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Items: 1 to 50 of 192

1.

The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability.

Pérez V, Bermedo-Garcia F, Zelada D, Court FA, Pérez MÁ, Fuenzalida M, Ábrigo J, Cabello-Verrugio C, Moya-Alvarado G, Tapia JC, Valenzuela V, Hetz C, Bronfman FC, Henríquez JP.

Acta Neuropathol Commun. 2019 Sep 12;7(1):147. doi: 10.1186/s40478-019-0802-7.

PMID:
31514753
2.

Publisher Correction: Pharmacological targeting of the unfolded protein response for disease intervention.

Hetz C, Axten JM, Patterson JB.

Nat Chem Biol. 2019 Aug 22. doi: 10.1038/s41589-019-0363-x. [Epub ahead of print]

PMID:
31439938
3.

Small Molecules to Improve ER Proteostasis in Disease.

Gonzalez-Teuber V, Albert-Gasco H, Auyeung VC, Papa FR, Mallucci GR, Hetz C.

Trends Pharmacol Sci. 2019 Sep;40(9):684-695. doi: 10.1016/j.tips.2019.07.003. Epub 2019 Jul 31. Review.

PMID:
31377018
4.

Pharmacological targeting of the unfolded protein response for disease intervention.

Hetz C, Axten JM, Patterson JB.

Nat Chem Biol. 2019 Aug;15(8):764-775. doi: 10.1038/s41589-019-0326-2. Epub 2019 Jul 18. Review. Erratum in: Nat Chem Biol. 2019 Aug 22;:.

PMID:
31320759
5.

Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.

Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C.

Nat Cell Biol. 2019 Jul;21(7):913. doi: 10.1038/s41556-019-0355-9.

PMID:
31201389
6.

β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation.

Pinto C, Medinas DB, Fuentes-Villalobos F, Maripillán J, Castro AF, Martínez AD, Osses N, Hetz C, Henríquez JP.

Neurobiol Dis. 2019 Oct;130:104497. doi: 10.1016/j.nbd.2019.104497. Epub 2019 Jun 7.

PMID:
31176720
7.

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics.

Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, Kerkhofs M, Vicente R, Kaufman RJ, Inestrosa NC, Gonzalez-Billault C, Wiseman RL, Agostinis P, Bultynck G, Court FA, Kroemer G, Cárdenas JC, Hetz C.

Nat Cell Biol. 2019 Jun;21(6):755-767. doi: 10.1038/s41556-019-0329-y. Epub 2019 May 20. Erratum in: Nat Cell Biol. 2019 Jun 14;:.

PMID:
31110288
8.

Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion.

Limia CM, Sauzay C, Urra H, Hetz C, Chevet E, Avril T.

Cancers (Basel). 2019 May 6;11(5). pii: E631. doi: 10.3390/cancers11050631. Review.

9.

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis.

Beltran S, Nassif M, Vicencio E, Arcos J, Labrador L, Cortes BI, Cortez C, Bergmann CA, Espinoza S, Hernandez MF, Matamala JM, Bargsted L, Matus S, Rojas-Rivera D, Bertrand MJM, Medinas DB, Hetz C, Manque PA, Woehlbier U.

Mol Neurodegener. 2019 Mar 27;14(1):14. doi: 10.1186/s13024-019-0313-9.

10.

Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease.

Martinez A, Lopez N, Gonzalez C, Hetz C.

Biol Cell. 2019 Jun;111(6):161-168. doi: 10.1111/boc.201800068. Epub 2019 Mar 25. Review.

PMID:
30860281
11.

Brain organoids: a next step for humanized Alzheimer's disease models?

Gerakis Y, Hetz C.

Mol Psychiatry. 2019 Apr;24(4):474-478. doi: 10.1038/s41380-018-0343-7. Epub 2019 Jan 7. No abstract available.

PMID:
30617271
12.

ER stress links aging to sporadic ALS.

Medinas DB, Cabral-Miranda F, Hetz C.

Aging (Albany NY). 2019 Jan 5;11(1):5-6. doi: 10.18632/aging.101705. No abstract available.

13.

Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases.

García-González P, Cabral-Miranda F, Hetz C, Osorio F.

Front Immunol. 2018 Nov 2;9:2541. doi: 10.3389/fimmu.2018.02541. eCollection 2018. Review.

14.

Cyclosporine A binding to COX-2 reveals a novel signaling pathway that activates the IRE1α unfolded protein response sensor.

Groenendyk J, Paskevicius T, Urra H, Viricel C, Wang K, Barakat K, Hetz C, Kurgan L, Agellon LB, Michalak M.

Sci Rep. 2018 Nov 12;8(1):16678. doi: 10.1038/s41598-018-34891-w.

15.

Publisher Correction: IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A.

Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C.

Nat Cell Biol. 2018 Oct;20(10):1228. doi: 10.1038/s41556-018-0186-0.

PMID:
30089843
16.

Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis.

Medinas DB, Rozas P, Martínez Traub F, Woehlbier U, Brown RH, Bosco DA, Hetz C.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8209-8214. doi: 10.1073/pnas.1801109115. Epub 2018 Jul 23.

17.

A new model to study cell-to-cell transfer of αSynuclein in vivo.

Mercado G, López N, Martínez A, Sardi SP, Hetz C.

Biochem Biophys Res Commun. 2018 Sep 10;503(3):1385-1393. doi: 10.1016/j.bbrc.2018.07.053. Epub 2018 Jul 17.

PMID:
30025892
18.

IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A.

Urra H, Henriquez DR, Cánovas J, Villarroel-Campos D, Carreras-Sureda A, Pulgar E, Molina E, Hazari YM, Limia CM, Alvarez-Rojas S, Figueroa R, Vidal RL, Rodriguez DA, Rivera CA, Court FA, Couve A, Qi L, Chevet E, Akai R, Iwawaki T, Concha ML, Glavic Á, Gonzalez-Billault C, Hetz C.

Nat Cell Biol. 2018 Aug;20(8):942-953. doi: 10.1038/s41556-018-0141-0. Epub 2018 Jul 16. Erratum in: Nat Cell Biol. 2018 Oct;20(10):1228.

PMID:
30013108
19.

ER Proteostasis Control of Neuronal Physiology and Synaptic Function.

Martínez G, Khatiwada S, Costa-Mattioli M, Hetz C.

Trends Neurosci. 2018 Sep;41(9):610-624. doi: 10.1016/j.tins.2018.05.009. Epub 2018 Jun 23. Review.

PMID:
29945734
20.

Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease.

Lebeaupin C, Vallée D, Hazari Y, Hetz C, Chevet E, Bailly-Maitre B.

J Hepatol. 2018 Oct;69(4):927-947. doi: 10.1016/j.jhep.2018.06.008. Epub 2018 Jun 27. Review.

21.

ER stress sensing mechanism: Putting off the brake on UPR transducers.

Rojas-Rivera D, Rodriguez DA, Sepulveda D, Hetz C.

Oncotarget. 2018 Apr 13;9(28):19461-19462. doi: 10.18632/oncotarget.25114. eCollection 2018 Apr 13. No abstract available.

22.

Gene Therapy Strategies to Restore ER Proteostasis in Disease.

Valenzuela V, Jackson KL, Sardi SP, Hetz C.

Mol Ther. 2018 Jun 6;26(6):1404-1413. doi: 10.1016/j.ymthe.2018.04.004. Epub 2018 Apr 7. Review.

23.

Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis.

Matamala JM, Arias-Carrasco R, Sanchez C, Uhrig M, Bargsted L, Matus S, Maracaja-Coutinho V, Abarzua S, van Zundert B, Verdugo R, Manque P, Hetz C.

Neurobiol Aging. 2018 Apr;64:123-138. doi: 10.1016/j.neurobiolaging.2017.12.020. Epub 2017 Dec 29.

PMID:
29458840
24.

Unraveling the role of motoneuron autophagy in ALS.

Valenzuela V, Nassif M, Hetz C.

Autophagy. 2018;14(4):733-737. doi: 10.1080/15548627.2018.1432327. Epub 2018 Mar 13. Review.

25.

Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases.

González-Quiroz M, Urra H, Limia CM, Hetz C.

Semin Cancer Biol. 2018 Jun;50:42-52. doi: 10.1016/j.semcancer.2018.01.011. Epub 2018 Jan 31. Review.

PMID:
29369790
26.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.

27.

Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease.

Mercado G, Castillo V, Soto P, López N, Axten JM, Sardi SP, Hoozemans JJM, Hetz C.

Neurobiol Dis. 2018 Apr;112:136-148. doi: 10.1016/j.nbd.2018.01.004. Epub 2018 Jan 31.

PMID:
29355603
28.

Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α.

Sepulveda D, Rojas-Rivera D, Rodríguez DA, Groenendyk J, Köhler A, Lebeaupin C, Ito S, Urra H, Carreras-Sureda A, Hazari Y, Vasseur-Cognet M, Ali MMU, Chevet E, Campos G, Godoy P, Vaisar T, Bailly-Maitre B, Nagata K, Michalak M, Sierralta J, Hetz C.

Mol Cell. 2018 Jan 18;69(2):238-252.e7. doi: 10.1016/j.molcel.2017.12.028.

29.

Dual IRE1 RNase functions dictate glioblastoma development.

Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F, Bourien H, Logotheti M, Jégou G, Pallares-Lupon N, Schmit K, Le Reste PJ, Etcheverry A, Mosser J, Barroso K, Vauléon E, Maurel M, Samali A, Patterson JB, Pluquet O, Hetz C, Quillien V, Chatziioannou A, Chevet E.

EMBO Mol Med. 2018 Mar;10(3). pii: e7929. doi: 10.15252/emmm.201707929.

30.

(off)Targeting UPR signaling: the race toward intervening ER proteostasis.

Pérez-Arancibia R, Rivas A, Hetz C.

Expert Opin Ther Targets. 2018 Feb;22(2):97-100. doi: 10.1080/14728222.2018.1420169. Epub 2017 Dec 23. No abstract available.

PMID:
29260915
31.

Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease.

Gerakis Y, Hetz C.

FEBS J. 2018 Mar;285(6):995-1011. doi: 10.1111/febs.14332. Epub 2017 Dec 15. Review.

32.

The Unfolded Protein Response and Cell Fate Control.

Hetz C, Papa FR.

Mol Cell. 2018 Jan 18;69(2):169-181. doi: 10.1016/j.molcel.2017.06.017. Epub 2017 Nov 5. Review.

33.

Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model.

Bargsted L, Medinas DB, Martínez Traub F, Rozas P, Muñoz N, Nassif M, Jerez C, Catenaccio A, Court FA, Hetz C, Matus S.

Sci Rep. 2017 Oct 27;7(1):14266. doi: 10.1038/s41598-017-14399-5.

34.

Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses.

Carreras-Sureda A, Pihán P, Hetz C.

Cell Calcium. 2018 Mar;70:24-31. doi: 10.1016/j.ceca.2017.08.004. Epub 2017 Aug 20. Review.

PMID:
29054537
35.

A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease.

Gerakis Y, Hetz C.

Neurobiol Aging. 2018 Mar;63:162-164. doi: 10.1016/j.neurobiolaging.2017.09.012. Epub 2017 Sep 22. Review.

PMID:
29042130
36.

Fine-tuning PERK signaling to control cell fate under stress.

Urra H, Hetz C.

Nat Struct Mol Biol. 2017 Oct 5;24(10):789-790. doi: 10.1038/nsmb.3478. No abstract available.

PMID:
28981072
37.

Proteostasis disturbance in amyotrophic lateral sclerosis.

Medinas DB, Valenzuela V, Hetz C.

Hum Mol Genet. 2017 Oct 1;26(R2):R91-R104. doi: 10.1093/hmg/ddx274. Review.

PMID:
28977445
38.

ER Stress and Neurodegenerative Disease: A Cause or Effect Relationship?

Cabral-Miranda F, Hetz C.

Curr Top Microbiol Immunol. 2018;414:131-157. doi: 10.1007/82_2017_52. Review.

PMID:
28864830
39.

ER stress and the unfolded protein response in neurodegeneration.

Hetz C, Saxena S.

Nat Rev Neurol. 2017 Aug;13(8):477-491. doi: 10.1038/nrneurol.2017.99. Epub 2017 Jul 21. Review.

PMID:
28731040
40.

Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis.

Medinas DB, González JV, Falcon P, Hetz C.

Front Mol Neurosci. 2017 Jul 5;10:216. doi: 10.3389/fnmol.2017.00216. eCollection 2017.

41.

BCL-2 family: integrating stress responses at the ER to control cell demise.

Pihán P, Carreras-Sureda A, Hetz C.

Cell Death Differ. 2017 Sep;24(9):1478-1487. doi: 10.1038/cdd.2017.82. Epub 2017 Jun 16. Review.

42.

BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response.

Castillo K, Rojas-Rivera D, Lisbona F, Caballero B, Nassif M, Court FA, Schuck S, Ibar C, Walter P, Sierralta J, Glavic A, Hetz C.

EMBO J. 2017 Jun 1;36(11):1640. doi: 10.15252/embj.201797020. No abstract available.

43.

Drug repurposing to target proteostasis and prevent neurodegeneration: accelerating translational efforts.

Mercado G, Hetz C.

Brain. 2017 Jun 1;140(6):1544-1547. doi: 10.1093/brain/awx107. No abstract available.

PMID:
28549133
44.

Endoplasmic reticulum proteostasis impairment in aging.

Martínez G, Duran-Aniotz C, Cabral-Miranda F, Vivar JP, Hetz C.

Aging Cell. 2017 Aug;16(4):615-623. doi: 10.1111/acel.12599. Epub 2017 Apr 23. Review.

45.

The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics.

Carreras-Sureda A, Pihán P, Hetz C.

Front Oncol. 2017 Apr 3;7:55. doi: 10.3389/fonc.2017.00055. eCollection 2017. Review.

46.

IRE1 signaling exacerbates Alzheimer's disease pathogenesis.

Duran-Aniotz C, Cornejo VH, Espinoza S, Ardiles ÁO, Medinas DB, Salazar C, Foley A, Gajardo I, Thielen P, Iwawaki T, Scheper W, Soto C, Palacios AG, Hoozemans JJM, Hetz C.

Acta Neuropathol. 2017 Sep;134(3):489-506. doi: 10.1007/s00401-017-1694-x. Epub 2017 Mar 24.

PMID:
28341998
47.

The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo.

Park KW, Eun Kim G, Morales R, Moda F, Moreno-Gonzalez I, Concha-Marambio L, Lee AS, Hetz C, Soto C.

Sci Rep. 2017 Mar 23;7:44723. doi: 10.1038/srep44723.

48.

Endoplasmic reticulum proteostasis in glioblastoma-From molecular mechanisms to therapeutic perspectives.

Obacz J, Avril T, Le Reste PJ, Urra H, Quillien V, Hetz C, Chevet E.

Sci Signal. 2017 Mar 14;10(470). pii: eaal2323. doi: 10.1126/scisignal.aal2323. Review.

PMID:
28292956
49.

Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.

González AE, Muñoz VC, Cavieres VA, Bustamante HA, Cornejo VH, Januário YC, González I, Hetz C, daSilva LL, Rojas-Fernández A, Hay RT, Mardones GA, Burgos PV.

FASEB J. 2017 Jun;31(6):2446-2459. doi: 10.1096/fj.201600713R. Epub 2017 Mar 2.

PMID:
28254759
50.

A Molecular Reporter for Monitoring Autophagic Flux in Nervous System In Vivo.

Castillo K, Valenzuela V, Oñate M, Hetz C.

Methods Enzymol. 2017;588:109-131. doi: 10.1016/bs.mie.2016.09.077. Epub 2016 Nov 29.

PMID:
28237096

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