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Items: 1 to 50 of 208

1.

Transmission of drug-resistant tuberculosis in HIV-endemic settings.

Khan PY, Yates TA, Osman M, Warren RM, van der Heijden Y, Padayatchi N, Nardell EA, Moore D, Mathema B, Gandhi N, Eldholm V, Dheda K, Hesseling AC, Mizrahi V, Rustomjee R, Pym A.

Lancet Infect Dis. 2018 Dec 13. pii: S1473-3099(18)30537-1. doi: 10.1016/S1473-3099(18)30537-1. [Epub ahead of print] Review.

PMID:
30554996
2.

Global shortages of BCG vaccine and tuberculous meningitis in children.

du Preez K, Seddon JA, Schaaf HS, Hesseling AC, Starke JR, Osman M, Lombard CJ, Solomons R.

Lancet Glob Health. 2019 Jan;7(1):e28-e29. doi: 10.1016/S2214-109X(18)30474-1. No abstract available.

3.

Acceptability of a Novel Levofloxacin Dispersible Tablet Formulation in Young Children Exposed to Multidrug-Resistant Tuberculosis.

Purchase SE, Garcia-Prats AJ, De Koker P, Draper HR, Osman M, Seddon JA, Schaaf HS, Hesseling AC.

Pediatr Infect Dis J. 2018 Dec 13. doi: 10.1097/INF.0000000000002268. [Epub ahead of print]

PMID:
30550511
4.

Specimen Pooling as a Diagnostic Strategy for Microbiologic Confirmation in Children With Intrathoracic Tuberculosis.

Walters E, van der Zalm MM, Demers AM, Whitelaw A, Palmer M, Bosch C, Draper HR, Schaaf HS, Goussard P, Lombard CJ, Gie RP, Hesseling AC.

Pediatr Infect Dis J. 2018 Nov 9. doi: 10.1097/INF.0000000000002240. [Epub ahead of print]

PMID:
30418355
5.

Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.

Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T.

EMBO Mol Med. 2018 Nov 2. pii: e9288. doi: 10.15252/emmm.201809288. [Epub ahead of print]

6.

Moving Toward Tuberculosis Elimination: Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.

Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Hoi LV, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P.

Am J Respir Crit Care Med. 2018 Oct 18. doi: 10.1164/rccm.201806-1053PP. [Epub ahead of print]

PMID:
30335466
7.

Time to act on injectable-free regimens for children with multidrug-resistant tuberculosis.

Seddon JA, Schaaf HS, Marais BJ, McKenna L, Garcia-Prats AJ, Hesseling AC, Hughes J, Howell P, Detjen A, Amanullah F, Singh U, Master I, Perez-Velez CM, Misra N, Becerra MC, Furin JJ.

Lancet Respir Med. 2018 Sep;6(9):662-664. doi: 10.1016/S2213-2600(18)30329-1. No abstract available.

PMID:
30191832
8.

Burden, spectrum and outcomes of children with tuberculosis diagnosed at a district-level hospital in South Africa.

du Preez K, du Plessis L, O'Connell N, Hesseling AC.

Int J Tuberc Lung Dis. 2018 Sep 1;22(9):1037-1043. doi: 10.5588/ijtld.17.0893.

PMID:
30092869
9.

Resource utilization for multidrug-resistant tuberculosis household contact investigations (A5300/I2003).

Swindells S, Gupta A, Kim S, Hughes MD, Sanchez J, Mave V, Dawson R, Kumarasamy N, Comins K, Smith B, Rustomjee R, Naini L, Shah NS, Hesseling A, Churchyard G.

Int J Tuberc Lung Dis. 2018 Sep 1;22(9):1016-1022. doi: 10.5588/ijtld.18.0163.

PMID:
30092866
10.

Molecular Detection of Mycobacterium tuberculosis from Stools in Young Children by Use of a Novel Centrifugation-Free Processing Method.

Walters E, Scott L, Nabeta P, Demers AM, Reubenson G, Bosch C, David A, van der Zalm M, Havumaki J, Palmer M, Hesseling AC, Ncayiyana J, Stevens W, Alland D, Denkinger C, Banada P.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00781-18. doi: 10.1128/JCM.00781-18. Print 2018 Sep.

11.

Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis.

Harausz EP, Garcia-Prats AJ, Law S, Schaaf HS, Kredo T, Seddon JA, Menzies D, Turkova A, Achar J, Amanullah F, Barry P, Becerra M, Chan ED, Chan PC, Ioana Chiotan D, Crossa A, Drobac PC, Fairlie L, Falzon D, Flood J, Gegia M, Hicks RM, Isaakidis P, Kadri SM, Kampmann B, Madhi SA, Marais E, Mariandyshev A, Méndez-Echevarría A, Moore BK, Nargiza P, Ozere I, Padayatchi N, Ur-Rehman S, Rybak N, Santiago-Garcia B, Shah NS, Sharma S, Shim TS, Skrahina A, Soriano-Arandes A, van den Boom M, van der Werf MJ, van der Werf TS, Williams B, Yablokova E, Yim JJ, Furin J, Hesseling AC; Collaborative Group for Meta-Analysis of Paediatric Individual Patient Data in MDR-TB.

PLoS Med. 2018 Jul 11;15(7):e1002591. doi: 10.1371/journal.pmed.1002591. eCollection 2018 Jul.

12.

Tuberculosis preventive treatment preferences among care givers of children in Lesotho: a pilot study.

Hirsch-Moverman Y, Mantell JE, Lebelo L, Wynn C, Hesseling AC, Howard AA, Nachman S, Frederix K, Maama LB, El-Sadr WM.

Int J Tuberc Lung Dis. 2018 Aug 1;22(8):858-862. doi: 10.5588/ijtld.17.0809.

PMID:
29991393
13.

Relative bioavailability of bedaquiline tablets suspended in water: Implications for dosing in children.

Svensson EM, du Bois J, Kitshoff R, de Jager VR, Wiesner L, Norman J, Nachman S, Smith B, Diacon AH, Hesseling AC, Garcia-Prats AJ.

Br J Clin Pharmacol. 2018 Jun 27. doi: 10.1111/bcp.13696. [Epub ahead of print]

14.

Clinical and Cardiac Safety of Long-term Levofloxacin in Children Treated for Multidrug-resistant Tuberculosis.

Garcia-Prats AJ, Draper HR, Finlayson H, Winckler J, Burger A, Fourie B, Thee S, Hesseling AC, Schaaf HS.

Clin Infect Dis. 2018 Nov 13;67(11):1777-1780. doi: 10.1093/cid/ciy416.

PMID:
29788331
15.

The determination of capreomycin in human plasma by LC-MS/MS using ion-pairing chromatography and solid-phase extraction.

Thuboy B, Kellermann T, Castel S, Norman J, Joubert A, Garcia-Prats AJ, Hesseling AC, Wiesner L.

Biomed Chromatogr. 2018 May 3:e4269. doi: 10.1002/bmc.4269. [Epub ahead of print]

PMID:
29726023
16.

Reply to Drancourt, "Culturing Stools To Detect Mycobacterium tuberculosis".

Walters E, Demers AM, van der Zalm MM, Whitelaw A, Palmer M, Bosch C, Draper HR, Gie RP, Hesseling AC.

J Clin Microbiol. 2018 Apr 25;56(5). pii: e00056-18. doi: 10.1128/JCM.00056-18. Print 2018 May. No abstract available.

17.

Shorter treatment for minimal tuberculosis (TB) in children (SHINE): a study protocol for a randomised controlled trial.

Chabala C, Turkova A, Thomason MJ, Wobudeya E, Hissar S, Mave V, van der Zalm M, Palmer M, Kapasa M, Bhavani PK, Balaji S, Raichur PA, Demers AM, Hoddinott G, Owen-Powell E, Kinikar A, Musoke P, Mulenga V, Aarnoutse R, McIlleron H, Hesseling A, Crook AM, Cotton M, Gibb DM; SHINE trial team.

Trials. 2018 Apr 19;19(1):237. doi: 10.1186/s13063-018-2608-5.

18.

Community engagement for paediatric MDR-TB clinical trials: principles to support ethical trial implementation.

Hoddinott G, Staples S, Brown R, Simwinga M, Mubekapi-Musadaidzwa C, Hesseling AC, Hendricks G, De Koker P, McKenna L.

Int J Tuberc Lung Dis. 2018 May 1;22(5):40-45. doi: 10.5588/ijtld.17.0356.

PMID:
29665952
19.

Conducting efficacy trials in children with MDR-TB: what is the rationale and how should they be done?

Seddon JA, Weld ED, Schaaf HS, Garcia-Prats AJ, Kim S, Hesseling AC.

Int J Tuberc Lung Dis. 2018 May 1;22(5):24-33. doi: 10.5588/ijtld.17.0359.

20.

Current status of pharmacokinetic and safety studies of multidrug-resistant tuberculosis treatment in children.

Garcia-Prats AJ, Svensson EM, Weld ED, Schaaf HS, Hesseling AC.

Int J Tuberc Lung Dis. 2018 May 1;22(5):15-23. doi: 10.5588/ijtld.17.0355.

PMID:
29665949
21.

Feeding-Related Gut Microbial Composition Associates With Peripheral T-Cell Activation and Mucosal Gene Expression in African Infants.

Wood LF, Brown BP, Lennard K, Karaoz U, Havyarimana E, Passmore JS, Hesseling AC, Edlefsen PT, Kuhn L, Mulder N, Brodie EL, Sodora DL, Jaspan HB.

Clin Infect Dis. 2018 Sep 28;67(8):1237-1246. doi: 10.1093/cid/ciy265.

22.

Complementary surveillance strategies are needed to better characterise the epidemiology, care pathways and treatment outcomes of tuberculosis in children.

du Preez K, Schaaf HS, Dunbar R, Walters E, Swartz A, Solomons R, Hesseling AC.

BMC Public Health. 2018 Mar 23;18(1):397. doi: 10.1186/s12889-018-5252-9.

23.

Effect of Coadministration of Lidocaine on the Pain and Pharmacokinetics of Intramuscular Amikacin in Children With Multidrug-Resistant Tuberculosis: A Randomized Crossover Trial.

Garcia-Prats AJ, Rose PC, Draper HR, Seddon JA, Norman J, McIlleron HM, Hesseling AC, Schaaf HS.

Pediatr Infect Dis J. 2018 Dec;37(12):1199-1203. doi: 10.1097/INF.0000000000001983.

PMID:
29561515
24.

High Incidence of Tuberculosis Infection in HIV-exposed Children Exiting an Isoniazid Preventive Therapy Trial.

Cranmer LM, Draper HR, Mandalakas AM, Kim S, McSherry G, Krezinski E, Coetzee J, Mitchell C, Nachman S, van der Linde M, Cotton MF, Hesseling AC; IMPAACT P1041 Team.

Pediatr Infect Dis J. 2018 Oct;37(10):e254-e256. doi: 10.1097/INF.0000000000001946.

PMID:
29462104
25.

Clinical Evaluation of a Blood Assay to Diagnose Paucibacillary Tuberculosis via Bacterial Antigens.

Liu C, Lyon CJ, Bu Y, Deng Z, Walters E, Li Y, Zhang L, Hesseling AC, Graviss EA, Hu Y.

Clin Chem. 2018 May;64(5):791-800. doi: 10.1373/clinchem.2017.273698. Epub 2018 Jan 18.

26.

Social science is needed to understand the impact of paediatric MDR-TB treatment on children and their families.

Hoddinott G, Hesseling AC.

Int J Tuberc Lung Dis. 2018 Jan 1;22(1):4. doi: 10.5588/ijtld.17.0814. No abstract available.

PMID:
29297419
27.

The PREVENT study to evaluate the effectiveness and acceptability of a community-based intervention to prevent childhood tuberculosis in Lesotho: study protocol for a cluster randomized controlled trial.

Hirsch-Moverman Y, Howard AA, Frederix K, Lebelo L, Hesseling A, Nachman S, Mantell JE, Lekhela T, Maama LB, El-Sadr WM.

Trials. 2017 Nov 21;18(1):552. doi: 10.1186/s13063-017-2184-0.

28.

Levofloxacin Population Pharmacokinetics in South African Children Treated for Multidrug-Resistant Tuberculosis.

Denti P, Garcia-Prats AJ, Draper HR, Wiesner L, Winckler J, Thee S, Dooley KE, Savic RM, McIlleron HM, Schaaf HS, Hesseling AC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01521-17. doi: 10.1128/AAC.01521-17. Print 2018 Feb.

29.

Pharmacokinetics and Drug-Drug Interactions of Lopinavir-Ritonavir Administered with First- and Second-Line Antituberculosis Drugs in HIV-Infected Children Treated for Multidrug-Resistant Tuberculosis.

van der Laan LE, Garcia-Prats AJ, Schaaf HS, Tikiso T, Wiesner L, de Kock M, Winckler J, Norman J, McIlleron H, Denti P, Hesseling AC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e00420-17. doi: 10.1128/AAC.00420-17. Print 2018 Feb.

30.

Correction to: The impact of drug resistance on the risk of tuberculosis infection and disease in child household contacts: a cross sectional study.

Golla V, Snow K, Mandalakas AM, Schaaf HS, Du Preez K, Hesseling AC, Seddon JA.

BMC Infect Dis. 2017 Nov 7;17(1):713. doi: 10.1186/s12879-017-2806-x.

31.

Tuberculous Pericardial Effusions in Children.

Obihara NJ, Walters E, Lawrenson J, Garcia-Prats AJ, Hesseling AC, Schaaf HS.

J Pediatric Infect Dis Soc. 2018 Dec 3;7(4):346-349. doi: 10.1093/jpids/pix087.

PMID:
29096017
32.

Excellent Treatment Outcomes in Children Treated for Tuberculosis Under Routine Operational Conditions in Cape Town, South Africa.

Osman M, Lee K, Du Preez K, Dunbar R, Hesseling AC, Seddon JA.

Clin Infect Dis. 2017 Oct 16;65(9):1444-1452. doi: 10.1093/cid/cix602.

33.

Safety and Immunogenicity of Newborn MVA85A Vaccination and Selective, Delayed Bacille Calmette-Guerin for Infants of Human Immunodeficiency Virus-Infected Mothers: A Phase 2 Randomized, Controlled Trial.

Nemes E, Hesseling AC, Tameris M, Mauff K, Downing K, Mulenga H, Rose P, van der Zalm M, Mbaba S, Van As D, Hanekom WA, Walzl G, Scriba TJ, McShane H, Hatherill M; MVA029 Study Team .

Clin Infect Dis. 2018 Feb 1;66(4):554-563. doi: 10.1093/cid/cix834.

34.

Stool Culture for Diagnosis of Pulmonary Tuberculosis in Children.

Walters E, Demers AM, van der Zalm MM, Whitelaw A, Palmer M, Bosch C, Draper HR, Gie RP, Hesseling AC.

J Clin Microbiol. 2017 Dec;55(12):3355-3365. doi: 10.1128/JCM.00801-17. Epub 2017 Sep 13.

35.

The impact of drug resistance on the risk of tuberculosis infection and disease in child household contacts: a cross sectional study.

Golla V, Snow K, Mandalakas AM, Schaaf HS, Du Preez K, Hesseling AC, Seddon JA.

BMC Infect Dis. 2017 Aug 29;17(1):593. doi: 10.1186/s12879-017-2668-2.

36.

Operational implementation and impact of The Union's online childhood TB training course in South Africa.

du Plessis L, Black F, Detjen A, Hesseling AC, du Preez K.

Public Health Action. 2017 Jun 21;7(2):175-177. doi: 10.5588/pha.16.0116.

37.

Tuberculosis in adolescents and young adults: epidemiology and treatment outcomes in the Western Cape.

Snow K, Hesseling AC, Naidoo P, Graham SM, Denholm J, du Preez K.

Int J Tuberc Lung Dis. 2017 Jun 1;21(6):651-657. doi: 10.5588/ijtld.16.0866.

PMID:
28482959
38.

BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial.

Gasper MA, Hesseling AC, Mohar I, Myer L, Azenkot T, Passmore JS, Hanekom W, Cotton MF, Crispe IN, Sodora DL, Jaspan HB.

JCI Insight. 2017 Apr 6;2(7):e91963. doi: 10.1172/jci.insight.91963.

39.

Antiretroviral treatment in HIV-infected children who require a rifamycin-containing regimen for tuberculosis.

Rabie H, Decloedt EH, Garcia-Prats AJ, Cotton MF, Frigati L, Lallemant M, Hesseling A, Schaaf HS.

Expert Opin Pharmacother. 2017 Apr;18(6):589-598. doi: 10.1080/14656566.2017.1309023. Epub 2017 Mar 27. Review.

PMID:
28346018
40.

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis.

Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, Murray M, Furin J, Nardell EA, London L, Lessem E, Theron G, van Helden P, Niemann S, Merker M, Dowdy D, Van Rie A, Siu GK, Pasipanodya JG, Rodrigues C, Clark TG, Sirgel FA, Esmail A, Lin HH, Atre SR, Schaaf HS, Chang KC, Lange C, Nahid P, Udwadia ZF, Horsburgh CR Jr, Churchyard GJ, Menzies D, Hesseling AC, Nuermberger E, McIlleron H, Fennelly KP, Goemaere E, Jaramillo E, Low M, Jara CM, Padayatchi N, Warren RM.

Lancet Respir Med. 2017 Mar 15. pii: S2213-2600(17)30079-6. doi: 10.1016/S2213-2600(17)30079-6. [Epub ahead of print] Review.

PMID:
28344011
41.

The time has come: sparing injectables in paediatric MDR-TB.

Weld ED, Garcia-Prats AJ, Furin JJ, Bailey TC, Hesseling AC, Dooley KE.

Lancet Respir Med. 2017 Mar 15. pii: S2213-2600(17)30078-4. doi: 10.1016/S2213-2600(17)30078-4. [Epub ahead of print] No abstract available.

PMID:
28344008
42.

Xpert MTB/RIF on Stool Is Useful for the Rapid Diagnosis of Tuberculosis in Young Children With Severe Pulmonary Disease.

Walters E, van der Zalm MM, Palmer M, Bosch C, Demers AM, Draper H, Goussard P, Schaaf HS, Friedrich SO, Whitelaw A, Warren R, Gie RP, Hesseling AC.

Pediatr Infect Dis J. 2017 Sep;36(9):837-843. doi: 10.1097/INF.0000000000001563.

43.

Re: "It May Be Too Early to Try to Prove the Effect of Deworming on Tuberculin Reactivity".

Van der Zalm MM, van Soelen N, Mandalakas AM, Jacobsen M, Detjen AK, Marx FM, Grewal HM, Cotton MF, Walzl G, Hesseling AC.

Pediatr Infect Dis J. 2017 Feb;36(2):241-242. doi: 10.1097/INF.0000000000001408. No abstract available.

PMID:
28079838
44.

Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa.

Loxton AG, Knaul JK, Grode L, Gutschmidt A, Meller C, Eisele B, Johnstone H, van der Spuy G, Maertzdorf J, Kaufmann SH, Hesseling AC, Walzl G, Cotton MF; VPM Study Group.

Clin Vaccine Immunol. 2017 Feb 6;24(2). pii: e00439-16. doi: 10.1128/CVI.00439-16. Print 2017 Feb.

45.

Pediatric multidrug-resistant tuberculosis clinical trials: challenges and opportunities.

McAnaw SE, Hesseling AC, Seddon JA, Dooley KE, Garcia-Prats AJ, Kim S, Jenkins HE, Schaaf HS, Sterling TR, Horsburgh CR.

Int J Infect Dis. 2017 Mar;56:194-199. doi: 10.1016/j.ijid.2016.11.423. Epub 2016 Dec 9. Review.

46.

Phenotypically resembling myeloid derived suppressor cells are increased in children with HIV and exposed/infected with Mycobacterium tuberculosis.

Du Plessis N, Jacobs R, Gutschmidt A, Fang Z, van Helden PD, Lutz MB, Hesseling AC, Walzl G.

Eur J Immunol. 2017 Jan;47(1):107-118. doi: 10.1002/eji.201646658. Epub 2016 Dec 16.

47.

New and Repurposed Drugs for Pediatric Multidrug-Resistant Tuberculosis. Practice-based Recommendations.

Harausz EP, Garcia-Prats AJ, Seddon JA, Schaaf HS, Hesseling AC, Achar J, Bernheimer J, Cruz AT, D'Ambrosio L, Detjen A, Graham SM, Hughes J, Jonckheere S, Marais BJ, Migliori GB, McKenna L, Skrahina A, Tadolini M, Wilson P, Furin J; Sentinel Project on Pediatric Drug-Resistant Tuberculosis.

Am J Respir Crit Care Med. 2017 May 15;195(10):1300-1310. doi: 10.1164/rccm.201606-1227CI. Review.

48.

Tuberculosis Disease during Pregnancy and Treatment Outcomes in HIV-Infected and Uninfected Women at a Referral Hospital in Cape Town.

Bekker A, Schaaf HS, Draper HR, Kriel M, Hesseling AC.

PLoS One. 2016 Nov 3;11(11):e0164249. doi: 10.1371/journal.pone.0164249. eCollection 2016.

49.

Outcome of culture-confirmed isoniazid-resistant rifampicin-susceptible tuberculosis in children.

Garcia-Prats AJ, du Plessis L, Draper HR, Burger A, Seddon JA, Zimri K, Hesseling AC, Schaaf HS.

Int J Tuberc Lung Dis. 2016 Nov;20(11):1469-1476.

PMID:
27776587
50.

The safety and tolerability of the second-line injectable antituberculosis drugs in children.

Garcia-Prats AJ, Schaaf HS, Hesseling AC.

Expert Opin Drug Saf. 2016 Nov;15(11):1491-1500. Epub 2016 Aug 22. Review.

PMID:
27548570

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