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Items: 12


Structure and tailspike glycosidase machinery of ORF212 from E. coli O157:H7 phage CBA120 (TSP3).

Greenfield J, Shang X, Luo H, Zhou Y, Heselpoth RD, Nelson DC, Herzberg O.

Sci Rep. 2019 May 14;9(1):7349. doi: 10.1038/s41598-019-43748-9.


Lysocins: Bioengineered Antimicrobials That Deliver Lysins across the Outer Membrane of Gram-Negative Bacteria.

Heselpoth RD, Euler CW, Schuch R, Fischetti VA.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00342-19. doi: 10.1128/AAC.00342-19. Print 2019 Jun.


Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal.

Harhala M, Nelson DC, Miernikiewicz P, Heselpoth RD, Brzezicka B, Majewska J, Linden SB, Shang X, Szymczak A, Lecion D, Marek-Bukowiec K, Kłak M, Wojciechowicz B, Lahutta K, Konieczny A, Dąbrowska K.

Viruses. 2018 Nov 15;10(11). pii: E638. doi: 10.3390/v10110638.


A bacteriophage endolysin that eliminates intracellular streptococci.

Shen Y, Barros M, Vennemann T, Gallagher DT, Yin Y, Linden SB, Heselpoth RD, Spencer DJ, Donovan DM, Moult J, Fischetti VA, Heinrich F, Lösche M, Nelson DC.

Elife. 2016 Mar 15;5. pii: e13152. doi: 10.7554/eLife.13152.


Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection.

Yang X, Lin YP, Heselpoth RD, Buyuktanir O, Qin J, Kung F, Nelson DC, Leong JM, Pal U.

Cell Microbiol. 2016 Jan;18(1):97-110. doi: 10.1111/cmi.12487. Epub 2015 Aug 31.


Increasing the stability of the bacteriophage endolysin PlyC using rationale-based FoldX computational modeling.

Heselpoth RD, Yin Y, Moult J, Nelson DC.

Protein Eng Des Sel. 2015 Apr;28(4):85-92. doi: 10.1093/protein/gzv004. Epub 2015 Mar 3.


Quantitative analysis of the thermal stability of the gamma phage endolysin PlyG: a biophysical and kinetic approach to assaying therapeutic potential.

Heselpoth RD, Owens JM, Nelson DC.

Virology. 2015 Mar;477:125-132. doi: 10.1016/j.virol.2014.11.003. Epub 2014 Nov 26.


Characterization of AlgMsp, an alginate lyase from Microbulbifer sp. 6532A.

Swift SM, Hudgens JW, Heselpoth RD, Bales PM, Nelson DC.

PLoS One. 2014 Nov 19;9(11):e112939. doi: 10.1371/journal.pone.0112939. eCollection 2014.


Biochemical and biophysical characterization of PlyGRCS, a bacteriophage endolysin active against methicillin-resistant Staphylococcus aureus.

Linden SB, Zhang H, Heselpoth RD, Shen Y, Schmelcher M, Eichenseher F, Nelson DC.

Appl Microbiol Biotechnol. 2015 Jan;99(2):741-52. doi: 10.1007/s00253-014-5930-1. Epub 2014 Jul 20.


Crystal structure of ORF210 from E. coli O157:H1 phage CBA120 (TSP1), a putative tailspike protein.

Chen C, Bales P, Greenfield J, Heselpoth RD, Nelson DC, Herzberg O.

PLoS One. 2014 Mar 26;9(3):e93156. doi: 10.1371/journal.pone.0093156. eCollection 2014.


A new screening method for the directed evolution of thermostable bacteriolytic enzymes.

Heselpoth RD, Nelson DC.

J Vis Exp. 2012 Nov 7;(69). pii: 4216. doi: 10.3791/4216.


X-ray crystal structure of the streptococcal specific phage lysin PlyC.

McGowan S, Buckle AM, Mitchell MS, Hoopes JT, Gallagher DT, Heselpoth RD, Shen Y, Reboul CF, Law RH, Fischetti VA, Whisstock JC, Nelson DC.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12752-7. doi: 10.1073/pnas.1208424109. Epub 2012 Jul 17.

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