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Items: 1 to 50 of 64

1.

Drosophila C virus systemic infection leads to intestinal obstruction.

Chtarbanova S, Lamiable O, Lee KZ, Galiana D, Troxler L, Meignin C, Hetru C, Hoffmann JA, Daeffler L, Imler JL.

J Virol. 2014 Dec;88(24):14057-69. doi: 10.1128/JVI.02320-14. Epub 2014 Sep 24.

2.

Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge.

Fukuyama H, Verdier Y, Guan Y, Makino-Okamura C, Shilova V, Liu X, Maksoud E, Matsubayashi J, Haddad I, Spirohn K, Ono K, Hetru C, Rossier J, Ideker T, Boutros M, Vinh J, Hoffmann JA.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10717-22. doi: 10.1073/pnas.1304380110. Epub 2013 Jun 7.

3.

Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila.

Kemp C, Mueller S, Goto A, Barbier V, Paro S, Bonnay F, Dostert C, Troxler L, Hetru C, Meignin C, Pfeffer S, Hoffmann JA, Imler JL.

J Immunol. 2013 Jan 15;190(2):650-8. doi: 10.4049/jimmunol.1102486. Epub 2012 Dec 19.

4.

Lawrence's book review unfair to Hoffmann.

Ezekowitz A, Dimarcq JL, Kafatos F, Levashina E, Ferrandon D, Hetru C, Imler JL, Reichhart JM.

Curr Biol. 2012 Jun 19;22(12):R482. doi: 10.1016/j.cub.2012.05.015. No abstract available.

5.

Crystal structure of Diedel, a marker of the immune response of Drosophila melanogaster.

Coste F, Kemp C, Bobezeau V, Hetru C, Kellenberger C, Imler JL, Roussel A.

PLoS One. 2012;7(3):e33416. doi: 10.1371/journal.pone.0033416. Epub 2012 Mar 19.

6.

Virulence on the fly: Drosophila melanogaster as a model genetic organism to decipher host-pathogen interactions.

Limmer S, Quintin J, Hetru C, Ferrandon D.

Curr Drug Targets. 2011 Jun;12(7):978-99. Review.

PMID:
21366519
7.

Analysis of thioester-containing proteins during the innate immune response of Drosophila melanogaster.

Bou Aoun R, Hetru C, Troxler L, Doucet D, Ferrandon D, Matt N.

J Innate Immun. 2011;3(1):52-64. doi: 10.1159/000321554. Epub 2010 Nov 9.

8.

NF-kappaB in the immune response of Drosophila.

Hetru C, Hoffmann JA.

Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a000232. doi: 10.1101/cshperspect.a000232. Epub 2009 Oct 7. Review.

9.

The N-terminal domain of Drosophila Gram-negative binding protein 3 (GNBP3) defines a novel family of fungal pattern recognition receptors.

Mishima Y, Quintin J, Aimanianda V, Kellenberger C, Coste F, Clavaud C, Hetru C, Hoffmann JA, Latgé JP, Ferrandon D, Roussel A.

J Biol Chem. 2009 Oct 16;284(42):28687-97. doi: 10.1074/jbc.M109.034587. Epub 2009 Aug 19.

10.

The genome of the model beetle and pest Tribolium castaneum.

Tribolium Genome Sequencing Consortium, Richards S, Gibbs RA, Weinstock GM, Brown SJ, Denell R, Beeman RW, Gibbs R, Beeman RW, Brown SJ, Bucher G, Friedrich M, Grimmelikhuijzen CJ, Klingler M, Lorenzen M, Richards S, Roth S, Schröder R, Tautz D, Zdobnov EM, Muzny D, Gibbs RA, Weinstock GM, Attaway T, Bell S, Buhay CJ, Chandrabose MN, Chavez D, Clerk-Blankenburg KP, Cree A, Dao M, Davis C, Chacko J, Dinh H, Dugan-Rocha S, Fowler G, Garner TT, Garnes J, Gnirke A, Hawes A, Hernandez J, Hines S, Holder M, Hume J, Jhangiani SN, Joshi V, Khan ZM, Jackson L, Kovar C, Kowis A, Lee S, Lewis LR, Margolis J, Morgan M, Nazareth LV, Nguyen N, Okwuonu G, Parker D, Richards S, Ruiz SJ, Santibanez J, Savard J, Scherer SE, Schneider B, Sodergren E, Tautz D, Vattahil S, Villasana D, White CS, Wright R, Park Y, Beeman RW, Lord J, Oppert B, Lorenzen M, Brown S, Wang L, Savard J, Tautz D, Richards S, Weinstock G, Gibbs RA, Liu Y, Worley K, Weinstock G, Elsik CG, Reese JT, Elhaik E, Landan G, Graur D, Arensburger P, Atkinson P, Beeman RW, Beidler J, Brown SJ, Demuth JP, Drury DW, Du YZ, Fujiwara H, Lorenzen M, Maselli V, Osanai M, Park Y, Robertson HM, Tu Z, Wang JJ, Wang S, Richards S, Song H, Zhang L, Sodergren E, Werner D, Stanke M, Morgenstern B, Solovyev V, Kosarev P, Brown G, Chen HC, Ermolaeva O, Hlavina W, Kapustin Y, Kiryutin B, Kitts P, Maglott D, Pruitt K, Sapojnikov V, Souvorov A, Mackey AJ, Waterhouse RM, Wyder S, Zdobnov EM, Zdobnov EM, Wyder S, Kriventseva EV, Kadowaki T, Bork P, Aranda M, Bao R, Beermann A, Berns N, Bolognesi R, Bonneton F, Bopp D, Brown SJ, Bucher G, Butts T, Chaumot A, Denell RE, Ferrier DE, Friedrich M, Gordon CM, Jindra M, Klingler M, Lan Q, Lattorff HM, Laudet V, von Levetsow C, Liu Z, Lutz R, Lynch JA, da Fonseca RN, Posnien N, Reuter R, Roth S, Savard J, Schinko JB, Schmitt C, Schoppmeier M, Schröder R, Shippy TD, Simonnet F, Marques-Souza H, Tautz D, Tomoyasu Y, Trauner J, Van der Zee M, Vervoort M, Wittkopp N, Wimmer EA, Yang X, Jones AK, Sattelle DB, Ebert PR, Nelson D, Scott JG, Beeman RW, Muthukrishnan S, Kramer KJ, Arakane Y, Beeman RW, Zhu Q, Hogenkamp D, Dixit R, Oppert B, Jiang H, Zou Z, Marshall J, Elpidina E, Vinokurov K, Oppert C, Zou Z, Evans J, Lu Z, Zhao P, Sumathipala N, Altincicek B, Vilcinskas A, Williams M, Hultmark D, Hetru C, Jiang H, Grimmelikhuijzen CJ, Hauser F, Cazzamali G, Williamson M, Park Y, Li B, Tanaka Y, Predel R, Neupert S, Schachtner J, Verleyen P, Raible F, Bork P, Friedrich M, Walden KK, Robertson HM, Angeli S, Forêt S, Bucher G, Schuetz S, Maleszka R, Wimmer EA, Beeman RW, Lorenzen M, Tomoyasu Y, Miller SC, Grossmann D, Bucher G.

Nature. 2008 Apr 24;452(7190):949-55. doi: 10.1038/nature06784. Epub 2008 Mar 23.

PMID:
18362917
11.

Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan.

Leone P, Bischoff V, Kellenberger C, Hetru C, Royet J, Roussel A.

Mol Immunol. 2008 May;45(9):2521-30. doi: 10.1016/j.molimm.2008.01.015. Epub 2008 Mar 4.

PMID:
18304640
12.

The Drosophila systemic immune response: sensing and signalling during bacterial and fungal infections.

Ferrandon D, Imler JL, Hetru C, Hoffmann JA.

Nat Rev Immunol. 2007 Nov;7(11):862-74. Review.

PMID:
17948019
13.

Comparative genomic analysis of the Tribolium immune system.

Zou Z, Evans JD, Lu Z, Zhao P, Williams M, Sumathipala N, Hetru C, Hultmark D, Jiang H.

Genome Biol. 2007;8(8):R177.

14.

Immune pathways and defence mechanisms in honey bees Apis mellifera.

Evans JD, Aronstein K, Chen YP, Hetru C, Imler JL, Jiang H, Kanost M, Thompson GJ, Zou Z, Hultmark D.

Insect Mol Biol. 2006 Oct;15(5):645-56.

15.

Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila.

Kocks C, Cho JH, Nehme N, Ulvila J, Pearson AM, Meister M, Strom C, Conto SL, Hetru C, Stuart LM, Stehle T, Hoffmann JA, Reichhart JM, Ferrandon D, Rämet M, Ezekowitz RA.

Cell. 2005 Oct 21;123(2):335-46.

16.

The Jak-STAT signaling pathway is required but not sufficient for the antiviral response of drosophila.

Dostert C, Jouanguy E, Irving P, Troxler L, Galiana-Arnoux D, Hetru C, Hoffmann JA, Imler JL.

Nat Immunol. 2005 Sep;6(9):946-53. Epub 2005 Aug 7.

PMID:
16086017
17.

New insights into Drosophila larval haemocyte functions through genome-wide analysis.

Irving P, Ubeda JM, Doucet D, Troxler L, Lagueux M, Zachary D, Hoffmann JA, Hetru C, Meister M.

Cell Microbiol. 2005 Mar;7(3):335-50.

PMID:
15679837
18.

Toll-dependent and Toll-independent immune responses in Drosophila.

Imler JL, Ferrandon D, Royet J, Reichhart JM, Hetru C, Hoffmann JA.

J Endotoxin Res. 2004;10(4):241-6. Review.

PMID:
15373968
19.

Is innate enough? The innate immune response in Drosophila.

Irving P, Troxler L, Hetru C.

C R Biol. 2004 Jun;327(6):557-70. Review.

PMID:
15330255
20.

Thanatin activity on multidrug resistant clinical isolates of Enterobacter aerogenes and Klebsiella pneumoniae.

Pagès JM, Dimarcq JL, Quenin S, Hetru C.

Int J Antimicrob Agents. 2003 Sep;22(3):265-9.

PMID:
13678832
21.

Drosophila melanogaster antimicrobial defense.

Hetru C, Troxler L, Hoffmann JA.

J Infect Dis. 2003 Jun 15;187 Suppl 2:S327-34. Review.

PMID:
12792847
22.

Immunity-related genes and gene families in Anopheles gambiae.

Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C, Brey PT, Collins FH, Danielli A, Dimopoulos G, Hetru C, Hoa NT, Hoffmann JA, Kanzok SM, Letunic I, Levashina EA, Loukeris TG, Lycett G, Meister S, Michel K, Moita LF, Müller HM, Osta MA, Paskewitz SM, Reichhart JM, Rzhetsky A, Troxler L, Vernick KD, Vlachou D, Volz J, von Mering C, Xu J, Zheng L, Bork P, Kafatos FC.

Science. 2002 Oct 4;298(5591):159-65.

23.

A genome-wide analysis of immune responses in Drosophila.

Irving P, Troxler L, Heuer TS, Belvin M, Kopczynski C, Reichhart JM, Hoffmann JA, Hetru C.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15119-24. Epub 2001 Dec 11.

24.

Solution structures of the antifungal heliomicin and a selected variant with both antibacterial and antifungal activities.

Lamberty M, Caille A, Landon C, Tassin-Moindrot S, Hetru C, Bulet P, Vovelle F.

Biochemistry. 2001 Oct 9;40(40):11995-2003.

PMID:
11580275
25.

The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila.

Rutschmann S, Jung AC, Hetru C, Reichhart JM, Hoffmann JA, Ferrandon D.

Immunity. 2000 May;12(5):569-80.

26.

The antimicrobial host defense of Drosophila.

Meister M, Hetru C, Hoffmann JA.

Curr Top Microbiol Immunol. 2000;248:17-36. Review. No abstract available.

PMID:
10793472
27.

Androctonin, a hydrophilic disulphide-bridged non-haemolytic anti-microbial peptide: a plausible mode of action.

Hetru C, Letellier L, Oren Z, Hoffmann JA, Shai Y.

Biochem J. 2000 Feb 1;345 Pt 3:653-64.

28.

Androctonin, a novel antimicrobial peptide from scorpion Androctonus australis: solution structure and molecular dynamics simulations in the presence of a lipid monolayer.

Mandard N, Sy D, Maufrais C, Bonmatin JM, Bulet P, Hetru C, Vovelle F.

J Biomol Struct Dyn. 1999 Oct;17(2):367-80.

PMID:
10563585
29.

Antimicrobial peptides in insects; structure and function.

Bulet P, Hetru C, Dimarcq JL, Hoffmann D.

Dev Comp Immunol. 1999 Jun-Jul;23(4-5):329-44. Review.

PMID:
10426426
30.

The structure of a glycosylated protein hormone responsible for sex determination in the isopod, Armadillidium vulgare.

Martin G, Sorokine O, Moniatte M, Bulet P, Hetru C, Van Dorsselaer A.

Eur J Biochem. 1999 Jun;262(3):727-36.

31.

Cysteine-rich antimicrobial peptides in invertebrates.

Dimarcq JL, Bulet P, Hetru C, Hoffmann J.

Biopolymers. 1998;47(6):465-77. Review.

PMID:
10333738
32.

Isolation, characterization and chemical synthesis of a new insect defensin from Chironomus plumosus (Diptera).

Lauth X, Nesin A, Briand JP, Roussel JP, Hetru C.

Insect Biochem Mol Biol. 1998 Dec;28(12):1059-66.

PMID:
9887520
33.

Solution structure of thanatin, a potent bactericidal and fungicidal insect peptide, determined from proton two-dimensional nuclear magnetic resonance data.

Mandard N, Sodano P, Labbe H, Bonmatin JM, Bulet P, Hetru C, Ptak M, Vovelle F.

Eur J Biochem. 1998 Sep 1;256(2):404-10.

34.

Solution structure of drosomycin, the first inducible antifungal protein from insects.

Landon C, Sodano P, Hetru C, Hoffmann J, Ptak M.

Protein Sci. 1997 Sep;6(9):1878-84.

35.

Strategies for the isolation and characterization of antimicrobial peptides of invertebrates.

Hetru C, Bulet P.

Methods Mol Biol. 1997;78:35-49. No abstract available.

PMID:
9276295
36.

Innate immunity. Isolation of several cysteine-rich antimicrobial peptides from the blood of a mollusc, Mytilus edulis.

Charlet M, Chernysh S, Philippe H, Hetru C, Hoffmann JA, Bulet P.

J Biol Chem. 1996 Sep 6;271(36):21808-13.

37.
38.

Enlarged scale chemical synthesis and range of activity of drosocin, an O-glycosylated antibacterial peptide of Drosophila.

Bulet P, Urge L, Ohresser S, Hetru C, Otvos L Jr.

Eur J Biochem. 1996 May 15;238(1):64-9.

39.

Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides.

Fehlbaum P, Bulet P, Chernysh S, Briand JP, Roussel JP, Letellier L, Hetru C, Hoffmann JA.

Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1221-5.

40.

Innate immunity in higher insects.

Hoffmann JA, Reichhart JM, Hetru C.

Curr Opin Immunol. 1996 Feb;8(1):8-13. Review.

PMID:
8729440
41.

Metchnikowin, a novel immune-inducible proline-rich peptide from Drosophila with antibacterial and antifungal properties.

Levashina EA, Ohresser S, Bulet P, Reichhart JM, Hetru C, Hoffmann JA.

Eur J Biochem. 1995 Oct 15;233(2):694-700.

42.

Insect immunity: isolation of three novel inducible antibacterial defensins from the vector mosquito, Aedes aegypti.

Lowenberger C, Bulet P, Charlet M, Hetru C, Hodgeman B, Christensen BM, Hoffmann JA.

Insect Biochem Mol Biol. 1995 Jul;25(7):867-73.

PMID:
7633471
43.

Insect immunity. The inducible antibacterial peptide diptericin carries two O-glycans necessary for biological activity.

Bulet P, Hegy G, Lambert J, van Dorsselaer A, Hoffmann JA, Hetru C.

Biochemistry. 1995 Jun 6;34(22):7394-400.

PMID:
7779781
44.

Refined three-dimensional solution structure of insect defensin A.

Cornet B, Bonmatin JM, Hetru C, Hoffmann JA, Ptak M, Vovelle F.

Structure. 1995 May 15;3(5):435-48.

45.

The secondary structure of the insect defensin A depends on its environment. A circular dichroism study.

Maget-Dana R, Bonmatin JM, Hetru C, Ptak M, Maurizot JC.

Biochimie. 1995;77(4):240-4.

PMID:
8589051
46.

Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides.

Fehlbaum P, Bulet P, Michaut L, Lagueux M, Broekaert WF, Hetru C, Hoffmann JA.

J Biol Chem. 1994 Dec 30;269(52):33159-63.

47.

Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus.

Cociancich S, Dupont A, Hegy G, Lanot R, Holder F, Hetru C, Hoffmann JA, Bulet P.

Biochem J. 1994 Jun 1;300 ( Pt 2):567-75.

48.

The inducible antibacterial peptides of insects.

Cociancich S, Bulet P, Hetru C, Hoffmann JA.

Parasitol Today. 1994 Apr;10(4):132-9.

PMID:
15275477
49.

Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus.

Cociancich S, Ghazi A, Hetru C, Hoffmann JA, Letellier L.

J Biol Chem. 1993 Sep 15;268(26):19239-45.

50.

A novel inducible antibacterial peptide of Drosophila carries an O-glycosylated substitution.

Bulet P, Dimarcq JL, Hetru C, Lagueux M, Charlet M, Hegy G, Van Dorsselaer A, Hoffmann JA.

J Biol Chem. 1993 Jul 15;268(20):14893-7.

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