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Items: 18

1.

Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues.

Court MH, Zhang X, Ding X, Yee KK, Hesse LM, Finel M.

Xenobiotica. 2012 Mar;42(3):266-77. doi: 10.3109/00498254.2011.618954. Epub 2011 Oct 13.

PMID:
21995321
2.

Evidence for oxazepam as an in vivo probe of UGT2B15: oxazepam clearance is reduced by UGT2B15 D85Y polymorphism but unaffected by UGT2B17 deletion.

He X, Hesse LM, Hazarika S, Masse G, Harmatz JS, Greenblatt DJ, Court MH.

Br J Clin Pharmacol. 2009 Nov;68(5):721-30. doi: 10.1111/j.1365-2125.2009.03519.x.

3.

Nicotine glucuronidation and the human UDP-glucuronosyltransferase UGT2B10.

Kaivosaari S, Toivonen P, Hesse LM, Koskinen M, Court MH, Finel M.

Mol Pharmacol. 2007 Sep;72(3):761-8. Epub 2007 Jun 18.

PMID:
17576790
4.

Ritonavir has minimal impact on the pharmacokinetic disposition of a single dose of bupropion administered to human volunteers.

Hesse LM, Greenblatt DJ, von Moltke LL, Court MH.

J Clin Pharmacol. 2006 May;46(5):567-76.

PMID:
16638740
5.

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: I. Identification of polymorphisms in the 5'-regulatory and exon 1 regions, and association with human liver UGT1A6 gene expression and glucuronidation.

Krishnaswamy S, Hao Q, Al-Rohaimi A, Hesse LM, von Moltke LL, Greenblatt DJ, Court MH.

J Pharmacol Exp Ther. 2005 Jun;313(3):1331-9. Epub 2005 Mar 10.

PMID:
15761114
6.

UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S).

Krishnaswamy S, Hao Q, Al-Rohaimi A, Hesse LM, von Moltke LL, Greenblatt DJ, Court MH.

J Pharmacol Exp Ther. 2005 Jun;313(3):1340-6. Epub 2005 Mar 10.

PMID:
15761113
7.

Pharmacogenetic determinants of interindividual variability in bupropion hydroxylation by cytochrome P450 2B6 in human liver microsomes.

Hesse LM, He P, Krishnaswamy S, Hao Q, Hogan K, von Moltke LL, Greenblatt DJ, Court MH.

Pharmacogenetics. 2004 Apr;14(4):225-38. Erratum in: Pharmacogenetics. 2005 Apr;15(4):265.

PMID:
15083067
8.

Effect of age on in vitro triazolam biotransformation in male human liver microsomes.

Patki KC, von Moltke LL, Harmatz JS, Hesse LM, Court MH, Greenblatt DJ.

J Pharmacol Exp Ther. 2004 Mar;308(3):874-9. Epub 2003 Nov 21.

PMID:
14634046
9.

Effect of bupropion on CYP2B6 and CYP3A4 catalytic activity, immunoreactive protein and mRNA levels in primary human hepatocytes: comparison with rifampicin.

Hesse LM, Sakai Y, Vishnuvardhan D, Li AP, von Moltke LL, Greenblatt DJ.

J Pharm Pharmacol. 2003 Sep;55(9):1229-39.

PMID:
14604466
10.

Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men.

Olubodun JO, Ochs HR, von Moltke LL, Roubenoff R, Hesse LM, Harmatz JS, Shader RI, Greenblatt DJ.

Br J Clin Pharmacol. 2003 Sep;56(3):297-304.

11.

Clinically important drug interactions with zopiclone, zolpidem and zaleplon.

Hesse LM, von Moltke LL, Greenblatt DJ.

CNS Drugs. 2003;17(7):513-32. Review.

PMID:
12751920
12.

Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir.

Weemhoff JL, von Moltke LL, Richert C, Hesse LM, Harmatz JS, Greenblatt DJ.

J Pharm Pharmacol. 2003 Mar;55(3):381-6.

PMID:
12724045
13.

Quantitation of CYP2B6, constitutive androstane receptor, and pregnane X receptor mRNA levels.

Hesse LM, Court MH.

Drug Metab Dispos. 2003 May;31(5):685; author reply 686. No abstract available.

PMID:
12718301
14.

Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein.

von Moltke LL, Weemhoff JL, Perloff MD, Hesse LM, Harmatz JS, Roth-Schechter BF, Greenblatt DJ.

Biopharm Drug Dispos. 2002 Dec;23(9):361-7.

PMID:
12469329
15.

CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.

Hesse LM, Venkatakrishnan K, von Moltke LL, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2001 Feb;29(2):133-40.

PMID:
11159802
16.

Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion.

Hesse LM, von Moltke LL, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2001 Feb;29(2):100-2.

PMID:
11159797
17.

Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes.

Court MH, Duan SX, Hesse LM, Venkatakrishnan K, Greenblatt DJ.

Anesthesiology. 2001 Jan;94(1):110-9.

PMID:
11135730
18.

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ.

Drug Metab Dispos. 2000 Oct;28(10):1176-83.

PMID:
10997936

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