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Population pharmacokinetics and dosing of ethionamide in children with tuberculosis.

Bjugård Nyberg H, Draper HR, Garcia-Prats AJ, Thee S, Bekker A, Zar HJ, Hooker AC, Schaaf HS, McIlleron H, Hesseling AC, Denti P.

Antimicrob Agents Chemother. 2019 Dec 23. pii: AAC.01984-19. doi: 10.1128/AAC.01984-19. [Epub ahead of print]


Notification of relapse and other previously treated tuberculosis in the 52 health districts of South Africa.

Marx FM, Cohen T, Lombard C, Hesseling AC, Dlamini SS, Beyers N, Naidoo P.

Int J Tuberc Lung Dis. 2019 Aug 1;23(8):891-899. doi: 10.5588/ijtld.18.0609.


Inclusion of key populations in clinical trials of new antituberculosis treatments: Current barriers and recommendations for pregnant and lactating women, children, and HIV-infected persons.

Gupta A, Hughes MD, Garcia-Prats AJ, McIntire K, Hesseling AC.

PLoS Med. 2019 Aug 15;16(8):e1002882. doi: 10.1371/journal.pmed.1002882. eCollection 2019 Aug.


Alternative dosing guidelines to improve outcomes in childhood tuberculosis: a mathematical modelling study.

Radtke KK, Dooley KE, Dodd PJ, Garcia-Prats AJ, McKenna L, Hesseling AC, Savic RM.

Lancet Child Adolesc Health. 2019 Sep;3(9):636-645. doi: 10.1016/S2352-4642(19)30196-8. Epub 2019 Jul 16.


The evolving research agenda for paediatric tuberculosis infection.

Seddon JA, Whittaker E, Kampmann B, Lewinsohn DA, Osman M, Hesseling AC, Rustomjee R, Amanullah F.

Lancet Infect Dis. 2019 Sep;19(9):e322-e329. doi: 10.1016/S1473-3099(18)30787-4. Epub 2019 Jun 17. Review.


Morbidity and mortality up to 5 years post tuberculosis treatment in South Africa: A pilot study.

Osman M, Welte A, Dunbar R, Brown R, Hoddinott G, Hesseling AC, Marx FM.

Int J Infect Dis. 2019 Aug;85:57-63. doi: 10.1016/j.ijid.2019.05.024. Epub 2019 May 24.


Pharmacokinetics, optimal dosing, and safety of linezolid in children with multidrug-resistant tuberculosis: Combined data from two prospective observational studies.

Garcia-Prats AJ, Schaaf HS, Draper HR, Garcia-Cremades M, Winckler J, Wiesner L, Hesseling AC, Savic RM.

PLoS Med. 2019 Apr 30;16(4):e1002789. doi: 10.1371/journal.pmed.1002789. eCollection 2019 Apr.


Feasibility of Identifying Household Contacts of Rifampin-and Multidrug-resistant Tuberculosis Cases at High Risk of Progression to Tuberculosis Disease.

Gupta A, Swindells S, Kim S, Hughes MD, Naini L, Wu X, Dawson R, Mave V, Sanchez J, Mendoza A, Gonzales P, Kumarasamy N, Comins K, Conradie F, Shenje J, Fontain SN, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Lalloo UG, Ferreira ACG, Mugah C, Harrington M, Jones L, Cox SR, Smith B, Shah NS, Hesseling AC, Churchyard G.

Clin Infect Dis. 2020 Jan 16;70(3):425-435. doi: 10.1093/cid/ciz235.


Treatment Outcomes in Global Systematic Review and Patient Meta-Analysis of Children with Extensively Drug-Resistant Tuberculosis.

Osman M, Harausz EP, Garcia-Prats AJ, Schaaf HS, Moore BK, Hicks RM, Achar J, Amanullah F, Barry P, Becerra M, Chiotan DI, Drobac PC, Flood J, Furin J, Gegia M, Isaakidis P, Mariandyshev A, Ozere I, Shah NS, Skrahina A, Yablokova E, Seddon JA, Hesseling AC; Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR TB.

Emerg Infect Dis. 2019 Mar;25(3):441-450. doi: 10.3201/eid2503.180852.


Pharmacokinetics, Safety, and Dosing of Novel Pediatric Levofloxacin Dispersible Tablets in Children with Multidrug-Resistant Tuberculosis Exposure.

Garcia-Prats AJ, Purchase SE, Osman M, Draper HR, Schaaf HS, Wiesner L, Denti P, Hesseling AC.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e01865-18. doi: 10.1128/AAC.01865-18. Print 2019 Apr.


Levofloxacin versus placebo for the prevention of tuberculosis disease in child contacts of multidrug-resistant tuberculosis: study protocol for a phase III cluster randomised controlled trial (TB-CHAMP).

Seddon JA, Garcia-Prats AJ, Purchase SE, Osman M, Demers AM, Hoddinott G, Crook AM, Owen-Powell E, Thomason MJ, Turkova A, Gibb DM, Fairlie L, Martinson N, Schaaf HS, Hesseling AC.

Trials. 2018 Dec 20;19(1):693. doi: 10.1186/s13063-018-3070-0.


Transmission of drug-resistant tuberculosis in HIV-endemic settings.

Khan PY, Yates TA, Osman M, Warren RM, van der Heijden Y, Padayatchi N, Nardell EA, Moore D, Mathema B, Gandhi N, Eldholm V, Dheda K, Hesseling AC, Mizrahi V, Rustomjee R, Pym A.

Lancet Infect Dis. 2019 Mar;19(3):e77-e88. doi: 10.1016/S1473-3099(18)30537-1. Epub 2018 Dec 13. Review. Erratum in: Lancet Infect Dis. 2019 Mar 6;:.


Global shortages of BCG vaccine and tuberculous meningitis in children.

du Preez K, Seddon JA, Schaaf HS, Hesseling AC, Starke JR, Osman M, Lombard CJ, Solomons R.

Lancet Glob Health. 2019 Jan;7(1):e28-e29. doi: 10.1016/S2214-109X(18)30474-1. No abstract available.


Acceptability of a Novel Levofloxacin Dispersible Tablet Formulation in Young Children Exposed to Multidrug-resistant Tuberculosis.

Purchase SE, Garcia-Prats AJ, De Koker P, Draper HR, Osman M, Seddon JA, Schaaf HS, Hesseling AC.

Pediatr Infect Dis J. 2019 Jun;38(6):608-610. doi: 10.1097/INF.0000000000002268.


Specimen Pooling as a Diagnostic Strategy for Microbiologic Confirmation in Children with Intrathoracic Tuberculosis.

Walters E, van der Zalm MM, Demers AM, Whitelaw A, Palmer M, Bosch C, Draper HR, Schaaf HS, Goussard P, Lombard CJ, Gie RP, Hesseling AC.

Pediatr Infect Dis J. 2019 Jun;38(6):e128-e131. doi: 10.1097/INF.0000000000002240.


Incidence of tuberculosis and the influence of surveillance strategy on tuberculosis case-finding and all-cause mortality: a cluster randomised trial in Indian neonates vaccinated with BCG.

Jenum S, Selvam S, Jesuraj N, Ritz C, Hesseling AC, Cardenas V, Lau E, Doherty TM, Grewal HMS, Vaz M.

BMJ Open Respir Res. 2018 Oct 9;5(1):e000304. doi: 10.1136/bmjresp-2018-000304. eCollection 2018.


Time to act on injectable-free regimens for children with multidrug-resistant tuberculosis.

Seddon JA, Schaaf HS, Marais BJ, McKenna L, Garcia-Prats AJ, Hesseling AC, Hughes J, Howell P, Detjen A, Amanullah F, Singh U, Master I, Perez-Velez CM, Misra N, Becerra MC, Furin JJ.

Lancet Respir Med. 2018 Sep;6(9):662-664. doi: 10.1016/S2213-2600(18)30329-1. No abstract available.


Burden, spectrum and outcomes of children with tuberculosis diagnosed at a district-level hospital in South Africa.

du Preez K, du Plessis L, O'Connell N, Hesseling AC.

Int J Tuberc Lung Dis. 2018 Sep 1;22(9):1037-1043. doi: 10.5588/ijtld.17.0893.


Molecular Detection of Mycobacterium tuberculosis from Stools in Young Children by Use of a Novel Centrifugation-Free Processing Method.

Walters E, Scott L, Nabeta P, Demers AM, Reubenson G, Bosch C, David A, van der Zalm M, Havumaki J, Palmer M, Hesseling AC, Ncayiyana J, Stevens W, Alland D, Denkinger C, Banada P.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00781-18. doi: 10.1128/JCM.00781-18. Print 2018 Sep.


Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis.

Harausz EP, Garcia-Prats AJ, Law S, Schaaf HS, Kredo T, Seddon JA, Menzies D, Turkova A, Achar J, Amanullah F, Barry P, Becerra M, Chan ED, Chan PC, Ioana Chiotan D, Crossa A, Drobac PC, Fairlie L, Falzon D, Flood J, Gegia M, Hicks RM, Isaakidis P, Kadri SM, Kampmann B, Madhi SA, Marais E, Mariandyshev A, Méndez-Echevarría A, Moore BK, Nargiza P, Ozere I, Padayatchi N, Ur-Rehman S, Rybak N, Santiago-Garcia B, Shah NS, Sharma S, Shim TS, Skrahina A, Soriano-Arandes A, van den Boom M, van der Werf MJ, van der Werf TS, Williams B, Yablokova E, Yim JJ, Furin J, Hesseling AC; Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR-TB.

PLoS Med. 2018 Jul 11;15(7):e1002591. doi: 10.1371/journal.pmed.1002591. eCollection 2018 Jul.


Tuberculosis preventive treatment preferences among care givers of children in Lesotho: a pilot study.

Hirsch-Moverman Y, Mantell JE, Lebelo L, Wynn C, Hesseling AC, Howard AA, Nachman S, Frederix K, Maama LB, El-Sadr WM.

Int J Tuberc Lung Dis. 2018 Aug 1;22(8):858-862. doi: 10.5588/ijtld.17.0809.


Relative bioavailability of bedaquiline tablets suspended in water: Implications for dosing in children.

Svensson EM, du Bois J, Kitshoff R, de Jager VR, Wiesner L, Norman J, Nachman S, Smith B, Diacon AH, Hesseling AC, Garcia-Prats AJ.

Br J Clin Pharmacol. 2018 Jun 27. doi: 10.1111/bcp.13696. [Epub ahead of print]


Clinical and Cardiac Safety of Long-term Levofloxacin in Children Treated for Multidrug-resistant Tuberculosis.

Garcia-Prats AJ, Draper HR, Finlayson H, Winckler J, Burger A, Fourie B, Thee S, Hesseling AC, Schaaf HS.

Clin Infect Dis. 2018 Nov 13;67(11):1777-1780. doi: 10.1093/cid/ciy416.


The determination of capreomycin in human plasma by LC-MS/MS using ion-pairing chromatography and solid-phase extraction.

Thuboy B, Kellermann T, Castel S, Norman J, Joubert A, Garcia-Prats AJ, Hesseling AC, Wiesner L.

Biomed Chromatogr. 2018 May 3:e4269. doi: 10.1002/bmc.4269. [Epub ahead of print]


Reply to Drancourt, "Culturing Stools To Detect Mycobacterium tuberculosis".

Walters E, Demers AM, van der Zalm MM, Whitelaw A, Palmer M, Bosch C, Draper HR, Gie RP, Hesseling AC.

J Clin Microbiol. 2018 Apr 25;56(5). pii: e00056-18. doi: 10.1128/JCM.00056-18. Print 2018 May. No abstract available.


Community engagement for paediatric MDR-TB clinical trials: principles to support ethical trial implementation.

Hoddinott G, Staples S, Brown R, Simwinga M, Mubekapi-Musadaidzwa C, Hesseling AC, Hendricks G, De Koker P, McKenna L.

Int J Tuberc Lung Dis. 2018 May 1;22(5):40-45. doi: 10.5588/ijtld.17.0356.


Conducting efficacy trials in children with MDR-TB: what is the rationale and how should they be done?

Seddon JA, Weld ED, Schaaf HS, Garcia-Prats AJ, Kim S, Hesseling AC.

Int J Tuberc Lung Dis. 2018 May 1;22(5):24-33. doi: 10.5588/ijtld.17.0359.


Current status of pharmacokinetic and safety studies of multidrug-resistant tuberculosis treatment in children.

Garcia-Prats AJ, Svensson EM, Weld ED, Schaaf HS, Hesseling AC.

Int J Tuberc Lung Dis. 2018 May 1;22(5):15-23. doi: 10.5588/ijtld.17.0355. Review.


Feeding-Related Gut Microbial Composition Associates With Peripheral T-Cell Activation and Mucosal Gene Expression in African Infants.

Wood LF, Brown BP, Lennard K, Karaoz U, Havyarimana E, Passmore JS, Hesseling AC, Edlefsen PT, Kuhn L, Mulder N, Brodie EL, Sodora DL, Jaspan HB.

Clin Infect Dis. 2018 Sep 28;67(8):1237-1246. doi: 10.1093/cid/ciy265.


Complementary surveillance strategies are needed to better characterise the epidemiology, care pathways and treatment outcomes of tuberculosis in children.

du Preez K, Schaaf HS, Dunbar R, Walters E, Swartz A, Solomons R, Hesseling AC.

BMC Public Health. 2018 Mar 23;18(1):397. doi: 10.1186/s12889-018-5252-9.


Effect of Coadministration of Lidocaine on the Pain and Pharmacokinetics of Intramuscular Amikacin in Children With Multidrug-Resistant Tuberculosis: A Randomized Crossover Trial.

Garcia-Prats AJ, Rose PC, Draper HR, Seddon JA, Norman J, McIlleron HM, Hesseling AC, Schaaf HS.

Pediatr Infect Dis J. 2018 Dec;37(12):1199-1203. doi: 10.1097/INF.0000000000001983.


High Incidence of Tuberculosis Infection in HIV-exposed Children Exiting an Isoniazid Preventive Therapy Trial.

Cranmer LM, Draper HR, Mandalakas AM, Kim S, McSherry G, Krezinski E, Coetzee J, Mitchell C, Nachman S, van der Linde M, Cotton MF, Hesseling AC; IMPAACT P1041 Team.

Pediatr Infect Dis J. 2018 Oct;37(10):e254-e256. doi: 10.1097/INF.0000000000001946.


Clinical Evaluation of a Blood Assay to Diagnose Paucibacillary Tuberculosis via Bacterial Antigens.

Liu C, Lyon CJ, Bu Y, Deng Z, Walters E, Li Y, Zhang L, Hesseling AC, Graviss EA, Hu Y.

Clin Chem. 2018 May;64(5):791-800. doi: 10.1373/clinchem.2017.273698. Epub 2018 Jan 18.


Social science is needed to understand the impact of paediatric MDR-TB treatment on children and their families.

Hoddinott G, Hesseling AC.

Int J Tuberc Lung Dis. 2018 Jan 1;22(1):4. doi: 10.5588/ijtld.17.0814. No abstract available.


Levofloxacin Population Pharmacokinetics in South African Children Treated for Multidrug-Resistant Tuberculosis.

Denti P, Garcia-Prats AJ, Draper HR, Wiesner L, Winckler J, Thee S, Dooley KE, Savic RM, McIlleron HM, Schaaf HS, Hesseling AC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01521-17. doi: 10.1128/AAC.01521-17. Print 2018 Feb.


Pharmacokinetics and Drug-Drug Interactions of Lopinavir-Ritonavir Administered with First- and Second-Line Antituberculosis Drugs in HIV-Infected Children Treated for Multidrug-Resistant Tuberculosis.

van der Laan LE, Garcia-Prats AJ, Schaaf HS, Tikiso T, Wiesner L, de Kock M, Winckler J, Norman J, McIlleron H, Denti P, Hesseling AC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e00420-17. doi: 10.1128/AAC.00420-17. Print 2018 Feb.


Correction to: The impact of drug resistance on the risk of tuberculosis infection and disease in child household contacts: a cross sectional study.

Golla V, Snow K, Mandalakas AM, Schaaf HS, Du Preez K, Hesseling AC, Seddon JA.

BMC Infect Dis. 2017 Nov 7;17(1):713. doi: 10.1186/s12879-017-2806-x.


Tuberculous Pericardial Effusions in Children.

Obihara NJ, Walters E, Lawrenson J, Garcia-Prats AJ, Hesseling AC, Schaaf HS.

J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):346-349. doi: 10.1093/jpids/pix087.


Excellent Treatment Outcomes in Children Treated for Tuberculosis Under Routine Operational Conditions in Cape Town, South Africa.

Osman M, Lee K, Du Preez K, Dunbar R, Hesseling AC, Seddon JA.

Clin Infect Dis. 2017 Oct 16;65(9):1444-1452. doi: 10.1093/cid/cix602.


Safety and Immunogenicity of Newborn MVA85A Vaccination and Selective, Delayed Bacille Calmette-Guerin for Infants of Human Immunodeficiency Virus-Infected Mothers: A Phase 2 Randomized, Controlled Trial.

Nemes E, Hesseling AC, Tameris M, Mauff K, Downing K, Mulenga H, Rose P, van der Zalm M, Mbaba S, Van As D, Hanekom WA, Walzl G, Scriba TJ, McShane H, Hatherill M; MVA029 Study Team.

Clin Infect Dis. 2018 Feb 1;66(4):554-563. doi: 10.1093/cid/cix834.


Stool Culture for Diagnosis of Pulmonary Tuberculosis in Children.

Walters E, Demers AM, van der Zalm MM, Whitelaw A, Palmer M, Bosch C, Draper HR, Gie RP, Hesseling AC.

J Clin Microbiol. 2017 Dec;55(12):3355-3365. doi: 10.1128/JCM.00801-17. Epub 2017 Sep 13.


The impact of drug resistance on the risk of tuberculosis infection and disease in child household contacts: a cross sectional study.

Golla V, Snow K, Mandalakas AM, Schaaf HS, Du Preez K, Hesseling AC, Seddon JA.

BMC Infect Dis. 2017 Aug 29;17(1):593. doi: 10.1186/s12879-017-2668-2. Erratum in: BMC Infect Dis. 2017 Nov 7;17(1):713.


Operational implementation and impact of The Union's online childhood TB training course in South Africa.

du Plessis L, Black F, Detjen A, Hesseling AC, du Preez K.

Public Health Action. 2017 Jun 21;7(2):175-177. doi: 10.5588/pha.16.0116.


Tuberculosis in adolescents and young adults: epidemiology and treatment outcomes in the Western Cape.

Snow K, Hesseling AC, Naidoo P, Graham SM, Denholm J, du Preez K.

Int J Tuberc Lung Dis. 2017 Jun 1;21(6):651-657. doi: 10.5588/ijtld.16.0866.


BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial.

Gasper MA, Hesseling AC, Mohar I, Myer L, Azenkot T, Passmore JS, Hanekom W, Cotton MF, Crispe IN, Sodora DL, Jaspan HB.

JCI Insight. 2017 Apr 6;2(7):e91963. doi: 10.1172/jci.insight.91963.


The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis.

Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, Murray M, Furin J, Nardell EA, London L, Lessem E, Theron G, van Helden P, Niemann S, Merker M, Dowdy D, Van Rie A, Siu GK, Pasipanodya JG, Rodrigues C, Clark TG, Sirgel FA, Esmail A, Lin HH, Atre SR, Schaaf HS, Chang KC, Lange C, Nahid P, Udwadia ZF, Horsburgh CR Jr, Churchyard GJ, Menzies D, Hesseling AC, Nuermberger E, McIlleron H, Fennelly KP, Goemaere E, Jaramillo E, Low M, Jara CM, Padayatchi N, Warren RM.

Lancet Respir Med. 2017 Mar 15. pii: S2213-2600(17)30079-6. doi: 10.1016/S2213-2600(17)30079-6. [Epub ahead of print] Review.


The time has come: sparing injectables in paediatric MDR-TB.

Weld ED, Garcia-Prats AJ, Furin JJ, Bailey TC, Hesseling AC, Dooley KE.

Lancet Respir Med. 2017 Mar 15. pii: S2213-2600(17)30078-4. doi: 10.1016/S2213-2600(17)30078-4. [Epub ahead of print] No abstract available.


Xpert MTB/RIF on Stool Is Useful for the Rapid Diagnosis of Tuberculosis in Young Children With Severe Pulmonary Disease.

Walters E, van der Zalm MM, Palmer M, Bosch C, Demers AM, Draper H, Goussard P, Schaaf HS, Friedrich SO, Whitelaw A, Warren R, Gie RP, Hesseling AC.

Pediatr Infect Dis J. 2017 Sep;36(9):837-843. doi: 10.1097/INF.0000000000001563.


Re: "It May Be Too Early to Try to Prove the Effect of Deworming on Tuberculin Reactivity".

Van der Zalm MM, van Soelen N, Mandalakas AM, Jacobsen M, Detjen AK, Marx FM, Grewal HM, Cotton MF, Walzl G, Hesseling AC.

Pediatr Infect Dis J. 2017 Feb;36(2):241-242. doi: 10.1097/INF.0000000000001408. No abstract available.


Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa.

Loxton AG, Knaul JK, Grode L, Gutschmidt A, Meller C, Eisele B, Johnstone H, van der Spuy G, Maertzdorf J, Kaufmann SHE, Hesseling AC, Walzl G, Cotton MF.

Clin Vaccine Immunol. 2017 Feb 6;24(2). pii: e00439-16. doi: 10.1128/CVI.00439-16. Print 2017 Feb.

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