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Items: 37


Single Chromosome Aneuploidy Induces Genome-Wide Perturbation of Nuclear Organization and Gene Expression.

Braun R, Ronquist S, Wangsa D, Chen H, Anthuber L, Gemoll T, Wangsa D, Koparde V, Hunn C, Habermann JK, Heselmeyer-Haddad K, Rajapakse I, Ried T.

Neoplasia. 2019 Apr;21(4):401-412. doi: 10.1016/j.neo.2019.02.003. Epub 2019 Mar 22.


Single-cell genetic analysis of clonal dynamics in colorectal adenomas indicates CDX2 gain as a predictor of recurrence.

Fiedler D, Heselmeyer-Haddad K, Hirsch D, Hernandez LS, Torres I, Wangsa D, Hu Y, Zapata L, Rueschoff J, Belle S, Ried T, Gaiser T.

Int J Cancer. 2019 Apr 1;144(7):1561-1573. doi: 10.1002/ijc.31869. Epub 2018 Dec 11.


Dynamics of Genome Alterations in Crohn's Disease-Associated Colorectal Carcinogenesis.

Hirsch D, Wangsa D, Zhu YJ, Hu Y, Edelman DC, Meltzer PS, Heselmeyer-Haddad K, Ott C, Kienle P, Galata C, Horisberger K, Ried T, Gaiser T.

Clin Cancer Res. 2018 Oct 15;24(20):4997-5011. doi: 10.1158/1078-0432.CCR-18-0630. Epub 2018 Jul 2.


The evolution of single cell-derived colorectal cancer cell lines is dominated by the continued selection of tumor-specific genomic imbalances, despite random chromosomal instability.

Wangsa D, Braun R, Schiefer M, Gertz EM, Bronder D, Quintanilla I, Padilla-Nash HM, Torres I, Hunn C, Warner L, Buishand FO, Hu Y, Hirsch D, Gaiser T, Camps J, Schwartz R, Schäffer AA, Heselmeyer-Haddad K, Ried T.

Carcinogenesis. 2018 Jul 30;39(8):993-1005. doi: 10.1093/carcin/bgy068.


Aneuploidy, TP53 mutation, and amplification of MYC correlate with increased intratumor heterogeneity and poor prognosis of breast cancer patients.

Oltmann J, Heselmeyer-Haddad K, Hernandez LS, Meyer R, Torres I, Hu Y, Doberstein N, Killian JK, Petersen D, Zhu YJ, Edelman DC, Meltzer PS, Schwartz R, Gertz EM, Schäffer AA, Auer G, Habermann JK, Ried T.

Genes Chromosomes Cancer. 2018 Apr;57(4):165-175. doi: 10.1002/gcc.22515. Epub 2018 Jan 9.


Array comparative genomic hybridization of 18 pancreatic ductal adenocarcinomas and their autologous metastases.

Rausch V, Krieg A, Camps J, Behrens B, Beier M, Wangsa D, Heselmeyer-Haddad K, Baldus SE, Knoefel WT, Ried T, Stoecklein NH.

BMC Res Notes. 2017 Nov 6;10(1):560. doi: 10.1186/s13104-017-2886-0.


FISHtrees 3.0: Tumor Phylogenetics Using a Ploidy Probe.

Gertz EM, Chowdhury SA, Lee WJ, Wangsa D, Heselmeyer-Haddad K, Ried T, Schwartz R, Schäffer AA.

PLoS One. 2016 Jun 30;11(6):e0158569. doi: 10.1371/journal.pone.0158569. eCollection 2016.


Phylogenetic analysis of multiple FISH markers in oral tongue squamous cell carcinoma suggests that a diverse distribution of copy number changes is associated with poor prognosis.

Wangsa D, Chowdhury SA, Ryott M, Gertz EM, Elmberger G, Auer G, Åvall Lundqvist E, Küffer S, Ströbel P, Schäffer AA, Schwartz R, Munck-Wikland E, Ried T, Heselmeyer-Haddad K.

Int J Cancer. 2016 Jan 1;138(1):98-109. doi: 10.1002/ijc.29691. Epub 2015 Aug 28.


Inferring models of multiscale copy number evolution for single-tumor phylogenetics.

Chowdhury SA, Gertz EM, Wangsa D, Heselmeyer-Haddad K, Ried T, Schäffer AA, Schwartz R.

Bioinformatics. 2015 Jun 15;31(12):i258-67. doi: 10.1093/bioinformatics/btv233.


Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis.

Heselmeyer-Haddad KM, Berroa Garcia LY, Bradley A, Hernandez L, Hu Y, Habermann JK, Dumke C, Thorns C, Perner S, Pestova E, Burke C, Chowdhury SA, Schwartz R, Schäffer AA, Paris PL, Ried T.

Am J Pathol. 2014 Oct;184(10):2671-86. doi: 10.1016/j.ajpath.2014.06.030. Epub 2014 Aug 14.


Algorithms to model single gene, single chromosome, and whole genome copy number changes jointly in tumor phylogenetics.

Chowdhury SA, Shackney SE, Heselmeyer-Haddad K, Ried T, Schäffer AA, Schwartz R.

PLoS Comput Biol. 2014 Jul 31;10(7):e1003740. doi: 10.1371/journal.pcbi.1003740. eCollection 2014 Jul.


Phylogenetic analysis of multiprobe fluorescence in situ hybridization data from tumor cell populations.

Chowdhury SA, Shackney SE, Heselmeyer-Haddad K, Ried T, Schäffer AA, Schwartz R.

Bioinformatics. 2013 Jul 1;29(13):i189-98. doi: 10.1093/bioinformatics/btt205.


Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression.

Heselmeyer-Haddad K, Berroa Garcia LY, Bradley A, Ortiz-Melendez C, Lee WJ, Christensen R, Prindiville SA, Calzone KA, Soballe PW, Hu Y, Chowdhury SA, Schwartz R, Schäffer AA, Ried T.

Am J Pathol. 2012 Nov;181(5):1807-22. doi: 10.1016/j.ajpath.2012.07.012. Epub 2012 Oct 8.


Multicentric dermatofibrosarcoma protuberans in patients with adenosine deaminase-deficient severe combined immune deficiency.

Kesserwan C, Sokolic R, Cowen EW, Garabedian E, Heselmeyer-Haddad K, Lee CC, Pittaluga S, Ortiz C, Baird K, Lopez-Terrada D, Bridge J, Wayne AS, Candotti F.

J Allergy Clin Immunol. 2012 Mar;129(3):762-769.e1. doi: 10.1016/j.jaci.2011.10.028. Epub 2011 Dec 6.


Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo.

Goldenberg DM, Zagzag D, Heselmeyer-Haddad KM, Berroa Garcia LY, Ried T, Loo M, Chang CH, Gold DV.

Int J Cancer. 2012 Jul 1;131(1):49-58. doi: 10.1002/ijc.26327. Epub 2011 Aug 30.


Automated analysis of protein expression and gene amplification within the same cells of paraffin-embedded tumour tissue.

Gaiser T, Berroa-Garcia L, Kemmerling R, Dutta A, Ried T, Heselmeyer-Haddad K.

Cell Oncol (Dordr). 2011 Aug;34(4):337-42. doi: 10.1007/s13402-011-0032-x. Epub 2011 Jun 9.


Genome and transcriptome profiles of CD133-positive colorectal cancer cells.

Gaiser T, Camps J, Meinhardt S, Wangsa D, Nguyen QT, Varma S, Dittfeld C, Kunz-Schughart LA, Kemmerling R, Becker MR, Heselmeyer-Haddad K, Ried T.

Am J Pathol. 2011 Apr;178(4):1478-88. doi: 10.1016/j.ajpath.2010.12.036.


Genomic instability and oncogene amplifications in colorectal adenomas predict recurrence and synchronous carcinoma.

Habermann JK, Brucker CA, Freitag-Wolf S, Heselmeyer-Haddad K, Krüger S, Barenboim L, Downing T, Bruch HP, Auer G, Roblick UJ, Ried T.

Mod Pathol. 2011 Apr;24(4):542-55. doi: 10.1038/modpathol.2010.217. Epub 2010 Nov 19.


Automated analysis of protein expression and gene amplification within the same cells of paraffin-embedded tumour tissue.

Gaiser T, Berroa-Garcia L, Kemmerling R, Dutta A, Ried T, Heselmeyer-Haddad K.

Anal Cell Pathol (Amst). 2010;33(2):105-12. doi: 10.3233/ACP-CLO-2010-0532. Erratum in: Cell Oncol (Dordr). 2011 Aug;34(4):407-8.


Fluorescence in situ hybridization markers for prediction of cervical lymph node metastases.

Wangsa D, Heselmeyer-Haddad K, Ried P, Eriksson E, Schäffer AA, Morrison LE, Luo J, Auer G, Munck-Wikland E, Ried T, Lundqvist EA.

Am J Pathol. 2009 Dec;175(6):2637-45. doi: 10.2353/ajpath.2009.090289. Epub 2009 Nov 5.


Detection of genomic amplification of the human telomerase gene TERC, a potential marker for triage of women with HPV-positive, abnormal Pap smears.

Andersson S, Sowjanya P, Wangsa D, Hjerpe A, Johansson B, Auer G, Gravitt PE, Larsson C, Wallin KL, Ried T, Heselmeyer-Haddad K.

Am J Pathol. 2009 Nov;175(5):1831-47. doi: 10.2353/ajpath.2009.090122.


EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma.

Ryott M, Wangsa D, Heselmeyer-Haddad K, Lindholm J, Elmberger G, Auer G, Avall Lundqvist E, Ried T, Munck-Wikland E.

Eur J Cancer. 2009 Jun;45(9):1700-8. doi: 10.1016/j.ejca.2009.02.027. Epub 2009 Mar 28.


The use of genetic markers to identify lung cancer in fine needle aspiration samples.

Gill RK, Vazquez MF, Kramer A, Hames M, Zhang L, Heselmeyer-Haddad K, Ried T, Shilo K, Henschke C, Yankelevitz D, Jen J.

Clin Cancer Res. 2008 Nov 15;14(22):7481-7. doi: 10.1158/1078-0432.CCR-07-5242.


Frequent gain of the human telomerase gene TERC at 3q26 in cervical adenocarcinomas.

Andersson S, Wallin KL, Hellström AC, Morrison LE, Hjerpe A, Auer G, Ried T, Larsson C, Heselmeyer-Haddad K.

Br J Cancer. 2006 Aug 7;95(3):331-8. Epub 2006 Jul 18.


Genomic amplification of the human telomerase gene (TERC) in pap smears predicts the development of cervical cancer.

Heselmeyer-Haddad K, Sommerfeld K, White NM, Chaudhri N, Morrison LE, Palanisamy N, Wang ZY, Auer G, Steinberg W, Ried T.

Am J Pathol. 2005 Apr;166(4):1229-38.


Gain of chromosome 3q is an early and consistent genetic aberration in carcinomas of the vulva.

Stoltzfus P, Heselmeyer-Haddad K, Castro J, White N, Silfverswärd C, Sjövall K, Einhorn N, Tryggvason K, Auer G, Ried T, Nordström B.

Int J Gynecol Cancer. 2005 Jan-Feb;15(1):120-6.


A recurrent gain of chromosome arm 3q in primary squamous carcinoma of the vagina.

Habermann JK, Hellman K, Freitag S, Heselmeyer-Haddad K, Hellström AC, Shah K, Auer G, Ried T.

Cancer Genet Cytogenet. 2004 Jan 1;148(1):7-13.


Detection of genomic amplification of the human telomerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervical dysplasia.

Heselmeyer-Haddad K, Janz V, Castle PE, Chaudhri N, White N, Wilber K, Morrison LE, Auer G, Burroughs FH, Sherman ME, Ried T.

Am J Pathol. 2003 Oct;163(4):1405-16.


Comparative genomic hybridization analysis of tonsillar cancer reveals a different pattern of genomic imbalances in human papillomavirus-positive and -negative tumors.

Dahlgren L, Mellin H, Wangsa D, Heselmeyer-Haddad K, Björnestål L, Lindholm J, Munck-Wikland E, Auer G, Ried T, Dalianis T.

Int J Cancer. 2003 Nov 1;107(2):244-9.


Cytogenetic evidence that circulating epithelial cells in patients with carcinoma are malignant.

Fehm T, Sagalowsky A, Clifford E, Beitsch P, Saboorian H, Euhus D, Meng S, Morrison L, Tucker T, Lane N, Ghadimi BM, Heselmeyer-Haddad K, Ried T, Rao C, Uhr J.

Clin Cancer Res. 2002 Jul;8(7):2073-84.


Detection of chromosomal aneuploidies and gene copy number changes in fine needle aspirates is a specific, sensitive, and objective genetic test for the diagnosis of breast cancer.

Heselmeyer-Haddad K, Chaudhri N, Stoltzfus P, Cheng JC, Wilber K, Morrison L, Auer G, Ried T.

Cancer Res. 2002 Apr 15;62(8):2365-9.


Spectral karyotyping in cancer cytogenetics.

Hilgenfeld E, Montagna C, Padilla-Nash H, Stapleton L, Heselmeyer-Haddad K, Ried T.

Methods Mol Med. 2002;68:29-44. No abstract available.


[Interphase cytogenetics with DNA-probes for chromosome 8 to detect circulating tumor cells in breast cancer patients].

Ghadimi BM, Uhr J, Tucker T, Heselmeyer-Haddad K, Auer G, Ried T, Becker H.

Zentralbl Chir. 2001 Nov;126(11):922-5. German.


Jumping translocations are common in solid tumor cell lines and result in recurrent fusions of whole chromosome arms.

Padilla-Nash HM, Heselmeyer-Haddad K, Wangsa D, Zhang H, Ghadimi BM, Macville M, Augustus M, Schröck E, Hilgenfeld E, Ried T.

Genes Chromosomes Cancer. 2001 Apr;30(4):349-63.


Interphase cytogenetics: at the interface of genetics and morphology.

Ghadimi BM, Heselmeyer-Haddad K, Auer G, Ried T.

Anal Cell Pathol. 1999;19(1):3-6. Review. No abstract available.


Genomic changes defining the genesis, progression, and malignancy potential in solid human tumors: a phenotype/genotype correlation.

Ried T, Heselmeyer-Haddad K, Blegen H, Schröck E, Auer G.

Genes Chromosomes Cancer. 1999 Jul;25(3):195-204. Review.


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