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Cystic Fibrosis Plasma Blunts the Immune Response to Bacterial Infection.

Zhang X, Pan A, Jia S, Ideozu JE, Woods K, Murkowski K, Hessner MJ, Simpson PM, Levy H.

Am J Respir Cell Mol Biol. 2019 Sep;61(3):301-311. doi: 10.1165/rcmb.2018-0114OC.


Identification of molecular signatures of cystic fibrosis disease status with plasma-based functional genomics.

Levy H, Jia S, Pan A, Zhang X, Kaldunski M, Nugent ML, Reske M, Feliciano RA, Quintero D, Renda MM, Woods KJ, Murkowski K, Johnson K, Verbsky J, Dasu T, Ideozu JE, McColley S, Quasney MW, Dahmer MK, Avner E, Farrell PM, Cannon CL, Jacob H, Simpson PM, Hessner MJ.

Physiol Genomics. 2019 Jan 1;51(1):27-41. doi: 10.1152/physiolgenomics.00109.2018. Epub 2018 Dec 12.


A Serum-Induced Transcriptome and Serum Cytokine Signature Obtained at Diagnosis Correlates with the Development of Early Pancreatic Ductal Adenocarcinoma Metastasis.

Tsai S, McOlash L, Jia S, Zhang J, Simpson P, Kaldunski ML, Aldakkak M, Grewal J, Palen K, Dwinell MB, Johnson BD, Mackinnon A, Hessner MJ, Gershan JA.

Cancer Epidemiol Biomarkers Prev. 2019 Apr;28(4):680-689. doi: 10.1158/1055-9965.EPI-18-0813. Epub 2018 Dec 7.


Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes.

Cabrera SM, Engle S, Kaldunski M, Jia S, Geoffrey R, Simpson P, Szabo A, Speake C, Greenbaum CJ; Type 1 Diabetes TrialNet CTLA4-Ig (Abatacept) Study Group, Chen YG, Hessner MJ.

Diabetologia. 2018 Nov;61(11):2356-2370. doi: 10.1007/s00125-018-4708-x. Epub 2018 Aug 30.


Determinants for Participation in Human Papillomavirus Self-Sampling among Nonattenders to Cervical Cancer Screening in Denmark.

Harder E, Thomsen LT, Hertzum-Larsen R, Albieri V, Hessner MV, Juul KE, Bonde J, Frederiksen K, Kjaer SK.

Cancer Epidemiol Biomarkers Prev. 2018 Nov;27(11):1342-1351. doi: 10.1158/1055-9965.EPI-18-0480. Epub 2018 Aug 14.


Correction: Identification of a serum-induced transcriptional signature associated with metastatic cervical cancer.

Palatnik A, Ye S, Kendziorski C, Iden M, Zigman JS, Hessner MJ, Rader JS.

PLoS One. 2018 Feb 23;13(2):e0193687. doi: 10.1371/journal.pone.0193687. eCollection 2018.


Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility.

Henschel AM, Cabrera SM, Kaldunski ML, Jia S, Geoffrey R, Roethle MF, Lam V, Chen YG, Wang X, Salzman NH, Hessner MJ.

PLoS One. 2018 Jan 2;13(1):e0190351. doi: 10.1371/journal.pone.0190351. eCollection 2018.


Intestinal alkaline phosphatase deficiency leads to dysbiosis and bacterial translocation in the newborn intestine.

Fawley J, Koehler S, Cabrera S, Lam V, Fredrich K, Hessner M, Salzman N, Gourlay D.

J Surg Res. 2017 Oct;218:35-42. doi: 10.1016/j.jss.2017.03.049. Epub 2017 Apr 13.


Identification of a serum-induced transcriptional signature associated with metastatic cervical cancer.

Palatnik A, Ye S, Kendziorski C, Iden M, Zigman JS, Hessner MJ, Rader JS.

PLoS One. 2017 Aug 30;12(8):e0181242. doi: 10.1371/journal.pone.0181242. eCollection 2017. Erratum in: PLoS One. 2018 Feb 23;13(2):e0193687.


Increased Expression of Plasma-Induced ABCC1 mRNA in Cystic Fibrosis.

Ideozu JE, Zhang X, Pan A, Ashrafi Z, Woods KJ, Hessner MJ, Simpson P, Levy H.

Int J Mol Sci. 2017 Aug 11;18(8). pii: E1752. doi: 10.3390/ijms18081752.


Longitudinal analysis of hepatic transcriptome and serum metabolome demonstrates altered lipid metabolism following the onset of hyperglycemia in spontaneously diabetic biobreeding rats.

Regnell SE, Hessner MJ, Jia S, Åkesson L, Stenlund H, Moritz T, La Torre D, Lernmark Å.

PLoS One. 2017 Feb 13;12(2):e0171372. doi: 10.1371/journal.pone.0171372. eCollection 2017.


TGF-β1 along with other platelet contents augments Treg cells to suppress anti-FVIII immune responses in hemophilia A mice.

Haribhai D, Luo X, Chen J, Jia S, Shi L, Schroeder JA, Weiler H, Aster RH, Hessner MJ, Hu J, Williams CB, Shi Q.

Blood Adv. 2016 Dec 13;1(2):139-151. doi: 10.1182/bloodadvances.2016001453.


Investigation of coordination and order in transcription regulation of innate and adaptive immunity genes in type 1 diabetes.

Gao S, Wolanyk N, Chen Y, Jia S, Hessner MJ, Wang X.

BMC Med Genomics. 2017 Jan 31;10(1):7. doi: 10.1186/s12920-017-0243-8.


Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes.

Olsen JA, Kenna LA, Spelios MG, Hessner MJ, Akirav EM.

PLoS One. 2016 Apr 25;11(4):e0152662. doi: 10.1371/journal.pone.0152662. eCollection 2016.


The cohesin-associated protein Wapal is required for proper Polycomb-mediated gene silencing.

Stelloh C, Reimer MH, Pulakanti K, Blinka S, Peterson J, Pinello L, Jia S, Roumiantsev S, Hessner MJ, Milanovich S, Yuan GC, Rao S.

Epigenetics Chromatin. 2016 Apr 15;9:14. doi: 10.1186/s13072-016-0063-7. eCollection 2016.


Alternatively Activated Macrophages Boost Induced Regulatory T and Th17 Cell Responses during Immunotherapy for Colitis.

Haribhai D, Ziegelbauer J, Jia S, Upchurch K, Yan K, Schmitt EG, Salzman NH, Simpson P, Hessner MJ, Chatila TA, Williams CB.

J Immunol. 2016 Apr 15;196(8):3305-17. doi: 10.4049/jimmunol.1501956. Epub 2016 Feb 29.


Blood-based signatures in type 1 diabetes.

Cabrera SM, Chen YG, Hagopian WA, Hessner MJ.

Diabetologia. 2016 Mar;59(3):414-25. doi: 10.1007/s00125-015-3843-x. Epub 2015 Dec 23. Review.


Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset.

Cabrera SM, Wang X, Chen YG, Jia S, Kaldunski ML, Greenbaum CJ; Type 1 Diabetes TrialNet Canakinumab Study Group, Mandrup-Poulsen T; AIDA Study Group, Hessner MJ.

Eur J Immunol. 2016 Apr;46(4):1030-46. doi: 10.1002/eji.201546005. Epub 2016 Jan 21.


Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effects.

Gehrand AL, Kaldunski ML, Bruder ED, Jia S, Hessner MJ, Raff H.

Physiol Rep. 2015 Dec;3(12). pii: e12646. doi: 10.14814/phy2.12646.


Plasma-induced signatures reveal an extracellular milieu possessing an immunoregulatory bias in treatment-naive paediatric inflammatory bowel disease.

Gurram B, Salzman NH, Kaldunski ML, Jia S, Li BU, Stephens M, Sood MR, Hessner MJ.

Clin Exp Immunol. 2016 Apr;184(1):36-49. doi: 10.1111/cei.12753. Epub 2016 Jan 29.


Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice.

Liang HP, Kerschen EJ, Basu S, Hernandez I, Zogg M, Jia S, Hessner MJ, Toso R, Rezaie AR, Fernández JA, Camire RM, Ruf W, Griffin JH, Weiler H.

Blood. 2015 Nov 19;126(21):2415-23. doi: 10.1182/blood-2015-05-644401. Epub 2015 Sep 4. Erratum in: Blood. 2018 May 31;131(22):2509.


Innate inflammation in type 1 diabetes.

Cabrera SM, Henschel AM, Hessner MJ.

Transl Res. 2016 Jan;167(1):214-27. doi: 10.1016/j.trsl.2015.04.011. Epub 2015 Apr 29. Review.


EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice.

Liang HP, Kerschen EJ, Hernandez I, Basu S, Zogg M, Botros F, Jia S, Hessner MJ, Griffin JH, Ruf W, Weiler H.

Blood. 2015 Apr 30;125(18):2845-54. doi: 10.1182/blood-2014-11-610717. Epub 2015 Mar 2. Erratum in: Blood. 2018 May 31;131(22):2508.


Identification of a novel gene for diabetic traits in rats, mice, and humans.

Tsaih SW, Holl K, Jia S, Kaldunski M, Tschannen M, He H, Andrae JW, Li SH, Stoddard A, Wiederhold A, Parrington J, Ruas da Silva M, Galione A, Meigs J; Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC) Investigators, Hoffmann RG, Simpson P, Jacob H, Hessner M, Solberg Woods LC.

Genetics. 2014 Sep;198(1):17-29. doi: 10.1534/genetics.114.162982.


Molecular signatures differentiate immune states in type 1 diabetic families.

Chen YG, Cabrera SM, Jia S, Kaldunski ML, Kramer J, Cheong S, Geoffrey R, Roethle MF, Woodliff JE, Greenbaum CJ, Wang X, Hessner MJ.

Diabetes. 2014 Nov;63(11):3960-73. doi: 10.2337/db14-0214. Epub 2014 Apr 23.


The importance of gender of patients and general practitioners in relation to treatment practices for overweight.

Rohde JF, Hessner MV, Lous J, Müller P, Hølund U, Heitmann BL.

PLoS One. 2014 Apr 22;9(4):e95706. doi: 10.1371/journal.pone.0095706. eCollection 2014.


Diubiquitin (Ubd) is a susceptibility gene for virus-triggered autoimmune diabetes in rats.

Cort L, Habib M, Eberwine RA, Hessner MJ, Mordes JP, Blankenhorn EP.

Genes Immun. 2014 Apr-May;15(3):168-75. doi: 10.1038/gene.2013.72. Epub 2014 Jan 23.


Gene targeting in NOD mouse embryos using zinc-finger nucleases.

Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM.

Diabetes. 2014 Jan;63(1):68-74. doi: 10.2337/db13-0192. Epub 2013 Aug 23.


Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes.

Chen YG, Mordes JP, Blankenhorn EP, Kashmiri H, Kaldunski ML, Jia S, Geoffrey R, Wang X, Hessner MJ.

Genes Immun. 2013 Sep;14(6):387-400. doi: 10.1038/gene.2013.31. Epub 2013 Jun 6.


Evaluation of Genomic Evidence for Oxidative Stress in Experimental Radiation Nephropathy.

Cohen EP, Lenarczyk M, Fish BL, Jia S, Hessner MJ, Moulder JE.

J Genet Disord Genet Rep. 2013 Jan 1;2(1). pii: 1000101.


Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE.

Christy AL, Walker ME, Hessner MJ, Brown MA.

J Autoimmun. 2013 May;42:50-61. doi: 10.1016/j.jaut.2012.11.003. Epub 2012 Dec 23.


IL-10 produced by induced regulatory T cells (iTregs) controls colitis and pathogenic ex-iTregs during immunotherapy.

Schmitt EG, Haribhai D, Williams JB, Aggarwal P, Jia S, Charbonnier LM, Yan K, Lorier R, Turner A, Ziegelbauer J, Georgiev P, Simpson P, Salzman NH, Hessner MJ, Broeckel U, Chatila TA, Williams CB.

J Immunol. 2012 Dec 15;189(12):5638-48. doi: 10.4049/jimmunol.1200936. Epub 2012 Nov 2.


Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes.

Bogdani M, Henschel AM, Kansra S, Fuller JM, Geoffrey R, Jia S, Kaldunski ML, Pavletich S, Prosser S, Chen YG, Lernmark A, Hessner MJ.

J Endocrinol. 2013 Jan 18;216(2):111-23. doi: 10.1530/JOE-12-0385. Print 2013 Feb.


Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes.

Levy H, Wang X, Kaldunski M, Jia S, Kramer J, Pavletich SJ, Reske M, Gessel T, Yassai M, Quasney MW, Dahmer MK, Gorski J, Hessner MJ.

Genes Immun. 2012 Dec;13(8):593-604. doi: 10.1038/gene.2012.41. Epub 2012 Sep 13.


Predicting disease-related subnetworks for type 1 diabetes using a new network activity score.

Gao S, Jia S, Hessner MJ, Wang X.

OMICS. 2012 Oct;16(10):566-78. doi: 10.1089/omi.2012.0029. Epub 2012 Aug 23.


Requirements for growth and IL-10 expression of highly purified human T regulatory cells.

Bonacci B, Edwards B, Jia S, Williams CB, Hessner MJ, Gauld SB, Verbsky JW.

J Clin Immunol. 2012 Oct;32(5):1118-28. doi: 10.1007/s10875-012-9701-4. Epub 2012 May 5.


A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity.

Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, Ziegelbauer J, Yassai M, Li SH, Relland LM, Wise PM, Chen A, Zheng YQ, Simpson PM, Gorski J, Salzman NH, Hessner MJ, Chatila TA, Williams CB.

Immunity. 2011 Jul 22;35(1):109-22. doi: 10.1016/j.immuni.2011.03.029. Epub 2011 Jun 30.


Use of transcriptional signatures induced in lymphoid and myeloid cell lines as an inflammatory biomarker in Type 1 diabetes.

Jia S, Kaldunski M, Jailwala P, Geoffrey R, Kramer J, Wang X, Hessner MJ.

Physiol Genomics. 2011 Jun 15;43(11):697-709. doi: 10.1152/physiolgenomics.00235.2010. Epub 2011 Mar 15.


Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease.

Worthey EA, Mayer AN, Syverson GD, Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu T, Tschannen MR, Veith RL, Basehore MJ, Broeckel U, Tomita-Mitchell A, Arca MJ, Casper JT, Margolis DA, Bick DP, Hessner MJ, Routes JM, Verbsky JW, Jacob HJ, Dimmock DP.

Genet Med. 2011 Mar;13(3):255-62. doi: 10.1097/GIM.0b013e3182088158.


Global analysis of phase locking in gene expression during cell cycle: the potential in network modeling.

Gao S, Hartman JL 4th, Carter JL, Hessner MJ, Wang X.

BMC Syst Biol. 2010 Dec 3;4:167. doi: 10.1186/1752-0509-4-167.


Characterization of soy-based changes in Wnt-frizzled signaling in prostate cancer.

Liss MA, Schlicht M, Kahler A, Fitzgerald R, Thomassi T, Degueme A, Hessner M, Datta MW.

Cancer Genomics Proteomics. 2010 Sep-Oct;7(5):245-52. Erratum in: Cancer Genomics Proteomics. 2011 Mar-Apr;8(2):103.


Geno-transcriptomic dissection of proteinuria in the uninephrectomized rat uncovers a molecular complexity with sexual dimorphism.

Yagil Y, Hessner M, Schulz H, Gosele C, Lebedev L, Barkalifa R, Sapojnikov M, Hubner N, Yagil C.

Physiol Genomics. 2010 Nov 29;42A(4):301-16. doi: 10.1152/physiolgenomics.00149.2010. Epub 2010 Sep 28.


Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice.

Kerschen E, Hernandez I, Zogg M, Jia S, Hessner MJ, Fernandez JA, Griffin JH, Huettner CS, Castellino FJ, Weiler H.

J Clin Invest. 2010 Sep;120(9):3167-78. doi: 10.1172/JCI42629. Epub 2010 Aug 16.


Identification of a serum-induced transcriptional signature associated with type 1 diabetes in the BioBreeding rat.

Kaldunski M, Jia S, Geoffrey R, Basken J, Prosser S, Kansra S, Mordes JP, Lernmark A, Wang X, Hessner MJ.

Diabetes. 2010 Oct;59(10):2375-85. doi: 10.2337/db10-0372. Epub 2010 Aug 3.


Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses.

Das R, Komorowski R, Hessner MJ, Subramanian H, Huettner CS, Cua D, Drobyski WR.

Blood. 2010 Jun 24;115(25):5249-58. doi: 10.1182/blood-2009-11-255422. Epub 2010 Apr 9.


Differential effects of leptin receptor mutation on male and female BBDR Gimap5-/Gimap5- spontaneously diabetic rats.

Moralejo DH, Hansen CT, Treuting P, Hessner MJ, Fuller JM, Van Yserloo B, Jensen R, Osborne W, Kwitek AE, Lernmark A.

Physiol Genomics. 2010 Mar 3;41(1):9-20. doi: 10.1152/physiolgenomics.00186.2009. Epub 2009 Dec 8.


MB49 murine urothelial carcinoma: molecular and phenotypic comparison to human cell lines as a model of the direct tumor response to bacillus Calmette-Guerin.

Chen F, Zhang G, Cao Y, Hessner MJ, See WA.

J Urol. 2009 Dec;182(6):2932-7. doi: 10.1016/j.juro.2009.08.018. Epub 2009 Oct 23.


Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation.

Jailwala P, Waukau J, Glisic S, Jana S, Ehlenbach S, Hessner M, Alemzadeh R, Matsuyama S, Laud P, Wang X, Ghosh S.

PLoS One. 2009 Aug 5;4(8):e6527. doi: 10.1371/journal.pone.0006527.


An autoinflammatory disease due to homozygous deletion of the IL1RN locus.

Reddy S, Jia S, Geoffrey R, Lorier R, Suchi M, Broeckel U, Hessner MJ, Verbsky J.

N Engl J Med. 2009 Jun 4;360(23):2438-44. doi: 10.1056/NEJMoa0809568.

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