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Items: 21


Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice.

Wang C, Zhang L, Ndong JC, Hettinghouse A, Sun G, Chen C, Zhang C, Liu R, Liu CJ.

J Neuroinflammation. 2019 Nov 27;16(1):238. doi: 10.1186/s12974-019-1630-1.


A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction.

Zhang C, Cui M, Cui Y, Hettinghouse A, Liu CJ.

J Vis Exp. 2019 Aug 27;(150). doi: 10.3791/59656.


A novel mechanism of EAE resistance highlights the conflicting roles of progranulin-mediated immunosuppression and antigen processing.

Hettinghouse A, Gao G, Liu CJ.

Cell Mol Immunol. 2019 Sep 11. doi: 10.1038/s41423-019-0292-3. [Epub ahead of print] No abstract available.


Progranulin promotes diabetic fracture healing in mice with type 1 diabetes.

Wei J, Zhang L, Ding Y, Liu R, Guo Y, Hettinghouse A, Buza J, De La Croix J, Li X, Einhorn TA, Liu CJ.

Ann N Y Acad Sci. 2019 Aug 18. doi: 10.1111/nyas.14208. [Epub ahead of print]


Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis.

Liu R, Chen Y, Fu W, Wang S, Cui Y, Zhao X, Lei ZN, Hettinghouse A, Liu J, Wang C, Zhang C, Bi Y, Xiao G, Chen ZS, Liu CJ.

Ann Rheum Dis. 2019 Nov;78(11):1524-1535. doi: 10.1136/annrheumdis-2019-215543. Epub 2019 Jul 13.


Progranulin: A conductor of receptors orchestra, a chaperone of lysosomal enzymes and a therapeutic target for multiple diseases.

Cui Y, Hettinghouse A, Liu CJ.

Cytokine Growth Factor Rev. 2019 Feb;45:53-64. doi: 10.1016/j.cytogfr.2019.01.002. Epub 2019 Jan 30. Review.


Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review.

Chen Y, Liu R, Hettinghouse A, Wang S, Liu G, Liu CJ.

JBJS Rev. 2019 Jan;7(1):e10. doi: 10.2106/JBJS.RVW.18.00052.


Brain-penetrant heat shock protein amplifier arimoclomol enhances GCase activity in in vitro Gaucher disease models.

Hettinghouse A, Liu CJ.

EBioMedicine. 2018 Dec;38:7-8. doi: 10.1016/j.ebiom.2018.11.052. Epub 2018 Dec 3. No abstract available.


Progranulin associates with hexosaminidase A and ameliorates GM2 ganglioside accumulation and lysosomal storage in Tay-Sachs disease.

Chen Y, Jian J, Hettinghouse A, Zhao X, Setchell KDR, Sun Y, Liu CJ.

J Mol Med (Berl). 2018 Dec;96(12):1359-1373. doi: 10.1007/s00109-018-1703-0. Epub 2018 Oct 20.


Targeting tumor necrosis factor receptors in ankylosing spondylitis.

Lata M, Hettinghouse AS, Liu CJ.

Ann N Y Acad Sci. 2019 Apr;1442(1):5-16. doi: 10.1111/nyas.13933. Epub 2018 Jul 15. Review.


Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.

Wei JL, Fu W, Hettinghouse A, He WJ, Lipson KE, Liu CJ.

Arthritis Rheumatol. 2018 Nov;70(11):1745-1756. doi: 10.1002/art.40552. Epub 2018 Sep 24.


Molecular regulations and therapeutic targets of Gaucher disease.

Chen Y, Sud N, Hettinghouse A, Liu CJ.

Cytokine Growth Factor Rev. 2018 Jun;41:65-74. doi: 10.1016/j.cytogfr.2018.04.003. Epub 2018 Apr 11. Review.


RNA-Seq analysis of interferon inducible p204-mediated network in anti-tumor immunity.

Jian J, Wei W, Yin G, Hettinghouse A, Liu C, Shi Y.

Sci Rep. 2018 Apr 24;8(1):6495. doi: 10.1038/s41598-018-24561-2.


p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice.

Yi YS, Jian J, Gonzalez-Gugel E, Shi YX, Tian Q, Fu W, Hettinghouse A, Song W, Liu R, He M, Qi H, Yang J, Du X, Xiao G, Chen L, Liu CJ.

EBioMedicine. 2018 Mar;29:78-91. doi: 10.1016/j.ebiom.2018.02.012. Epub 2018 Feb 16.


Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models.

Wei JL, Fu W, Ding YJ, Hettinghouse A, Lendhey M, Schwarzkopf R, Kennedy OD, Liu CJ.

Arthritis Res Ther. 2017 Dec 19;19(1):280. doi: 10.1186/s13075-017-1485-8.


Progranulin acts as a shared chaperone and regulates multiple lysosomal enzymes.

Jian J, Hettinghouse A, Liu CJ.

Genes Dis. 2017 Sep;4(3):125-126. doi: 10.1016/j.gendis.2017.05.001. Epub 2017 Jun 23.


Multifunctional molecule ERp57: From cancer to neurodegenerative diseases.

Hettinghouse A, Liu R, Liu CJ.

Pharmacol Ther. 2018 Jan;181:34-48. doi: 10.1016/j.pharmthera.2017.07.011. Epub 2017 Jul 16. Review.


Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease.

Jian J, Tian QY, Hettinghouse A, Zhao S, Liu H, Wei J, Grunig G, Zhang W, Setchell KDR, Sun Y, Overkleeft HS, Chan GL, Liu CJ.

EBioMedicine. 2016 Nov;13:212-224. doi: 10.1016/j.ebiom.2016.10.010. Epub 2016 Oct 24.


Chondro-protective effects of low intensity pulsed ultrasound.

Uddin SM, Richbourgh B, Ding Y, Hettinghouse A, Komatsu DE, Qin YX, Liu CJ.

Osteoarthritis Cartilage. 2016 Nov;24(11):1989-1998. doi: 10.1016/j.joca.2016.06.014. Epub 2016 Jun 27.


Progranulin: A key player in autoimmune diseases.

Jian J, Li G, Hettinghouse A, Liu C.

Cytokine. 2018 Jan;101:48-55. doi: 10.1016/j.cyto.2016.08.007. Epub 2016 Aug 12. Review.


The role of progranulin in arthritis.

Wei J, Hettinghouse A, Liu C.

Ann N Y Acad Sci. 2016 Nov;1383(1):5-20. doi: 10.1111/nyas.13191. Epub 2016 Aug 9. Review.


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