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Inflammatory Microenvironment of Acute Myocardial Infarction Prevents Regeneration of Heart with Stem Cells Therapy.

Khodayari S, Khodayari H, Amiri AZ, Eslami M, Farhud D, Hescheler J, Nayernia K.

Cell Physiol Biochem. 2019;53(5):887-909. doi: 10.33594/000000180. Review.


Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations.

Hamad S, Derichsweiler D, Papadopoulos S, Nguemo F, Šarić T, Sachinidis A, Brockmeier K, Hescheler J, Boukens BJ, Pfannkuche K.

Theranostics. 2019 Sep 25;9(24):7222-7238. doi: 10.7150/thno.32058. eCollection 2019.


Functional implications of Cav 2.3 R-type voltage-gated calcium channels in the murine auditory system - novel vistas from brainstem-evoked response audiometry.

Lundt A, Soós J, Seidel R, Henseler C, Müller R, Raj Ginde V, Imran Arshaad M, Ehninger D, Hescheler J, Sachinidis A, Broich K, Wormuth C, Papazoglou A, Weiergräber M.

Eur J Neurosci. 2019 Oct 11. doi: 10.1111/ejn.14591. [Epub ahead of print]


The Effect of Antiarrhythmic Drugs on the Beat Rate Variability of Human Embryonic and Human Induced Pluripotent Stem Cell Derived Cardiomyocytes.

Niehoff J, Matzkies M, Nguemo F, Hescheler J, Reppel M.

Sci Rep. 2019 Oct 1;9(1):14106. doi: 10.1038/s41598-019-50557-7.


Ketamine Increases Proliferation of Human iPSC-Derived Neuronal Progenitor Cells via Insulin-Like Growth Factor 2 and Independent of the NMDA Receptor.

Grossert A, Mehrjardi NZ, Bailey SJ, Lindsay MA, Hescheler J, Šarić T, Teusch N.

Cells. 2019 Sep 24;8(10). pii: E1139. doi: 10.3390/cells8101139.


Complex Clearance Mechanisms After Intraventricular Hemorrhage and rt-PA Treatment-a Review on Clinical Trials.

Bosche B, Mergenthaler P, Doeppner TR, Hescheler J, Molcanyi M.

Transl Stroke Res. 2019 Sep 14. doi: 10.1007/s12975-019-00735-6. [Epub ahead of print] Review.


Intracerebroventricular administration of histidine reduces kainic acid-induced convulsive seizures in mice.

Alpdogan S, Neumaier F, Dibué-Adjei M, Hescheler J, Schneider T.

Exp Brain Res. 2019 Oct;237(10):2481-2493. doi: 10.1007/s00221-019-05605-z. Epub 2019 Jul 18.


Application of Stem Cell Technologies to Regenerate Injured Myocardium and Improve Cardiac Function.

Mardanpour P, Nayernia K, Khodayari S, Khodayari H, Molcanyi M, Hescheler J.

Cell Physiol Biochem. 2019;53(1):101-120. doi: 10.33594/000000124. Review.


Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice.

Lundt A, Soos J, Henseler C, Arshaad MI, Müller R, Ehninger D, Hescheler J, Sachinidis A, Broich K, Wormuth C, Papazoglou A, Weiergräber M.

J Vis Exp. 2019 May 10;(147). doi: 10.3791/59200.


In Vitro Grown Micro-Tissues for Cardiac Cell Replacement Therapy in Vivo.

Sahito RGA, Sheng X, Maass M, Mikhael N, Hamad S, Heras-Bautista CO, Derichsweiler D, Spitkovsky D, Suhr F, Khalil M, Brockmeier K, Halbach M, Saric T, Hescheler J, Krausgrill B, Pfannkuche K.

Cell Physiol Biochem. 2019;52(6):1309-1324. doi: 10.33594/000000092.


Cav3.2 T-Type Calcium Channels Are Physiologically Mandatory for the Auditory System.

Lundt A, Seidel R, Soós J, Henseler C, Müller R, Bakki M, Arshaad MI, Ehninger D, Hescheler J, Sachinidis A, Broich K, Wormuth C, Papazoglou A, Weiergräber M.

Neuroscience. 2019 Jun 15;409:81-100. doi: 10.1016/j.neuroscience.2019.04.024. Epub 2019 Apr 25.


Parabolic, Flight-Induced, Acute Hypergravity and Microgravity Effects on the Beating Rate of Human Cardiomyocytes.

Acharya A, Brungs S, Lichterfeld Y, Hescheler J, Hemmersbach R, Boeuf H, Sachinidis A.

Cells. 2019 Apr 14;8(4). pii: E352. doi: 10.3390/cells8040352.


Different Responses to Drug Safety Screening Targets between Human Neonatal and Infantile Heart Tissue and Cardiac Bodies Derived from Human-Induced Pluripotent Stem Cells.

Trieschmann J, Haustein M, Köster A, Hescheler J, Brockmeier K, Bennink G, Hannes T.

Stem Cells Int. 2019 Mar 6;2019:6096294. doi: 10.1155/2019/6096294. eCollection 2019.


Gender specific click and tone burst evoked ABR datasets from mice lacking the Cav3.2 T-type voltage-gated calcium channel.

Lundt A, Henseler C, Wormuth C, Soos J, Seidel R, Müller R, Arshaad MI, Broich K, Hescheler J, Sachinidis A, Ehninger D, Papazoglou A, Weiergräber M.

BMC Res Notes. 2019 Mar 20;12(1):157. doi: 10.1186/s13104-019-4169-4.


Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart.

Ahuja G, Bartsch D, Yao W, Geissen S, Frank S, Aguirre A, Russ N, Messling JE, Dodzian J, Lagerborg KA, Vargas NE, Muck JS, Brodesser S, Baldus S, Sachinidis A, Hescheler J, Dieterich C, Trifunovic A, Papantonis A, Petrascheck M, Klinke A, Jain M, Valenzano DR, Kurian L.

EMBO Rep. 2019 Apr;20(4). pii: e47407. doi: 10.15252/embr.201847407. Epub 2019 Mar 18.


Modulation of Cav2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity.

Albanna W, Lüke JN, Schubert GA, Dibué-Adjei M, Kotliar K, Hescheler J, Clusmann H, Steiger HJ, Hänggi D, Kamp MA, Schneider T, Neumaier F.

Mol Cell Neurosci. 2019 Apr;96:35-46. doi: 10.1016/j.mcn.2019.03.003. Epub 2019 Mar 12.


Long Term Perinatal Deltamethrin Exposure Alters Electrophysiological Properties of Embryonic Ventricular Cardiomyocyte.

Luo HY, Masika J, Guan XW, Nie L, Ao DH, Qi Y, Shi R, Hescheler J, Zeng Y.

Curr Med Sci. 2019 Feb;39(1):21-27. doi: 10.1007/s11596-019-1995-5. Epub 2019 Mar 13.


Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts.

Heras-Bautista CO, Mikhael N, Lam J, Shinde V, Katsen-Globa A, Dieluweit S, Molcanyi M, Uvarov V, Jütten P, Sahito RGA, Mederos-Henry F, Piechot A, Brockmeier K, Hescheler J, Sachinidis A, Pfannkuche K.

Acta Biomater. 2019 Apr 15;89:180-192. doi: 10.1016/j.actbio.2019.03.017. Epub 2019 Mar 9.


STAT3 Phosphorylation Mediating DMSO's Function on Fetal Cardiomyocyte Proliferation with Developmental Changes.

Hu H, Xue J, Dong R, Zhao Y, Song C, Zhao H, Hescheler J, Zhang Y, Liang H.

Int Heart J. 2019 Mar 20;60(2):392-399. doi: 10.1536/ihj.18-206. Epub 2019 Feb 8.


yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs.

Frank S, Ahuja G, Bartsch D, Russ N, Yao W, Kuo JC, Derks JP, Akhade VS, Kargapolova Y, Georgomanolis T, Messling JE, Gramm M, Brant L, Rehimi R, Vargas NE, Kuroczik A, Yang TP, Sahito RGA, Franzen J, Hescheler J, Sachinidis A, Peifer M, Rada-Iglesias A, Kanduri M, Costa IG, Kanduri C, Papantonis A, Kurian L.

Cell Stem Cell. 2019 Feb 7;24(2):318-327.e8. doi: 10.1016/j.stem.2018.11.005. Epub 2018 Dec 13.


Gender specific click and tone burst evoked ABR datasets from mice lacking the Cav2.3 R-type voltage-gated calcium channel.

Lundt A, Henseler C, Wormuth C, Soos J, Seidel R, Müller R, Arshaad MI, Broich K, Hescheler J, Sachinidis A, Ehninger D, Papazoglou A, Weiergräber M.

Data Brief. 2018 Oct 24;21:1263-1266. doi: 10.1016/j.dib.2018.10.056. eCollection 2018 Dec.


Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis.

Albanna W, Kotliar K, Lüke JN, Alpdogan S, Conzen C, Lindauer U, Clusmann H, Hescheler J, Vilser W, Schneider T, Schubert GA.

PLoS One. 2018 Oct 4;13(10):e0204689. doi: 10.1371/journal.pone.0204689. eCollection 2018.


Acute molecular effects of pressure-controlled intermittent coronary sinus occlusion in patients with advanced heart failure.

Mohl W, Spitzer E, Mader RM, Wagh V, Nguemo F, Milasinovic D, Jusić A, Khazen C, Szodorai E, Birkenberg B, Lubec G, Hescheler J, Serruys PW.

ESC Heart Fail. 2018 Dec;5(6):1176-1183. doi: 10.1002/ehf2.12354. Epub 2018 Sep 19.


Parallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart.

Sabour D, Machado RSR, Pinto JP, Rohani S, Sahito RGA, Hescheler J, Futschik ME, Sachinidis A.

Mol Ther Nucleic Acids. 2018 Sep 7;12:158-173. doi: 10.1016/j.omtn.2018.04.018. Epub 2018 May 4.


In vitro and in vivo phosphorylation of the Cav2.3 voltage-gated R-type calcium channel.

Schneider T, Alpdogan S, Hescheler J, Neumaier F.

Channels (Austin). 2018;12(1):326-334. doi: 10.1080/19336950.2018.1516984. Review.


In Reply to "Corpus Callosotomy for Drug-Resistant Schizophrenia; Novel Treatment Based on Pathophysiology".

Neumaier F, Paterno M, Alpdogan S, Tevoufouet EE, Schneider T, Hescheler J, Albanna W.

World Neurosurg. 2018 Aug;116:485. doi: 10.1016/j.wneu.2018.04.206. No abstract available.


Reciprocal modulation of Cav 2.3 voltage-gated calcium channels by copper(II) ions and kainic acid.

Neumaier F, Akhtar-Schäfer I, Lüke JN, Dibué-Adjei M, Hescheler J, Schneider T.

J Neurochem. 2018 Nov;147(3):310-322. doi: 10.1111/jnc.14546. Epub 2018 Aug 30.


Thiamine preserves mitochondrial function in a rat model of traumatic brain injury, preventing inactivation of the 2-oxoglutarate dehydrogenase complex.

Mkrtchyan GV, Üçal M, Müllebner A, Dumitrescu S, Kames M, Moldzio R, Molcanyi M, Schaefer S, Weidinger A, Schaefer U, Hescheler J, Duvigneau JC, Redl H, Bunik VI, Kozlov AV.

Biochim Biophys Acta Bioenerg. 2018 Sep;1859(9):925-931. doi: 10.1016/j.bbabio.2018.05.005. Epub 2018 May 16.


Modulation of Differentiation Processes in Murine Embryonic Stem Cells Exposed to Parabolic Flight-Induced Acute Hypergravity and Microgravity.

Acharya A, Brungs S, Henry M, Rotshteyn T, Singh Yaduvanshi N, Wegener L, Jentzsch S, Hescheler J, Hemmersbach R, Boeuf H, Sachinidis A.

Stem Cells Dev. 2018 Jun 15;27(12):838-847. doi: 10.1089/scd.2017.0294. Epub 2018 Apr 9.


Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5.

Filipova D, Henry M, Rotshteyn T, Brunn A, Carstov M, Deckert M, Hescheler J, Sachinidis A, Pfitzer G, Papadopoulos S.

PLoS One. 2018 Mar 15;13(3):e0194428. doi: 10.1371/journal.pone.0194428. eCollection 2018.


Protein phosphorylation maintains the normal function of cloned human Cav2.3 channels.

Neumaier F, Alpdogan S, Hescheler J, Schneider T.

J Gen Physiol. 2018 Mar 5;150(3):491-510. doi: 10.1085/jgp.201711880. Epub 2018 Feb 16.


Skeletal Extracellular Matrix Supports Cardiac Differentiation of Embryonic Stem Cells: a Potential Scaffold for Engineered Cardiac Tissue.

Hong X, Yuan Y, Sun X, Zhou M, Guo G, Zhang Q, Hescheler J, Xi J.

Cell Physiol Biochem. 2018;45(1):319-331. doi: 10.1159/000486813. Epub 2018 Jan 19.


Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells.

Nemade H, Chaudhari U, Acharya A, Hescheler J, Hengstler JG, Papadopoulos S, Sachinidis A.

Arch Toxicol. 2018 Apr;92(4):1507-1524. doi: 10.1007/s00204-018-2170-7. Epub 2018 Feb 3.


Unconjugated bilirubin modulates neuronal signaling only in wild-type mice, but not after ablation of the R-type/Cav 2.3 voltage-gated calcium channel.

Albanna W, Neumaier F, Lüke JN, Kotliar K, Conzen C, Lindauer U, Hescheler J, Clusmann H, Schneider T, Schubert GA.

CNS Neurosci Ther. 2018 Mar;24(3):222-230. doi: 10.1111/cns.12791. Epub 2017 Dec 23.


Altered Functional Expression of β-Adrenergic Receptors in Rhesus Monkey Embryonic Stem Cell-Derived Cardiomyocytes.

Eldabah N, Nembo EN, Penner M, Semmler J, Swelem R, Hassab A, Molcanyi M, Hescheler J, Nguemo F.

Stem Cells Dev. 2018 Mar 1;27(5):336-346. doi: 10.1089/scd.2017.0053. Epub 2018 Feb 12.


Puerarin Enhances Ca2+ Reuptake and Ca2+ Content of Sarcoplasmic Reticulum in Murine Embryonic Stem Cell-Derived Cardiomyocytes via Upregulation of SERCA2a.

Wang L, Cui Y, Liu Q, Song Y, Hu Q, Tang M, Hescheler J, Xi J.

Cell Physiol Biochem. 2017;44(3):1199-1212. doi: 10.1159/000485450. Epub 2017 Nov 28.


Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo.

Dibué-Adjei M, Kamp MA, Alpdogan S, Tevoufouet EE, Neiss WF, Hescheler J, Schneider T.

Cell Physiol Biochem. 2017;44(3):935-947. doi: 10.1159/000485361. Epub 2017 Nov 24.


Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.

Semmler J, Kormann J, Srinivasan SP, Köster A, Sälzer D, Reppel M, Hescheler J, Plomann M, Nguemo F.

Pharmacol Res. 2018 Feb;128:200-210. doi: 10.1016/j.phrs.2017.10.004. Epub 2017 Oct 28.


Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives.

Gaspar JA, Srinivasan SP, Sureshkumar P, Doss MX, Hescheler J, Papadopoulos S, Sachinidis A.

Sci Rep. 2017 Oct 27;7(1):14285. doi: 10.1038/s41598-017-14561-z.


A practical guide to the preparation and use of metal ion-buffered systems for physiological research.

Neumaier F, Alpdogan S, Hescheler J, Schneider T.

Acta Physiol (Oxf). 2018 Mar;222(3). doi: 10.1111/apha.12988. Epub 2017 Nov 12. Review.


Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes.

Chaudhari U, Nemade H, Sureshkumar P, Vinken M, Ates G, Rogiers V, Hescheler J, Hengstler JG, Sachinidis A.

Arch Toxicol. 2018 Jan;92(1):371-381. doi: 10.1007/s00204-017-2065-z. Epub 2017 Sep 22.


From state-of-the-art cell therapy to endogenous cardiac repair.

Mohl W, Henry TD, Milasinovic D, Nguemo F, Hescheler J, Perin EC.

EuroIntervention. 2017 Aug 25;13(6):760-772. doi: 10.4244/EIJ-D-17-00467. Review.


Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina.

Albanna W, Lueke JN, Sjapic V, Kotliar K, Hescheler J, Clusmann H, Sjapic S, Alpdogan S, Schneider T, Schubert GA, Neumaier F.

Curr Eye Res. 2017 Nov;42(11):1518-1526. doi: 10.1080/02713683.2017.1339807. Epub 2017 Aug 25.


Murine Short Axis Ventricular Heart Slices for Electrophysiological Studies.

Peinkofer G, Hescheler J, Halbach M.

J Vis Exp. 2017 Jun 4;(124). doi: 10.3791/55725.


Decreased neural precursor cell pool in NADPH oxidase 2-deficiency: From mouse brain to neural differentiation of patient derived iPSC.

Nayernia Z, Colaianna M, Robledinos-Antón N, Gutzwiller E, Sloan-Béna F, Stathaki E, Hibaoui Y, Cuadrado A, Hescheler J, Stasia MJ, Saric T, Jaquet V, Krause KH.

Redox Biol. 2017 Oct;13:82-93. doi: 10.1016/j.redox.2017.04.026. Epub 2017 Apr 24.


STRIP2 Is Indispensable for the Onset of Embryonic Stem Cell Differentiation.

Sabour D, Srinivasan SP, Rohani S, Wagh V, Gaspar JA, Panek D, Ardestani MA, Doss MX, Riet N, Abken H, Hescheler J, Papadopoulos S, Sachinidis A.

Mol Ther Methods Clin Dev. 2017 Apr 14;5:116-129. doi: 10.1016/j.omtm.2017.04.001. eCollection 2017 Jun 16.


Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes.

Chaudhari U, Ellis JK, Wagh V, Nemade H, Hescheler J, Keun HC, Sachinidis A.

Amino Acids. 2017 Dec;49(12):1955-1963. doi: 10.1007/s00726-017-2419-0. Epub 2017 Apr 18.


Rapid establishment of the European Bank for induced Pluripotent Stem Cells (EBiSC) - the Hot Start experience.

De Sousa PA, Steeg R, Wachter E, Bruce K, King J, Hoeve M, Khadun S, McConnachie G, Holder J, Kurtz A, Seltmann S, Dewender J, Reimann S, Stacey G, O'Shea O, Chapman C, Healy L, Zimmermann H, Bolton B, Rawat T, Atkin I, Veiga A, Kuebler B, Serano BM, Saric T, Hescheler J, Brüstle O, Peitz M, Thiele C, Geijsen N, Holst B, Clausen C, Lako M, Armstrong L, Gupta SK, Kvist AJ, Hicks R, Jonebring A, Brolén G, Ebneth A, Cabrera-Socorro A, Foerch P, Geraerts M, Stummann TC, Harmon S, George C, Streeter I, Clarke L, Parkinson H, Harrison PW, Faulconbridge A, Cherubin L, Burdett T, Trigueros C, Patel MJ, Lucas C, Hardy B, Predan R, Dokler J, Brajnik M, Keminer O, Pless O, Gribbon P, Claussen C, Ringwald A, Kreisel B, Courtney A, Allsopp TE.

Stem Cell Res. 2017 Apr;20:105-114. doi: 10.1016/j.scr.2017.03.002. Epub 2017 Mar 7.


Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor.

Jovancevic N, Dendorfer A, Matzkies M, Kovarova M, Heckmann JC, Osterloh M, Boehm M, Weber L, Nguemo F, Semmler J, Hescheler J, Milting H, Schleicher E, Gelis L, Hatt H.

Basic Res Cardiol. 2017 Mar;112(2):13. doi: 10.1007/s00395-017-0600-y. Epub 2017 Jan 23.


Mesenchymal stem cells-seeded bio-ceramic construct for bone regeneration in large critical-size bone defect in rabbit.

Maiti SK, Ninu AR, Sangeetha P, Mathew DD, Tamilmahan P, Kritaniya D, Kumar N, Hescheler J.

J Stem Cells Regen Med. 2016 Nov 29;12(2):87-99. eCollection 2016.

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