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Items: 1 to 50 of 230

1.

Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.

Fedirko V, Jenab M, Méplan C, Jones JS, Zhu W, Schomburg L, Siddiq A, Hybsier S, Overvad K, Tjønneland A, Omichessan H, Perduca V, Boutron-Ruault MC, Kühn T, Katzke V, Aleksandrova K, Trichopoulou A, Karakatsani A, Kotanidou A, Tumino R, Panico S, Masala G, Agnoli C, Naccarati A, Bueno-de-Mesquita B, Vermeulen RCH, Weiderpass E, Skeie G, Nøst TH, Lujan-Barroso L, Quirós JR, Huerta JM, Rodríguez-Barranco M, Barricarte A, Gylling B, Harlid S, Bradbury KE, Wareham N, Khaw KT, Gunter M, Murphy N, Freisling H, Tsilidis K, Aune D, Riboli E, Hesketh JE, Hughes DJ.

Nutrients. 2019 Apr 25;11(4). pii: E935. doi: 10.3390/nu11040935.

2.

Protective effects of selenium-glutathione-enriched probiotics on CCl4-induced liver fibrosis.

Liu Y, Liu Q, Hesketh J, Huang D, Gan F, Hao S, Tang S, Guo Y, Huang K.

J Nutr Biochem. 2018 Aug;58:138-149. doi: 10.1016/j.jnutbio.2018.04.011. Epub 2018 May 1.

PMID:
29933196
3.

Genetic variants in selenoprotein genes modulate biomarkers of selenium status in response to Brazil nut supplementation (the SU.BRA.NUT study).

Donadio JLS, Rogero MM, Guerra-Shinohara EM, Barbosa F Jr, Desmarchelier C, Borel P, Sneddon AA, Hesketh JE, Cozzolino SMF.

Clin Nutr. 2019 Apr;38(2):539-548. doi: 10.1016/j.clnu.2018.03.011. Epub 2018 Mar 23.

4.

Influence of Genetic Variations in Selenoprotein Genes on the Pattern of Gene Expression after Supplementation with Brazil Nuts.

Donadio JLS, Rogero MM, Cockell S, Hesketh J, Cozzolino SMF.

Nutrients. 2017 Jul 11;9(7). pii: E739. doi: 10.3390/nu9070739.

5.

Expression profiling indicating low selenium-sensitive microRNA levels linked to cell cycle and cell stress response pathways in the CaCo-2 cell line.

McCann MJ, Rotjanapun K, Hesketh JE, Roy NC.

Br J Nutr. 2017 May;117(9):1212-1221. doi: 10.1017/S0007114517001143. Epub 2017 Jun 2.

PMID:
28571588
6.

Metabolic programming of a beige adipocyte phenotype by genistein.

Aziz SA, Wakeling LA, Miwa S, Alberdi G, Hesketh JE, Ford D.

Mol Nutr Food Res. 2017 Feb;61(2). doi: 10.1002/mnfr.201600574. Epub 2016 Dec 6.

7.

Selenoprotein Gene Nomenclature.

Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonović M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y.

J Biol Chem. 2016 Nov 11;291(46):24036-24040. Epub 2016 Sep 19.

8.

Modeling and gene knockdown to assess the contribution of nonsense-mediated decay, premature termination, and selenocysteine insertion to the selenoprotein hierarchy.

Zupanic A, Meplan C, Huguenin GV, Hesketh JE, Shanley DP.

RNA. 2016 Jul;22(7):1076-84. doi: 10.1261/rna.055749.115. Epub 2016 May 20.

9.

Incorporating corrosion measurement in hip wear simulators: An added complication or a necessity?

Neville A, Hesketh J, Beadling AR, Bryant MG, Dowson D.

Proc Inst Mech Eng H. 2016 May;230(5):406-20. doi: 10.1177/0954411916642484.

10.

Transcriptomics and proteomics show that selenium affects inflammation, cytoskeleton, and cancer pathways in human rectal biopsies.

Méplan C, Johnson IT, Polley AC, Cockell S, Bradburn DM, Commane DM, Arasaradnam RP, Mulholland F, Zupanic A, Mathers JC, Hesketh J.

FASEB J. 2016 Aug;30(8):2812-25. doi: 10.1096/fj.201600251R. Epub 2016 Apr 21.

11.

Rapid evolution of the intersexual genetic correlation for fitness in Drosophila melanogaster.

Collet JM, Fuentes S, Hesketh J, Hill MS, Innocenti P, Morrow EH, Fowler K, Reuter M.

Evolution. 2016 Apr;70(4):781-95. doi: 10.1111/evo.12892. Epub 2016 Mar 17.

12.

Low folate and selenium in the mouse maternal diet alters liver gene expression patterns in the offspring after weaning.

Barnett MP, Bermingham EN, Young W, Bassett SA, Hesketh JE, Maciel-Dominguez A, McNabb WC, Roy NC.

Nutrients. 2015 May 8;7(5):3370-86. doi: 10.3390/nu7053370.

13.

Ochratoxin A promotes porcine circovirus type 2 replication in vitro and in vivo.

Gan F, Zhang Z, Hu Z, Hesketh J, Xue H, Chen X, Hao S, Huang Y, Cole Ezea P, Parveen F, Huang K.

Free Radic Biol Med. 2015 Mar;80:33-47. doi: 10.1016/j.freeradbiomed.2014.12.016. Epub 2014 Dec 24.

PMID:
25542137
14.

Association between maternal micronutrient status, oxidative stress, and common genetic variants in antioxidant enzymes at 15 weeks׳ gestation in nulliparous women who subsequently develop preeclampsia.

Mistry HD, Gill CA, Kurlak LO, Seed PT, Hesketh JE, Méplan C, Schomburg L, Chappell LC, Morgan L, Poston L; SCOPE Consortium.

Free Radic Biol Med. 2015 Jan;78:147-55. doi: 10.1016/j.freeradbiomed.2014.10.580. Epub 2014 Nov 6.

15.

Selenium-enriched foods are more effective at increasing glutathione peroxidase (GPx) activity compared with selenomethionine: a meta-analysis.

Bermingham EN, Hesketh JE, Sinclair BR, Koolaard JP, Roy NC.

Nutrients. 2014 Sep 29;6(10):4002-31. doi: 10.3390/nu6104002.

16.

Detecting translational regulation by change point analysis of ribosome profiling data sets.

Zupanic A, Meplan C, Grellscheid SN, Mathers JC, Kirkwood TB, Hesketh JE, Shanley DP.

RNA. 2014 Oct;20(10):1507-18. doi: 10.1261/rna.045286.114. Epub 2014 Aug 21.

17.

Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort.

Hughes DJ, Fedirko V, Jenab M, Schomburg L, Méplan C, Freisling H, Bueno-de-Mesquita HB, Hybsier S, Becker NP, Czuban M, Tjønneland A, Outzen M, Boutron-Ruault MC, Racine A, Bastide N, Kühn T, Kaaks R, Trichopoulos D, Trichopoulou A, Lagiou P, Panico S, Peeters PH, Weiderpass E, Skeie G, Dagrun E, Chirlaque MD, Sánchez MJ, Ardanaz E, Ljuslinder I, Wennberg M, Bradbury KE, Vineis P, Naccarati A, Palli D, Boeing H, Overvad K, Dorronsoro M, Jakszyn P, Cross AJ, Quirós JR, Stepien M, Kong SY, Duarte-Salles T, Riboli E, Hesketh JE.

Int J Cancer. 2015 Mar 1;136(5):1149-61. doi: 10.1002/ijc.29071. Epub 2014 Jul 21.

18.

The composition of tribofilms produced on metal-on-metal hip bearings.

Hesketh J, Ward M, Dowson D, Neville A.

Biomaterials. 2014 Feb;35(7):2113-9. doi: 10.1016/j.biomaterials.2013.11.065. Epub 2013 Dec 13.

19.

An LC/MS/MS method for stable isotope dilution studies of β-carotene bioavailability, bioconversion, and vitamin A status in humans.

Oxley A, Berry P, Taylor GA, Cowell J, Hall MJ, Hesketh J, Lietz G, Boddy AV.

J Lipid Res. 2014 Feb;55(2):319-28. doi: 10.1194/jlr.D040204. Epub 2013 Oct 24.

20.

Selenium and cancer: a story that should not be forgotten-insights from genomics.

Méplan C, Hesketh J.

Cancer Treat Res. 2014;159:145-66. doi: 10.1007/978-3-642-38007-5_9. Review.

PMID:
24114479
21.

Association between polymorphisms in glutathione peroxidase and selenoprotein P genes, glutathione peroxidase activity, HRT use and breast cancer risk.

Méplan C, Dragsted LO, Ravn-Haren G, Tjønneland A, Vogel U, Hesketh J.

PLoS One. 2013 Sep 10;8(9):e73316. doi: 10.1371/journal.pone.0073316. eCollection 2013.

22.

The single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene influences endothelial cell function: interaction with selenium and fatty acids.

Crosley LK, Bashir S, Nicol F, Arthur JR, Hesketh JE, Sneddon AA.

Mol Nutr Food Res. 2013 Dec;57(12):2185-94. doi: 10.1002/mnfr.201300216. Epub 2013 Aug 12.

23.

Selenium alters miRNA profile in an intestinal cell line: evidence that miR-185 regulates expression of GPX2 and SEPSH2.

Maciel-Dominguez A, Swan D, Ford D, Hesketh J.

Mol Nutr Food Res. 2013 Dec;57(12):2195-205. doi: 10.1002/mnfr.201300168. Epub 2013 Aug 12.

PMID:
23934683
24.

Interaction of porcine circovirus type 2 replication with intracellular redox status in vitro.

Chen X, Ren F, Hesketh J, Shi X, Li J, Gan F, Hu Z, Huang K.

Redox Rep. 2013;18(5):186-92. doi: 10.1179/1351000213Y.0000000058. Epub 2013 Jul 23.

PMID:
23902724
25.

Genetic drift in antagonistic genes leads to divergence in sex-specific fitness between experimental populations of Drosophila melanogaster.

Hesketh J, Fowler K, Reuter M.

Evolution. 2013 May;67(5):1503-10. doi: 10.1111/evo.12032. Epub 2013 Jan 28.

PMID:
23617925
26.

Polymorphisms in thioredoxin reductase and selenoprotein K genes and selenium status modulate risk of prostate cancer.

Méplan C, Rohrmann S, Steinbrecher A, Schomburg L, Jansen E, Linseisen J, Hesketh J.

PLoS One. 2012;7(11):e48709. doi: 10.1371/journal.pone.0048709. Epub 2012 Nov 1.

27.

Personalised nutrition: how far has nutrigenomics progressed?

Hesketh J.

Eur J Clin Nutr. 2013 May;67(5):430-5. doi: 10.1038/ejcn.2012.145. Epub 2012 Oct 24. Review.

PMID:
23093344
28.

CUG binding protein 1 binds to a specific region within the human albumin 3' untranslated region.

Khaziapoul S, Pearson MJ, Pryme IF, Stern B, Hesketh JE.

Biochem Biophys Res Commun. 2012 Oct 5;426(4):539-43. doi: 10.1016/j.bbrc.2012.08.123. Epub 2012 Sep 7.

PMID:
22982313
29.

Glutathione peroxidase 4 has a major role in protecting mitochondria from oxidative damage and maintaining oxidative phosphorylation complexes in gut epithelial cells.

Cole-Ezea P, Swan D, Shanley D, Hesketh J.

Free Radic Biol Med. 2012 Aug 1;53(3):488-97. doi: 10.1016/j.freeradbiomed.2012.05.029. Epub 2012 May 25.

PMID:
22634395
30.

Albumin 3'untranslated region facilitates increased recombinant protein production from Chinese hamster ovary cells.

Pearson MJ, Khazaipoul S, Optun A, Pryme IF, Stern B, Hesketh JE.

Biotechnol J. 2012 Nov;7(11):1405-11. doi: 10.1002/biot.201200044. Epub 2012 Jun 29.

PMID:
22623341
31.

Selenium blocks porcine circovirus type 2 replication promotion induced by oxidative stress by improving GPx1 expression.

Chen X, Ren F, Hesketh J, Shi X, Li J, Gan F, Huang K.

Free Radic Biol Med. 2012 Aug 1;53(3):395-405. doi: 10.1016/j.freeradbiomed.2012.04.035. Epub 2012 May 8.

PMID:
22580339
32.

Selenium promotes T-cell response to TCR-stimulation and ConA, but not PHA in primary porcine splenocytes.

Ren F, Chen X, Hesketh J, Gan F, Huang K.

PLoS One. 2012;7(4):e35375. doi: 10.1371/journal.pone.0035375. Epub 2012 Apr 17.

33.

Reactive oxygen species regulate the replication of porcine circovirus type 2 via NF-κB pathway.

Chen X, Ren F, Hesketh J, Shi X, Li J, Gan F, Huang K.

Virology. 2012 Apr 25;426(1):66-72. doi: 10.1016/j.virol.2012.01.023. Epub 2012 Feb 11.

34.

The influence of selenium and selenoprotein gene variants on colorectal cancer risk.

Méplan C, Hesketh J.

Mutagenesis. 2012 Mar;27(2):177-86. doi: 10.1093/mutage/ger058. Review.

PMID:
22294765
35.

Marginal selenium deficiency down-regulates inflammation-related genes in splenic leukocytes of the mouse.

Kipp AP, Banning A, van Schothorst EM, Méplan C, Coort SL, Evelo CT, Keijer J, Hesketh J, Brigelius-Flohé R.

J Nutr Biochem. 2012 Sep;23(9):1170-7. doi: 10.1016/j.jnutbio.2011.06.011. Epub 2011 Dec 1.

PMID:
22137268
36.

Single nucleotide polymorphisms upstream from the β-carotene 15,15'-monoxygenase gene influence provitamin A conversion efficiency in female volunteers.

Lietz G, Oxley A, Leung W, Hesketh J.

J Nutr. 2012 Jan;142(1):161S-5S. doi: 10.3945/jn.111.140756. Epub 2011 Nov 23.

PMID:
22113863
37.

Differential effects of selenium and knock-down of glutathione peroxidases on TNFα and flagellin inflammatory responses in gut epithelial cells.

Gong G, Méplan C, Gautrey H, Hall J, Hesketh JE.

Genes Nutr. 2012 Apr;7(2):167-78. doi: 10.1007/s12263-011-0256-4. Epub 2011 Nov 9.

38.
39.

Polymorphisms affecting trace element bioavailability.

Mathers JC, Méplan C, Hesketh JE.

Int J Vitam Nutr Res. 2010 Oct;80(4-5):314-8. doi: 10.1024/0300-9831/a000039. Review.

PMID:
21462115
40.

A T/C polymorphism in the GPX4 3'UTR affects the selenoprotein expression pattern and cell viability in transfected Caco-2 cells.

Gautrey H, Nicol F, Sneddon AA, Hall J, Hesketh J.

Biochim Biophys Acta. 2011 Jun;1810(6):584-91. doi: 10.1016/j.bbagen.2011.03.016. Epub 2011 Apr 1. Erratum in: Biochim Biophys Acta. 2011 Jun;1810(6):iii.

41.

The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research.

van Ommen B, El-Sohemy A, Hesketh J, Kaput J, Fenech M, Evelo CT, McArdle HJ, Bouwman J, Lietz G, Mathers JC, Fairweather-Tait S, van Kranen H, Elliott R, Wopereis S, Ferguson LR, Méplan C, Perozzi G, Allen L, Rivero D; Micronutrient Genomics Project Working Group.

Genes Nutr. 2010 Dec;5(4):285-96. doi: 10.1007/s12263-010-0192-8. Epub 2010 Oct 30.

42.

Polymorphisms in the selenoprotein S and 15-kDa selenoprotein genes are associated with altered susceptibility to colorectal cancer.

Sutherland A, Kim DH, Relton C, Ahn YO, Hesketh J.

Genes Nutr. 2010 Sep;5(3):215-23. doi: 10.1007/s12263-010-0176-8. Epub 2010 May 13.

43.

Effects of selenium status and polymorphisms in selenoprotein genes on prostate cancer risk in a prospective study of European men.

Steinbrecher A, Méplan C, Hesketh J, Schomburg L, Endermann T, Jansen E, Akesson B, Rohrmann S, Linseisen J.

Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2958-68. doi: 10.1158/1055-9965.EPI-10-0364. Epub 2010 Sep 17.

44.

Selenium in human health and disease.

Fairweather-Tait SJ, Bao Y, Broadley MR, Collings R, Ford D, Hesketh JE, Hurst R.

Antioxid Redox Signal. 2011 Apr 1;14(7):1337-83. doi: 10.1089/ars.2010.3275. Epub 2011 Jan 6. Review.

PMID:
20812787
45.

The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes.

Al-Souhibani N, Al-Ahmadi W, Hesketh JE, Blackshear PJ, Khabar KS.

Oncogene. 2010 Jul 22;29(29):4205-15. doi: 10.1038/onc.2010.168. Epub 2010 May 24.

46.

Genetic variants in selenoprotein genes increase risk of colorectal cancer.

Méplan C, Hughes DJ, Pardini B, Naccarati A, Soucek P, Vodickova L, Hlavatá I, Vrána D, Vodicka P, Hesketh JE.

Carcinogenesis. 2010 Jun;31(6):1074-9. doi: 10.1093/carcin/bgq076. Epub 2010 Apr 8.

PMID:
20378690
47.

Inter-individual variation in DNA damage and base excision repair in young, healthy non-smokers: effects of dietary supplementation and genotype.

Caple F, Williams EA, Spiers A, Tyson J, Burtle B, Daly AK, Mathers JC, Hesketh JE.

Br J Nutr. 2010 Jun;103(11):1585-93. doi: 10.1017/S0007114509993540. Epub 2010 Jan 19.

PMID:
20082738
48.

Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to limited selenium intake in mouse colon.

Kipp A, Banning A, van Schothorst EM, Méplan C, Schomburg L, Evelo C, Coort S, Gaj S, Keijer J, Hesketh J, Brigelius-Flohé R.

Mol Nutr Food Res. 2009 Dec;53(12):1561-72. doi: 10.1002/mnfr.200900105.

PMID:
19810021
49.

Capturing nursing information in the United Kingdom through use of a conceptual model.

Lloyd D, Tang P, Clark J, Hesketh J, Paget A, Baker B.

Stud Health Technol Inform. 2009;146:683-7.

PMID:
19592928
50.

Fine mapping of interactions between eEF1alpha protein and 3'UTR of metallothionein-1 mRNA.

Fan K, Chrzanowska-Lightowlers ZM, Hesketh JE.

Biochem Biophys Res Commun. 2009 Aug 14;386(1):82-8. doi: 10.1016/j.bbrc.2009.05.146. Epub 2009 Jun 6.

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