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Items: 1 to 50 of 83

1.

Resting Heart Rate Variability (HRV) in Adolescents and Young Adults from a Genetically-Informed Perspective.

Bourdon JL, Moore AA, Eastman M, Savage JE, Hazlett L, Vrana SR, Hettema JM, Roberson-Nay R.

Behav Genet. 2018 Jul 11. doi: 10.1007/s10519-018-9915-1. [Epub ahead of print]

PMID:
29995284
2.

Genetic and Environmental Contributions of Negative Valence Systems to Internalizing Pathways.

Cecilione JL, Rappaport LM, Hahn SE, Anderson AE, Hazlett LE, Burchett JR, Moore AA, Savage JE, Hettema JM, Roberson-Nay R.

Twin Res Hum Genet. 2018 Feb;21(1):12-23. doi: 10.1017/thg.2017.72.

3.

Clinical Correlates of Carbon Dioxide Hypersensitivity in Children.

Rappaport LM, Sheerin C, Carney DM, Towbin KE, Leibenluft E, Pine DS, Brotman MA, Roberson-Nay R, Hettema JM.

J Am Acad Child Adolesc Psychiatry. 2017 Dec;56(12):1089-1096.e1. doi: 10.1016/j.jaac.2017.09.423. Epub 2017 Sep 27.

PMID:
29173743
4.

Polygenic risk for severe psychopathology among Europeans is associated with major depressive disorder in Han Chinese women.

Edwards AC, Docherty AR, Moscati A, Bigdeli TB, Peterson RE, Webb BT, Bacanu SA, Hettema JM, Flint J, Kendler KS.

Psychol Med. 2018 Apr;48(5):777-789. doi: 10.1017/S0033291717002148. Epub 2017 Oct 3.

5.

Anxiety symptoms and children's eye gaze during fear learning.

Michalska KJ, Machlin L, Moroney E, Lowet DS, Hettema JM, Roberson-Nay R, Averbeck BB, Brotman MA, Nelson EE, Leibenluft E, Pine DS.

J Child Psychol Psychiatry. 2017 Nov;58(11):1276-1286. doi: 10.1111/jcpp.12749. Epub 2017 Jul 24.

PMID:
28736915
6.

Latent structure of negative valence measures in childhood.

Lee M, Aggen SH, Carney DM, Hahn S, Moroney E, Machlin L, Brotman MA, Towbin KE, Leibenluft E, Pine DS, Roberson-Nay R, Hettema JM.

Depress Anxiety. 2017 Aug;34(8):742-751. doi: 10.1002/da.22656. Epub 2017 May 22.

7.

Clinical characteristics of latent classes of CO2 hypersensitivity in adolescents and young adults.

Rappaport LM, Sheerin C, Savage JE, Hettema JM, Roberson-Nay R.

Behav Res Ther. 2017 Jun;93:95-103. doi: 10.1016/j.brat.2017.03.015. Epub 2017 Mar 30.

8.

Test-retest reliability of the facial expression labeling task.

Cecilione JL, Rappaport LM, Verhulst B, Carney DM, Blair RJR, Brotman MA, Leibenluft E, Pine DS, Roberson-Nay R, Hettema JM.

Psychol Assess. 2017 Dec;29(12):1537-1542. doi: 10.1037/pas0000439. Epub 2017 Feb 23.

PMID:
28230406
9.

Test-retest reliability and validity of a frustration paradigm and irritability measures.

Tseng WL, Moroney E, Machlin L, Roberson-Nay R, Hettema JM, Carney D, Stoddard J, Towbin KA, Pine DS, Leibenluft E, Brotman MA.

J Affect Disord. 2017 Apr 1;212:38-45. doi: 10.1016/j.jad.2017.01.024. Epub 2017 Jan 23.

PMID:
28135689
10.

The Inventory of Callous-Unemotional Traits (ICU) in Children: Reliability and Heritability.

Moore AA, Carney D, Moroney E, Machlin L, Towbin KE, Brotman MA, Pine DS, Leibenluft E, Roberson-Nay R, Hettema JM.

Behav Genet. 2017 Mar;47(2):141-151. doi: 10.1007/s10519-016-9831-1. Epub 2016 Dec 1.

11.

The Twin Study of Negative Valence Emotional Constructs.

Carney DM, Moroney E, Machlin L, Hahn S, Savage JE, Lee M, Towbin KA, Brotman MA, Pine DS, Leibenluft E, Roberson-Nay R, Hettema JM.

Twin Res Hum Genet. 2016 Oct;19(5):456-64. doi: 10.1017/thg.2016.59. Epub 2016 Jul 26.

12.

Assessment and characterization of phenotypic heterogeneity of anxiety disorders across five large cohorts.

Lee M, Aggen SH, Otowa T, Castelao E, Preisig M, Grabe HJ, Hartman CA, Oldehinkel AJ, Middeldorp CM, Tiemeier H, Hettema JM.

Int J Methods Psychiatr Res. 2016 Dec;25(4):255-266. doi: 10.1002/mpr.1519. Epub 2016 Jul 15.

13.

The genetics of anxiety-related negative valence system traits.

Savage JE, Sawyers C, Roberson-Nay R, Hettema JM.

Am J Med Genet B Neuropsychiatr Genet. 2017 Mar;174(2):156-177. doi: 10.1002/ajmg.b.32459. Epub 2016 May 19. Review.

14.
15.

Meta-analysis of genome-wide association studies of anxiety disorders.

Otowa T, Hek K, Lee M, Byrne EM, Mirza SS, Nivard MG, Bigdeli T, Aggen SH, Adkins D, Wolen A, Fanous A, Keller MC, Castelao E, Kutalik Z, der Auwera SV, Homuth G, Nauck M, Teumer A, Milaneschi Y, Hottenga JJ, Direk N, Hofman A, Uitterlinden A, Mulder CL, Henders AK, Medland SE, Gordon S, Heath AC, Madden PA, Pergadia ML, van der Most PJ, Nolte IM, van Oort FV, Hartman CA, Oldehinkel AJ, Preisig M, Grabe HJ, Middeldorp CM, Penninx BW, Boomsma D, Martin NG, Montgomery G, Maher BS, van den Oord EJ, Wray NR, Tiemeier H, Hettema JM.

Mol Psychiatry. 2016 Oct;21(10):1485. doi: 10.1038/mp.2016.11. Epub 2016 Feb 9. No abstract available.

PMID:
26857599
16.

Meta-analysis of genome-wide association studies of anxiety disorders.

Otowa T, Hek K, Lee M, Byrne EM, Mirza SS, Nivard MG, Bigdeli T, Aggen SH, Adkins D, Wolen A, Fanous A, Keller MC, Castelao E, Kutalik Z, Van der Auwera S, Homuth G, Nauck M, Teumer A, Milaneschi Y, Hottenga JJ, Direk N, Hofman A, Uitterlinden A, Mulder CL, Henders AK, Medland SE, Gordon S, Heath AC, Madden PA, Pergadia ML, van der Most PJ, Nolte IM, van Oort FV, Hartman CA, Oldehinkel AJ, Preisig M, Grabe HJ, Middeldorp CM, Penninx BW, Boomsma D, Martin NG, Montgomery G, Maher BS, van den Oord EJ, Wray NR, Tiemeier H, Hettema JM.

Mol Psychiatry. 2016 Oct;21(10):1391-9. doi: 10.1038/mp.2015.197. Epub 2016 Jan 12. Erratum in: Mol Psychiatry. 2016 Oct;21(10):1485.

17.

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.

van den Berg SM, de Moor MH, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppälä I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abdellaoui A, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Smith GD, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimäki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Mbarek H, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Nivard MG, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L; Generation Scotland, Porteous D, Minelli A, Palmer AA, Rujescu D, Ciullo M, Hayward C, Rudan I, Metspalu A, Kaprio J, Deary IJ, Räikkönen K, Wilson JF, Keltikangas-Järvinen L, Bierut LJ, Hettema JM, Grabe HJ, Penninx BW, van Duijn CM, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Martin NG, Boomsma DI.

Behav Genet. 2016 Mar;46(2):170-82. doi: 10.1007/s10519-015-9735-5. Epub 2015 Sep 11.

18.

Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression.

Davies MN, Verdi S, Burri A, Trzaskowski M, Lee M, Hettema JM, Jansen R, Boomsma DI, Spector TD.

PLoS One. 2015 Aug 14;10(8):e0134865. doi: 10.1371/journal.pone.0134865. eCollection 2015.

19.

Identification and validation of mixed anxiety-depression.

Hettema JM, Aggen SH, Kubarych TS, Neale MC, Kendler KS.

Psychol Med. 2015 Oct;45(14):3075-84. doi: 10.1017/S0033291715001038. Epub 2015 Jun 8.

PMID:
26050714
20.

Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.

Genetics of Personality Consortium, de Moor MH, van den Berg SM, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N, Gordon SD, Hansell NK, Hart AB, Seppälä I, Huffman JE, Konte B, Lahti J, Lee M, Miller M, Nutile T, Tanaka T, Teumer A, Viktorin A, Wedenoja J, Abecasis GR, Adkins DE, Agrawal A, Allik J, Appel K, Bigdeli TB, Busonero F, Campbell H, Costa PT, Davey Smith G, Davies G, de Wit H, Ding J, Engelhardt BE, Eriksson JG, Fedko IO, Ferrucci L, Franke B, Giegling I, Grucza R, Hartmann AM, Heath AC, Heinonen K, Henders AK, Homuth G, Hottenga JJ, Iacono WG, Janzing J, Jokela M, Karlsson R, Kemp JP, Kirkpatrick MG, Latvala A, Lehtimäki T, Liewald DC, Madden PA, Magri C, Magnusson PK, Marten J, Maschio A, Medland SE, Mihailov E, Milaneschi Y, Montgomery GW, Nauck M, Ouwens KG, Palotie A, Pettersson E, Polasek O, Qian Y, Pulkki-Råback L, Raitakari OT, Realo A, Rose RJ, Ruggiero D, Schmidt CO, Slutske WS, Sorice R, Starr JM, St Pourcain B, Sutin AR, Timpson NJ, Trochet H, Vermeulen S, Vuoksimaa E, Widen E, Wouda J, Wright MJ, Zgaga L, Porteous D, Minelli A, Palmer AA, Rujescu D, Ciullo M, Hayward C, Rudan I, Metspalu A, Kaprio J, Deary IJ, Räikkönen K, Wilson JF, Keltikangas-Järvinen L, Bierut LJ, Hettema JM, Grabe HJ, van Duijn CM, Evans DM, Schlessinger D, Pedersen NL, Terracciano A, McGue M, Penninx BW, Martin NG, Boomsma DI.

JAMA Psychiatry. 2015 Jul;72(7):642-50. doi: 10.1001/jamapsychiatry.2015.0554.

21.

Different genetic factors underlie fear conditioning and episodic memory.

Fredrikson M, Annas P, Hettema JM.

Psychiatr Genet. 2015 Aug;25(4):155-62. doi: 10.1097/YPG.0000000000000088.

PMID:
25967536
22.

Validation of candidate anxiety disorder genes using a carbon dioxide challenge task.

Savage JE, McMichael O, Gorlin EI, Beadel JR, Teachman B, Vladimirov VI, Hettema JM, Roberson-Nay R.

Biol Psychol. 2015 Jul;109:61-6. doi: 10.1016/j.biopsycho.2015.04.006. Epub 2015 Apr 22.

23.

Genetics of anxiety disorders: Genetic epidemiological and molecular studies in humans.

Shimada-Sugimoto M, Otowa T, Hettema JM.

Psychiatry Clin Neurosci. 2015 Jul;69(7):388-401. doi: 10.1111/pcn.12291. Epub 2015 Apr 5. Review.

24.

Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology.

Hettema JM, Chen X, Sun C, Brown TA.

Psychol Med. 2015 Jul;45(10):2227-36. doi: 10.1017/S0033291715000021. Epub 2015 Feb 23.

PMID:
25702797
25.

Genome-wide and gene-based association studies of anxiety disorders in European and African American samples.

Otowa T, Maher BS, Aggen SH, McClay JL, van den Oord EJ, Hettema JM.

PLoS One. 2014 Nov 12;9(11):e112559. doi: 10.1371/journal.pone.0112559. eCollection 2014.

26.

Obsessive compulsive symptom dimensions and neuroticism: An examination of shared genetic and environmental risk.

Bergin J, Verhulst B, Aggen SH, Neale MC, Kendler KS, Bienvenu OJ, Hettema JM.

Am J Med Genet B Neuropsychiatr Genet. 2014 Dec;165B(8):647-53. doi: 10.1002/ajmg.b.32269. Epub 2014 Sep 17.

27.

The impact of childhood parental loss on risk for mood, anxiety and substance use disorders in a population-based sample of male twins.

Otowa T, York TP, Gardner CO, Kendler KS, Hettema JM.

Psychiatry Res. 2014 Dec 15;220(1-2):404-9. doi: 10.1016/j.psychres.2014.07.053. Epub 2014 Aug 1.

28.

The structure of genetic and environmental risk factors for fears and phobias.

Loken EK, Hettema JM, Aggen SH, Kendler KS.

Psychol Med. 2014 Aug;44(11):2375-84. doi: 10.1017/S0033291713003012. Epub 2014 Jan 2.

29.

Parenting and risk for mood, anxiety and substance use disorders: a study in population-based male twins.

Otowa T, Gardner CO, Kendler KS, Hettema JM.

Soc Psychiatry Psychiatr Epidemiol. 2013 Nov;48(11):1841-9. doi: 10.1007/s00127-013-0656-4. Epub 2013 Jan 24.

30.

Genetic association between RGS1 and internalizing disorders.

Hettema JM, An SS, van den Oord EJ, Neale MC, Kendler KS, Chen X.

Psychiatr Genet. 2013 Apr;23(2):56-60. doi: 10.1097/YPG.0b013e32835d7048.

31.

Genetic association study between RGS2 and anxiety-related phenotypes.

Hettema JM, Sun C, Chen X, Kendler KS.

Psychiatr Genet. 2013 Apr;23(2):92. doi: 10.1097/YPG.0b013e32835d70b3. No abstract available.

PMID:
23277133
32.

Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D.

Adkins DE, Clark SL, Åberg K, Hettema JM, Bukszár J, McClay JL, Souza RP, van den Oord EJ.

Transl Psychiatry. 2012 Jul 3;2:e129. doi: 10.1038/tp.2012.57.

33.

Citalopram, QTc interval prolongation, and torsade de pointes. How should we apply the recent FDA ruling?

Vieweg WV, Hasnain M, Howland RH, Hettema JM, Kogut C, Wood MA, Pandurangi AK.

Am J Med. 2012 Sep;125(9):859-68. doi: 10.1016/j.amjmed.2011.12.002. Epub 2012 Jun 27. Review.

PMID:
22748401
34.

Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.

Webb BT, Guo AY, Maher BS, Zhao Z, van den Oord EJ, Kendler KS, Riley BP, Gillespie NA, Prescott CA, Middeldorp CM, Willemsen G, de Geus EJ, Hottenga JJ, Boomsma DI, Slagboom EP, Wray NR, Montgomery GW, Martin NG, Wright MJ, Heath AC, Madden PA, Gelernter J, Knowles JA, Hamilton SP, Weissman MM, Fyer AJ, Huezo-Diaz P, McGuffin P, Farmer A, Craig IW, Lewis C, Sham P, Crowe RR, Flint J, Hettema JM.

Eur J Hum Genet. 2012 Oct;20(10):1078-84. doi: 10.1038/ejhg.2012.47. Epub 2012 Apr 4.

35.

Childhood separation anxiety disorder and adult onset panic attacks share a common genetic diathesis.

Roberson-Nay R, Eaves LJ, Hettema JM, Kendler KS, Silberg JL.

Depress Anxiety. 2012 Apr;29(4):320-7. doi: 10.1002/da.21931. Epub 2012 Mar 27.

36.

Support for involvement of glutamate decarboxylase 1 and neuropeptide Y in anxiety susceptibility.

Donner J, Sipilä T, Ripatti S, Kananen L, Chen X, Kendler KS, Lönnqvist J, Pirkola S, Hettema JM, Hovatta I.

Am J Med Genet B Neuropsychiatr Genet. 2012 Apr;159B(3):316-27. doi: 10.1002/ajmg.b.32029. Epub 2012 Feb 10.

PMID:
22328461
37.

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.

Libert S, Pointer K, Bell EL, Das A, Cohen DE, Asara JM, Kapur K, Bergmann S, Preisig M, Otowa T, Kendler KS, Chen X, Hettema JM, van den Oord EJ, Rubio JP, Guarente L.

Cell. 2011 Dec 23;147(7):1459-72. doi: 10.1016/j.cell.2011.10.054. Epub 2011 Dec 8.

38.

Genetic and environmental contributions to the relationship between education and anxiety disorders - a twin study.

Tambs K, Kendler KS, Reichborn-Kjennerud T, Aggen SH, Harris JR, Neale MC, Hettema JM, Sundet JM, Battaglia M, Røysamb E.

Acta Psychiatr Scand. 2012 Mar;125(3):203-12. doi: 10.1111/j.1600-0447.2011.01799.x. Epub 2011 Nov 24.

39.

Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.

Clark SL, Adkins DE, Aberg K, Hettema JM, McClay JL, Souza RP, van den Oord EJ.

Psychol Med. 2012 Jun;42(6):1151-62. doi: 10.1017/S003329171100239X. Epub 2011 Nov 1.

40.

Pilot multimodal twin imaging study of generalized anxiety disorder.

Hettema JM, Kettenmann B, Ahluwalia V, McCarthy C, Kates WR, Schmitt JE, Silberg JL, Neale MC, Kendler KS, Fatouros P.

Depress Anxiety. 2012 Mar;29(3):202-9. doi: 10.1002/da.20901. Epub 2011 Oct 12.

41.

Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.

Hettema JM, Webb BT, Guo AY, Zhao Z, Maher BS, Chen X, An SS, Sun C, Aggen SH, Kendler KS, Kuo PH, Otowa T, Flint J, van den Oord EJ.

Biol Psychiatry. 2011 Nov 1;70(9):888-96. doi: 10.1016/j.biopsych.2011.07.012. Epub 2011 Aug 25.

42.

The AVPR1A gene and substance use disorders: association, replication, and functional evidence.

Maher BS, Vladimirov VI, Latendresse SJ, Thiselton DL, McNamee R, Kang M, Bigdeli TB, Chen X, Riley BP, Hettema JM, Chilcoat H, Heidbreder C, Muglia P, Murrelle EL, Dick DM, Aliev F, Agrawal A, Edenberg HJ, Kramer J, Nurnberger J, Tischfield JA, Devlin B, Ferrell RE, Kirillova GP, Tarter RE, Kendler KS, Vanyukov MM.

Biol Psychiatry. 2011 Sep 15;70(6):519-27. doi: 10.1016/j.biopsych.2011.02.023. Epub 2011 Apr 22.

43.

A genomewide association study of citalopram response in major depressive disorder-a psychometric approach.

Adkins DE, Aberg K, McClay JL, Hettema JM, Kornstein SG, Bukszár J, van den Oord EJ.

Biol Psychiatry. 2010 Sep 15;68(6):e25-7. doi: 10.1016/j.biopsych.2010.05.018. No abstract available.

44.

Advances in molecular genetics of panic disorder.

Maron E, Hettema JM, Shlik J.

Mol Psychiatry. 2010 Jul;15(7):681-701. doi: 10.1038/mp.2009.145. Epub 2010 Jan 5. Review.

PMID:
20048750
45.

Association study between GABA receptor genes and anxiety spectrum disorders.

Pham X, Sun C, Chen X, van den Oord EJ, Neale MC, Kendler KS, Hettema JM.

Depress Anxiety. 2009;26(11):998-1003. doi: 10.1002/da.20628.

46.

An association between Epac-1 gene variants and anxiety and depression in two independent samples.

Middeldorp CM, Vink JM, Hettema JM, de Geus EJ, Kendler KS, Willemsen G, Neale MC, Boomsma DI, Chen X.

Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):214-9. doi: 10.1002/ajmg.b.30976.

47.

Follow-up association study of novel neuroticism gene MAMDC1.

Hettema JM, van den Oord EJ, An SS, Kendler KS, Chen X.

Psychiatr Genet. 2009 Aug;19(4):213-4. doi: 10.1097/YPG.0b013e32832cec22. No abstract available.

48.

Association study of CREB1 with Major Depressive Disorder and related phenotypes.

Hettema JM, An SS, van den Oord EJ, Neale MC, Kendler KS, Chen X.

Am J Med Genet B Neuropsychiatr Genet. 2009 Dec 5;150B(8):1128-32. doi: 10.1002/ajmg.b.30935.

49.

Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.

Chen X, Chen J, Williamson VS, An SS, Hettema JM, Aggen SH, Neale MC, Kendler KS.

Am J Med Genet B Neuropsychiatr Genet. 2009 Oct 5;150B(7):926-33. doi: 10.1002/ajmg.b.30919.

50.

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