. 2015 Aug 28;464(3):737-42. doi: 10.1016/j.bbrc.2015.07.017. Epub 2015 Jul 15.

PMID:
26187672
17.

Endoscopic papillectomy and KRAS expression in the treatment of adenoma in the major duodenal papilla.

Haraldsson E, Swahn F, Verbeke C, Mattsson JS, Enochsson L, Ung KA, Lundell L, Heuchel R, Löhr JM, Arnelo U.

Scand J Gastroenterol. 2015;50(11):1419-27. doi: 10.3109/00365521.2015.1046912. Epub 2015 May 14.

PMID:
25971870
18.

Desmoplasia and chemoresistance in pancreatic cancer.

Schober M, Jesenofsky R, Faissner R, Weidenauer C, Hagmann W, Michl P, Heuchel RL, Haas SL, Löhr JM.

Cancers (Basel). 2014 Oct 21;6(4):2137-54. doi: 10.3390/cancers6042137. Review.

19.

Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis.

Marschallinger J, Krampert M, Couillard-Despres S, Heuchel R, Bogdahn U, Aigner L.

Exp Gerontol. 2014 Sep;57:149-54. doi: 10.1016/j.exger.2014.05.011. Epub 2014 May 24.

20.

Experimental orthotopic transplantation of a tissue-engineered oesophagus in rats.

Sjöqvist S, Jungebluth P, Lim ML, Haag JC, Gustafsson Y, Lemon G, Baiguera S, Burguillos MA, Del Gaudio C, Rodríguez AB, Sotnichenko A, Kublickiene K, Ullman H, Kielstein H, Damberg P, Bianco A, Heuchel R, Zhao Y, Ribatti D, Ibarra C, Joseph B, Taylor DA, Macchiarini P.

Nat Commun. 2014 Apr 15;5:3562. doi: 10.1038/ncomms4562. Retraction in: Nat Commun. 2017 Mar 21;8:15077. Erratum in: Nat Commun. 2018 Apr 10;9:16208.

21.

Real-time assessment of tissue hypoxia in vivo with combined photoacoustics and high-frequency ultrasound.

Gerling M, Zhao Y, Nania S, Norberg KJ, Verbeke CS, Englert B, Kuiper RV, Bergström A, Hassan M, Neesse A, Löhr JM, Heuchel RL.

Theranostics. 2014 Mar 18;4(6):604-13. doi: 10.7150/thno.7996. eCollection 2014.

22.

Smad7 regulates terminal maturation of chondrocytes in the growth plate.

Estrada KD, Wang W, Retting KN, Chien CT, Elkhoury FF, Heuchel R, Lyons KM.

Dev Biol. 2013 Oct 15;382(2):375-84. doi: 10.1016/j.ydbio.2013.08.021. Epub 2013 Aug 29.

23.

Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension.

Wei LH, Huang XR, Zhang Y, Li YQ, Chen HY, Heuchel R, Yan BP, Yu CM, Lan HY.

PLoS One. 2013 Jul 23;8(7):e70195. doi: 10.1371/journal.pone.0070195. Print 2013.

24.

Inhibitory role of Smad7 in hepatocarcinogenesis in mice and in vitro.

Wang J, Zhao J, Chu ES, Mok MT, Go MY, Man K, Heuchel R, Lan HY, Chang Z, Sung JJ, Yu J.

J Pathol. 2013 Aug;230(4):441-52. doi: 10.1002/path.4206.

PMID:
23625826
25.

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.

Longati P, Jia X, Eimer J, Wagman A, Witt MR, Rehnmark S, Verbeke C, Toftgård R, Löhr M, Heuchel RL.

BMC Cancer. 2013 Feb 27;13:95. doi: 10.1186/1471-2407-13-95.

26.

Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice.

Liu GX, Li YQ, Huang XR, Wei L, Chen HY, Shi YJ, Heuchel RL, Lan HY.

PLoS One. 2013;8(1):e53573. doi: 10.1371/journal.pone.0053573. Epub 2013 Jan 3.

27.

Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I, Zagorac S, Alcala S, Rodriguez-Arabaolaza I, Ramirez JC, Torres-Ruíz R, Garcia E, Hidalgo M, Cebrián DÁ, Heuchel R, Löhr M, Berger F, Bartenstein P, Aicher A, Heeschen C.

Cell Stem Cell. 2011 Nov 4;9(5):433-46. doi: 10.1016/j.stem.2011.10.001. Erratum in: Cell Stem Cell. 2012 Jan 6;10(1):104.

28.

Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β.

Dahal BK, Heuchel R, Pullamsetti SS, Wilhelm J, Ghofrani HA, Weissmann N, Seeger W, Grimminger F, Schermuly RT.

Pulm Circ. 2011 Apr-Jun;1(2):259-68. doi: 10.4103/2045-8932.83448.

29.

Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene.

Pazirandeh A, Sultana T, Mirza M, Rozell B, Hultenby K, Wallis K, Vennström B, Davis B, Arner A, Heuchel R, Löhr M, Philipson L, Sollerbrant K.

PLoS One. 2011;6(6):e20203. doi: 10.1371/journal.pone.0020203. Epub 2011 Jun 3.

30.

The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential.

Chen HY, Huang XR, Wang W, Li JH, Heuchel RL, Chung AC, Lan HY.

Diabetes. 2011 Feb;60(2):590-601. doi: 10.2337/db10-0403. Epub 2010 Oct 27.

31.

CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice.

Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, de Angelis MH, Dikic I.

EMBO J. 2010 Jul 21;29(14):2421-32. doi: 10.1038/emboj.2010.120. Epub 2010 Jun 15.

32.

Smad7 regulates the adult neural stem/progenitor cell pool in a transforming growth factor beta- and bone morphogenetic protein-independent manner.

Krampert M, Chirasani SR, Wachs FP, Aigner R, Bogdahn U, Yingling JM, Heldin CH, Aigner L, Heuchel R.

Mol Cell Biol. 2010 Jul;30(14):3685-94. doi: 10.1128/MCB.00434-09. Epub 2010 May 17.

33.

The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner.

Lu N, Carracedo S, Ranta J, Heuchel R, Soininen R, Gullberg D.

Matrix Biol. 2010 Apr;29(3):166-76. doi: 10.1016/j.matbio.2009.11.003. Epub 2009 Nov 12.

PMID:
19913614
34.

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice.

Chung AC, Huang XR, Zhou L, Heuchel R, Lai KN, Lan HY.

Nephrol Dial Transplant. 2009 May;24(5):1443-54. doi: 10.1093/ndt/gfn699. Epub 2008 Dec 18.

PMID:
19096081
35.

A gain-of-function mutation in the PDGFR-beta alters the kinetics of injury response in liver and skin.

Krampert M, Heldin CH, Heuchel RL.

Lab Invest. 2008 Nov;88(11):1204-14. doi: 10.1038/labinvest.2008.81. Epub 2008 Sep 1.

36.

Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice.

Hamzavi J, Ehnert S, Godoy P, Ciuclan L, Weng H, Mertens PR, Heuchel R, Dooley S.

J Cell Mol Med. 2008 Oct;12(5B):2130-44. doi: 10.1111/j.1582-4934.2008.00262.x. Epub 2008 Feb 4.

38.

Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes.

Weng HL, Ciuclan L, Liu Y, Hamzavi J, Godoy P, Gaitantzi H, Kanzler S, Heuchel R, Ueberham U, Gebhardt R, Breitkopf K, Dooley S.

Hepatology. 2007 Oct;46(4):1257-70.

PMID:
17657819
39.

Platelet-derived growth factor receptor-beta constitutive activity promotes angiogenesis in vivo and in vitro.

Magnusson PU, Looman C, Ahgren A, Wu Y, Claesson-Welsh L, Heuchel RL.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2142-9. Epub 2007 Jul 26. Erratum in: Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):e11.

PMID:
17656670
40.

An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta.

Looman C, Sun T, Yu Y, Zieba A, Ahgren A, Feinstein R, Forsberg H, Hellberg C, Heldin CH, Zhang XQ, Forsberg-Nilsson K, Khoo N, Fundele R, Heuchel R.

Int J Dev Biol. 2007;51(5):361-70.

41.

Expression and function of the gene encoding the voltage-dependent calcium channel beta3-subunit in the mouse placenta.

Singh U, Sun T, Looman C, Heuchel R, Elliott R, Freichel M, Meissner M, Flockerzi V, Fundele R.

Placenta. 2007 May-Jun;28(5-6):412-20. Epub 2006 Jul 5.

PMID:
16822546
42.

Deletion of exon I of SMAD7 in mice results in altered B cell responses.

Li R, Rosendahl A, Brodin G, Cheng AM, Ahgren A, Sundquist C, Kulkarni S, Pawson T, Heldin CH, Heuchel RL.

J Immunol. 2006 Jun 1;176(11):6777-84.

43.

Platelet-derived growth factor receptor-beta promotes early endothelial cell differentiation.

Rolny C, Nilsson I, Magnusson P, Armulik A, Jakobsson L, Wentzel P, Lindblom P, Norlin J, Betsholtz C, Heuchel R, Welsh M, Claesson-Welsh L.

Blood. 2006 Sep 15;108(6):1877-86. Epub 2006 May 11.

44.

Tandem Sp1/Sp3 sites together with an Ets-1 site cooperate to mediate alpha11 integrin chain expression in mesenchymal cells.

Lu N, Heuchel R, Barczyk M, Zhang WM, Gullberg D.

Matrix Biol. 2006 Mar;25(2):118-29. Epub 2005 Nov 18.

PMID:
16300938
45.

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.

Chiara F, Goumans MJ, Forsberg H, Ahgrén A, Rasola A, Aspenström P, Wernstedt C, Hellberg C, Heldin CH, Heuchel R.

J Biol Chem. 2004 Oct 8;279(41):42516-27. Epub 2004 Jul 28.

46.

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.

Furuhashi M, Sjöblom T, Abramsson A, Ellingsen J, Micke P, Li H, Bergsten-Folestad E, Eriksson U, Heuchel R, Betsholtz C, Heldin CH, Ostman A.

Cancer Res. 2004 Apr 15;64(8):2725-33.

48.
49.

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation.

Arsura M, Panta GR, Bilyeu JD, Cavin LG, Sovak MA, Oliver AA, Factor V, Heuchel R, Mercurio F, Thorgeirsson SS, Sonenshein GE.

Oncogene. 2003 Jan 23;22(3):412-25.

PMID:
12545162
50.

Retention of PDGFR-beta function in mice in the absence of phosphatidylinositol 3'-kinase and phospholipase Cgamma signaling pathways.

Tallquist MD, Klinghoffer RA, Heuchel R, Mueting-Nelsen PF, Corrin PD, Heldin CH, Johnson RJ, Soriano P.

Genes Dev. 2000 Dec 15;14(24):3179-90.

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