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Items: 1 to 50 of 65

2.

Antibacterial properties and clinical potential of pleuromutilins.

Goethe O, Heuer A, Ma X, Wang Z, Herzon SB.

Nat Prod Rep. 2018 Jul 6. doi: 10.1039/c8np00042e. [Epub ahead of print] Review.

PMID:
29979463
3.

Directed C-H Bond Oxidation of (+)-Pleuromutilin.

Ma X, Kucera R, Goethe OF, Murphy SK, Herzon SB.

J Org Chem. 2018 Jul 6;83(13):6843-6892. doi: 10.1021/acs.joc.8b00462. Epub 2018 May 1.

PMID:
29664634
4.

DNA Repair: Unconventional Lesions Require Unconventional Repair.

Herzon SB.

Biochemistry. 2018 Feb 20;57(7):1057-1058. doi: 10.1021/acs.biochem.7b01241. Epub 2018 Feb 6. No abstract available.

PMID:
29406697
5.

ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.

Tripathi P, Shine EE, Healy AR, Kim CS, Herzon SB, Bruner SD, Crawford JM.

J Am Chem Soc. 2017 Dec 13;139(49):17719-17722. doi: 10.1021/jacs.7b09971. Epub 2017 Nov 28.

PMID:
29112397
6.

Development of a Modular Synthetic Route to (+)-Pleuromutilin, (+)-12-epi-Mutilins, and Related Structures.

Zeng M, Murphy SK, Herzon SB.

J Am Chem Soc. 2017 Nov 15;139(45):16377-16388. doi: 10.1021/jacs.7b09869. Epub 2017 Nov 2.

PMID:
29048164
7.

A complex stereochemical relay approach to the antimalarial alkaloid ocimicide A1. Evidence for a structural revision.

Nikolayevskiy H, Moe Tun MK, Rablen PR, Ben Mamoun C, Herzon SB.

Chem Sci. 2017 Jul 1;8(7):4867-4871. doi: 10.1039/c7sc01127j. Epub 2017 May 4.

8.

The Mechanism of Action of (-)-Lomaiviticin A.

Herzon SB.

Acc Chem Res. 2017 Oct 17;50(10):2577-2588. doi: 10.1021/acs.accounts.7b00347. Epub 2017 Sep 28.

9.

Introduction: Natural Product Synthesis.

Herzon SB, Vanderwal CD.

Chem Rev. 2017 Sep 27;117(18):11649-11650. doi: 10.1021/acs.chemrev.7b00520. No abstract available.

PMID:
28950704
10.

Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective.

Healy AR, Herzon SB.

J Am Chem Soc. 2017 Oct 25;139(42):14817-14824. doi: 10.1021/jacs.7b07807. Epub 2017 Oct 12. Review.

PMID:
28949546
11.

Scalable Synthesis of a Key Intermediate for the Production of Pleuromutilin-Based Antibiotics.

Murphy SK, Zeng M, Herzon SB.

Org Lett. 2017 Sep 15;19(18):4980-4983. doi: 10.1021/acs.orglett.7b02476. Epub 2017 Aug 31.

PMID:
28858512
12.

Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway.

Guntaka NS, Healy AR, Crawford JM, Herzon SB, Bruner SD.

ACS Chem Biol. 2017 Oct 20;12(10):2598-2608. doi: 10.1021/acschembio.7b00479. Epub 2017 Sep 8.

PMID:
28846367
13.

A modular and enantioselective synthesis of the pleuromutilin antibiotics.

Murphy SK, Zeng M, Herzon SB.

Science. 2017 Jun 2;356(6341):956-959. doi: 10.1126/science.aan0003.

PMID:
28572392
14.

Hydroheteroarylation of Unactivated Alkenes Using N-Methoxyheteroarenium Salts.

Ma X, Dang H, Rose JA, Rablen P, Herzon SB.

J Am Chem Soc. 2017 Apr 26;139(16):5998-6007. doi: 10.1021/jacs.7b02388. Epub 2017 Apr 12.

PMID:
28359149
15.

Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.

Trautman EP, Healy AR, Shine EE, Herzon SB, Crawford JM.

J Am Chem Soc. 2017 Mar 22;139(11):4195-4201. doi: 10.1021/jacs.7b00659. Epub 2017 Mar 10.

16.

Mechanism of Nucleophilic Activation of (-)-Lomaiviticin A.

Xue M, Herzon SB.

J Am Chem Soc. 2016 Dec 7;138(48):15559-15562. Epub 2016 Nov 28.

17.

A Mechanistic Model for Colibactin-Induced Genotoxicity.

Healy AR, Nikolayevskiy H, Patel JR, Crawford JM, Herzon SB.

J Am Chem Soc. 2016 Dec 7;138(48):15563-15570. Epub 2016 Nov 28.

18.

Stereoselective Multicomponent Reactions Using Zincate Nucleophiles: β-Dicarbonyl Synthesis and Functionalization.

Murphy SK, Zeng M, Herzon SB.

Org Lett. 2016 Oct 7;18(19):4880-4883. Epub 2016 Sep 27.

PMID:
27670226
19.

Synthesis of Ketones and Esters from Heteroatom-Functionalized Alkenes by Cobalt-Mediated Hydrogen Atom Transfer.

Ma X, Herzon SB.

J Org Chem. 2016 Oct 7;81(19):8673-8695. Epub 2016 Sep 26.

PMID:
27598718
20.

Intermolecular Hydropyridylation of Unactivated Alkenes.

Ma X, Herzon SB.

J Am Chem Soc. 2016 Jul 20;138(28):8718-21. doi: 10.1021/jacs.6b05271. Epub 2016 Jul 12.

PMID:
27384921
21.

Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.

Colis LC, Herzon SB.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3122-3126. doi: 10.1016/j.bmcl.2016.04.090. Epub 2016 Apr 30.

22.

Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.

Healy AR, Vizcaino MI, Crawford JM, Herzon SB.

J Am Chem Soc. 2016 Apr 27;138(16):5426-32. doi: 10.1021/jacs.6b02276. Epub 2016 Apr 12.

23.

Structural basis for DNA cleavage by the potent antiproliferative agent (-)-lomaiviticin A.

Woo CM, Li Z, Paulson EK, Herzon SB.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2851-6. doi: 10.1073/pnas.1519846113. Epub 2016 Feb 29.

24.

Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay.

Surovtseva YV, Jairam V, Salem AF, Sundaram RK, Bindra RS, Herzon SB.

J Am Chem Soc. 2016 Mar 23;138(11):3844-55. doi: 10.1021/jacs.6b00162. Epub 2016 Mar 9.

25.

Non-classical selectivities in the reduction of alkenes by cobalt-mediated hydrogen atom transfer.

Ma X, Herzon SB.

Chem Sci. 2015 Nov 1;6(11):6250-6255. doi: 10.1039/c5sc02476e. Epub 2015 Aug 21.

26.

A concise synthesis of (+)-batzelladine B from simple pyrrole-based starting materials.

Parr BT, Economou C, Herzon SB.

Nature. 2015 Sep 24;525(7570):507-10. doi: 10.1038/nature14902. Epub 2015 Sep 16.

27.

Synthesis of 1,3-Amino Alcohols, 1,3-Diols, Amines, and Carboxylic Acids from Terminal Alkynes.

Zeng M, Herzon SB.

J Org Chem. 2015 Sep 4;80(17):8604-18. doi: 10.1021/acs.joc.5b01220. Epub 2015 Aug 18.

PMID:
26203776
28.
29.

Mechanism of action studies of lomaiviticin A and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines.

Colis LC, Hegan DC, Kaneko M, Glazer PM, Herzon SB.

J Am Chem Soc. 2015 May 6;137(17):5741-7. doi: 10.1021/ja513117p. Epub 2015 Apr 22.

30.

The discovery of a novel route to highly substituted α-tropolones enables expedient entry to the core of the gukulenins.

Kats-Kagan R, Herzon SB.

Org Lett. 2015 Apr 17;17(8):2030-3. doi: 10.1021/acs.orglett.5b00841. Epub 2015 Apr 3.

PMID:
25839211
31.

Substrate-modified functional group reactivity: hasubanan and acutumine alkaloid syntheses.

King SM, Herzon SB.

J Org Chem. 2014 Oct 3;79(19):8937-47. doi: 10.1021/jo501516x. Epub 2014 Aug 19.

PMID:
25135456
32.

Analysis of diazofluorene DNA binding and damaging activity: DNA cleavage by a synthetic monomeric diazofluorene.

Woo CM, Ranjan N, Arya DP, Herzon SB.

Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9325-8. doi: 10.1002/anie.201404137. Epub 2014 Jul 9.

33.

Broad-spectrum catalysts for the ambient temperature anti-Markovnikov hydration of alkynes.

Li L, Zeng M, Herzon SB.

Angew Chem Int Ed Engl. 2014 Jul 21;53(30):7892-5. doi: 10.1002/anie.201404320. Epub 2014 Jun 25.

PMID:
24964738
34.

The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA.

Colis LC, Woo CM, Hegan DC, Li Z, Glazer PM, Herzon SB.

Nat Chem. 2014 Jun;6(6):504-10. doi: 10.1038/nchem.1944. Epub 2014 May 11.

35.

A method for the selective hydrogenation of alkenyl halides to alkyl halides.

King SM, Ma X, Herzon SB.

J Am Chem Soc. 2014 May 14;136(19):6884-7. doi: 10.1021/ja502885c. Epub 2014 Apr 30.

PMID:
24824195
36.
37.

A highly active and air-stable ruthenium complex for the ambient temperature anti-Markovnikov reductive hydration of terminal alkynes.

Zeng M, Li L, Herzon SB.

J Am Chem Soc. 2014 May 14;136(19):7058-67. doi: 10.1021/ja501738a. Epub 2014 May 1.

PMID:
24786693
38.

The Hasubanan and Acutumine Alkaloids.

King SM, Herzon SB.

Alkaloids Chem Biol. 2014;73:161-222. doi: 10.1016/B978-0-12-411565-1.00003-2. Epub 2013 Dec 25.

PMID:
26521650
39.

Temporal separation of catalytic activities allows anti-Markovnikov reductive functionalization of terminal alkynes.

Li L, Herzon SB.

Nat Chem. 2014 Jan;6(1):22-7. doi: 10.1038/nchem.1799. Epub 2013 Nov 17.

PMID:
24345942
40.

Development of enantioselective synthetic routes to the hasubanan and acutumine alkaloids.

Calandra NA, King SM, Herzon SB.

J Org Chem. 2013 Oct 18;78(20):10031-57. doi: 10.1021/jo401889b. Epub 2013 Sep 27.

PMID:
24032758
41.

Insights into lomaiviticin biosynthesis. Isolation and structure elucidation of (-)-homoseongomycin.

Woo CM, Gholap SL, Herzon SB.

J Nat Prod. 2013 Jul 26;76(7):1238-41. doi: 10.1021/np400355h. Epub 2013 Jun 26.

PMID:
23803003
42.

Direct synthesis of β-N-glycosides by the reductive glycosylation of azides with protected and native carbohydrate donors.

Zheng J, Urkalan KB, Herzon SB.

Angew Chem Int Ed Engl. 2013 Jun 3;52(23):6068-71. doi: 10.1002/anie.201301264. Epub 2013 Apr 22.

43.

Total syntheses of (-)-acutumine and (-)-dechloroacutumine.

King SM, Calandra NA, Herzon SB.

Angew Chem Int Ed Engl. 2013 Mar 25;52(13):3642-5. doi: 10.1002/anie.201210076. Epub 2013 Feb 20. No abstract available.

PMID:
23427090
44.

Regioselective reductive hydration of alkynes to form branched or linear alcohols.

Li L, Herzon SB.

J Am Chem Soc. 2012 Oct 24;134(42):17376-9. doi: 10.1021/ja307145e. Epub 2012 Oct 16.

PMID:
23072212
45.

Synthesis of (R)-(+)-4-methylcyclohex-2-ene-1-one.

Tun MK, Herzon SB.

J Org Chem. 2012 Oct 19;77(20):9422-5. doi: 10.1021/jo3017956. Epub 2012 Oct 3.

PMID:
23030397
46.

Development of enantioselective synthetic routes to (-)-kinamycin F and (-)-lomaiviticin aglycon.

Woo CM, Gholap SL, Lu L, Kaneko M, Li Z, Ravikumar PC, Herzon SB.

J Am Chem Soc. 2012 Oct 17;134(41):17262-73. doi: 10.1021/ja307497h. Epub 2012 Oct 3.

47.
48.

Room temperature, palladium-mediated P-arylation of secondary phosphine oxides.

Bloomfield AJ, Herzon SB.

Org Lett. 2012 Sep 7;14(17):4370-3. doi: 10.1021/ol301831k. Epub 2012 Aug 20.

PMID:
22905711
49.

Real-time kinetics of surfactant molecule transfer between emulsion particles probed by in situ second harmonic generation spectroscopy.

You Y, Bloomfield A, Liu J, Fu L, Herzon SB, Yan EC.

J Am Chem Soc. 2012 Mar 7;134(9):4264-8. doi: 10.1021/ja2104608. Epub 2012 Feb 24.

PMID:
22339377
50.

The pharmacology and therapeutic potential of (-)-huperzine A.

Tun MK, Herzon SB.

J Exp Pharmacol. 2012 Sep 5;4:113-23. doi: 10.2147/JEP.S27084. eCollection 2012. Review.

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