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Items: 1 to 50 of 58


Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.

Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer MW.

Life Sci Alliance. 2020 Jan 20;3(1). pii: e201900623. doi: 10.26508/lsa.201900623. Print 2020 Jan.


Age Mosaicism across Multiple Scales in Adult Tissues.

Arrojo E Drigo R, Lev-Ram V, Tyagi S, Ramachandra R, Deerinck T, Bushong E, Phan S, Orphan V, Lechene C, Ellisman MH, Hetzer MW.

Cell Metab. 2019 Aug 6;30(2):343-351.e3. doi: 10.1016/j.cmet.2019.05.010. Epub 2019 Jun 6.


Predicting age from the transcriptome of human dermal fibroblasts.

Fleischer JG, Schulte R, Tsai HH, Tyagi S, Ibarra A, Shokhirev MN, Huang L, Hetzer MW, Navlakha S.

Genome Biol. 2018 Dec 20;19(1):221. doi: 10.1186/s13059-018-1599-6.


Visualization of long-lived proteins reveals age mosaicism within nuclei of postmitotic cells.

Toyama BH, Arrojo E Drigo R, Lev-Ram V, Ramachandra R, Deerinck TJ, Lechene C, Ellisman MH, Hetzer MW.

J Cell Biol. 2019 Feb 4;218(2):433-444. doi: 10.1083/jcb.201809123. Epub 2018 Dec 14.


Coaching from the sidelines: the nuclear periphery in genome regulation.

Buchwalter A, Kaneshiro JM, Hetzer MW.

Nat Rev Genet. 2019 Jan;20(1):39-50. doi: 10.1038/s41576-018-0063-5. Review.


Tpr regulates the total number of nuclear pore complexes per cell nucleus.

McCloskey A, Ibarra A, Hetzer MW.

Genes Dev. 2018 Oct 1;32(19-20):1321-1331. doi: 10.1101/gad.315523.118. Epub 2018 Sep 18.


Nup98 recruits the Wdr82-Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells.

Franks TM, McCloskey A, Shokirev MN, Benner C, Rathore A, Hetzer MW.

Genes Dev. 2017 Nov 15;31(22):2222-2234. doi: 10.1101/gad.306753.117. Epub 2017 Dec 21.


Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.

Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer MW, Gage FH.

Cell Stem Cell. 2017 Nov 2;21(5):618-634.e7. doi: 10.1016/j.stem.2017.08.012. Epub 2017 Sep 14.


Corrigendum: p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.

van de Ven RAH, de Groot JS, Park D, van Domselaar R, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PWB.

Nat Commun. 2017 Sep 6;8:16030. doi: 10.1038/ncomms16030. eCollection 2017.


Nucleolar expansion and elevated protein translation in premature aging.

Buchwalter A, Hetzer MW.

Nat Commun. 2017 Aug 30;8(1):328. doi: 10.1038/s41467-017-00322-z.


Corrigendum: Evolution of a transcriptional regulator from a transmembrane nucleoporin.

Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage FH, Hetzer MW.

Genes Dev. 2017 Apr 15;31(8):845. doi: 10.1101/gad.300699.117. No abstract available.


p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis.

van de Ven RA, de Groot JS, Park D, van Domselaar R, de Jong D, Szuhai K, van der Wall E, Rueda OM, Ali HR, Caldas C, van Diest PJ, Hetzer MW, Sahai E, Derksen PW.

Nat Commun. 2016 Dec 22;7:13874. doi: 10.1038/ncomms13874. Erratum in: Nat Commun. 2017 Sep 06;8:16030.


Nucleoporin-mediated regulation of cell identity genes.

Ibarra A, Benner C, Tyagi S, Cool J, Hetzer MW.

Genes Dev. 2016 Oct 15;30(20):2253-2258. Epub 2016 Nov 2.


Nuclear envelope rupture is induced by actin-based nucleus confinement.

Hatch EM, Hetzer MW.

J Cell Biol. 2016 Oct 10;215(1):27-36. Epub 2016 Oct 3.


Evolution of a transcriptional regulator from a transmembrane nucleoporin.

Franks TM, Benner C, Narvaiza I, Marchetto MC, Young JM, Malik HS, Gage FH, Hetzer MW.

Genes Dev. 2016 May 15;30(10):1155-71. doi: 10.1101/gad.280941.116. Epub 2016 May 19. Erratum in: Genes Dev. 2017 Apr 15;31(8):845.


Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats.

Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer MW, Beck M.

Cell Syst. 2015 Sep 23;1(3):224-37. doi: 10.1016/j.cels.2015.08.012. Epub 2015 Sep 17.


Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.

Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer MW, Gage FH.

Cell Stem Cell. 2015 Dec 3;17(6):705-718. doi: 10.1016/j.stem.2015.09.001. Epub 2015 Oct 8.


Linking Micronuclei to Chromosome Fragmentation.

Hatch EM, Hetzer MW.

Cell. 2015 Jun 18;161(7):1502-4. doi: 10.1016/j.cell.2015.06.005.


The nucleoporin Nup153 regulates embryonic stem cell pluripotency through gene silencing.

Jacinto FV, Benner C, Hetzer MW.

Genes Dev. 2015 Jun 15;29(12):1224-38. doi: 10.1101/gad.260919.115. Epub 2015 Jun 16.



Hatch EM, Hetzer MW.

Curr Biol. 2015 May 18;25(10):R397-9. doi: 10.1016/j.cub.2015.02.033. No abstract available.


The nucleoporin gp210/Nup210 controls muscle differentiation by regulating nuclear envelope/ER homeostasis.

Gomez-Cavazos JS, Hetzer MW.

J Cell Biol. 2015 Mar 16;208(6):671-81. doi: 10.1083/jcb.201410047.


Nuclear pore proteins and the control of genome functions.

Ibarra A, Hetzer MW.

Genes Dev. 2015 Feb 15;29(4):337-49. doi: 10.1101/gad.256495.114. Review.


Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics.

Buchwalter AL, Liang Y, Hetzer MW.

Mol Biol Cell. 2014 Aug 15;25(16):2472-84. doi: 10.1091/mbc.E14-04-0865. Epub 2014 Jun 18.


Nuclear pores set the speed limit for mitosis.

Buchwalter A, Hetzer MW.

Cell. 2014 Feb 27;156(5):868-9. doi: 10.1016/j.cell.2014.02.004.


Identification of long-lived proteins reveals exceptional stability of essential cellular structures.

Toyama BH, Savas JN, Park SK, Harris MS, Ingolia NT, Yates JR 3rd, Hetzer MW.

Cell. 2013 Aug 29;154(5):971-982. doi: 10.1016/j.cell.2013.07.037.


Catastrophic nuclear envelope collapse in cancer cell micronuclei.

Hatch EM, Fischer AH, Deerinck TJ, Hetzer MW.

Cell. 2013 Jul 3;154(1):47-60. doi: 10.1016/j.cell.2013.06.007.


Anomalous diffusion of single particles in cytoplasm.

Regner BM, Vučinić D, Domnisoru C, Bartol TM, Hetzer MW, Tartakovsky DM, Sejnowski TJ.

Biophys J. 2013 Apr 16;104(8):1652-60. doi: 10.1016/j.bpj.2013.01.049.


Dynamic association of NUP98 with the human genome.

Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer MW.

PLoS Genet. 2013;9(2):e1003308. doi: 10.1371/journal.pgen.1003308. Epub 2013 Feb 28.


Protein homeostasis: live long, won't prosper.

Toyama BH, Hetzer MW.

Nat Rev Mol Cell Biol. 2013 Jan;14(1):55-61. doi: 10.1038/nrm3496. Review.


The role of Nup98 in transcription regulation in healthy and diseased cells.

Franks TM, Hetzer MW.

Trends Cell Biol. 2013 Mar;23(3):112-7. doi: 10.1016/j.tcb.2012.10.013. Epub 2012 Dec 13.


Outfits for different occasions: tissue-specific roles of Nuclear Envelope proteins.

Gomez-Cavazos JS, Hetzer MW.

Curr Opin Cell Biol. 2012 Dec;24(6):775-83. doi: 10.1016/ Epub 2012 Sep 17. Review.


RNP export by nuclear envelope budding.

Hatch EM, Hetzer MW.

Cell. 2012 May 11;149(4):733-5. doi: 10.1016/j.cell.2012.04.018.


Transient nuclear envelope rupturing during interphase in human cancer cells.

Vargas JD, Hatch EM, Anderson DJ, Hetzer MW.

Nucleus. 2012 Jan-Feb;3(1):88-100. doi: 10.4161/nucl.18954.


Extremely long-lived nuclear pore proteins in the rat brain.

Savas JN, Toyama BH, Xu T, Yates JR 3rd, Hetzer MW.

Science. 2012 Feb 24;335(6071):942. doi: 10.1126/science.1217421. Epub 2012 Feb 2.


A change in nuclear pore complex composition regulates cell differentiation.

D'Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer MW.

Dev Cell. 2012 Feb 14;22(2):446-58. doi: 10.1016/j.devcel.2011.11.021. Epub 2012 Jan 19.


POM121 and Sun1 play a role in early steps of interphase NPC assembly.

Talamas JA, Hetzer MW.

J Cell Biol. 2011 Jul 11;194(1):27-37. doi: 10.1083/jcb.201012154. Epub 2011 Jul 4.


Nuclear pore complexes: guardians of the nuclear genome.

Capelson M, Doucet C, Hetzer MW.

Cold Spring Harb Symp Quant Biol. 2010;75:585-97. doi: 10.1101/sqb.2010.75.059. Epub 2011 Apr 18. Review.


Functional interactions between nucleoporins and chromatin.

Liang Y, Hetzer MW.

Curr Opin Cell Biol. 2011 Feb;23(1):65-70. doi: 10.1016/ Epub 2010 Oct 26. Review.


Nuclear pore biogenesis into an intact nuclear envelope.

Doucet CM, Hetzer MW.

Chromosoma. 2010 Oct;119(5):469-77. doi: 10.1007/s00412-010-0289-2. Epub 2010 Aug 19. Review.


Cell cycle-dependent differences in nuclear pore complex assembly in metazoa.

Doucet CM, Talamas JA, Hetzer MW.

Cell. 2010 Jun 11;141(6):1030-41. doi: 10.1016/j.cell.2010.04.036.


The role of the nuclear pore complex in aging of post-mitotic cells.

Hetzer MW.

Aging (Albany NY). 2010 Mar 20;2(2):74-5. No abstract available.


The nuclear envelope.

Hetzer MW.

Cold Spring Harb Perspect Biol. 2010 Mar;2(3):a000539. doi: 10.1101/cshperspect.a000539. Review.


Chromatin-bound nuclear pore components regulate gene expression in higher eukaryotes.

Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer MW.

Cell. 2010 Feb 5;140(3):372-83. doi: 10.1016/j.cell.2009.12.054.


Border control at the nucleus: biogenesis and organization of the nuclear membrane and pore complexes.

Hetzer MW, Wente SR.

Dev Cell. 2009 Nov;17(5):606-16. doi: 10.1016/j.devcel.2009.10.007. Review.


Recruitment of functionally distinct membrane proteins to chromatin mediates nuclear envelope formation in vivo.

Anderson DJ, Vargas JD, Hsiao JP, Hetzer MW.

J Cell Biol. 2009 Jul 27;186(2):183-91. doi: 10.1083/jcb.200901106. Epub 2009 Jul 20. Erratum in: J Cell Biol. 2009 Sep 21;186(6):929.


The role of nuclear pores in gene regulation, development and disease.

Capelson M, Hetzer MW.

EMBO Rep. 2009 Jul;10(7):697-705. doi: 10.1038/embor.2009.147. Epub 2009 Jun 19. Review. Erratum in: EMBO Rep. 2009 Aug;10(8):934.


ER membrane-bending proteins are necessary for de novo nuclear pore formation.

Dawson TR, Lazarus MD, Hetzer MW, Wente SR.

J Cell Biol. 2009 Mar 9;184(5):659-75. doi: 10.1083/jcb.200806174.


Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells.

D'Angelo MA, Raices M, Panowski SH, Hetzer MW.

Cell. 2009 Jan 23;136(2):284-95. doi: 10.1016/j.cell.2008.11.037.


Reorganization of the nuclear envelope during open mitosis.

Kutay U, Hetzer MW.

Curr Opin Cell Biol. 2008 Dec;20(6):669-77. doi: 10.1016/ Epub 2008 Nov 2. Review.


Structure, dynamics and function of nuclear pore complexes.

D'Angelo MA, Hetzer MW.

Trends Cell Biol. 2008 Oct;18(10):456-66. doi: 10.1016/j.tcb.2008.07.009. Epub 2008 Sep 9. Review.

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